YBR013C_p

Putative protein of unknown function, haploid deletion mutant exhibits synthetic phenotype with alpha-synuclein

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR013C / YBR013C

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:4.52|P-value:4.97E-6 ID:SGTC_22|Compound:0964-0034|FD-Score:3.29|P-value:6.66E-4 ID:SGTC_113|Compound:0099-0221|FD-Score:3.88|P-value:7.47E-5 ID:SGTC_130|Compound:0136-0219|FD-Score:-3.33|P-value:4.70E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:-3.29|P-value:5.44E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:3.41|P-value:4.32E-4 ID:SGTC_223|Compound:busulfan|FD-Score:4.44|P-value:6.93E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:4.69|P-value:2.18E-6 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:5.46|P-value:4.39E-8 ID:SGTC_258|Compound:haloperidol|FD-Score:3.55|P-value:2.65E-4 ID:SGTC_323|Compound:4013-0906|FD-Score:4.22|P-value:1.81E-5 ID:SGTC_353|Compound:1988-1175|FD-Score:-3.26|P-value:5.93E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:8.67|P-value:9.07E-18 ID:SGTC_358|Compound:0075-0058|FD-Score:4.08|P-value:3.27E-5 ID:SGTC_359|Compound:0081-0058|FD-Score:3.67|P-value:1.66E-4 ID:SGTC_394|Compound:menadione|FD-Score:-3.17|P-value:8.02E-4 ID:SGTC_413|Compound:propylparaben|FD-Score:5.38|P-value:6.81E-8 ID:SGTC_470|Compound:aa-861|FD-Score:3.70|P-value:1.50E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:4.76|P-value:1.61E-6 ID:SGTC_553|Compound:k007-0256|FD-Score:5.09|P-value:3.08E-7 ID:SGTC_678|Compound:1218-2179|FD-Score:3.59|P-value:2.27E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:3.65|P-value:1.78E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:3.72|P-value:1.37E-4 ID:SGTC_890|Compound:0929-0006|FD-Score:3.22|P-value:8.40E-4 ID:SGTC_997|Compound:3996-0078|FD-Score:3.59|P-value:2.27E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:3.51|P-value:3.01E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:4.82|P-value:1.18E-6 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.42|P-value:4.17E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:3.85|P-value:8.56E-5 ID:SGTC_1140|Compound:3229-1848|FD-Score:6.98|P-value:3.96E-12 ID:SGTC_1141|Compound:3253-0389|FD-Score:3.43|P-value:4.07E-4 ID:SGTC_1142|Compound:3253-1408|FD-Score:-3.27|P-value:5.81E-4 ID:SGTC_1143|Compound:3454-2408|FD-Score:4.21|P-value:1.90E-5 ID:SGTC_1233|Compound:0325-0408|FD-Score:4.13|P-value:2.74E-5 ID:SGTC_1269|Compound:0831-0796|FD-Score:3.44|P-value:3.96E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:3.92|P-value:6.26E-5 ID:SGTC_1354|Compound:1498-1681|FD-Score:7.15|P-value:1.18E-12 ID:SGTC_1390|Compound:3413-2614|FD-Score:4.91|P-value:7.83E-7 ID:SGTC_1644|Compound:st010134|FD-Score:4.25|P-value:1.61E-5 ID:SGTC_1788|Compound:fluconazole|FD-Score:5.76|P-value:8.34E-9 ID:SGTC_1856|Compound:st057054|FD-Score:6.70|P-value:2.49E-11 ID:SGTC_1861|Compound:st057647|FD-Score:4.95|P-value:6.36E-7 ID:SGTC_1895|Compound:st058434|FD-Score:4.42|P-value:7.76E-6 ID:SGTC_1913|Compound:st060213|FD-Score:3.59|P-value:2.28E-4 ID:SGTC_1922|Compound:5578187|FD-Score:3.39|P-value:4.76E-4 ID:SGTC_1950|Compound:st077106|FD-Score:4.48|P-value:5.83E-6 ID:SGTC_2113|Compound:5491891|FD-Score:4.50|P-value:5.23E-6 ID:SGTC_2140|Compound:5586273|FD-Score:4.05|P-value:3.83E-5 ID:SGTC_2293|Compound:7624732|FD-Score:7.27|P-value:5.04E-13 ID:SGTC_2299|Compound:7976368|FD-Score:3.52|P-value:2.98E-4 ID:SGTC_2301|Compound:7769476|FD-Score:-3.25|P-value:6.20E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-3.63|P-value:1.60E-4 ID:SGTC_2319|Compound:6033012|FD-Score:4.29|P-value:1.35E-5 ID:SGTC_2327|Compound:6189656|FD-Score:4.00|P-value:4.60E-5 ID:SGTC_2332|Compound:7982454|FD-Score:3.78|P-value:1.11E-4 ID:SGTC_2333|Compound:9017922|FD-Score:4.01|P-value:4.51E-5 ID:SGTC_2334|Compound:9017922|FD-Score:3.21|P-value:8.81E-4 ID:SGTC_2376|Compound:9072922|FD-Score:-3.37|P-value:4.07E-4 ID:SGTC_2380|Compound:9035439|FD-Score:3.25|P-value:7.56E-4 ID:SGTC_2384|Compound:9036245|FD-Score:4.88|P-value:9.09E-7 ID:SGTC_2394|Compound:5221648|FD-Score:-3.48|P-value:2.74E-4 ID:SGTC_2398|Compound:5228213|FD-Score:-3.39|P-value:3.79E-4 ID:SGTC_2399|Compound:5884133|FD-Score:-3.78|P-value:8.96E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.17|P-value:9.81E-4 ID:SGTC_2462|Compound:5162487|FD-Score:5.69|P-value:1.26E-8 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.22|P-value:8.49E-4 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:3.73|P-value:1.32E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:3.21|P-value:8.75E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:3.63|P-value:1.93E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.94|P-value:5.96E-5 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.68|P-value:1.63E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:4.77|P-value:1.52E-6 ID:SGTC_2767|Compound:sibutramine|FD-Score:7.17|P-value:1.02E-12 ID:SGTC_2792|Compound:7535235|FD-Score:4.89|P-value:8.56E-7 ID:SGTC_2973|Compound:9094665|FD-Score:3.28|P-value:6.75E-4 ID:SGTC_2977|Compound:9011197|FD-Score:6.98|P-value:3.74E-12 ID:SGTC_2981|Compound:9013952|FD-Score:6.61|P-value:4.51E-11 ID:SGTC_2982|Compound:9019404|FD-Score:-3.68|P-value:1.30E-4 ID:SGTC_2988|Compound:9073640|FD-Score:3.63|P-value:1.97E-4 ID:SGTC_3045|Compound:9092950|FD-Score:-3.29|P-value:5.48E-4 ID:SGTC_3104|Compound:9120930|FD-Score:3.26|P-value:7.23E-4 ID:SGTC_3112|Compound:9123419|FD-Score:-3.40|P-value:3.64E-4 ID:SGTC_3185|Compound:9108267|FD-Score:-3.24|P-value:6.33E-4 ID:SGTC_3319|Compound:9138450|FD-Score:4.36|P-value:1.01E-5 ID:SGTC_3322|Compound:9139058|FD-Score:3.44|P-value:3.93E-4 ID:SGTC_3346|Compound:9158254|FD-Score:3.67|P-value:1.69E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:4.52|P-value:4.97E-6 ID:SGTC_22|Compound:0964-0034|FD-Score:3.29|P-value:6.66E-4 ID:SGTC_113|Compound:0099-0221|FD-Score:3.88|P-value:7.47E-5 ID:SGTC_130|Compound:0136-0219|FD-Score:-3.33|P-value:4.70E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:-3.29|P-value:5.44E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:3.41|P-value:4.32E-4 ID:SGTC_223|Compound:busulfan|FD-Score:4.44|P-value:6.93E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:4.69|P-value:2.18E-6 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:5.46|P-value:4.39E-8 ID:SGTC_258|Compound:haloperidol|FD-Score:3.55|P-value:2.65E-4 ID:SGTC_323|Compound:4013-0906|FD-Score:4.22|P-value:1.81E-5 ID:SGTC_353|Compound:1988-1175|FD-Score:-3.26|P-value:5.93E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:8.67|P-value:9.07E-18 ID:SGTC_358|Compound:0075-0058|FD-Score:4.08|P-value:3.27E-5 ID:SGTC_359|Compound:0081-0058|FD-Score:3.67|P-value:1.66E-4 ID:SGTC_394|Compound:menadione|FD-Score:-3.17|P-value:8.02E-4 ID:SGTC_413|Compound:propylparaben|FD-Score:5.38|P-value:6.81E-8 ID:SGTC_470|Compound:aa-861|FD-Score:3.70|P-value:1.50E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:4.76|P-value:1.61E-6 ID:SGTC_553|Compound:k007-0256|FD-Score:5.09|P-value:3.08E-7 ID:SGTC_678|Compound:1218-2179|FD-Score:3.59|P-value:2.27E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:3.65|P-value:1.78E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:3.72|P-value:1.37E-4 ID:SGTC_890|Compound:0929-0006|FD-Score:3.22|P-value:8.40E-4 ID:SGTC_997|Compound:3996-0078|FD-Score:3.59|P-value:2.27E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:3.51|P-value:3.01E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:4.82|P-value:1.18E-6 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.42|P-value:4.17E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:3.85|P-value:8.56E-5 ID:SGTC_1140|Compound:3229-1848|FD-Score:6.98|P-value:3.96E-12 ID:SGTC_1141|Compound:3253-0389|FD-Score:3.43|P-value:4.07E-4 ID:SGTC_1142|Compound:3253-1408|FD-Score:-3.27|P-value:5.81E-4 ID:SGTC_1143|Compound:3454-2408|FD-Score:4.21|P-value:1.90E-5 ID:SGTC_1233|Compound:0325-0408|FD-Score:4.13|P-value:2.74E-5 ID:SGTC_1269|Compound:0831-0796|FD-Score:3.44|P-value:3.96E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:3.92|P-value:6.26E-5 ID:SGTC_1354|Compound:1498-1681|FD-Score:7.15|P-value:1.18E-12 ID:SGTC_1390|Compound:3413-2614|FD-Score:4.91|P-value:7.83E-7 ID:SGTC_1644|Compound:st010134|FD-Score:4.25|P-value:1.61E-5 ID:SGTC_1788|Compound:fluconazole|FD-Score:5.76|P-value:8.34E-9 ID:SGTC_1856|Compound:st057054|FD-Score:6.70|P-value:2.49E-11 ID:SGTC_1861|Compound:st057647|FD-Score:4.95|P-value:6.36E-7 ID:SGTC_1895|Compound:st058434|FD-Score:4.42|P-value:7.76E-6 ID:SGTC_1913|Compound:st060213|FD-Score:3.59|P-value:2.28E-4 ID:SGTC_1922|Compound:5578187|FD-Score:3.39|P-value:4.76E-4 ID:SGTC_1950|Compound:st077106|FD-Score:4.48|P-value:5.83E-6 ID:SGTC_2113|Compound:5491891|FD-Score:4.50|P-value:5.23E-6 ID:SGTC_2140|Compound:5586273|FD-Score:4.05|P-value:3.83E-5 ID:SGTC_2293|Compound:7624732|FD-Score:7.27|P-value:5.04E-13 ID:SGTC_2299|Compound:7976368|FD-Score:3.52|P-value:2.98E-4 ID:SGTC_2301|Compound:7769476|FD-Score:-3.25|P-value:6.20E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-3.63|P-value:1.60E-4 ID:SGTC_2319|Compound:6033012|FD-Score:4.29|P-value:1.35E-5 ID:SGTC_2327|Compound:6189656|FD-Score:4.00|P-value:4.60E-5 ID:SGTC_2332|Compound:7982454|FD-Score:3.78|P-value:1.11E-4 ID:SGTC_2333|Compound:9017922|FD-Score:4.01|P-value:4.51E-5 ID:SGTC_2334|Compound:9017922|FD-Score:3.21|P-value:8.81E-4 ID:SGTC_2376|Compound:9072922|FD-Score:-3.37|P-value:4.07E-4 ID:SGTC_2380|Compound:9035439|FD-Score:3.25|P-value:7.56E-4 ID:SGTC_2384|Compound:9036245|FD-Score:4.88|P-value:9.09E-7 ID:SGTC_2394|Compound:5221648|FD-Score:-3.48|P-value:2.74E-4 ID:SGTC_2398|Compound:5228213|FD-Score:-3.39|P-value:3.79E-4 ID:SGTC_2399|Compound:5884133|FD-Score:-3.78|P-value:8.96E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.17|P-value:9.81E-4 ID:SGTC_2462|Compound:5162487|FD-Score:5.69|P-value:1.26E-8 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.22|P-value:8.49E-4 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:3.73|P-value:1.32E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:3.21|P-value:8.75E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:3.63|P-value:1.93E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.94|P-value:5.96E-5 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.68|P-value:1.63E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:4.77|P-value:1.52E-6 ID:SGTC_2767|Compound:sibutramine|FD-Score:7.17|P-value:1.02E-12 ID:SGTC_2792|Compound:7535235|FD-Score:4.89|P-value:8.56E-7 ID:SGTC_2973|Compound:9094665|FD-Score:3.28|P-value:6.75E-4 ID:SGTC_2977|Compound:9011197|FD-Score:6.98|P-value:3.74E-12 ID:SGTC_2981|Compound:9013952|FD-Score:6.61|P-value:4.51E-11 ID:SGTC_2982|Compound:9019404|FD-Score:-3.68|P-value:1.30E-4 ID:SGTC_2988|Compound:9073640|FD-Score:3.63|P-value:1.97E-4 ID:SGTC_3045|Compound:9092950|FD-Score:-3.29|P-value:5.48E-4 ID:SGTC_3104|Compound:9120930|FD-Score:3.26|P-value:7.23E-4 ID:SGTC_3112|Compound:9123419|FD-Score:-3.40|P-value:3.64E-4 ID:SGTC_3185|Compound:9108267|FD-Score:-3.24|P-value:6.33E-4 ID:SGTC_3319|Compound:9138450|FD-Score:4.36|P-value:1.01E-5 ID:SGTC_3322|Compound:9139058|FD-Score:3.44|P-value:3.93E-4 ID:SGTC_3346|Compound:9158254|FD-Score:3.67|P-value:1.69E-4

Top fitness defect scores for YBR013C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_354 2783-3500 8.67 4.9 µM 9.07E-18 cell wall 7 2.23E-18
2 SGTC_2293 7624732 7.27 200.0 µM 5.04E-13 2 1.81E-13
3 SGTC_2767 sibutramine 7.17 71.5 µM 1.02E-12 1 3.76E-13
4 SGTC_1354 1498-1681 7.15 81.0 µM 1.18E-12 2 4.36E-13
5 SGTC_2977 9011197 6.98 71.4 µM 3.74E-12 2 1.44E-12
6 SGTC_1140 3229-1848 6.98 3.0 µM 3.96E-12 1 1.52E-12
7 SGTC_1856 st057054 6.70 55.7 µM 2.49E-11 3 1.02E-11
8 SGTC_2981 9013952 6.61 39.0 µM 4.51E-11 11 1.89E-11
9 SGTC_1788 fluconazole 5.76 20.0 µM 8.34E-9 azole & statin 32 4.20E-9
10 SGTC_2462 5162487 5.69 171.8 µM 1.26E-8 7 6.46E-9
11 SGTC_239 5hr heat shock (37°C) + mitomycin C 5.46 819.4 µM 4.39E-8 heat shock/prefoldin 14 2.35E-8
12 SGTC_413 propylparaben 5.38 100.0 µM 6.81E-8 amide catabolism 6 3.70E-8
13 SGTC_553 k007-0256 5.09 45.7 µM 3.08E-7 heme biosynthesis & mitochondrial translocase 10 1.76E-7
14 SGTC_1861 st057647 4.95 17.4 µM 6.36E-7 5 3.74E-7
15 SGTC_1390 3413-2614 4.91 145.0 µM 7.83E-7 fatty acid desaturase (OLE1) 9 4.64E-7
16 SGTC_2792 7535235 4.89 81.8 µM 8.56E-7 fatty acid desaturase (OLE1) 17 5.09E-7
17 SGTC_2384 9036245 4.88 200.0 µM 9.09E-7 18 5.41E-7
18 SGTC_1053 3366-3204 4.82 134.0 µM 1.18E-6 cell wall 18 7.10E-7
19 SGTC_2682 pyrogallin 4.77 40.0 µM 1.52E-6 copper-dependent oxidative stress 15 9.23E-7
20 SGTC_535 2293-4129 4.76 48.2 µM 1.61E-6 NEO1 44 9.78E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.110 1.77E-10 YGR219W_d YGR219W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRPL9/YGR220C
0.101 4.81E-9 YDL198C GGC1 hom Mitochondrial GTP/GDP transporter, essential for mitochondrial genome maintenance; has a role in mitochondrial iron transport; member of the mitochondrial carrier family
0.100 5.92E-9 YGL129C RSM23 hom Mitochondrial ribosomal protein of the small subunit, has similarity to mammalian apoptosis mediator proteins; null mutation prevents induction of apoptosis by overproduction of metacaspase Mca1p
0.088 3.89E-7 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.084 1.25E-6 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.083 1.32E-6 YMR137C PSO2 hom Nuclease required for DNA single- and double-strand break repair; acts at a post-incision step in repair of breaks that result from interstrand cross-links produced by a variety of mono- and bi-functional psoralen derivatives; induced by UV-irradiation; forms nuclear foci upon DNA replication stress
0.083 1.48E-6 YJR115W_p YJR115W_p hom Putative protein of unknown function; YJR115W has a paralog, ECM13, that arose from the whole genome duplication
0.082 1.77E-6 YMR098C ATP25 hom Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene
0.082 1.73E-6 YNL284C MRPL10 hom Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels
0.082 1.87E-6 YNL213C RRG9 hom Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.081 2.55E-6 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.081 2.71E-6 YJR041C URB2 het Nucleolar protein required for normal metabolism of the rRNA primary transcript, proposed to be involved in ribosome biogenesis
0.080 3.28E-6 YJL041W NSP1 het FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nup82p, Gle2p and two other FG-nucleoporins (Nup159p and Nup116p); also found in stable complex with Nic96p and two other FG-nucleoproteins (Nup49p and Nup57p); forms foci at the nuclear periphery upon DNA replication stress
0.079 4.12E-6 YGL261C_p PAU11_p hom Putative protein of unknown function and member of the seripauperin multigene family encoded mainly in subtelomeric regions; mRNA expression appears to be regulated by SUT1 and UPC2
0.079 5.26E-6 YPL001W HAT1 hom Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl coenzyme A, to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair