YBR018C / GAL7

Galactose-1-phosphate uridyl transferase, synthesizes glucose-1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolism

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR018C / GAL7

Click on Significant Values for Screen Details ID:SGTC_46|Compound:0329-0187a|FD-Score:-4.43|P-value:1.26E-6 ID:SGTC_163|Compound:1327-0036|FD-Score:-2.94|P-value:8.63E-4 ID:SGTC_192|Compound:3455-0609|FD-Score:3.31|P-value:2.73E-4 ID:SGTC_195|Compound:4234-0266|FD-Score:5.18|P-value:2.74E-8 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:4.66|P-value:5.27E-7 ID:SGTC_610|Compound:4215-0184|FD-Score:3.10|P-value:6.04E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:3.00|P-value:8.75E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:3.02|P-value:8.04E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:3.40|P-value:1.87E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:6.21|P-value:3.61E-11 ID:SGTC_946|Compound:3434-1334|FD-Score:3.10|P-value:6.01E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:3.74|P-value:4.65E-5 ID:SGTC_952|Compound:1185-0122|FD-Score:7.67|P-value:4.04E-16 ID:SGTC_1040|Compound:k898-0338|FD-Score:-3.06|P-value:5.47E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:4.65|P-value:5.41E-7 ID:SGTC_1214|Compound:0358-0031|FD-Score:-3.23|P-value:2.91E-4 ID:SGTC_1626|Compound:st003712|FD-Score:4.10|P-value:8.98E-6 ID:SGTC_1633|Compound:st005664|FD-Score:3.17|P-value:4.70E-4 ID:SGTC_1643|Compound:st009866|FD-Score:-2.91|P-value:9.53E-4 ID:SGTC_1649|Compound:st011737|FD-Score:3.72|P-value:4.97E-5 ID:SGTC_1766|Compound:st045414|FD-Score:6.07|P-value:9.21E-11 ID:SGTC_1768|Compound:st044301|FD-Score:3.23|P-value:3.72E-4 ID:SGTC_1804|Compound:st050076|FD-Score:3.19|P-value:4.36E-4 ID:SGTC_1987|Compound:st072290|FD-Score:3.04|P-value:7.52E-4 ID:SGTC_2180|Compound:6301957|FD-Score:-3.04|P-value:6.08E-4 ID:SGTC_2191|Compound:5911152|FD-Score:3.07|P-value:6.66E-4 ID:SGTC_2201|Compound:6605497|FD-Score:3.18|P-value:4.51E-4 ID:SGTC_2216|Compound:7189485|FD-Score:3.22|P-value:3.80E-4 ID:SGTC_2218|Compound:6965428|FD-Score:5.32|P-value:1.20E-8 ID:SGTC_2266|Compound:7929956|FD-Score:3.23|P-value:3.68E-4 ID:SGTC_2277|Compound:7947813|FD-Score:-3.15|P-value:3.94E-4 ID:SGTC_2284|Compound:7945075|FD-Score:3.48|P-value:1.37E-4 ID:SGTC_2286|Compound:7945697|FD-Score:-3.43|P-value:1.29E-4 ID:SGTC_2478|Compound:5763493|FD-Score:6.03|P-value:1.27E-10 ID:SGTC_2482|Compound:5981709|FD-Score:3.99|P-value:1.48E-5 ID:SGTC_2488|Compound:5268135|FD-Score:-4.35|P-value:1.87E-6 ID:SGTC_2533|Compound:agelasine|FD-Score:-2.90|P-value:9.80E-4 ID:SGTC_2570|Compound:licareol|FD-Score:4.27|P-value:3.93E-6 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.93|P-value:2.00E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:-2.96|P-value:8.01E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:-3.55|P-value:8.04E-5 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:5.19|P-value:2.69E-8 ID:SGTC_2741|Compound:miltefosine|FD-Score:5.29|P-value:1.46E-8 ID:SGTC_2742|Compound:clothiapine|FD-Score:3.56|P-value:9.84E-5 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.49|P-value:1.30E-4 ID:SGTC_2783|Compound:7738165|FD-Score:4.84|P-value:1.96E-7 ID:SGTC_2835|Compound:9006588|FD-Score:-3.85|P-value:2.12E-5 ID:SGTC_2853|Compound:9015042|FD-Score:-3.61|P-value:6.06E-5 ID:SGTC_3009|Compound:9080819|FD-Score:3.15|P-value:5.00E-4 ID:SGTC_3056|Compound:9094900|FD-Score:3.18|P-value:4.57E-4 ID:SGTC_3077|Compound:9117319|FD-Score:4.38|P-value:2.26E-6 ID:SGTC_3090|Compound:9117696|FD-Score:3.05|P-value:7.22E-4 ID:SGTC_3129|Compound:9127257|FD-Score:-3.24|P-value:2.81E-4 ID:SGTC_3235|Compound:9132602|FD-Score:3.53|P-value:1.13E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:-4.43|P-value:1.26E-6 ID:SGTC_163|Compound:1327-0036|FD-Score:-2.94|P-value:8.63E-4 ID:SGTC_192|Compound:3455-0609|FD-Score:3.31|P-value:2.73E-4 ID:SGTC_195|Compound:4234-0266|FD-Score:5.18|P-value:2.74E-8 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:4.66|P-value:5.27E-7 ID:SGTC_610|Compound:4215-0184|FD-Score:3.10|P-value:6.04E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:3.00|P-value:8.75E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:3.02|P-value:8.04E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:3.40|P-value:1.87E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:6.21|P-value:3.61E-11 ID:SGTC_946|Compound:3434-1334|FD-Score:3.10|P-value:6.01E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:3.74|P-value:4.65E-5 ID:SGTC_952|Compound:1185-0122|FD-Score:7.67|P-value:4.04E-16 ID:SGTC_1040|Compound:k898-0338|FD-Score:-3.06|P-value:5.47E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:4.65|P-value:5.41E-7 ID:SGTC_1214|Compound:0358-0031|FD-Score:-3.23|P-value:2.91E-4 ID:SGTC_1626|Compound:st003712|FD-Score:4.10|P-value:8.98E-6 ID:SGTC_1633|Compound:st005664|FD-Score:3.17|P-value:4.70E-4 ID:SGTC_1643|Compound:st009866|FD-Score:-2.91|P-value:9.53E-4 ID:SGTC_1649|Compound:st011737|FD-Score:3.72|P-value:4.97E-5 ID:SGTC_1766|Compound:st045414|FD-Score:6.07|P-value:9.21E-11 ID:SGTC_1768|Compound:st044301|FD-Score:3.23|P-value:3.72E-4 ID:SGTC_1804|Compound:st050076|FD-Score:3.19|P-value:4.36E-4 ID:SGTC_1987|Compound:st072290|FD-Score:3.04|P-value:7.52E-4 ID:SGTC_2180|Compound:6301957|FD-Score:-3.04|P-value:6.08E-4 ID:SGTC_2191|Compound:5911152|FD-Score:3.07|P-value:6.66E-4 ID:SGTC_2201|Compound:6605497|FD-Score:3.18|P-value:4.51E-4 ID:SGTC_2216|Compound:7189485|FD-Score:3.22|P-value:3.80E-4 ID:SGTC_2218|Compound:6965428|FD-Score:5.32|P-value:1.20E-8 ID:SGTC_2266|Compound:7929956|FD-Score:3.23|P-value:3.68E-4 ID:SGTC_2277|Compound:7947813|FD-Score:-3.15|P-value:3.94E-4 ID:SGTC_2284|Compound:7945075|FD-Score:3.48|P-value:1.37E-4 ID:SGTC_2286|Compound:7945697|FD-Score:-3.43|P-value:1.29E-4 ID:SGTC_2478|Compound:5763493|FD-Score:6.03|P-value:1.27E-10 ID:SGTC_2482|Compound:5981709|FD-Score:3.99|P-value:1.48E-5 ID:SGTC_2488|Compound:5268135|FD-Score:-4.35|P-value:1.87E-6 ID:SGTC_2533|Compound:agelasine|FD-Score:-2.90|P-value:9.80E-4 ID:SGTC_2570|Compound:licareol|FD-Score:4.27|P-value:3.93E-6 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.93|P-value:2.00E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:-2.96|P-value:8.01E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:-3.55|P-value:8.04E-5 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:5.19|P-value:2.69E-8 ID:SGTC_2741|Compound:miltefosine|FD-Score:5.29|P-value:1.46E-8 ID:SGTC_2742|Compound:clothiapine|FD-Score:3.56|P-value:9.84E-5 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.49|P-value:1.30E-4 ID:SGTC_2783|Compound:7738165|FD-Score:4.84|P-value:1.96E-7 ID:SGTC_2835|Compound:9006588|FD-Score:-3.85|P-value:2.12E-5 ID:SGTC_2853|Compound:9015042|FD-Score:-3.61|P-value:6.06E-5 ID:SGTC_3009|Compound:9080819|FD-Score:3.15|P-value:5.00E-4 ID:SGTC_3056|Compound:9094900|FD-Score:3.18|P-value:4.57E-4 ID:SGTC_3077|Compound:9117319|FD-Score:4.38|P-value:2.26E-6 ID:SGTC_3090|Compound:9117696|FD-Score:3.05|P-value:7.22E-4 ID:SGTC_3129|Compound:9127257|FD-Score:-3.24|P-value:2.81E-4 ID:SGTC_3235|Compound:9132602|FD-Score:3.53|P-value:1.13E-4

Top fitness defect scores for YBR018C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_952 1185-0122 7.67 232.0 µM 4.04E-16 1 8.88E-15
2 SGTC_884 0851-0618 6.21 334.0 µM 3.61E-11 1 2.67E-10
3 SGTC_1766 st045414 6.07 44.8 µM 9.21E-11 RPP1 & pyrimidine depletion 6 6.23E-10
4 SGTC_2478 5763493 6.03 32.3 µM 1.27E-10 10 8.33E-10
5 SGTC_2218 6965428 5.32 193.0 µM 1.20E-8 TSC3-RPN4 4 5.12E-8
6 SGTC_2741 miltefosine 5.29 3.0 µM 1.46E-8 24 6.15E-8
7 SGTC_2634 4'-methoxyflavone 5.19 100.0 µM 2.69E-8 10 1.07E-7
8 SGTC_195 4234-0266 5.18 16.6 µM 2.74E-8 13 1.08E-7
9 SGTC_2783 7738165 4.84 71.4 µM 1.96E-7 13 6.48E-7
10 SGTC_423 5-fluorouracil 4.66 457.0 µM 5.27E-7 exosome 10 1.59E-6
11 SGTC_1166 k206-0078 4.65 225.0 µM 5.41E-7 7 1.63E-6
12 SGTC_3077 9117319 4.38 49.5 µM 2.26E-6 11 5.96E-6
13 SGTC_2570 licareol 4.27 100.0 µM 3.93E-6 22 9.84E-6
14 SGTC_1626 st003712 4.10 1.8 µM 8.98E-6 20 2.09E-5
15 SGTC_2482 5981709 3.99 142.7 µM 1.48E-5 PDR1 35 3.30E-5
16 SGTC_2571 chrysanthemic acid 3.93 100.0 µM 2.00E-5 17 4.32E-5
17 SGTC_950 1165-0508 3.74 94.1 µM 4.65E-5 36 9.31E-5
18 SGTC_1649 st011737 3.72 51.3 µM 4.97E-5 34 9.91E-5
19 SGTC_2742 clothiapine 3.56 36.3 µM 9.84E-5 NEO1 19 1.85E-4
20 SGTC_3235 9132602 3.53 49.5 µM 1.13E-4 36 2.09E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.117 9.66E-12 YLR336C SGD1 het Essential nuclear protein, required for biogenesis of the small ribosomal subunit; has a possible role in the osmoregulatory glycerol response; putative homolog of human NOM1 which is implicated in acute myeloid leukemia
0.107 5.47E-10 YKL172W EBP2 het Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering
0.100 6.26E-9 YPL044C_d YPL044C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP4/YPL043W
0.098 1.36E-8 YCL028W RNQ1 hom [PIN(+)] prion, an infectious protein conformation that is generally an ordered protein aggregate
0.097 2.07E-8 YPL043W NOP4 het Nucleolar protein, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs)
0.090 1.62E-7 YNL160W YGP1 hom Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; has similarity to Sps100p
0.087 3.94E-7 YGR195W SKI6 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4)
0.085 8.87E-7 YDL046W NPC2 hom Functional homolog of human NPC2/He1, which is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomes
0.082 1.98E-6 YOL077C BRX1 het Nucleolar protein, constituent of 66S pre-ribosomal particles; depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subunits; possesses a sigma(70)-like RNA-binding motif
0.080 3.95E-6 YNL181W_p YNL181W_p het Putative oxidoreductase; required for cell viability
0.079 6.55E-6 YKR099W BAS1 hom Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes
0.077 8.91E-6 YLR093C NYV1 hom v-SNARE component of the vacuolar SNARE complex involved in vesicle fusion; inhibits ATP-dependent Ca(2+) transport activity of Pmc1p in the vacuolar membrane
0.077 9.08E-6 YDR426C_d YDR426C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SNX41
0.075 1.25E-5 YOR059C YOR059C hom Lipid particle protein of unknown function; contains a putative lipase serine active site; induced by transcription factor Rpn4p; protein abundance increases in response to DNA replication stress
0.072 3.13E-5 YDR509W_d YDR509W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data