YBR021W / FUR4

Plasma membrane localized uracil permease; expression is tightly regulated by uracil levels and environmental cues; conformational alterations induced by unfolding or substrate binding result in Rsp5p-mediated ubiquitination and degradation

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR021W / FUR4

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:3.89|P-value:9.01E-4 ID:SGTC_53|Compound:0973-0023|FD-Score:11.00|P-value:2.42E-19 ID:SGTC_55|Compound:0767-0285|FD-Score:5.63|P-value:2.95E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:7.82|P-value:1.48E-10 ID:SGTC_85|Compound:0868-0259|FD-Score:6.29|P-value:2.10E-7 ID:SGTC_98|Compound:0074-0023|FD-Score:-3.94|P-value:6.25E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:4.44|P-value:1.84E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:12.00|P-value:2.35E-22 ID:SGTC_138|Compound:0850-0259|FD-Score:5.28|P-value:1.09E-5 ID:SGTC_187|Compound:1488-2104|FD-Score:4.81|P-value:5.62E-5 ID:SGTC_206|Compound:4546-0025|FD-Score:5.52|P-value:4.49E-6 ID:SGTC_298|Compound:1391-0729|FD-Score:3.87|P-value:9.68E-4 ID:SGTC_305|Compound:1682-2595|FD-Score:10.20|P-value:1.09E-16 ID:SGTC_318|Compound:1488-0629|FD-Score:-3.93|P-value:6.51E-4 ID:SGTC_328|Compound:k915-0120|FD-Score:4.29|P-value:2.86E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.95|P-value:6.16E-4 ID:SGTC_398|Compound:bronopol|FD-Score:6.87|P-value:1.56E-8 ID:SGTC_452|Compound:diindolylmethane|FD-Score:9.71|P-value:2.34E-15 ID:SGTC_467|Compound:ro 31-8220|FD-Score:9.63|P-value:4.00E-15 ID:SGTC_486|Compound:niguldipine|FD-Score:14.30|P-value:2.55E-31 ID:SGTC_512|Compound:prima-1|FD-Score:4.22|P-value:3.50E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:7.18|P-value:3.73E-9 ID:SGTC_556|Compound:4058-0063|FD-Score:6.46|P-value:1.02E-7 ID:SGTC_767|Compound:0929-0023|FD-Score:5.27|P-value:1.12E-5 ID:SGTC_786|Compound:4544-0069|FD-Score:5.41|P-value:6.76E-6 ID:SGTC_807|Compound:1315-0151|FD-Score:5.48|P-value:5.28E-6 ID:SGTC_809|Compound:3998-0021|FD-Score:10.40|P-value:2.13E-17 ID:SGTC_818|Compound:4072-2707|FD-Score:4.70|P-value:7.92E-5 ID:SGTC_882|Compound:0843-0131|FD-Score:-5.21|P-value:1.05E-5 ID:SGTC_917|Compound:harmaline|FD-Score:4.25|P-value:3.24E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:11.70|P-value:2.58E-21 ID:SGTC_974|Compound:1326-0144|FD-Score:4.20|P-value:3.80E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:4.06|P-value:5.68E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:4.50|P-value:1.51E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:12.10|P-value:5.81E-23 ID:SGTC_1202|Compound:1988-0068|FD-Score:9.34|P-value:2.47E-14 ID:SGTC_1210|Compound:3013-0140|FD-Score:4.02|P-value:6.37E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:4.42|P-value:1.95E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.93|P-value:8.12E-4 ID:SGTC_1471|Compound:k673-0312|FD-Score:12.40|P-value:6.14E-24 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:9.03|P-value:1.69E-13 ID:SGTC_1687|Compound:st020778|FD-Score:4.28|P-value:2.94E-4 ID:SGTC_1717|Compound:st033143|FD-Score:6.16|P-value:3.64E-7 ID:SGTC_1759|Compound:st043059|FD-Score:4.02|P-value:6.33E-4 ID:SGTC_1774|Compound:st048371|FD-Score:8.39|P-value:6.72E-12 ID:SGTC_1778|Compound:st046819|FD-Score:3.95|P-value:7.63E-4 ID:SGTC_1814|Compound:st052110|FD-Score:18.00|P-value:3.39E-48 ID:SGTC_1817|Compound:st052116|FD-Score:11.50|P-value:5.90E-21 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:5.58|P-value:3.63E-6 ID:SGTC_1916|Compound:st067606|FD-Score:4.42|P-value:1.94E-4 ID:SGTC_1950|Compound:st077106|FD-Score:9.16|P-value:7.69E-14 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:6.29|P-value:2.09E-7 ID:SGTC_1974|Compound:st069448|FD-Score:5.48|P-value:5.34E-6 ID:SGTC_1983|Compound:st071813|FD-Score:5.03|P-value:2.68E-5 ID:SGTC_2074|Compound:5212007|FD-Score:4.67|P-value:8.88E-5 ID:SGTC_2082|Compound:5219693|FD-Score:17.70|P-value:1.16E-46 ID:SGTC_2145|Compound:5634607|FD-Score:5.37|P-value:7.85E-6 ID:SGTC_2251|Compound:lansoprazole|FD-Score:6.94|P-value:1.16E-8 ID:SGTC_2280|Compound:7785178|FD-Score:5.15|P-value:1.73E-5 ID:SGTC_2286|Compound:7945697|FD-Score:5.71|P-value:2.17E-6 ID:SGTC_2292|Compound:7671323|FD-Score:11.70|P-value:1.65E-21 ID:SGTC_2297|Compound:7971671|FD-Score:20.40|P-value:1.54E-61 ID:SGTC_2330|Compound:7979373|FD-Score:6.97|P-value:9.81E-9 ID:SGTC_2351|Compound:9026858|FD-Score:30.70|P-value:1.55E-136 ID:SGTC_2360|Compound:9040895|FD-Score:-5.34|P-value:6.50E-6 ID:SGTC_2367|Compound:9070478|FD-Score:6.45|P-value:1.05E-7 ID:SGTC_2393|Compound:9031399|FD-Score:27.90|P-value:7.60E-113 ID:SGTC_2402|Compound:5553605|FD-Score:-3.83|P-value:8.57E-4 ID:SGTC_2437|Compound:5741531|FD-Score:4.23|P-value:3.44E-4 ID:SGTC_2444|Compound:5485484|FD-Score:3.93|P-value:8.12E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:-4.50|P-value:1.19E-4 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:4.06|P-value:5.61E-4 ID:SGTC_2523|Compound:spermine|FD-Score:-4.75|P-value:5.25E-5 ID:SGTC_2528|Compound:xanthyletin|FD-Score:4.72|P-value:7.44E-5 ID:SGTC_2551|Compound:apiole|FD-Score:5.86|P-value:1.19E-6 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:5.35|P-value:8.40E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.25|P-value:1.21E-5 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:5.11|P-value:2.01E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.92|P-value:8.47E-4 ID:SGTC_2845|Compound:9003024|FD-Score:7.69|P-value:2.85E-10 ID:SGTC_3033|Compound:9090887|FD-Score:4.27|P-value:3.04E-4 ID:SGTC_3074|Compound:9116018|FD-Score:7.55|P-value:5.81E-10 ID:SGTC_3201|Compound:9113999|FD-Score:8.35|P-value:8.20E-12 ID:SGTC_3215|Compound:9129942|FD-Score:5.01|P-value:2.87E-5 ID:SGTC_3224|Compound:9130643|FD-Score:-5.30|P-value:7.57E-6 ID:SGTC_3355|Compound:9151058|FD-Score:9.81|P-value:1.26E-15 ID:SGTC_7|Compound:0192-1582|FD-Score:3.89|P-value:9.01E-4 ID:SGTC_53|Compound:0973-0023|FD-Score:11.00|P-value:2.42E-19 ID:SGTC_55|Compound:0767-0285|FD-Score:5.63|P-value:2.95E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:7.82|P-value:1.48E-10 ID:SGTC_85|Compound:0868-0259|FD-Score:6.29|P-value:2.10E-7 ID:SGTC_98|Compound:0074-0023|FD-Score:-3.94|P-value:6.25E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:4.44|P-value:1.84E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:12.00|P-value:2.35E-22 ID:SGTC_138|Compound:0850-0259|FD-Score:5.28|P-value:1.09E-5 ID:SGTC_187|Compound:1488-2104|FD-Score:4.81|P-value:5.62E-5 ID:SGTC_206|Compound:4546-0025|FD-Score:5.52|P-value:4.49E-6 ID:SGTC_298|Compound:1391-0729|FD-Score:3.87|P-value:9.68E-4 ID:SGTC_305|Compound:1682-2595|FD-Score:10.20|P-value:1.09E-16 ID:SGTC_318|Compound:1488-0629|FD-Score:-3.93|P-value:6.51E-4 ID:SGTC_328|Compound:k915-0120|FD-Score:4.29|P-value:2.86E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.95|P-value:6.16E-4 ID:SGTC_398|Compound:bronopol|FD-Score:6.87|P-value:1.56E-8 ID:SGTC_452|Compound:diindolylmethane|FD-Score:9.71|P-value:2.34E-15 ID:SGTC_467|Compound:ro 31-8220|FD-Score:9.63|P-value:4.00E-15 ID:SGTC_486|Compound:niguldipine|FD-Score:14.30|P-value:2.55E-31 ID:SGTC_512|Compound:prima-1|FD-Score:4.22|P-value:3.50E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:7.18|P-value:3.73E-9 ID:SGTC_556|Compound:4058-0063|FD-Score:6.46|P-value:1.02E-7 ID:SGTC_767|Compound:0929-0023|FD-Score:5.27|P-value:1.12E-5 ID:SGTC_786|Compound:4544-0069|FD-Score:5.41|P-value:6.76E-6 ID:SGTC_807|Compound:1315-0151|FD-Score:5.48|P-value:5.28E-6 ID:SGTC_809|Compound:3998-0021|FD-Score:10.40|P-value:2.13E-17 ID:SGTC_818|Compound:4072-2707|FD-Score:4.70|P-value:7.92E-5 ID:SGTC_882|Compound:0843-0131|FD-Score:-5.21|P-value:1.05E-5 ID:SGTC_917|Compound:harmaline|FD-Score:4.25|P-value:3.24E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:11.70|P-value:2.58E-21 ID:SGTC_974|Compound:1326-0144|FD-Score:4.20|P-value:3.80E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:4.06|P-value:5.68E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:4.50|P-value:1.51E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:12.10|P-value:5.81E-23 ID:SGTC_1202|Compound:1988-0068|FD-Score:9.34|P-value:2.47E-14 ID:SGTC_1210|Compound:3013-0140|FD-Score:4.02|P-value:6.37E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:4.42|P-value:1.95E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.93|P-value:8.12E-4 ID:SGTC_1471|Compound:k673-0312|FD-Score:12.40|P-value:6.14E-24 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:9.03|P-value:1.69E-13 ID:SGTC_1687|Compound:st020778|FD-Score:4.28|P-value:2.94E-4 ID:SGTC_1717|Compound:st033143|FD-Score:6.16|P-value:3.64E-7 ID:SGTC_1759|Compound:st043059|FD-Score:4.02|P-value:6.33E-4 ID:SGTC_1774|Compound:st048371|FD-Score:8.39|P-value:6.72E-12 ID:SGTC_1778|Compound:st046819|FD-Score:3.95|P-value:7.63E-4 ID:SGTC_1814|Compound:st052110|FD-Score:18.00|P-value:3.39E-48 ID:SGTC_1817|Compound:st052116|FD-Score:11.50|P-value:5.90E-21 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:5.58|P-value:3.63E-6 ID:SGTC_1916|Compound:st067606|FD-Score:4.42|P-value:1.94E-4 ID:SGTC_1950|Compound:st077106|FD-Score:9.16|P-value:7.69E-14 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:6.29|P-value:2.09E-7 ID:SGTC_1974|Compound:st069448|FD-Score:5.48|P-value:5.34E-6 ID:SGTC_1983|Compound:st071813|FD-Score:5.03|P-value:2.68E-5 ID:SGTC_2074|Compound:5212007|FD-Score:4.67|P-value:8.88E-5 ID:SGTC_2082|Compound:5219693|FD-Score:17.70|P-value:1.16E-46 ID:SGTC_2145|Compound:5634607|FD-Score:5.37|P-value:7.85E-6 ID:SGTC_2251|Compound:lansoprazole|FD-Score:6.94|P-value:1.16E-8 ID:SGTC_2280|Compound:7785178|FD-Score:5.15|P-value:1.73E-5 ID:SGTC_2286|Compound:7945697|FD-Score:5.71|P-value:2.17E-6 ID:SGTC_2292|Compound:7671323|FD-Score:11.70|P-value:1.65E-21 ID:SGTC_2297|Compound:7971671|FD-Score:20.40|P-value:1.54E-61 ID:SGTC_2330|Compound:7979373|FD-Score:6.97|P-value:9.81E-9 ID:SGTC_2351|Compound:9026858|FD-Score:30.70|P-value:1.55E-136 ID:SGTC_2360|Compound:9040895|FD-Score:-5.34|P-value:6.50E-6 ID:SGTC_2367|Compound:9070478|FD-Score:6.45|P-value:1.05E-7 ID:SGTC_2393|Compound:9031399|FD-Score:27.90|P-value:7.60E-113 ID:SGTC_2402|Compound:5553605|FD-Score:-3.83|P-value:8.57E-4 ID:SGTC_2437|Compound:5741531|FD-Score:4.23|P-value:3.44E-4 ID:SGTC_2444|Compound:5485484|FD-Score:3.93|P-value:8.12E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:-4.50|P-value:1.19E-4 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:4.06|P-value:5.61E-4 ID:SGTC_2523|Compound:spermine|FD-Score:-4.75|P-value:5.25E-5 ID:SGTC_2528|Compound:xanthyletin|FD-Score:4.72|P-value:7.44E-5 ID:SGTC_2551|Compound:apiole|FD-Score:5.86|P-value:1.19E-6 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:5.35|P-value:8.40E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.25|P-value:1.21E-5 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:5.11|P-value:2.01E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.92|P-value:8.47E-4 ID:SGTC_2845|Compound:9003024|FD-Score:7.69|P-value:2.85E-10 ID:SGTC_3033|Compound:9090887|FD-Score:4.27|P-value:3.04E-4 ID:SGTC_3074|Compound:9116018|FD-Score:7.55|P-value:5.81E-10 ID:SGTC_3201|Compound:9113999|FD-Score:8.35|P-value:8.20E-12 ID:SGTC_3215|Compound:9129942|FD-Score:5.01|P-value:2.87E-5 ID:SGTC_3224|Compound:9130643|FD-Score:-5.30|P-value:7.57E-6 ID:SGTC_3355|Compound:9151058|FD-Score:9.81|P-value:1.26E-15

Top fitness defect scores for YBR021W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2351 9026858 30.70 72.3 µM 1.55E-136 RNA processing & uracil transport 1 2.23E-207
2 SGTC_2393 9031399 27.90 185.9 µM 7.60E-113 RNA processing & uracil transport 1 3.00E-171
3 SGTC_2297 7971671 20.40 152.3 µM 1.54E-61 RNA processing & uracil transport 1 5.29E-93
4 SGTC_1814 st052110 18.00 31.5 µM 3.39E-48 RNA processing & uracil transport 1 1.18E-72
5 SGTC_2082 5219693 17.70 150.0 µM 1.16E-46 RNA processing & uracil transport 1 2.57E-70
6 SGTC_486 niguldipine 14.30 82.0 µM 2.55E-31 amide catabolism 2 6.34E-47
7 SGTC_1471 k673-0312 12.40 37.0 µM 6.14E-24 RNA processing & uracil transport 1 1.13E-35
8 SGTC_1167 k781-0610 12.10 148.0 µM 5.81E-23 RNA processing & uracil transport 1 3.46E-34
9 SGTC_122 0236-0016 12.00 402.4 µM 2.35E-22 RNA processing & uracil transport 1 2.92E-33
10 SGTC_2292 7671323 11.70 168.1 µM 1.65E-21 RNA processing & uracil transport 1 5.67E-32
11 SGTC_923 1900-2434 11.70 73.3 µM 2.58E-21 RNA processing & uracil transport 1 1.12E-31
12 SGTC_1817 st052116 11.50 64.4 µM 5.90E-21 RNA processing & uracil transport 1 3.95E-31
13 SGTC_53 0973-0023 11.00 40.0 µM 2.42E-19 RNA processing & uracil transport 1 1.14E-28
14 SGTC_809 3998-0021 10.40 90.0 µM 2.13E-17 RNA processing & uracil transport 1 1.04E-25
15 SGTC_305 1682-2595 10.20 20.8 µM 1.09E-16 RNA processing & uracil transport 1 1.25E-24
16 SGTC_3355 9151058 9.81 44.0 µM 1.26E-15 RNA processing & uracil transport 1 5.18E-23
17 SGTC_452 diindolylmethane 9.71 8.0 µM 2.34E-15 RNA processing & uracil transport 1 1.32E-22
18 SGTC_467 ro 31-8220 9.63 72.8 µM 4.00E-15 calcium & mitochondrial duress 8 3.01E-22
19 SGTC_1202 1988-0068 9.34 29.6 µM 2.47E-14 RNA processing & uracil transport 2 4.79E-21
20 SGTC_1950 st077106 9.16 7.2 µM 7.69E-14 RNA processing & uracil transport 2 2.70E-20

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.200 1.98E-31 YDR469W SDC1 hom Subunit of the COMPASS (Set1C) complex, which methylates lysine 4 of histone H3 and is required in chromatin silencing at telomeres; contains a Dpy-30 domain that mediates interaction with Bre2p; similar to C. elegans and human DPY-30
0.193 1.83E-29 YBL067C UBP13 hom Putative ubiquitin-specific protease that cleaves Ub-protein fusions; UBP13 has a paralog, UBP9, that arose from the whole genome duplication
0.171 2.67E-23 YJL080C SCP160 hom Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins
0.159 1.72E-20 YOL145C CTR9 hom Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cyclin genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; contains TPR repeats
0.158 3.72E-20 YGL244W RTF1 hom Subunit of RNAPII-associated chromatin remodeling Paf1 complex; regulates gene expression by directing cotranscriptional histone modification, influences transcription and chromatin structure through several independent functional domains; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay
0.148 6.16E-18 YAL023C PMT2 hom Protein O-mannosyltransferase of the ER membrane; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; involved in ER quality control; acts in a complex with Pmt1p, can instead interact with Pmt5p; antifungal drug target; PMT2 has a paralog, PMT3, that arose from the whole genome duplication
0.144 4.23E-17 YKL037W AIM26 hom Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss; null mutation confers sensitivity to tunicamycin and DTT
0.144 4.27E-17 YGR252W GCN5 hom Acetyltransferase, modifies N-terminal lysines on histones H2B and H3; acetylates Rsc4p, a subunit of the RSC chromatin-remodeling complex, altering replication stress tolerance; catalytic subunit of the ADA and SAGA histone acetyltransferase complexes; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; greater involvement in repression of RNAPII-dependent transcription than in activation
0.144 4.44E-17 YNR060W FRE4 hom Ferric reductase, reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels
0.143 1.10E-16 YLR029C RPL15A het Ribosomal 60S subunit protein L15A; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15A has a paralog, RPL15B, that arose from the whole genome duplication
0.141 1.92E-16 YLR436C ECM30 hom Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants have abormal relative levels of mannose and glucose and have Gap1p sorting and transport defects; (GFP)-fusion protein localizes to the cytoplasm
0.141 2.83E-16 YLR418C CDC73 hom Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; protein abundance increases in response to DNA replication stress
0.138 1.09E-15 YGL215W CLG1 hom Cyclin-like protein that interacts with Pho85p; has sequence similarity to G1 cyclins PCL1 and PCL2
0.132 1.55E-14 YER133W GLC7 het Type 1 serine/threonine protein phosphatase catalytic subunit; involved in various processes including glycogen metabolism, sporulation, mitosis; accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; import into nucleus is inhibited during spindle assembly checkpoint arrest
0.130 4.79E-14 YAL038W CDC19 het Pyruvate kinase; functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration; regulated via allosteric activation by fructose bisphosphate; CDC19 has a paralog, PYK2, that arose from the whole genome duplication