HIPHOP chemogenomics database

YBR013C_p

Putative protein of unknown function, haploid deletion mutant exhibits synthetic phenotype with alpha-synuclein

Zygosity: Homozygous strain

fixedexpanded
Profile for YBR013C / YBR013C

Click on Significant Values for Screen Details

Top fitness defect scores for YBR013C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_354	2783-3500	8.67	4.9 µM	9.07E-18	cell wall	7	2.23E-18
2	SGTC_2293	7624732	7.27	200.0 µM	5.04E-13		2	1.81E-13
3	SGTC_2767	sibutramine	7.17	71.5 µM	1.02E-12		1	3.76E-13
4	SGTC_1354	1498-1681	7.15	81.0 µM	1.18E-12		2	4.36E-13
5	SGTC_2977	9011197	6.98	71.4 µM	3.74E-12		2	1.44E-12
6	SGTC_1140	3229-1848	6.98	3.0 µM	3.96E-12		1	1.52E-12
7	SGTC_1856	st057054	6.70	55.7 µM	2.49E-11		3	1.02E-11
8	SGTC_2981	9013952	6.61	39.0 µM	4.51E-11		11	1.89E-11
9	SGTC_1788	fluconazole	5.76	20.0 µM	8.34E-9	azole & statin	32	4.20E-9
10	SGTC_2462	5162487	5.69	171.8 µM	1.26E-8		7	6.46E-9
11	SGTC_239	5hr heat shock (37°C) + mitomycin C	5.46	819.4 µM	4.39E-8	heat shock/prefoldin	14	2.35E-8
12	SGTC_413	propylparaben	5.38	100.0 µM	6.81E-8	amide catabolism	6	3.70E-8
13	SGTC_553	k007-0256	5.09	45.7 µM	3.08E-7	heme biosynthesis & mitochondrial translocase	10	1.76E-7
14	SGTC_1861	st057647	4.95	17.4 µM	6.36E-7		5	3.74E-7
15	SGTC_1390	3413-2614	4.91	145.0 µM	7.83E-7	fatty acid desaturase (OLE1)	9	4.64E-7
16	SGTC_2792	7535235	4.89	81.8 µM	8.56E-7	fatty acid desaturase (OLE1)	17	5.09E-7
17	SGTC_2384	9036245	4.88	200.0 µM	9.09E-7		18	5.41E-7
18	SGTC_1053	3366-3204	4.82	134.0 µM	1.18E-6	cell wall	18	7.10E-7
19	SGTC_2682	pyrogallin	4.77	40.0 µM	1.52E-6	copper-dependent oxidative stress	15	9.23E-7
20	SGTC_535	2293-4129	4.76	48.2 µM	1.61E-6	NEO1	44	9.78E-7

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.110	1.77E-10	YGR219W_d	YGR219W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRPL9/YGR220C
0.101	4.81E-9	YDL198C	GGC1	hom	Mitochondrial GTP/GDP transporter, essential for mitochondrial genome maintenance; has a role in mitochondrial iron transport; member of the mitochondrial carrier family
0.100	5.92E-9	YGL129C	RSM23	hom	Mitochondrial ribosomal protein of the small subunit, has similarity to mammalian apoptosis mediator proteins; null mutation prevents induction of apoptosis by overproduction of metacaspase Mca1p
0.088	3.89E-7	YJR120W	YJR120W	hom	Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.084	1.25E-6	YOR330C	MIP1	hom	Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.083	1.32E-6	YMR137C	PSO2	hom	Nuclease required for DNA single- and double-strand break repair; acts at a post-incision step in repair of breaks that result from interstrand cross-links produced by a variety of mono- and bi-functional psoralen derivatives; induced by UV-irradiation; forms nuclear foci upon DNA replication stress
0.083	1.48E-6	YJR115W_p	YJR115W_p	hom	Putative protein of unknown function; YJR115W has a paralog, ECM13, that arose from the whole genome duplication
0.082	1.77E-6	YMR098C	ATP25	hom	Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene
0.082	1.73E-6	YNL284C	MRPL10	hom	Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels
0.082	1.87E-6	YNL213C	RRG9	hom	Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.081	2.55E-6	YMR035W	IMP2	hom	Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.081	2.71E-6	YJR041C	URB2	het	Nucleolar protein required for normal metabolism of the rRNA primary transcript, proposed to be involved in ribosome biogenesis
0.080	3.28E-6	YJL041W	NSP1	het	FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nup82p, Gle2p and two other FG-nucleoporins (Nup159p and Nup116p); also found in stable complex with Nic96p and two other FG-nucleoproteins (Nup49p and Nup57p); forms foci at the nuclear periphery upon DNA replication stress
0.079	4.12E-6	YGL261C_p	PAU11_p	hom	Putative protein of unknown function and member of the seripauperin multigene family encoded mainly in subtelomeric regions; mRNA expression appears to be regulated by SUT1 and UPC2
0.079	5.26E-6	YPL001W	HAT1	hom	Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl coenzyme A, to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair