YBR033W_p / EDS1

Putative zinc cluster protein, predicted to be a transcription factor; not an essential gene; EDS1 has a paralog, RGT1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR033W / EDS1

Click on Significant Values for Screen Details ID:SGTC_86|Compound:0417-1630|FD-Score:-3.06|P-value:9.03E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:3.43|P-value:2.01E-4 ID:SGTC_291|Compound:4130-1278|FD-Score:3.93|P-value:2.55E-5 ID:SGTC_359|Compound:0081-0058|FD-Score:3.69|P-value:7.30E-5 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.13|P-value:6.14E-4 ID:SGTC_463|Compound:ikarugamyin|FD-Score:3.23|P-value:4.37E-4 ID:SGTC_482|Compound:fipronil|FD-Score:3.27|P-value:3.82E-4 ID:SGTC_484|Compound:loperamide|FD-Score:4.53|P-value:1.55E-6 ID:SGTC_519|Compound:k048-0011|FD-Score:6.67|P-value:3.43E-12 ID:SGTC_636|Compound:0kpi-0074|FD-Score:-3.39|P-value:2.77E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:3.19|P-value:5.07E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:3.45|P-value:1.87E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:3.86|P-value:3.55E-5 ID:SGTC_896|Compound:0964-0007|FD-Score:3.25|P-value:4.04E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:3.00|P-value:9.99E-4 ID:SGTC_904|Compound:1141-0088|FD-Score:-3.58|P-value:1.30E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:3.91|P-value:2.80E-5 ID:SGTC_1074|Compound:carmofur|FD-Score:-3.18|P-value:5.87E-4 ID:SGTC_1084|Compound:voriconazole|FD-Score:4.56|P-value:1.33E-6 ID:SGTC_1094|Compound:duloxetine|FD-Score:4.19|P-value:8.11E-6 ID:SGTC_1101|Compound:ebselen|FD-Score:3.96|P-value:2.29E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-6.24|P-value:8.77E-11 ID:SGTC_1132|Compound:3456-3614|FD-Score:4.38|P-value:3.23E-6 ID:SGTC_1253|Compound:0550-0034|FD-Score:-3.30|P-value:3.82E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:-3.21|P-value:5.24E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:-3.58|P-value:1.31E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.19|P-value:4.98E-4 ID:SGTC_1421|Compound:4029-0249|FD-Score:4.13|P-value:1.05E-5 ID:SGTC_1445|Compound:4239-0156|FD-Score:4.62|P-value:9.83E-7 ID:SGTC_1608|Compound:st001473|FD-Score:-3.38|P-value:2.86E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.95|P-value:2.41E-5 ID:SGTC_1696|Compound:st025591|FD-Score:4.07|P-value:1.37E-5 ID:SGTC_1734|Compound:st037168|FD-Score:-3.31|P-value:3.65E-4 ID:SGTC_1886|Compound:st057356|FD-Score:-3.89|P-value:3.61E-5 ID:SGTC_1893|Compound:st059353|FD-Score:-4.40|P-value:3.48E-6 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.48|P-value:1.90E-4 ID:SGTC_1933|Compound:st074711|FD-Score:4.15|P-value:9.44E-6 ID:SGTC_1938|Compound:st074717|FD-Score:3.37|P-value:2.53E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-3.08|P-value:8.44E-4 ID:SGTC_2108|Compound:5365811|FD-Score:-3.67|P-value:9.08E-5 ID:SGTC_2109|Compound:5483026|FD-Score:-4.07|P-value:1.65E-5 ID:SGTC_2117|Compound:5521686|FD-Score:-3.63|P-value:1.05E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.24|P-value:4.22E-4 ID:SGTC_2185|Compound:6113692|FD-Score:-3.45|P-value:2.16E-4 ID:SGTC_2279|Compound:7948423|FD-Score:3.65|P-value:8.33E-5 ID:SGTC_2321|Compound:7390090|FD-Score:3.04|P-value:8.70E-4 ID:SGTC_2336|Compound:9001819|FD-Score:4.10|P-value:1.19E-5 ID:SGTC_2369|Compound:9071472|FD-Score:6.31|P-value:4.22E-11 ID:SGTC_2375|Compound:9072683|FD-Score:3.37|P-value:2.59E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.85|P-value:3.74E-5 ID:SGTC_2444|Compound:5485484|FD-Score:3.36|P-value:2.69E-4 ID:SGTC_2445|Compound:5742597|FD-Score:4.48|P-value:1.97E-6 ID:SGTC_2449|Compound:5812982|FD-Score:-3.18|P-value:5.96E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:-3.18|P-value:5.85E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.11|P-value:6.83E-4 ID:SGTC_2826|Compound:7992541|FD-Score:-3.17|P-value:6.14E-4 ID:SGTC_2841|Compound:9004761|FD-Score:3.55|P-value:1.29E-4 ID:SGTC_2882|Compound:9058044|FD-Score:3.09|P-value:7.29E-4 ID:SGTC_2885|Compound:9057732|FD-Score:3.21|P-value:4.72E-4 ID:SGTC_2927|Compound:9011802|FD-Score:6.87|P-value:8.28E-13 ID:SGTC_2968|Compound:9090663|FD-Score:3.01|P-value:9.69E-4 ID:SGTC_2990|Compound:9074105|FD-Score:-3.24|P-value:4.69E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.10|P-value:7.07E-4 ID:SGTC_2996|Compound:9066192|FD-Score:6.18|P-value:1.06E-10 ID:SGTC_3029|Compound:9088683|FD-Score:4.24|P-value:6.27E-6 ID:SGTC_3161|Compound:9100388|FD-Score:-3.17|P-value:6.23E-4 ID:SGTC_3340|Compound:9146634|FD-Score:6.42|P-value:2.00E-11 ID:SGTC_86|Compound:0417-1630|FD-Score:-3.06|P-value:9.03E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:3.43|P-value:2.01E-4 ID:SGTC_291|Compound:4130-1278|FD-Score:3.93|P-value:2.55E-5 ID:SGTC_359|Compound:0081-0058|FD-Score:3.69|P-value:7.30E-5 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.13|P-value:6.14E-4 ID:SGTC_463|Compound:ikarugamyin|FD-Score:3.23|P-value:4.37E-4 ID:SGTC_482|Compound:fipronil|FD-Score:3.27|P-value:3.82E-4 ID:SGTC_484|Compound:loperamide|FD-Score:4.53|P-value:1.55E-6 ID:SGTC_519|Compound:k048-0011|FD-Score:6.67|P-value:3.43E-12 ID:SGTC_636|Compound:0kpi-0074|FD-Score:-3.39|P-value:2.77E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:3.19|P-value:5.07E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:3.45|P-value:1.87E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:3.86|P-value:3.55E-5 ID:SGTC_896|Compound:0964-0007|FD-Score:3.25|P-value:4.04E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:3.00|P-value:9.99E-4 ID:SGTC_904|Compound:1141-0088|FD-Score:-3.58|P-value:1.30E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:3.91|P-value:2.80E-5 ID:SGTC_1074|Compound:carmofur|FD-Score:-3.18|P-value:5.87E-4 ID:SGTC_1084|Compound:voriconazole|FD-Score:4.56|P-value:1.33E-6 ID:SGTC_1094|Compound:duloxetine|FD-Score:4.19|P-value:8.11E-6 ID:SGTC_1101|Compound:ebselen|FD-Score:3.96|P-value:2.29E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-6.24|P-value:8.77E-11 ID:SGTC_1132|Compound:3456-3614|FD-Score:4.38|P-value:3.23E-6 ID:SGTC_1253|Compound:0550-0034|FD-Score:-3.30|P-value:3.82E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:-3.21|P-value:5.24E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:-3.58|P-value:1.31E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.19|P-value:4.98E-4 ID:SGTC_1421|Compound:4029-0249|FD-Score:4.13|P-value:1.05E-5 ID:SGTC_1445|Compound:4239-0156|FD-Score:4.62|P-value:9.83E-7 ID:SGTC_1608|Compound:st001473|FD-Score:-3.38|P-value:2.86E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.95|P-value:2.41E-5 ID:SGTC_1696|Compound:st025591|FD-Score:4.07|P-value:1.37E-5 ID:SGTC_1734|Compound:st037168|FD-Score:-3.31|P-value:3.65E-4 ID:SGTC_1886|Compound:st057356|FD-Score:-3.89|P-value:3.61E-5 ID:SGTC_1893|Compound:st059353|FD-Score:-4.40|P-value:3.48E-6 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.48|P-value:1.90E-4 ID:SGTC_1933|Compound:st074711|FD-Score:4.15|P-value:9.44E-6 ID:SGTC_1938|Compound:st074717|FD-Score:3.37|P-value:2.53E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-3.08|P-value:8.44E-4 ID:SGTC_2108|Compound:5365811|FD-Score:-3.67|P-value:9.08E-5 ID:SGTC_2109|Compound:5483026|FD-Score:-4.07|P-value:1.65E-5 ID:SGTC_2117|Compound:5521686|FD-Score:-3.63|P-value:1.05E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.24|P-value:4.22E-4 ID:SGTC_2185|Compound:6113692|FD-Score:-3.45|P-value:2.16E-4 ID:SGTC_2279|Compound:7948423|FD-Score:3.65|P-value:8.33E-5 ID:SGTC_2321|Compound:7390090|FD-Score:3.04|P-value:8.70E-4 ID:SGTC_2336|Compound:9001819|FD-Score:4.10|P-value:1.19E-5 ID:SGTC_2369|Compound:9071472|FD-Score:6.31|P-value:4.22E-11 ID:SGTC_2375|Compound:9072683|FD-Score:3.37|P-value:2.59E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.85|P-value:3.74E-5 ID:SGTC_2444|Compound:5485484|FD-Score:3.36|P-value:2.69E-4 ID:SGTC_2445|Compound:5742597|FD-Score:4.48|P-value:1.97E-6 ID:SGTC_2449|Compound:5812982|FD-Score:-3.18|P-value:5.96E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:-3.18|P-value:5.85E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.11|P-value:6.83E-4 ID:SGTC_2826|Compound:7992541|FD-Score:-3.17|P-value:6.14E-4 ID:SGTC_2841|Compound:9004761|FD-Score:3.55|P-value:1.29E-4 ID:SGTC_2882|Compound:9058044|FD-Score:3.09|P-value:7.29E-4 ID:SGTC_2885|Compound:9057732|FD-Score:3.21|P-value:4.72E-4 ID:SGTC_2927|Compound:9011802|FD-Score:6.87|P-value:8.28E-13 ID:SGTC_2968|Compound:9090663|FD-Score:3.01|P-value:9.69E-4 ID:SGTC_2990|Compound:9074105|FD-Score:-3.24|P-value:4.69E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.10|P-value:7.07E-4 ID:SGTC_2996|Compound:9066192|FD-Score:6.18|P-value:1.06E-10 ID:SGTC_3029|Compound:9088683|FD-Score:4.24|P-value:6.27E-6 ID:SGTC_3161|Compound:9100388|FD-Score:-3.17|P-value:6.23E-4 ID:SGTC_3340|Compound:9146634|FD-Score:6.42|P-value:2.00E-11

Top fitness defect scores for YBR033W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2927 9011802 6.87 47.9 µM 8.28E-13 2 3.24E-12
2 SGTC_519 k048-0011 6.67 62.8 µM 3.43E-12 1 1.25E-11
3 SGTC_3340 9146634 6.42 11.1 µM 2.00E-11 1 6.67E-11
4 SGTC_2369 9071472 6.31 200.0 µM 4.22E-11 3 1.35E-10
5 SGTC_2996 9066192 6.18 71.4 µM 1.06E-10 6 3.26E-10
6 SGTC_1445 4239-0156 4.62 97.7 µM 9.83E-7 13 1.90E-6
7 SGTC_1084 voriconazole 4.56 435.0 nM 1.33E-6 azole & statin 16 2.53E-6
8 SGTC_484 loperamide 4.53 105.0 µM 1.55E-6 1 2.92E-6
9 SGTC_2445 5742597 4.48 35.6 µM 1.97E-6 25 3.68E-6
10 SGTC_1132 3456-3614 4.38 2.5 µM 3.23E-6 tubulin folding & SWR complex 26 5.88E-6
11 SGTC_3029 9088683 4.24 49.5 µM 6.27E-6 21 1.10E-5
12 SGTC_1094 duloxetine 4.19 25.4 µM 8.11E-6 RPP1 & pyrimidine depletion 12 1.41E-5
13 SGTC_1933 st074711 4.15 15.9 µM 9.44E-6 36 1.63E-5
14 SGTC_1421 4029-0249 4.13 71.4 µM 1.05E-5 13 1.80E-5
15 SGTC_2336 9001819 4.10 198.7 µM 1.19E-5 heme biosynthesis & mitochondrial translocase 48 2.03E-5
16 SGTC_1696 st025591 4.07 34.8 µM 1.37E-5 SWF1 & branched chain AA biosynthesis 24 2.32E-5
17 SGTC_1101 ebselen 3.96 5.3 µM 2.29E-5 22 3.79E-5
18 SGTC_1680 diphenhydramine 3.95 100.0 µM 2.41E-5 NEO1 26 3.97E-5
19 SGTC_291 4130-1278 3.93 35.5 µM 2.55E-5 Golgi 17 4.18E-5
20 SGTC_1023 4482-3888 3.91 16.0 µM 2.80E-5 TSC3-RPN4 18 4.57E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.122 1.14E-12 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.121 2.24E-12 YDR122W KIN1 hom Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.114 3.93E-11 YLR216C CPR6 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity; protein abundance increases in response to DNA replication stress
0.114 4.22E-11 YER067W RGI1 hom Protein of unknown function; involved in energy metabolism under respiratory conditions; protein abundance is increased upon intracellular iron depletion; protein abundance increases in response to DNA replication stress
0.109 2.55E-10 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.105 1.24E-9 YOR082C_d YOR082C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene YOR083W
0.100 5.94E-9 YMR173W DDR48 hom DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress
0.100 6.02E-9 YPL036W PMA2 hom Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential
0.097 1.74E-8 YGR025W_d YGR025W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.095 3.12E-8 YCL035C GRX1 hom Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.094 4.63E-8 YIL089W YIL089W hom Protein of unknown function found in the ER and vacuole lumen; overexpression of YIL089W affects endocytic protein trafficking
0.094 5.24E-8 YJR127C RSF2 hom Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.093 7.18E-8 YGL017W ATE1 hom Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway
0.090 1.77E-7 YBL086C_p YBL086C_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.090 2.06E-7 YOR159C SME1 het Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E