YBR024W / SCO2

Protein anchored to mitochondrial inner membrane; may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p; SCO2 has a paralog, SCO1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR024W / SCO2

Click on Significant Values for Screen Details ID:SGTC_47|Compound:0149-0135|FD-Score:3.84|P-value:4.30E-5 ID:SGTC_105|Compound:0111-0055|FD-Score:3.22|P-value:4.91E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:3.28|P-value:4.02E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:3.21|P-value:5.11E-4 ID:SGTC_347|Compound:4534-1311|FD-Score:-3.46|P-value:2.08E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:5.89|P-value:8.91E-10 ID:SGTC_520|Compound:3584-0023|FD-Score:4.67|P-value:9.19E-7 ID:SGTC_674|Compound:0498-0004|FD-Score:3.63|P-value:1.03E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:3.02|P-value:9.94E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:4.48|P-value:2.34E-6 ID:SGTC_1195|Compound:1502-0147|FD-Score:4.22|P-value:8.03E-6 ID:SGTC_1324|Compound:1418-0026|FD-Score:3.49|P-value:1.84E-4 ID:SGTC_1423|Compound:4048-0112|FD-Score:3.64|P-value:9.80E-5 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.27|P-value:4.20E-4 ID:SGTC_1519|Compound:esterone|FD-Score:3.14|P-value:6.58E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.16|P-value:6.16E-4 ID:SGTC_1563|Compound:conessine|FD-Score:4.05|P-value:1.73E-5 ID:SGTC_1608|Compound:st001473|FD-Score:3.17|P-value:6.01E-4 ID:SGTC_1656|Compound:st012921|FD-Score:3.31|P-value:3.63E-4 ID:SGTC_1663|Compound:st014140|FD-Score:4.78|P-value:5.23E-7 ID:SGTC_1684|Compound:st024538|FD-Score:-3.31|P-value:3.68E-4 ID:SGTC_1711|Compound:st032263|FD-Score:3.40|P-value:2.53E-4 ID:SGTC_1783|Compound:st039459|FD-Score:7.62|P-value:3.41E-15 ID:SGTC_1784|Compound:st039334|FD-Score:7.09|P-value:2.22E-13 ID:SGTC_1807|Compound:st050092|FD-Score:3.71|P-value:7.40E-5 ID:SGTC_1849|Compound:st056239|FD-Score:-3.17|P-value:6.02E-4 ID:SGTC_2049|Compound:5262831|FD-Score:3.86|P-value:4.04E-5 ID:SGTC_2066|Compound:5222451|FD-Score:3.20|P-value:5.42E-4 ID:SGTC_2088|Compound:5278280|FD-Score:3.95|P-value:2.67E-5 ID:SGTC_2111|Compound:5486399|FD-Score:3.10|P-value:7.53E-4 ID:SGTC_2149|Compound:5554786|FD-Score:3.66|P-value:9.01E-5 ID:SGTC_2310|Compound:7668677|FD-Score:3.27|P-value:4.16E-4 ID:SGTC_2425|Compound:5628681|FD-Score:3.25|P-value:4.42E-4 ID:SGTC_2471|Compound:5466956|FD-Score:3.31|P-value:3.56E-4 ID:SGTC_2475|Compound:5812728|FD-Score:3.34|P-value:3.21E-4 ID:SGTC_2895|Compound:9054447|FD-Score:4.35|P-value:4.45E-6 ID:SGTC_2907|Compound:7721985|FD-Score:3.34|P-value:3.17E-4 ID:SGTC_2998|Compound:9066762|FD-Score:-3.58|P-value:1.27E-4 ID:SGTC_3100|Compound:9120536|FD-Score:-3.05|P-value:9.20E-4 ID:SGTC_3232|Compound:9132874|FD-Score:3.65|P-value:9.46E-5 ID:SGTC_47|Compound:0149-0135|FD-Score:3.84|P-value:4.30E-5 ID:SGTC_105|Compound:0111-0055|FD-Score:3.22|P-value:4.91E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:3.28|P-value:4.02E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:3.21|P-value:5.11E-4 ID:SGTC_347|Compound:4534-1311|FD-Score:-3.46|P-value:2.08E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:5.89|P-value:8.91E-10 ID:SGTC_520|Compound:3584-0023|FD-Score:4.67|P-value:9.19E-7 ID:SGTC_674|Compound:0498-0004|FD-Score:3.63|P-value:1.03E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:3.02|P-value:9.94E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:4.48|P-value:2.34E-6 ID:SGTC_1195|Compound:1502-0147|FD-Score:4.22|P-value:8.03E-6 ID:SGTC_1324|Compound:1418-0026|FD-Score:3.49|P-value:1.84E-4 ID:SGTC_1423|Compound:4048-0112|FD-Score:3.64|P-value:9.80E-5 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.27|P-value:4.20E-4 ID:SGTC_1519|Compound:esterone|FD-Score:3.14|P-value:6.58E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.16|P-value:6.16E-4 ID:SGTC_1563|Compound:conessine|FD-Score:4.05|P-value:1.73E-5 ID:SGTC_1608|Compound:st001473|FD-Score:3.17|P-value:6.01E-4 ID:SGTC_1656|Compound:st012921|FD-Score:3.31|P-value:3.63E-4 ID:SGTC_1663|Compound:st014140|FD-Score:4.78|P-value:5.23E-7 ID:SGTC_1684|Compound:st024538|FD-Score:-3.31|P-value:3.68E-4 ID:SGTC_1711|Compound:st032263|FD-Score:3.40|P-value:2.53E-4 ID:SGTC_1783|Compound:st039459|FD-Score:7.62|P-value:3.41E-15 ID:SGTC_1784|Compound:st039334|FD-Score:7.09|P-value:2.22E-13 ID:SGTC_1807|Compound:st050092|FD-Score:3.71|P-value:7.40E-5 ID:SGTC_1849|Compound:st056239|FD-Score:-3.17|P-value:6.02E-4 ID:SGTC_2049|Compound:5262831|FD-Score:3.86|P-value:4.04E-5 ID:SGTC_2066|Compound:5222451|FD-Score:3.20|P-value:5.42E-4 ID:SGTC_2088|Compound:5278280|FD-Score:3.95|P-value:2.67E-5 ID:SGTC_2111|Compound:5486399|FD-Score:3.10|P-value:7.53E-4 ID:SGTC_2149|Compound:5554786|FD-Score:3.66|P-value:9.01E-5 ID:SGTC_2310|Compound:7668677|FD-Score:3.27|P-value:4.16E-4 ID:SGTC_2425|Compound:5628681|FD-Score:3.25|P-value:4.42E-4 ID:SGTC_2471|Compound:5466956|FD-Score:3.31|P-value:3.56E-4 ID:SGTC_2475|Compound:5812728|FD-Score:3.34|P-value:3.21E-4 ID:SGTC_2895|Compound:9054447|FD-Score:4.35|P-value:4.45E-6 ID:SGTC_2907|Compound:7721985|FD-Score:3.34|P-value:3.17E-4 ID:SGTC_2998|Compound:9066762|FD-Score:-3.58|P-value:1.27E-4 ID:SGTC_3100|Compound:9120536|FD-Score:-3.05|P-value:9.20E-4 ID:SGTC_3232|Compound:9132874|FD-Score:3.65|P-value:9.46E-5

Top fitness defect scores for YBR024W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1783 st039459 7.62 87.5 µM 3.41E-15 Golgi 3 1.25E-14
2 SGTC_1784 st039334 7.09 36.3 µM 2.22E-13 3 6.85E-13
3 SGTC_451 chloral hydrate 5.89 100.0 µM 8.91E-10 16 1.95E-9
4 SGTC_1663 st014140 4.78 55.4 µM 5.23E-7 60S ribosome export 10 8.85E-7
5 SGTC_520 3584-0023 4.67 682.0 µM 9.19E-7 13 1.52E-6
6 SGTC_975 1335-0046 4.48 28.5 µM 2.34E-6 RPP1 & pyrimidine depletion 22 3.72E-6
7 SGTC_2895 9054447 4.35 58.4 µM 4.45E-6 6 6.91E-6
8 SGTC_1195 1502-0147 4.22 41.1 µM 8.03E-6 17 1.22E-5
9 SGTC_1563 conessine 4.05 56.1 µM 1.73E-5 14 2.54E-5
10 SGTC_2088 5278280 3.95 127.4 µM 2.67E-5 22 3.85E-5
11 SGTC_2049 5262831 3.86 67.2 µM 4.04E-5 29 5.73E-5
12 SGTC_47 0149-0135 3.84 24.2 µM 4.30E-5 TSC3-RPN4 21 6.09E-5
13 SGTC_1807 st050092 3.71 58.9 µM 7.40E-5 60S ribosome export 18 1.03E-4
14 SGTC_2149 5554786 3.66 194.8 µM 9.01E-5 cell wall signaling 47 1.24E-4
15 SGTC_3232 9132874 3.65 49.5 µM 9.46E-5 RPP1 & pyrimidine depletion 22 1.30E-4
16 SGTC_1423 4048-0112 3.64 5.6 µM 9.80E-5 31 1.34E-4
17 SGTC_674 0498-0004 3.63 451.0 µM 1.03E-4 heme requiring 30 1.40E-4
18 SGTC_1324 1418-0026 3.49 34.4 µM 1.84E-4 26 2.46E-4
19 SGTC_1711 st032263 3.40 62.8 µM 2.53E-4 28 3.34E-4
20 SGTC_2907 7721985 3.34 69.9 µM 3.17E-4 51 4.15E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.170 3.82E-23 YNL268W LYP1 hom Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids
0.134 5.93E-15 YPL028W ERG10 het Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis
0.124 4.97E-13 YOR029W_d YOR029W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.100 6.73E-9 YMR113W FOL3 het Dihydrofolate synthetase, involved in folic acid biosynthesis; catalyzes the conversion of dihydropteroate to dihydrofolate in folate coenzyme biosynthesis
0.100 6.83E-9 YPR056W TFB4 het Subunit of TFIIH complex, involved in transcription initiation, similar to 34 kDa subunit of human TFIIH; interacts with Ssl1p
0.100 7.49E-9 YJR107W_p YJR107W_p hom Putative lipase
0.099 9.81E-9 YNL181W_p YNL181W_p het Putative oxidoreductase; required for cell viability
0.098 1.14E-8 YIR028W DAL4 hom Allantoin permease; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
0.095 3.91E-8 YBL088C TEL1 hom Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; regulates P-body formation induced by replication stress; homolog of human ataxia-telangiectasia mutated (ATM) gene, the gene responsible for ataxia telangiectasia (AT) (OMIM 607585)
0.088 3.66E-7 YPL266W DIM1 het Essential 18S rRNA dimethylase (dimethyladenosine transferase), responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing
0.082 2.00E-6 YDR002W YRB1 het Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1
0.081 2.38E-6 YMR083W ADH3 hom Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production
0.081 2.52E-6 YLR265C NEJ1 hom Protein involved in regulation of nonhomologous end joining; interacts with DNA ligase IV components Dnl4p and Lif1p; repressed by MAT heterozygosity; regulates cellular distribution of Lif1p
0.081 2.70E-6 YHR078W_p YHR078W_p hom High osmolarity-regulated gene of unknown function
0.079 4.67E-6 YER139C RTR1 hom CTD phosphatase; dephosphorylates S5-P in the C-terminal domain of Rpo21p; has a cysteine-rich motif required for function and conserved in eukaryotes; shuttles between the nucleus and cytoplasm; RTR1 has a paralog, RTR2, that arose from the whole genome duplication