YBR022W / POA1

Phosphatase that is highly specific for ADP-ribose 1''-phosphate, a tRNA splicing metabolite; may have a role in regulation of tRNA splicing

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR022W / POA1

Click on Significant Values for Screen Details ID:SGTC_20|Compound:0481-0013|FD-Score:4.14|P-value:3.28E-6 ID:SGTC_189|Compound:3970-0742|FD-Score:3.40|P-value:1.07E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:2.91|P-value:7.75E-4 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:3.48|P-value:7.68E-5 ID:SGTC_523|Compound:1934-0222|FD-Score:3.02|P-value:5.13E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:2.91|P-value:7.65E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:3.03|P-value:4.96E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:3.56|P-value:5.29E-5 ID:SGTC_650|Compound:1328-0195|FD-Score:3.04|P-value:4.76E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:3.50|P-value:7.06E-5 ID:SGTC_681|Compound:1642-0006|FD-Score:-2.94|P-value:6.73E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:3.04|P-value:4.69E-4 ID:SGTC_715|Compound:0868-0130|FD-Score:3.13|P-value:3.28E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:-4.64|P-value:2.16E-7 ID:SGTC_768|Compound:0384-0033|FD-Score:2.86|P-value:9.21E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:3.96|P-value:8.34E-6 ID:SGTC_790|Compound:1575-0012|FD-Score:5.97|P-value:3.98E-11 ID:SGTC_826|Compound:1683-5028|FD-Score:4.80|P-value:8.71E-8 ID:SGTC_841|Compound:0251-0215|FD-Score:-3.20|P-value:2.36E-4 ID:SGTC_848|Compound:0368-0089|FD-Score:3.45|P-value:8.69E-5 ID:SGTC_861|Compound:0443-0273|FD-Score:-3.28|P-value:1.75E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-3.18|P-value:2.61E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:3.22|P-value:2.32E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.13|P-value:3.36E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:3.10|P-value:3.82E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:3.07|P-value:4.24E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:3.36|P-value:1.27E-4 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:4.12|P-value:3.68E-6 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-4.28|P-value:1.52E-6 ID:SGTC_1648|Compound:st011736|FD-Score:-2.92|P-value:7.10E-4 ID:SGTC_1651|Compound:st011928|FD-Score:-2.89|P-value:8.14E-4 ID:SGTC_1726|Compound:st035556|FD-Score:3.58|P-value:5.02E-5 ID:SGTC_1845|Compound:st056753|FD-Score:5.33|P-value:3.41E-9 ID:SGTC_1846|Compound:st056244|FD-Score:2.98|P-value:5.88E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:3.90|P-value:1.09E-5 ID:SGTC_1910|Compound:st062352|FD-Score:3.25|P-value:2.02E-4 ID:SGTC_1914|Compound:st062367|FD-Score:-2.89|P-value:8.10E-4 ID:SGTC_2007|Compound:4011539|FD-Score:-3.09|P-value:3.68E-4 ID:SGTC_2014|Compound:4013930|FD-Score:4.30|P-value:1.48E-6 ID:SGTC_2151|Compound:5563267|FD-Score:2.85|P-value:9.83E-4 ID:SGTC_2162|Compound:5663267|FD-Score:4.35|P-value:1.09E-6 ID:SGTC_2164|Compound:5685496|FD-Score:3.77|P-value:2.11E-5 ID:SGTC_2215|Compound:7188065|FD-Score:2.93|P-value:7.19E-4 ID:SGTC_2261|Compound:9010538|FD-Score:2.92|P-value:7.37E-4 ID:SGTC_2368|Compound:9071271|FD-Score:4.50|P-value:4.91E-7 ID:SGTC_2400|Compound:5203494|FD-Score:2.97|P-value:6.27E-4 ID:SGTC_2442|Compound:5158906|FD-Score:3.11|P-value:3.56E-4 ID:SGTC_2481|Compound:5478948|FD-Score:4.93|P-value:4.00E-8 ID:SGTC_2485|Compound:5633444|FD-Score:-3.05|P-value:4.40E-4 ID:SGTC_2491|Compound:paeonol|FD-Score:2.97|P-value:6.19E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.35|P-value:1.37E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.05|P-value:5.34E-6 ID:SGTC_2584|Compound:androsterone|FD-Score:4.27|P-value:1.70E-6 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.52|P-value:6.36E-5 ID:SGTC_2601|Compound:securinine|FD-Score:6.13|P-value:1.32E-11 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.73|P-value:2.45E-5 ID:SGTC_2774|Compound:tamoxifen|FD-Score:4.62|P-value:2.55E-7 ID:SGTC_2807|Compound:7945238|FD-Score:3.49|P-value:7.40E-5 ID:SGTC_2856|Compound:9022925|FD-Score:3.04|P-value:4.75E-4 ID:SGTC_3306|Compound:9127676|FD-Score:2.86|P-value:9.42E-4 ID:SGTC_3315|Compound:9136395|FD-Score:2.94|P-value:7.05E-4 ID:SGTC_3325|Compound:9138760|FD-Score:-3.39|P-value:1.07E-4 ID:SGTC_20|Compound:0481-0013|FD-Score:4.14|P-value:3.28E-6 ID:SGTC_189|Compound:3970-0742|FD-Score:3.40|P-value:1.07E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:2.91|P-value:7.75E-4 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:3.48|P-value:7.68E-5 ID:SGTC_523|Compound:1934-0222|FD-Score:3.02|P-value:5.13E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:2.91|P-value:7.65E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:3.03|P-value:4.96E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:3.56|P-value:5.29E-5 ID:SGTC_650|Compound:1328-0195|FD-Score:3.04|P-value:4.76E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:3.50|P-value:7.06E-5 ID:SGTC_681|Compound:1642-0006|FD-Score:-2.94|P-value:6.73E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:3.04|P-value:4.69E-4 ID:SGTC_715|Compound:0868-0130|FD-Score:3.13|P-value:3.28E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:-4.64|P-value:2.16E-7 ID:SGTC_768|Compound:0384-0033|FD-Score:2.86|P-value:9.21E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:3.96|P-value:8.34E-6 ID:SGTC_790|Compound:1575-0012|FD-Score:5.97|P-value:3.98E-11 ID:SGTC_826|Compound:1683-5028|FD-Score:4.80|P-value:8.71E-8 ID:SGTC_841|Compound:0251-0215|FD-Score:-3.20|P-value:2.36E-4 ID:SGTC_848|Compound:0368-0089|FD-Score:3.45|P-value:8.69E-5 ID:SGTC_861|Compound:0443-0273|FD-Score:-3.28|P-value:1.75E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-3.18|P-value:2.61E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:3.22|P-value:2.32E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.13|P-value:3.36E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:3.10|P-value:3.82E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:3.07|P-value:4.24E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:3.36|P-value:1.27E-4 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:4.12|P-value:3.68E-6 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-4.28|P-value:1.52E-6 ID:SGTC_1648|Compound:st011736|FD-Score:-2.92|P-value:7.10E-4 ID:SGTC_1651|Compound:st011928|FD-Score:-2.89|P-value:8.14E-4 ID:SGTC_1726|Compound:st035556|FD-Score:3.58|P-value:5.02E-5 ID:SGTC_1845|Compound:st056753|FD-Score:5.33|P-value:3.41E-9 ID:SGTC_1846|Compound:st056244|FD-Score:2.98|P-value:5.88E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:3.90|P-value:1.09E-5 ID:SGTC_1910|Compound:st062352|FD-Score:3.25|P-value:2.02E-4 ID:SGTC_1914|Compound:st062367|FD-Score:-2.89|P-value:8.10E-4 ID:SGTC_2007|Compound:4011539|FD-Score:-3.09|P-value:3.68E-4 ID:SGTC_2014|Compound:4013930|FD-Score:4.30|P-value:1.48E-6 ID:SGTC_2151|Compound:5563267|FD-Score:2.85|P-value:9.83E-4 ID:SGTC_2162|Compound:5663267|FD-Score:4.35|P-value:1.09E-6 ID:SGTC_2164|Compound:5685496|FD-Score:3.77|P-value:2.11E-5 ID:SGTC_2215|Compound:7188065|FD-Score:2.93|P-value:7.19E-4 ID:SGTC_2261|Compound:9010538|FD-Score:2.92|P-value:7.37E-4 ID:SGTC_2368|Compound:9071271|FD-Score:4.50|P-value:4.91E-7 ID:SGTC_2400|Compound:5203494|FD-Score:2.97|P-value:6.27E-4 ID:SGTC_2442|Compound:5158906|FD-Score:3.11|P-value:3.56E-4 ID:SGTC_2481|Compound:5478948|FD-Score:4.93|P-value:4.00E-8 ID:SGTC_2485|Compound:5633444|FD-Score:-3.05|P-value:4.40E-4 ID:SGTC_2491|Compound:paeonol|FD-Score:2.97|P-value:6.19E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.35|P-value:1.37E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.05|P-value:5.34E-6 ID:SGTC_2584|Compound:androsterone|FD-Score:4.27|P-value:1.70E-6 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.52|P-value:6.36E-5 ID:SGTC_2601|Compound:securinine|FD-Score:6.13|P-value:1.32E-11 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.73|P-value:2.45E-5 ID:SGTC_2774|Compound:tamoxifen|FD-Score:4.62|P-value:2.55E-7 ID:SGTC_2807|Compound:7945238|FD-Score:3.49|P-value:7.40E-5 ID:SGTC_2856|Compound:9022925|FD-Score:3.04|P-value:4.75E-4 ID:SGTC_3306|Compound:9127676|FD-Score:2.86|P-value:9.42E-4 ID:SGTC_3315|Compound:9136395|FD-Score:2.94|P-value:7.05E-4 ID:SGTC_3325|Compound:9138760|FD-Score:-3.39|P-value:1.07E-4

Top fitness defect scores for YBR022W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2601 securinine 6.13 100.0 µM 1.32E-11 3 4.53E-10
2 SGTC_790 1575-0012 5.97 79.1 µM 3.98E-11 TSC3-RPN4 5 1.16E-9
3 SGTC_1845 st056753 5.33 3.0 µM 3.41E-9 TSC3-RPN4 16 5.02E-8
4 SGTC_2481 5478948 4.93 45.2 µM 4.00E-8 PDR1 18 4.06E-7
5 SGTC_826 1683-5028 4.80 118.0 µM 8.71E-8 7 7.84E-7
6 SGTC_2774 tamoxifen 4.62 10.9 µM 2.55E-7 7 1.95E-6
7 SGTC_2368 9071271 4.50 200.0 µM 4.91E-7 20 3.41E-6
8 SGTC_2162 5663267 4.35 200.0 µM 1.09E-6 9 6.70E-6
9 SGTC_2014 4013930 4.30 200.0 µM 1.48E-6 22 8.68E-6
10 SGTC_2584 androsterone 4.27 48.7 µM 1.70E-6 cell wall 109 9.77E-6
11 SGTC_20 0481-0013 4.14 4.9 µM 3.28E-6 18 1.71E-5
12 SGTC_1544 7-methoxy-4-methylcoumarin 4.12 105.0 µM 3.68E-6 12 1.89E-5
13 SGTC_2582 agaric acid 4.05 100.0 µM 5.34E-6 redox potentiating 305 2.59E-5
14 SGTC_786 4544-0069 3.96 423.0 µM 8.34E-6 26 3.78E-5
15 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 3.90 14.9 µM 1.09E-5 13 4.74E-5
16 SGTC_2164 5685496 3.77 200.0 µM 2.11E-5 28 8.32E-5
17 SGTC_2768 sulfasalazine 3.73 50.2 µM 2.45E-5 22 9.45E-5
18 SGTC_1726 st035556 3.58 14.6 µM 5.02E-5 48 1.74E-4
19 SGTC_602 3130-1533 3.56 38.1 µM 5.29E-5 25 1.82E-4
20 SGTC_2598 perillyl alcohol 3.52 100.0 µM 6.36E-5 51 2.13E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.175 2.15E-24 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.140 4.74E-16 YDR032C PST2 hom Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication
0.126 2.18E-13 YOL013C HRD1 hom Ubiquitin-protein ligase; required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; likely plays a general role in targeting proteins that persistently associate with and potentially obstruct the ER-localized translocon
0.119 5.32E-12 YBR134W_d YBR134W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.116 1.43E-11 YMR109W MYO5 hom One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
0.112 6.99E-11 YNL074C MLF3 hom Serine-rich protein of unknown function, predicted to be palmitoylated; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide
0.106 7.70E-10 YNR058W BIO3 hom 7,8-diamino-pelargonic acid aminotransferase (DAPA), catalyzes the second step in the biotin biosynthesis pathway; BIO3 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis
0.098 1.14E-8 YGL178W MPT5 hom mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity
0.097 1.61E-8 YGR090W UTP22 het Component of the small-subunit processome; required for nuclear export of tRNAs; may facilitate binding of Utp8p to aminoacylated tRNAs and their delivery to Los1p for export; conserved from yeast to mammals
0.097 1.73E-8 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.097 1.97E-8 YPR182W SMX3 het Core Sm protein Sm F; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm F
0.096 2.35E-8 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.095 3.12E-8 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.093 7.74E-8 YDR453C TSA2 hom Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutants; protein abundance increases in response to DNA replication stress
0.092 9.20E-8 YKL213C DOA1 hom WD repeat protein required for ubiquitin-mediated protein degradation; forms a complex with Cdc48p; plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase; protein increases in abundance and relocalizes from nucleus to nuclear periphery upon DNA replication stress