YBR027C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR027C / YBR027C

Click on Significant Values for Screen Details ID:SGTC_17|Compound:0960-0276|FD-Score:3.07|P-value:6.13E-4 ID:SGTC_47|Compound:0149-0135|FD-Score:3.42|P-value:1.66E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:8.00|P-value:6.27E-17 ID:SGTC_69|Compound:0096-0274|FD-Score:4.22|P-value:5.12E-6 ID:SGTC_121|Compound:0557-0495|FD-Score:3.65|P-value:6.60E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:4.25|P-value:4.41E-6 ID:SGTC_161|Compound:4065-0411|FD-Score:3.22|P-value:3.46E-4 ID:SGTC_162|Compound:k030-0015|FD-Score:3.22|P-value:3.54E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:4.53|P-value:1.12E-6 ID:SGTC_170|Compound:4197-0004|FD-Score:5.15|P-value:4.05E-8 ID:SGTC_190|Compound:3970-0790|FD-Score:-3.38|P-value:3.88E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:3.29|P-value:2.71E-4 ID:SGTC_306|Compound:1672-3436|FD-Score:-3.27|P-value:5.80E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:2.97|P-value:8.69E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:3.16|P-value:4.35E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:5.89|P-value:4.86E-10 ID:SGTC_801|Compound:0866-0028|FD-Score:4.11|P-value:8.45E-6 ID:SGTC_808|Compound:0711-0032|FD-Score:-3.40|P-value:3.59E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:4.08|P-value:9.80E-6 ID:SGTC_863|Compound:0466-0191|FD-Score:3.11|P-value:5.21E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:5.39|P-value:1.01E-8 ID:SGTC_1063|Compound:disulfiram|FD-Score:-4.41|P-value:5.11E-6 ID:SGTC_1076|Compound:itraconazole|FD-Score:-3.84|P-value:6.41E-5 ID:SGTC_1079|Compound:idarubicin|FD-Score:4.42|P-value:1.92E-6 ID:SGTC_1081|Compound:sertraline|FD-Score:5.29|P-value:1.87E-8 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.69|P-value:5.56E-5 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.12|P-value:5.12E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:3.07|P-value:6.08E-4 ID:SGTC_1314|Compound:1222-0010|FD-Score:5.76|P-value:1.06E-9 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.01|P-value:7.54E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:3.10|P-value:5.46E-4 ID:SGTC_1548|Compound:st061468|FD-Score:4.37|P-value:2.51E-6 ID:SGTC_1555|Compound:citronellol|FD-Score:-3.14|P-value:9.37E-4 ID:SGTC_1571|Compound:st070080|FD-Score:-4.21|P-value:1.28E-5 ID:SGTC_1712|Compound:st032288|FD-Score:4.45|P-value:1.67E-6 ID:SGTC_1729|Compound:st035615|FD-Score:4.30|P-value:3.58E-6 ID:SGTC_1754|Compound:st042065|FD-Score:4.64|P-value:6.53E-7 ID:SGTC_1764|Compound:st044502|FD-Score:3.17|P-value:4.19E-4 ID:SGTC_1801|Compound:st050089|FD-Score:3.02|P-value:7.31E-4 ID:SGTC_1817|Compound:st052116|FD-Score:3.41|P-value:1.69E-4 ID:SGTC_1897|Compound:st060201|FD-Score:4.12|P-value:8.17E-6 ID:SGTC_1941|Compound:st076221|FD-Score:3.38|P-value:1.93E-4 ID:SGTC_1974|Compound:st069448|FD-Score:3.39|P-value:1.83E-4 ID:SGTC_1987|Compound:st072290|FD-Score:3.64|P-value:6.61E-5 ID:SGTC_2013|Compound:4024628|FD-Score:3.50|P-value:1.19E-4 ID:SGTC_2014|Compound:4013930|FD-Score:3.44|P-value:1.52E-4 ID:SGTC_2140|Compound:5586273|FD-Score:3.63|P-value:7.09E-5 ID:SGTC_2236|Compound:dapsone|FD-Score:-3.30|P-value:5.15E-4 ID:SGTC_2317|Compound:5986382|FD-Score:4.99|P-value:1.03E-7 ID:SGTC_2342|Compound:7990637|FD-Score:4.15|P-value:7.18E-6 ID:SGTC_2345|Compound:9052315|FD-Score:3.64|P-value:6.67E-5 ID:SGTC_2394|Compound:5221648|FD-Score:3.68|P-value:5.60E-5 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:-3.60|P-value:1.68E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:-3.44|P-value:3.13E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:3.73|P-value:4.67E-5 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.07|P-value:5.98E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:3.67|P-value:5.96E-5 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:3.11|P-value:5.24E-4 ID:SGTC_2771|Compound:fluoxetine|FD-Score:-3.27|P-value:5.91E-4 ID:SGTC_2825|Compound:7998094|FD-Score:3.76|P-value:4.03E-5 ID:SGTC_2845|Compound:9003024|FD-Score:3.03|P-value:6.99E-4 ID:SGTC_2848|Compound:9016370|FD-Score:-3.94|P-value:4.14E-5 ID:SGTC_2850|Compound:9015429|FD-Score:3.41|P-value:1.68E-4 ID:SGTC_2856|Compound:9022925|FD-Score:3.12|P-value:5.03E-4 ID:SGTC_2960|Compound:9079389|FD-Score:3.97|P-value:1.60E-5 ID:SGTC_3066|Compound:9117245|FD-Score:-3.30|P-value:5.31E-4 ID:SGTC_3071|Compound:9117417|FD-Score:6.40|P-value:1.53E-11 ID:SGTC_3087|Compound:9117406|FD-Score:3.61|P-value:7.77E-5 ID:SGTC_3090|Compound:9117696|FD-Score:3.83|P-value:3.04E-5 ID:SGTC_3097|Compound:9117246|FD-Score:4.67|P-value:5.51E-7 ID:SGTC_3128|Compound:9127691|FD-Score:3.42|P-value:1.61E-4 ID:SGTC_3196|Compound:9111891|FD-Score:-3.50|P-value:2.54E-4 ID:SGTC_3203|Compound:9113543|FD-Score:-3.14|P-value:9.31E-4 ID:SGTC_3293|Compound:9120939|FD-Score:3.05|P-value:6.56E-4 ID:SGTC_3305|Compound:9127027|FD-Score:-3.35|P-value:4.41E-4 ID:SGTC_3311|Compound:9131146|FD-Score:6.49|P-value:8.62E-12 ID:SGTC_17|Compound:0960-0276|FD-Score:3.07|P-value:6.13E-4 ID:SGTC_47|Compound:0149-0135|FD-Score:3.42|P-value:1.66E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:8.00|P-value:6.27E-17 ID:SGTC_69|Compound:0096-0274|FD-Score:4.22|P-value:5.12E-6 ID:SGTC_121|Compound:0557-0495|FD-Score:3.65|P-value:6.60E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:4.25|P-value:4.41E-6 ID:SGTC_161|Compound:4065-0411|FD-Score:3.22|P-value:3.46E-4 ID:SGTC_162|Compound:k030-0015|FD-Score:3.22|P-value:3.54E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:4.53|P-value:1.12E-6 ID:SGTC_170|Compound:4197-0004|FD-Score:5.15|P-value:4.05E-8 ID:SGTC_190|Compound:3970-0790|FD-Score:-3.38|P-value:3.88E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:3.29|P-value:2.71E-4 ID:SGTC_306|Compound:1672-3436|FD-Score:-3.27|P-value:5.80E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:2.97|P-value:8.69E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:3.16|P-value:4.35E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:5.89|P-value:4.86E-10 ID:SGTC_801|Compound:0866-0028|FD-Score:4.11|P-value:8.45E-6 ID:SGTC_808|Compound:0711-0032|FD-Score:-3.40|P-value:3.59E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:4.08|P-value:9.80E-6 ID:SGTC_863|Compound:0466-0191|FD-Score:3.11|P-value:5.21E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:5.39|P-value:1.01E-8 ID:SGTC_1063|Compound:disulfiram|FD-Score:-4.41|P-value:5.11E-6 ID:SGTC_1076|Compound:itraconazole|FD-Score:-3.84|P-value:6.41E-5 ID:SGTC_1079|Compound:idarubicin|FD-Score:4.42|P-value:1.92E-6 ID:SGTC_1081|Compound:sertraline|FD-Score:5.29|P-value:1.87E-8 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.69|P-value:5.56E-5 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.12|P-value:5.12E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:3.07|P-value:6.08E-4 ID:SGTC_1314|Compound:1222-0010|FD-Score:5.76|P-value:1.06E-9 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.01|P-value:7.54E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:3.10|P-value:5.46E-4 ID:SGTC_1548|Compound:st061468|FD-Score:4.37|P-value:2.51E-6 ID:SGTC_1555|Compound:citronellol|FD-Score:-3.14|P-value:9.37E-4 ID:SGTC_1571|Compound:st070080|FD-Score:-4.21|P-value:1.28E-5 ID:SGTC_1712|Compound:st032288|FD-Score:4.45|P-value:1.67E-6 ID:SGTC_1729|Compound:st035615|FD-Score:4.30|P-value:3.58E-6 ID:SGTC_1754|Compound:st042065|FD-Score:4.64|P-value:6.53E-7 ID:SGTC_1764|Compound:st044502|FD-Score:3.17|P-value:4.19E-4 ID:SGTC_1801|Compound:st050089|FD-Score:3.02|P-value:7.31E-4 ID:SGTC_1817|Compound:st052116|FD-Score:3.41|P-value:1.69E-4 ID:SGTC_1897|Compound:st060201|FD-Score:4.12|P-value:8.17E-6 ID:SGTC_1941|Compound:st076221|FD-Score:3.38|P-value:1.93E-4 ID:SGTC_1974|Compound:st069448|FD-Score:3.39|P-value:1.83E-4 ID:SGTC_1987|Compound:st072290|FD-Score:3.64|P-value:6.61E-5 ID:SGTC_2013|Compound:4024628|FD-Score:3.50|P-value:1.19E-4 ID:SGTC_2014|Compound:4013930|FD-Score:3.44|P-value:1.52E-4 ID:SGTC_2140|Compound:5586273|FD-Score:3.63|P-value:7.09E-5 ID:SGTC_2236|Compound:dapsone|FD-Score:-3.30|P-value:5.15E-4 ID:SGTC_2317|Compound:5986382|FD-Score:4.99|P-value:1.03E-7 ID:SGTC_2342|Compound:7990637|FD-Score:4.15|P-value:7.18E-6 ID:SGTC_2345|Compound:9052315|FD-Score:3.64|P-value:6.67E-5 ID:SGTC_2394|Compound:5221648|FD-Score:3.68|P-value:5.60E-5 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:-3.60|P-value:1.68E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:-3.44|P-value:3.13E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:3.73|P-value:4.67E-5 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.07|P-value:5.98E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:3.67|P-value:5.96E-5 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:3.11|P-value:5.24E-4 ID:SGTC_2771|Compound:fluoxetine|FD-Score:-3.27|P-value:5.91E-4 ID:SGTC_2825|Compound:7998094|FD-Score:3.76|P-value:4.03E-5 ID:SGTC_2845|Compound:9003024|FD-Score:3.03|P-value:6.99E-4 ID:SGTC_2848|Compound:9016370|FD-Score:-3.94|P-value:4.14E-5 ID:SGTC_2850|Compound:9015429|FD-Score:3.41|P-value:1.68E-4 ID:SGTC_2856|Compound:9022925|FD-Score:3.12|P-value:5.03E-4 ID:SGTC_2960|Compound:9079389|FD-Score:3.97|P-value:1.60E-5 ID:SGTC_3066|Compound:9117245|FD-Score:-3.30|P-value:5.31E-4 ID:SGTC_3071|Compound:9117417|FD-Score:6.40|P-value:1.53E-11 ID:SGTC_3087|Compound:9117406|FD-Score:3.61|P-value:7.77E-5 ID:SGTC_3090|Compound:9117696|FD-Score:3.83|P-value:3.04E-5 ID:SGTC_3097|Compound:9117246|FD-Score:4.67|P-value:5.51E-7 ID:SGTC_3128|Compound:9127691|FD-Score:3.42|P-value:1.61E-4 ID:SGTC_3196|Compound:9111891|FD-Score:-3.50|P-value:2.54E-4 ID:SGTC_3203|Compound:9113543|FD-Score:-3.14|P-value:9.31E-4 ID:SGTC_3293|Compound:9120939|FD-Score:3.05|P-value:6.56E-4 ID:SGTC_3305|Compound:9127027|FD-Score:-3.35|P-value:4.41E-4 ID:SGTC_3311|Compound:9131146|FD-Score:6.49|P-value:8.62E-12

Top fitness defect scores for YBR027C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 8.00 9.0 µM 6.27E-17 cell wall 123 6.07E-16
2 SGTC_3311 9131146 6.49 2.9 µM 8.62E-12 cell wall 51 4.39E-11
3 SGTC_3071 9117417 6.40 49.5 µM 1.53E-11 fatty acid desaturase (OLE1) 5 7.55E-11
4 SGTC_793 0488-0545 5.89 106.0 µM 4.86E-10 2 1.98E-9
5 SGTC_1314 1222-0010 5.76 41.1 µM 1.06E-9 3 4.12E-9
6 SGTC_1012 4112-3522 5.39 18.0 µM 1.01E-8 7 3.46E-8
7 SGTC_1081 sertraline 5.29 6.0 µM 1.87E-8 60S ribosome export 13 6.16E-8
8 SGTC_170 4197-0004 5.15 226.0 µM 4.05E-8 5 1.28E-7
9 SGTC_2317 5986382 4.99 200.0 µM 1.03E-7 2 3.08E-7
10 SGTC_3097 9117246 4.67 49.5 µM 5.51E-7 3 1.49E-6
11 SGTC_1754 st042065 4.64 16.1 µM 6.53E-7 NEO1-PIK1 145 1.75E-6
12 SGTC_167 3672-0051 4.53 66.2 µM 1.12E-6 31 2.90E-6
13 SGTC_1712 st032288 4.45 53.4 µM 1.67E-6 calcium & mitochondrial duress 152 4.24E-6
14 SGTC_1079 idarubicin 4.42 2.4 µM 1.92E-6 DNA damage response 14 4.84E-6
15 SGTC_1548 st061468 4.37 90.8 µM 2.51E-6 6 6.22E-6
16 SGTC_1729 st035615 4.30 46.0 µM 3.58E-6 28 8.67E-6
17 SGTC_138 0850-0259 4.25 40.9 µM 4.41E-6 cell wall 179 1.05E-5
18 SGTC_69 0096-0274 4.22 206.7 µM 5.12E-6 mitochondrial processes 33 1.21E-5
19 SGTC_2342 7990637 4.15 118.9 µM 7.18E-6 RNA processing & uracil transport 28 1.67E-5
20 SGTC_1897 st060201 4.12 15.0 µM 8.17E-6 mitochondrial processes 16 1.88E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.286 1.91E-64 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.240 3.82E-45 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.224 1.88E-39 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
0.223 5.73E-39 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
0.220 4.91E-38 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.219 1.23E-37 YDL066W IDP1 hom Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
0.214 6.37E-36 YPL269W KAR9 hom Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase
0.213 6.62E-36 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.212 1.75E-35 YKL033W-A_p YKL033W-A_p hom Putative protein of unknown function; similar to uncharacterized proteins from other fungi
0.209 2.19E-34 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.208 3.89E-34 YDL021W GPM2 hom Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event
0.207 9.14E-34 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.203 1.46E-32 YPL115C BEM3 hom Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly
0.201 5.75E-32 YBL006C LDB7 hom Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
0.200 1.77E-31 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2