YBR032W_d

Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR032W / YBR032W

Click on Significant Values for Screen Details ID:SGTC_4|Compound:0960-0234|FD-Score:3.06|P-value:3.60E-4 ID:SGTC_105|Compound:0111-0055|FD-Score:3.14|P-value:2.63E-4 ID:SGTC_200|Compound:k038-0079|FD-Score:-3.11|P-value:4.38E-4 ID:SGTC_228|Compound:caffeine|FD-Score:3.25|P-value:1.68E-4 ID:SGTC_230|Compound:MPP+|FD-Score:3.63|P-value:3.18E-5 ID:SGTC_557|Compound:1315-0110|FD-Score:3.61|P-value:3.52E-5 ID:SGTC_573|Compound:3702-0553|FD-Score:-2.90|P-value:9.81E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:5.50|P-value:7.88E-10 ID:SGTC_757|Compound:1066-0008|FD-Score:-3.85|P-value:1.78E-5 ID:SGTC_802|Compound:4112-3352|FD-Score:-3.00|P-value:6.56E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:2.96|P-value:5.34E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:4.50|P-value:3.85E-7 ID:SGTC_947|Compound:3447-0010|FD-Score:-2.97|P-value:7.39E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:2.88|P-value:7.13E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.66|P-value:2.80E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.16|P-value:2.42E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:4.07|P-value:3.79E-6 ID:SGTC_1207|Compound:2099-0101|FD-Score:2.92|P-value:6.29E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:5.24|P-value:4.41E-9 ID:SGTC_1379|Compound:2144-0755|FD-Score:3.99|P-value:5.63E-6 ID:SGTC_1383|Compound:3049-0032|FD-Score:5.56|P-value:5.38E-10 ID:SGTC_1447|Compound:4239-0816|FD-Score:3.34|P-value:1.14E-4 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:-3.88|P-value:1.57E-5 ID:SGTC_1652|Compound:st011932|FD-Score:3.33|P-value:1.20E-4 ID:SGTC_1675|Compound:st018485|FD-Score:4.85|P-value:4.93E-8 ID:SGTC_1736|Compound:st036774|FD-Score:2.99|P-value:4.75E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:-3.26|P-value:2.42E-4 ID:SGTC_1826|Compound:st055655|FD-Score:3.97|P-value:6.29E-6 ID:SGTC_1902|Compound:st060212|FD-Score:2.98|P-value:4.83E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:2.88|P-value:7.14E-4 ID:SGTC_1931|Compound:st074438|FD-Score:2.89|P-value:6.97E-4 ID:SGTC_2126|Compound:5251174|FD-Score:2.94|P-value:5.70E-4 ID:SGTC_2375|Compound:9072683|FD-Score:3.01|P-value:4.44E-4 ID:SGTC_2644|Compound:guaiazulene|FD-Score:2.96|P-value:5.33E-4 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:3.32|P-value:1.25E-4 ID:SGTC_2781|Compound:5567276|FD-Score:3.52|P-value:5.09E-5 ID:SGTC_2795|Compound:7780010|FD-Score:3.11|P-value:2.95E-4 ID:SGTC_2920|Compound:7982904|FD-Score:3.09|P-value:3.18E-4 ID:SGTC_3075|Compound:9116269|FD-Score:4.14|P-value:2.66E-6 ID:SGTC_4|Compound:0960-0234|FD-Score:3.06|P-value:3.60E-4 ID:SGTC_105|Compound:0111-0055|FD-Score:3.14|P-value:2.63E-4 ID:SGTC_200|Compound:k038-0079|FD-Score:-3.11|P-value:4.38E-4 ID:SGTC_228|Compound:caffeine|FD-Score:3.25|P-value:1.68E-4 ID:SGTC_230|Compound:MPP+|FD-Score:3.63|P-value:3.18E-5 ID:SGTC_557|Compound:1315-0110|FD-Score:3.61|P-value:3.52E-5 ID:SGTC_573|Compound:3702-0553|FD-Score:-2.90|P-value:9.81E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:5.50|P-value:7.88E-10 ID:SGTC_757|Compound:1066-0008|FD-Score:-3.85|P-value:1.78E-5 ID:SGTC_802|Compound:4112-3352|FD-Score:-3.00|P-value:6.56E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:2.96|P-value:5.34E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:4.50|P-value:3.85E-7 ID:SGTC_947|Compound:3447-0010|FD-Score:-2.97|P-value:7.39E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:2.88|P-value:7.13E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.66|P-value:2.80E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.16|P-value:2.42E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:4.07|P-value:3.79E-6 ID:SGTC_1207|Compound:2099-0101|FD-Score:2.92|P-value:6.29E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:5.24|P-value:4.41E-9 ID:SGTC_1379|Compound:2144-0755|FD-Score:3.99|P-value:5.63E-6 ID:SGTC_1383|Compound:3049-0032|FD-Score:5.56|P-value:5.38E-10 ID:SGTC_1447|Compound:4239-0816|FD-Score:3.34|P-value:1.14E-4 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:-3.88|P-value:1.57E-5 ID:SGTC_1652|Compound:st011932|FD-Score:3.33|P-value:1.20E-4 ID:SGTC_1675|Compound:st018485|FD-Score:4.85|P-value:4.93E-8 ID:SGTC_1736|Compound:st036774|FD-Score:2.99|P-value:4.75E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:-3.26|P-value:2.42E-4 ID:SGTC_1826|Compound:st055655|FD-Score:3.97|P-value:6.29E-6 ID:SGTC_1902|Compound:st060212|FD-Score:2.98|P-value:4.83E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:2.88|P-value:7.14E-4 ID:SGTC_1931|Compound:st074438|FD-Score:2.89|P-value:6.97E-4 ID:SGTC_2126|Compound:5251174|FD-Score:2.94|P-value:5.70E-4 ID:SGTC_2375|Compound:9072683|FD-Score:3.01|P-value:4.44E-4 ID:SGTC_2644|Compound:guaiazulene|FD-Score:2.96|P-value:5.33E-4 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:3.32|P-value:1.25E-4 ID:SGTC_2781|Compound:5567276|FD-Score:3.52|P-value:5.09E-5 ID:SGTC_2795|Compound:7780010|FD-Score:3.11|P-value:2.95E-4 ID:SGTC_2920|Compound:7982904|FD-Score:3.09|P-value:3.18E-4 ID:SGTC_3075|Compound:9116269|FD-Score:4.14|P-value:2.66E-6

Top fitness defect scores for YBR032W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1383 3049-0032 5.56 20.7 µM 5.38E-10 60S ribosome export 2 1.37E-8
2 SGTC_655 k060-0012 5.50 42.0 µM 7.88E-10 1 1.89E-8
3 SGTC_1377 2944-0135 5.24 198.0 µM 4.41E-9 calcium & mitochondrial duress 16 8.05E-8
4 SGTC_1675 st018485 4.85 24.5 µM 4.93E-8 60S ribosome export 12 6.15E-7
5 SGTC_942 3253-1115 4.50 227.0 µM 3.85E-7 15 3.47E-6
6 SGTC_3075 9116269 4.14 49.5 µM 2.66E-6 16 1.77E-5
7 SGTC_1150 3909-7983 4.07 10.9 µM 3.79E-6 17 2.38E-5
8 SGTC_1379 2144-0755 3.99 36.5 µM 5.63E-6 22 3.33E-5
9 SGTC_1826 st055655 3.97 41.6 µM 6.29E-6 ERG2 39 3.65E-5
10 SGTC_1126 isoteolin 3.66 1.0 µM 2.80E-5 40 1.28E-4
11 SGTC_230 MPP+ 3.63 141.7 µM 3.18E-5 22 1.43E-4
12 SGTC_557 1315-0110 3.61 16.2 µM 3.52E-5 Golgi 29 1.56E-4
13 SGTC_2781 5567276 3.52 71.4 µM 5.09E-5 73 2.13E-4
14 SGTC_1447 4239-0816 3.34 81.9 µM 1.14E-4 54 4.18E-4
15 SGTC_1652 st011932 3.33 78.0 µM 1.20E-4 RSC complex & mRNA processing 30 4.37E-4
16 SGTC_2654 protoveratrine a 3.32 100.0 µM 1.25E-4 22 4.53E-4
17 SGTC_228 caffeine 3.25 993.1 µM 1.68E-4 22 5.83E-4
18 SGTC_1132 3456-3614 3.16 2.5 µM 2.42E-4 tubulin folding & SWR complex 101 7.90E-4
19 SGTC_105 0111-0055 3.14 734.8 µM 2.63E-4 28 8.48E-4
20 SGTC_2795 7780010 3.11 54.5 µM 2.95E-4 71 9.36E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.152 1.05E-18 YHR156C LIN1 hom Non-essential component of U5 snRNP; nuclear protein; physically interacts with Irr1p of cohesin complex; may link together proteins involved in chromosome segregation, mRNA splicing and DNA replication
0.121 2.10E-12 YNL244C SUI1 het Translation initiation factor eIF1; component of a complex involved in recognition of the initiator codon; modulates translation accuracy at the initiation phase
0.119 4.38E-12 YGL051W MST27 hom Putative integral membrane protein, involved in vesicle formation; forms complex with Mst28p; member of DUP240 gene family; binds COPI and COPII vesicles
0.095 3.67E-8 YLR099C ICT1 hom Lysophosphatidic acid acyltransferase; responsible for enhanced phospholipid synthesis during organic solvent stress; null displays increased sensitivity to Calcofluor white; highly expressed during organic solvent stress; ICT1 has a paralog, ECM18, that arose from the whole genome duplication
0.093 7.74E-8 YPL123C RNY1 hom Vacuolar RNase of the T(2) family, relocalizes to the cytosol where it cleaves tRNAs upon oxidative or stationary phase stress; promotes apoptosis under stress conditions and this function is independent of its catalytic activity
0.090 1.52E-7 YER091C-A_d YER091C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.090 1.60E-7 YER023W PRO3 het Delta 1-pyrroline-5-carboxylate reductase, catalyzes the last step in proline biosynthesis
0.089 2.19E-7 YMR101C SRT1 hom Cis-prenyltransferase involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase
0.084 9.69E-7 YPR068C HOS1 hom Class I histone deacetylase (HDAC) family member that deacetylates Smc3p on lysine residues at anaphase onset; has sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; interacts with the Tup1p-Ssn6p corepressor complex
0.084 1.11E-6 YIL092W_p YIL092W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus
0.084 1.26E-6 YLL057C JLP1 hom Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase, involved in sulfonate catabolism for use as a sulfur source; contains sequence that resembles a J domain (typified by the E. coli DnaJ protein); induced by sulphur starvation
0.083 1.72E-6 YBR060C ORC2 het Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; interacts with Spp1p and with trimethylated histone H3; phosphorylated by Cdc28p
0.082 2.20E-6 YLR437C DIF1 hom Protein that regulates the nuclear localization of ribonucleotide reductase Rnr2p and Rnr4p subunits; phosphorylated by Dun1p in response to DNA damage and degraded; N-terminal half has similarity to S. pombe Spd1 protein
0.082 2.27E-6 YNL095C_p YNL095C_p hom Putative protein of unknown function; predicted to contain a transmembrane domain; not an essential gene; YNL095C has a paralog, ECM3, that arose from the whole genome duplication
0.080 3.66E-6 YHR130C_d YHR130C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data