YBR016W

Tail-anchored plasma membrane protein with a conserved CYSTM module; predicted to be palmitoylated; has similarity to hydrophilins, which are involved in the adaptive response to hyperosmotic conditions; YBR016W has a paralog, YDL012C, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR016W / YBR016W

Click on Significant Values for Screen Details ID:SGTC_94|Compound:0334-0113|FD-Score:-3.63|P-value:1.37E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:4.27|P-value:1.08E-5 ID:SGTC_292|Compound:k038-0015|FD-Score:-3.65|P-value:1.29E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:5.25|P-value:8.69E-8 ID:SGTC_493|Compound:zm226600|FD-Score:-3.54|P-value:1.96E-4 ID:SGTC_559|Compound:1550-0661|FD-Score:6.84|P-value:4.95E-12 ID:SGTC_652|Compound:0437-0092|FD-Score:4.22|P-value:1.37E-5 ID:SGTC_696|Compound:1560-0013|FD-Score:3.49|P-value:2.62E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:3.88|P-value:5.71E-5 ID:SGTC_723|Compound:4182-0001|FD-Score:-3.31|P-value:4.44E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:6.50|P-value:4.90E-11 ID:SGTC_814|Compound:3342-0569|FD-Score:5.12|P-value:1.77E-7 ID:SGTC_821|Compound:1114-0266|FD-Score:-3.49|P-value:2.33E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:4.36|P-value:7.14E-6 ID:SGTC_828|Compound:2074-0507|FD-Score:5.29|P-value:7.14E-8 ID:SGTC_844|Compound:0330-0132|FD-Score:3.95|P-value:4.32E-5 ID:SGTC_955|Compound:1216-0110|FD-Score:3.77|P-value:9.08E-5 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.95|P-value:4.29E-5 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.38|P-value:3.90E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:4.94|P-value:4.51E-7 ID:SGTC_1101|Compound:ebselen|FD-Score:4.03|P-value:3.11E-5 ID:SGTC_1285|Compound:0929-0069|FD-Score:3.70|P-value:1.16E-4 ID:SGTC_1323|Compound:1348-1351|FD-Score:3.90|P-value:5.32E-5 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.76|P-value:9.35E-5 ID:SGTC_1417|Compound:3966-0327|FD-Score:4.99|P-value:3.48E-7 ID:SGTC_1608|Compound:st001473|FD-Score:-4.16|P-value:1.52E-5 ID:SGTC_1617|Compound:st002906|FD-Score:3.19|P-value:7.74E-4 ID:SGTC_1744|Compound:st037937|FD-Score:3.34|P-value:4.60E-4 ID:SGTC_1758|Compound:st042942|FD-Score:5.36|P-value:4.73E-8 ID:SGTC_1783|Compound:st039459|FD-Score:3.12|P-value:9.70E-4 ID:SGTC_1909|Compound:st060837|FD-Score:6.90|P-value:3.17E-12 ID:SGTC_1914|Compound:st062367|FD-Score:7.15|P-value:5.18E-13 ID:SGTC_1935|Compound:st074532|FD-Score:3.45|P-value:2.98E-4 ID:SGTC_1960|Compound:st011366|FD-Score:3.91|P-value:5.08E-5 ID:SGTC_1973|Compound:st070275|FD-Score:4.75|P-value:1.12E-6 ID:SGTC_1974|Compound:st069448|FD-Score:4.79|P-value:9.60E-7 ID:SGTC_2017|Compound:5132927|FD-Score:4.46|P-value:4.47E-6 ID:SGTC_2106|Compound:5357045|FD-Score:4.18|P-value:1.58E-5 ID:SGTC_2121|Compound:5257820|FD-Score:4.66|P-value:1.80E-6 ID:SGTC_2368|Compound:9071271|FD-Score:3.20|P-value:7.50E-4 ID:SGTC_2442|Compound:5158906|FD-Score:4.77|P-value:1.04E-6 ID:SGTC_2471|Compound:5466956|FD-Score:3.70|P-value:1.15E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.26|P-value:5.96E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.37|P-value:6.91E-6 ID:SGTC_2623|Compound:humulene|FD-Score:4.67|P-value:1.67E-6 ID:SGTC_2819|Compound:7996655|FD-Score:4.47|P-value:4.33E-6 ID:SGTC_2916|Compound:7875993|FD-Score:3.63|P-value:1.54E-4 ID:SGTC_2927|Compound:9011802|FD-Score:4.45|P-value:4.68E-6 ID:SGTC_2929|Compound:9013348|FD-Score:6.60|P-value:2.52E-11 ID:SGTC_2934|Compound:9036370|FD-Score:3.29|P-value:5.35E-4 ID:SGTC_2954|Compound:9074818|FD-Score:3.17|P-value:8.09E-4 ID:SGTC_3032|Compound:9089427|FD-Score:4.22|P-value:1.34E-5 ID:SGTC_3146|Compound:9095609|FD-Score:-3.14|P-value:8.05E-4 ID:SGTC_3153|Compound:9100258|FD-Score:-3.14|P-value:8.20E-4 ID:SGTC_3199|Compound:9111318|FD-Score:4.63|P-value:2.09E-6 ID:SGTC_3334|Compound:9142812|FD-Score:4.19|P-value:1.53E-5 ID:SGTC_94|Compound:0334-0113|FD-Score:-3.63|P-value:1.37E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:4.27|P-value:1.08E-5 ID:SGTC_292|Compound:k038-0015|FD-Score:-3.65|P-value:1.29E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:5.25|P-value:8.69E-8 ID:SGTC_493|Compound:zm226600|FD-Score:-3.54|P-value:1.96E-4 ID:SGTC_559|Compound:1550-0661|FD-Score:6.84|P-value:4.95E-12 ID:SGTC_652|Compound:0437-0092|FD-Score:4.22|P-value:1.37E-5 ID:SGTC_696|Compound:1560-0013|FD-Score:3.49|P-value:2.62E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:3.88|P-value:5.71E-5 ID:SGTC_723|Compound:4182-0001|FD-Score:-3.31|P-value:4.44E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:6.50|P-value:4.90E-11 ID:SGTC_814|Compound:3342-0569|FD-Score:5.12|P-value:1.77E-7 ID:SGTC_821|Compound:1114-0266|FD-Score:-3.49|P-value:2.33E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:4.36|P-value:7.14E-6 ID:SGTC_828|Compound:2074-0507|FD-Score:5.29|P-value:7.14E-8 ID:SGTC_844|Compound:0330-0132|FD-Score:3.95|P-value:4.32E-5 ID:SGTC_955|Compound:1216-0110|FD-Score:3.77|P-value:9.08E-5 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.95|P-value:4.29E-5 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.38|P-value:3.90E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:4.94|P-value:4.51E-7 ID:SGTC_1101|Compound:ebselen|FD-Score:4.03|P-value:3.11E-5 ID:SGTC_1285|Compound:0929-0069|FD-Score:3.70|P-value:1.16E-4 ID:SGTC_1323|Compound:1348-1351|FD-Score:3.90|P-value:5.32E-5 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.76|P-value:9.35E-5 ID:SGTC_1417|Compound:3966-0327|FD-Score:4.99|P-value:3.48E-7 ID:SGTC_1608|Compound:st001473|FD-Score:-4.16|P-value:1.52E-5 ID:SGTC_1617|Compound:st002906|FD-Score:3.19|P-value:7.74E-4 ID:SGTC_1744|Compound:st037937|FD-Score:3.34|P-value:4.60E-4 ID:SGTC_1758|Compound:st042942|FD-Score:5.36|P-value:4.73E-8 ID:SGTC_1783|Compound:st039459|FD-Score:3.12|P-value:9.70E-4 ID:SGTC_1909|Compound:st060837|FD-Score:6.90|P-value:3.17E-12 ID:SGTC_1914|Compound:st062367|FD-Score:7.15|P-value:5.18E-13 ID:SGTC_1935|Compound:st074532|FD-Score:3.45|P-value:2.98E-4 ID:SGTC_1960|Compound:st011366|FD-Score:3.91|P-value:5.08E-5 ID:SGTC_1973|Compound:st070275|FD-Score:4.75|P-value:1.12E-6 ID:SGTC_1974|Compound:st069448|FD-Score:4.79|P-value:9.60E-7 ID:SGTC_2017|Compound:5132927|FD-Score:4.46|P-value:4.47E-6 ID:SGTC_2106|Compound:5357045|FD-Score:4.18|P-value:1.58E-5 ID:SGTC_2121|Compound:5257820|FD-Score:4.66|P-value:1.80E-6 ID:SGTC_2368|Compound:9071271|FD-Score:3.20|P-value:7.50E-4 ID:SGTC_2442|Compound:5158906|FD-Score:4.77|P-value:1.04E-6 ID:SGTC_2471|Compound:5466956|FD-Score:3.70|P-value:1.15E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.26|P-value:5.96E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.37|P-value:6.91E-6 ID:SGTC_2623|Compound:humulene|FD-Score:4.67|P-value:1.67E-6 ID:SGTC_2819|Compound:7996655|FD-Score:4.47|P-value:4.33E-6 ID:SGTC_2916|Compound:7875993|FD-Score:3.63|P-value:1.54E-4 ID:SGTC_2927|Compound:9011802|FD-Score:4.45|P-value:4.68E-6 ID:SGTC_2929|Compound:9013348|FD-Score:6.60|P-value:2.52E-11 ID:SGTC_2934|Compound:9036370|FD-Score:3.29|P-value:5.35E-4 ID:SGTC_2954|Compound:9074818|FD-Score:3.17|P-value:8.09E-4 ID:SGTC_3032|Compound:9089427|FD-Score:4.22|P-value:1.34E-5 ID:SGTC_3146|Compound:9095609|FD-Score:-3.14|P-value:8.05E-4 ID:SGTC_3153|Compound:9100258|FD-Score:-3.14|P-value:8.20E-4 ID:SGTC_3199|Compound:9111318|FD-Score:4.63|P-value:2.09E-6 ID:SGTC_3334|Compound:9142812|FD-Score:4.19|P-value:1.53E-5

Top fitness defect scores for YBR016W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1914 st062367 7.15 72.6 µM 5.18E-13 1 4.22E-13
2 SGTC_1909 st060837 6.90 51.5 µM 3.17E-12 14 2.61E-12
3 SGTC_559 1550-0661 6.84 158.0 µM 4.95E-12 1 4.09E-12
4 SGTC_2929 9013348 6.60 24.6 µM 2.52E-11 4 2.10E-11
5 SGTC_791 1348-1292 6.50 225.0 µM 4.90E-11 7 4.10E-11
6 SGTC_1758 st042942 5.36 75.2 µM 4.73E-8 5 4.12E-8
7 SGTC_828 2074-0507 5.29 139.0 µM 7.14E-8 RPP1 & pyrimidine depletion 8 6.24E-8
8 SGTC_454 lyso-paf C-16 5.25 6.7 µM 8.69E-8 1 7.60E-8
9 SGTC_814 3342-0569 5.12 96.0 µM 1.77E-7 8 1.55E-7
10 SGTC_1417 3966-0327 4.99 90.4 µM 3.48E-7 5 3.07E-7
11 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 4.94 15.5 µM 4.51E-7 10 3.99E-7
12 SGTC_1974 st069448 4.79 26.9 µM 9.60E-7 12 8.52E-7
13 SGTC_2442 5158906 4.77 48.5 µM 1.04E-6 9 9.21E-7
14 SGTC_1973 st070275 4.75 50.2 µM 1.12E-6 5 9.99E-7
15 SGTC_2623 humulene 4.67 100.0 µM 1.67E-6 10 1.49E-6
16 SGTC_2121 5257820 4.66 149.6 µM 1.80E-6 5 1.60E-6
17 SGTC_3199 9111318 4.63 49.5 µM 2.09E-6 12 1.86E-6
18 SGTC_2819 7996655 4.47 46.4 µM 4.33E-6 11 3.88E-6
19 SGTC_2017 5132927 4.46 60.6 µM 4.47E-6 19 4.01E-6
20 SGTC_2927 9011802 4.45 47.9 µM 4.68E-6 16 4.20E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.096 2.47E-8 YJL147C_p YJL147C_p hom Mitochondrial protein of unknown function; homozygous diploid deletion strain has a sporulation defect characterized by elevated dityrosine in the soluble fraction; expression induced by calcium shortage; YJL147W is a non-essential gene
0.093 5.79E-8 YGR204W ADE3 hom Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine
0.088 3.20E-7 YGR010W NMA2 hom Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in de novo and salvage synthesis of NAD(+); NMA2 has a paralog, NMA1, that arose from the whole genome duplication
0.088 3.54E-7 YMR023C MSS1 hom Mitochondrial protein, forms a heterodimer complex with Mto1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; similar to human GTPBP3
0.082 1.71E-6 YOR235W_d IRC13_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays increased levels of spontaneous Rad52 foci
0.076 1.10E-5 YGR061C ADE6 hom Formylglycinamidine-ribonucleotide (FGAM)-synthetase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway
0.072 2.70E-5 YDR089W YDR089W hom Protein of unknown function; deletion confers resistance to nickel; contains an SPX domain, which is found in proteins involved in phosphate homeostasis; relocalizes from vacuole to cytoplasm upon DNA replication stress
0.072 3.06E-5 YNL108C_p YNL108C_p hom Putative protein of unknown function; similar to prokaryotic phosphotransfer enzymes; null mutant shows alterations in glucose metabolism; GFP-fusion protein localizes to the cytoplasm and nucleus; YNL108C has a paralog, TFC7, that arose from the whole genome duplication
0.070 5.01E-5 YOL057W YOL057W hom Dipeptidyl-peptidase III; cleaves dipeptides from the amino terminus of target proteins; highly active on synthetic substrate Arg-Arg-2-naphthylamide; mammalian ortholog may be a biomarker for some cancers
0.068 8.17E-5 YPL192C PRM3 hom Pheromone-regulated protein required for nuclear envelope fusion during karyogamy; localizes to the outer face of the nuclear membrane; interacts with Kar5p at the spindle pole body
0.068 8.32E-5 YHR044C DOG1 hom 2-deoxyglucose-6-phosphate phosphatase; paralogous to DOG2; member of a family of low molecular weight phosphatases; confers 2-deoxyglucose resistance when overexpressed, in vivo substrate has not yet been identified
0.068 8.38E-5 YPL248C GAL4 hom DNA-binding transcription factor required for the activation of the GAL genes in response to galactose; repressed by Gal80p and activated by Gal3p
0.067 1.03E-4 YCR071C IMG2 hom Mitochondrial ribosomal protein of the large subunit
0.066 1.29E-4 YNR058W BIO3 hom 7,8-diamino-pelargonic acid aminotransferase (DAPA), catalyzes the second step in the biotin biosynthesis pathway; BIO3 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis
0.065 1.63E-4 YPR182W SMX3 het Core Sm protein Sm F; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm F