YBR031W / RPL4A

Ribosomal 60S subunit protein L4A; N-terminally acetylated; homologous to mammalian ribosomal protein L4 and bacterial L4; RPL4A has a paralog, RPL4B, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR031W / RPL4A

Click on Significant Values for Screen Details ID:SGTC_26|Compound:0302-0163|FD-Score:3.03|P-value:8.37E-4 ID:SGTC_29|Compound:0299-0004|FD-Score:3.20|P-value:4.49E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:-3.81|P-value:3.85E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:4.01|P-value:1.59E-5 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:4.27|P-value:4.65E-6 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.09|P-value:6.73E-4 ID:SGTC_286|Compound:k060-0067|FD-Score:4.05|P-value:1.28E-5 ID:SGTC_672|Compound:1441-0018|FD-Score:3.85|P-value:3.17E-5 ID:SGTC_689|Compound:0833-0039|FD-Score:3.87|P-value:2.90E-5 ID:SGTC_714|Compound:4296-0578|FD-Score:-3.31|P-value:2.99E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:3.19|P-value:4.62E-4 ID:SGTC_849|Compound:0386-0493|FD-Score:3.57|P-value:1.06E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:3.37|P-value:2.29E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:3.91|P-value:2.46E-5 ID:SGTC_907|Compound:3448-6986|FD-Score:4.48|P-value:1.69E-6 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.12|P-value:5.99E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:3.14|P-value:5.65E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:3.23|P-value:4.05E-4 ID:SGTC_1084|Compound:voriconazole|FD-Score:3.17|P-value:4.93E-4 ID:SGTC_1148|Compound:3909-7663|FD-Score:3.73|P-value:5.43E-5 ID:SGTC_1167|Compound:k781-0610|FD-Score:4.99|P-value:1.10E-7 ID:SGTC_1177|Compound:0983-0204|FD-Score:-3.61|P-value:8.90E-5 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.31|P-value:2.91E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:9.66|P-value:5.98E-24 ID:SGTC_1181|Compound:1222-0449|FD-Score:4.45|P-value:1.90E-6 ID:SGTC_1183|Compound:1254-0324|FD-Score:3.54|P-value:1.21E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:3.34|P-value:2.58E-4 ID:SGTC_1498|Compound:4478-3555|FD-Score:3.26|P-value:3.52E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:-3.32|P-value:2.88E-4 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:3.23|P-value:4.00E-4 ID:SGTC_1647|Compound:st011722|FD-Score:2.99|P-value:9.42E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-3.02|P-value:8.67E-4 ID:SGTC_1831|Compound:st055328|FD-Score:-3.34|P-value:2.66E-4 ID:SGTC_2033|Compound:5192550|FD-Score:3.48|P-value:1.49E-4 ID:SGTC_2037|Compound:5169046|FD-Score:2.98|P-value:9.81E-4 ID:SGTC_2041|Compound:5107442|FD-Score:3.44|P-value:1.80E-4 ID:SGTC_2097|Compound:5376186|FD-Score:3.10|P-value:6.36E-4 ID:SGTC_2099|Compound:5377090|FD-Score:3.79|P-value:4.13E-5 ID:SGTC_2173|Compound:5763948|FD-Score:3.53|P-value:1.23E-4 ID:SGTC_2253|Compound:7938677|FD-Score:-3.66|P-value:7.42E-5 ID:SGTC_2259|Compound:7964009|FD-Score:-3.58|P-value:1.01E-4 ID:SGTC_2270|Compound:7924575|FD-Score:-4.03|P-value:1.45E-5 ID:SGTC_2273|Compound:7815444|FD-Score:-4.38|P-value:2.78E-6 ID:SGTC_2432|Compound:5630864|FD-Score:3.15|P-value:5.34E-4 ID:SGTC_2464|Compound:5717415|FD-Score:-3.93|P-value:2.26E-5 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.39|P-value:2.17E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:3.55|P-value:1.16E-4 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:3.06|P-value:7.39E-4 ID:SGTC_2932|Compound:9016711|FD-Score:2.98|P-value:9.77E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-3.10|P-value:6.60E-4 ID:SGTC_26|Compound:0302-0163|FD-Score:3.03|P-value:8.37E-4 ID:SGTC_29|Compound:0299-0004|FD-Score:3.20|P-value:4.49E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:-3.81|P-value:3.85E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:4.01|P-value:1.59E-5 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:4.27|P-value:4.65E-6 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.09|P-value:6.73E-4 ID:SGTC_286|Compound:k060-0067|FD-Score:4.05|P-value:1.28E-5 ID:SGTC_672|Compound:1441-0018|FD-Score:3.85|P-value:3.17E-5 ID:SGTC_689|Compound:0833-0039|FD-Score:3.87|P-value:2.90E-5 ID:SGTC_714|Compound:4296-0578|FD-Score:-3.31|P-value:2.99E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:3.19|P-value:4.62E-4 ID:SGTC_849|Compound:0386-0493|FD-Score:3.57|P-value:1.06E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:3.37|P-value:2.29E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:3.91|P-value:2.46E-5 ID:SGTC_907|Compound:3448-6986|FD-Score:4.48|P-value:1.69E-6 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.12|P-value:5.99E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:3.14|P-value:5.65E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:3.23|P-value:4.05E-4 ID:SGTC_1084|Compound:voriconazole|FD-Score:3.17|P-value:4.93E-4 ID:SGTC_1148|Compound:3909-7663|FD-Score:3.73|P-value:5.43E-5 ID:SGTC_1167|Compound:k781-0610|FD-Score:4.99|P-value:1.10E-7 ID:SGTC_1177|Compound:0983-0204|FD-Score:-3.61|P-value:8.90E-5 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.31|P-value:2.91E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:9.66|P-value:5.98E-24 ID:SGTC_1181|Compound:1222-0449|FD-Score:4.45|P-value:1.90E-6 ID:SGTC_1183|Compound:1254-0324|FD-Score:3.54|P-value:1.21E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:3.34|P-value:2.58E-4 ID:SGTC_1498|Compound:4478-3555|FD-Score:3.26|P-value:3.52E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:-3.32|P-value:2.88E-4 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:3.23|P-value:4.00E-4 ID:SGTC_1647|Compound:st011722|FD-Score:2.99|P-value:9.42E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-3.02|P-value:8.67E-4 ID:SGTC_1831|Compound:st055328|FD-Score:-3.34|P-value:2.66E-4 ID:SGTC_2033|Compound:5192550|FD-Score:3.48|P-value:1.49E-4 ID:SGTC_2037|Compound:5169046|FD-Score:2.98|P-value:9.81E-4 ID:SGTC_2041|Compound:5107442|FD-Score:3.44|P-value:1.80E-4 ID:SGTC_2097|Compound:5376186|FD-Score:3.10|P-value:6.36E-4 ID:SGTC_2099|Compound:5377090|FD-Score:3.79|P-value:4.13E-5 ID:SGTC_2173|Compound:5763948|FD-Score:3.53|P-value:1.23E-4 ID:SGTC_2253|Compound:7938677|FD-Score:-3.66|P-value:7.42E-5 ID:SGTC_2259|Compound:7964009|FD-Score:-3.58|P-value:1.01E-4 ID:SGTC_2270|Compound:7924575|FD-Score:-4.03|P-value:1.45E-5 ID:SGTC_2273|Compound:7815444|FD-Score:-4.38|P-value:2.78E-6 ID:SGTC_2432|Compound:5630864|FD-Score:3.15|P-value:5.34E-4 ID:SGTC_2464|Compound:5717415|FD-Score:-3.93|P-value:2.26E-5 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.39|P-value:2.17E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:3.55|P-value:1.16E-4 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:3.06|P-value:7.39E-4 ID:SGTC_2932|Compound:9016711|FD-Score:2.98|P-value:9.77E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-3.10|P-value:6.60E-4

Top fitness defect scores for YBR031W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1179 1021-1431 9.66 9.3 µM 5.98E-24 1 2.32E-22
2 SGTC_1167 k781-0610 4.99 148.0 µM 1.10E-7 RNA processing & uracil transport 11 3.00E-7
3 SGTC_907 3448-6986 4.48 75.5 µM 1.69E-6 14 3.82E-6
4 SGTC_1181 1222-0449 4.45 220.0 µM 1.90E-6 17 4.27E-6
5 SGTC_120 rhodamine 6G 4.27 52.3 µM 4.65E-6 mitochondrial processes 23 9.82E-6
6 SGTC_286 k060-0067 4.05 22.9 µM 1.28E-5 tubulin folding & SWR complex 24 2.52E-5
7 SGTC_118 0083-0097 4.01 135.3 µM 1.59E-5 translation 126 3.08E-5
8 SGTC_883 0850-0245 3.91 24.6 µM 2.46E-5 cell wall 32 4.62E-5
9 SGTC_689 0833-0039 3.87 98.0 µM 2.90E-5 ergosterol depletion effects on membrane 37 5.40E-5
10 SGTC_672 1441-0018 3.85 53.7 µM 3.17E-5 21 5.86E-5
11 SGTC_2099 5377090 3.79 177.4 µM 4.13E-5 28 7.49E-5
12 SGTC_1148 3909-7663 3.73 27.7 µM 5.43E-5 19 9.68E-5
13 SGTC_849 0386-0493 3.57 241.0 µM 1.06E-4 30 1.80E-4
14 SGTC_2761 levamisole 3.55 97.9 µM 1.16E-4 26 1.96E-4
15 SGTC_1183 1254-0324 3.54 198.0 µM 1.21E-4 36 2.03E-4
16 SGTC_2173 5763948 3.53 167.0 µM 1.23E-4 tubulin folding & SWR complex 22 2.07E-4
17 SGTC_2033 5192550 3.48 145.0 µM 1.49E-4 25 2.48E-4
18 SGTC_2041 5107442 3.44 45.3 µM 1.80E-4 RSC complex & mRNA processing 40 2.96E-4
19 SGTC_2603 homopterocarpin 3.39 100.0 µM 2.17E-4 72 3.52E-4
20 SGTC_863 0466-0191 3.37 129.0 µM 2.29E-4 cell wall 96 3.69E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.162 4.56E-21 YMR147W_p YMR147W_p hom Putative protein of unknown function
0.135 4.76E-15 YKL006W RPL14A hom Ribosomal 60S subunit protein L14A; N-terminally acetylated; homologous to mammalian ribosomal protein L14, no bacterial homolog; RPL14A has a paralog, RPL14B, that arose from the whole genome duplication
0.122 1.17E-12 YPR106W ISR1 hom Predicted protein kinase, overexpression causes sensitivity to staurosporine, which is a potent inhibitor of protein kinase C
0.117 1.25E-11 YBL027W RPL19B hom Ribosomal 60S subunit protein L19B; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19B has a paralog, RPL19A, that arose from the whole genome duplication
0.103 1.93E-9 YBL047C EDE1 hom Endocytic protein; involved in a network of interactions with other endocytic proteins, binds membranes in a ubiquitin-dependent manner, may also bind ubiquitinated membrane-associated proteins; interacts with Cmk2 and functions upstream of CMK2 in regulating non-apoptotic cell death
0.103 2.43E-9 YGL034C_d YGL034C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.095 4.14E-8 YJL157C FAR1 hom Cyclin-dependent kinase inhibitor; mediates cell cycle arrest in response to pheromone; also forms a complex with Cdc24p, Ste4p, and Ste18p that may specify the direction of polarized growth during mating; potential Cdc28p substrate; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.092 9.79E-8 YBR161W CSH1 hom Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Sur1p; CSH1 has a paralog, SUR1, that arose from the whole genome duplication
0.089 2.50E-7 YJL096W MRPL49 hom Mitochondrial ribosomal protein of the large subunit
0.086 6.36E-7 YKL069W YKL069W hom Methionine-R-sulfoxide reductase; reduces the R enantiomer of free Met-SO, in contrast to Ycl033Cp which reduces Met-R-SO in a peptide linkage; has a role in protection against oxidative stress; relative distribution to the nucleus increases upon DNA replication stress
0.079 5.01E-6 YKL167C MRP49 hom Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation
0.077 7.75E-6 YBR083W TEC1 hom Transcription factor targeting filamentation genes and Ty1 expression; Ste12p activation of most filamentation gene promoters depends on Tec1p and Tec1p transcriptional activity is dependent on its association with Ste12p; binds to TCS elements upstream of filamentation genes, which are regulated by Tec1p/Ste12p/Dig1p complex; competes with Dig2p for binding to Ste12p/Dig1p; positive regulator of chronological life span; TEA/ATTS DNA-binding domain family member
0.077 7.93E-6 YGL009C LEU1 hom Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway
0.076 1.07E-5 YLR403W SFP1 hom Regulates transcription of ribosomal protein and biogenesis genes; regulates response to nutrients and stress, G2/M transitions during mitotic cell cycle and DNA-damage response, and modulates cell size; regulated by TORC1 and Mrs6p; sequence of zinc finger, ChIP localization data, and protein-binding microarray (PBM) data, and computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p at others; can form the [ISP+] prion
0.075 1.31E-5 YMR020W FMS1 hom Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis