YBR035C / PDX3

Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR035C / PDX3

Click on Significant Values for Screen Details ID:SGTC_44|Compound:0929-0055|FD-Score:-3.32|P-value:2.49E-4 ID:SGTC_45|Compound:0kpi-0036|FD-Score:-4.76|P-value:3.10E-7 ID:SGTC_73|Compound:0327-0325|FD-Score:13.40|P-value:5.36E-45 ID:SGTC_147|Compound:4466-0538|FD-Score:-3.61|P-value:7.73E-5 ID:SGTC_156|Compound:3474-0145|FD-Score:5.05|P-value:6.69E-8 ID:SGTC_157|Compound:1348-1695|FD-Score:4.43|P-value:1.88E-6 ID:SGTC_171|Compound:k064-0041|FD-Score:15.50|P-value:3.98E-59 ID:SGTC_218|Compound:alverine citrate|FD-Score:3.37|P-value:2.17E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:6.61|P-value:2.48E-12 ID:SGTC_236|Compound:1509-0011|FD-Score:8.56|P-value:1.85E-19 ID:SGTC_256|Compound:clotrimazole|FD-Score:4.33|P-value:3.11E-6 ID:SGTC_346|Compound:4513-0042|FD-Score:2.99|P-value:9.15E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:5.17|P-value:3.36E-8 ID:SGTC_383|Compound:2324-0395|FD-Score:3.17|P-value:4.72E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:8.22|P-value:4.65E-18 ID:SGTC_490|Compound:phenamil|FD-Score:3.94|P-value:1.99E-5 ID:SGTC_547|Compound:1120-0019|FD-Score:7.35|P-value:8.52E-15 ID:SGTC_553|Compound:k007-0256|FD-Score:3.30|P-value:2.95E-4 ID:SGTC_556|Compound:4058-0063|FD-Score:5.19|P-value:3.11E-8 ID:SGTC_597|Compound:k018-0003|FD-Score:3.34|P-value:2.43E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:5.28|P-value:1.74E-8 ID:SGTC_625|Compound:k213-0058|FD-Score:3.86|P-value:2.80E-5 ID:SGTC_632|Compound:0781-2353|FD-Score:3.52|P-value:1.22E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:3.87|P-value:2.76E-5 ID:SGTC_659|Compound:k018-0002|FD-Score:3.49|P-value:1.36E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:5.23|P-value:2.43E-8 ID:SGTC_673|Compound:1082-0474|FD-Score:4.37|P-value:2.58E-6 ID:SGTC_754|Compound:3474-0146|FD-Score:3.39|P-value:2.05E-4 ID:SGTC_862|Compound:0452-0056|FD-Score:4.15|P-value:7.47E-6 ID:SGTC_895|Compound:0964-0006|FD-Score:3.63|P-value:7.76E-5 ID:SGTC_902|Compound:1120-0002|FD-Score:8.68|P-value:6.35E-20 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.01|P-value:8.66E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:5.05|P-value:6.90E-8 ID:SGTC_1055|Compound:3448-0672|FD-Score:5.62|P-value:2.21E-9 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.37|P-value:2.21E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:4.32|P-value:3.36E-6 ID:SGTC_1290|Compound:0986-0249|FD-Score:4.69|P-value:5.05E-7 ID:SGTC_1310|Compound:1188-0297|FD-Score:3.57|P-value:9.71E-5 ID:SGTC_1335|Compound:1486-0900|FD-Score:-5.36|P-value:9.58E-9 ID:SGTC_1339|Compound:1486-1321|FD-Score:-3.55|P-value:1.00E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.22|P-value:3.96E-4 ID:SGTC_1366|Compound:1683-0113|FD-Score:-3.06|P-value:6.71E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.27|P-value:3.27E-4 ID:SGTC_1501|Compound:4491-0275|FD-Score:4.07|P-value:1.11E-5 ID:SGTC_1635|Compound:st007035|FD-Score:4.37|P-value:2.52E-6 ID:SGTC_1660|Compound:st012960|FD-Score:5.31|P-value:1.45E-8 ID:SGTC_1672|Compound:st016598|FD-Score:3.93|P-value:2.10E-5 ID:SGTC_1674|Compound:st016616|FD-Score:-3.43|P-value:1.61E-4 ID:SGTC_1676|Compound:st018489|FD-Score:7.85|P-value:1.19E-16 ID:SGTC_1991|Compound:st073000|FD-Score:3.92|P-value:2.14E-5 ID:SGTC_2054|Compound:5233173|FD-Score:3.04|P-value:7.54E-4 ID:SGTC_2102|Compound:5377816|FD-Score:3.41|P-value:1.89E-4 ID:SGTC_2326|Compound:6164455|FD-Score:3.30|P-value:2.96E-4 ID:SGTC_2353|Compound:9059630|FD-Score:3.29|P-value:3.02E-4 ID:SGTC_2355|Compound:9061122|FD-Score:3.42|P-value:1.83E-4 ID:SGTC_2356|Compound:9061756|FD-Score:4.69|P-value:4.90E-7 ID:SGTC_2364|Compound:9055074|FD-Score:3.99|P-value:1.60E-5 ID:SGTC_2399|Compound:5884133|FD-Score:3.39|P-value:2.07E-4 ID:SGTC_2526|Compound:patulin|FD-Score:4.11|P-value:9.12E-6 ID:SGTC_2785|Compound:7756463|FD-Score:3.30|P-value:2.94E-4 ID:SGTC_2797|Compound:7859098|FD-Score:3.40|P-value:1.93E-4 ID:SGTC_2874|Compound:9043904|FD-Score:-3.31|P-value:2.59E-4 ID:SGTC_2878|Compound:9043973|FD-Score:-3.54|P-value:1.04E-4 ID:SGTC_2880|Compound:9042983|FD-Score:3.94|P-value:1.97E-5 ID:SGTC_2927|Compound:9011802|FD-Score:-3.07|P-value:6.46E-4 ID:SGTC_2939|Compound:9044578|FD-Score:-3.14|P-value:4.96E-4 ID:SGTC_2954|Compound:9074818|FD-Score:-3.21|P-value:3.83E-4 ID:SGTC_2969|Compound:9091408|FD-Score:3.80|P-value:3.69E-5 ID:SGTC_2975|Compound:9084847|FD-Score:3.52|P-value:1.22E-4 ID:SGTC_3012|Compound:9080433|FD-Score:3.31|P-value:2.84E-4 ID:SGTC_3074|Compound:9116018|FD-Score:-3.14|P-value:5.01E-4 ID:SGTC_3081|Compound:9117243|FD-Score:4.41|P-value:2.12E-6 ID:SGTC_3098|Compound:9119039|FD-Score:3.18|P-value:4.63E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-3.53|P-value:1.07E-4 ID:SGTC_3322|Compound:9139058|FD-Score:3.55|P-value:1.08E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:-3.32|P-value:2.49E-4 ID:SGTC_45|Compound:0kpi-0036|FD-Score:-4.76|P-value:3.10E-7 ID:SGTC_73|Compound:0327-0325|FD-Score:13.40|P-value:5.36E-45 ID:SGTC_147|Compound:4466-0538|FD-Score:-3.61|P-value:7.73E-5 ID:SGTC_156|Compound:3474-0145|FD-Score:5.05|P-value:6.69E-8 ID:SGTC_157|Compound:1348-1695|FD-Score:4.43|P-value:1.88E-6 ID:SGTC_171|Compound:k064-0041|FD-Score:15.50|P-value:3.98E-59 ID:SGTC_218|Compound:alverine citrate|FD-Score:3.37|P-value:2.17E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:6.61|P-value:2.48E-12 ID:SGTC_236|Compound:1509-0011|FD-Score:8.56|P-value:1.85E-19 ID:SGTC_256|Compound:clotrimazole|FD-Score:4.33|P-value:3.11E-6 ID:SGTC_346|Compound:4513-0042|FD-Score:2.99|P-value:9.15E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:5.17|P-value:3.36E-8 ID:SGTC_383|Compound:2324-0395|FD-Score:3.17|P-value:4.72E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:8.22|P-value:4.65E-18 ID:SGTC_490|Compound:phenamil|FD-Score:3.94|P-value:1.99E-5 ID:SGTC_547|Compound:1120-0019|FD-Score:7.35|P-value:8.52E-15 ID:SGTC_553|Compound:k007-0256|FD-Score:3.30|P-value:2.95E-4 ID:SGTC_556|Compound:4058-0063|FD-Score:5.19|P-value:3.11E-8 ID:SGTC_597|Compound:k018-0003|FD-Score:3.34|P-value:2.43E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:5.28|P-value:1.74E-8 ID:SGTC_625|Compound:k213-0058|FD-Score:3.86|P-value:2.80E-5 ID:SGTC_632|Compound:0781-2353|FD-Score:3.52|P-value:1.22E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:3.87|P-value:2.76E-5 ID:SGTC_659|Compound:k018-0002|FD-Score:3.49|P-value:1.36E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:5.23|P-value:2.43E-8 ID:SGTC_673|Compound:1082-0474|FD-Score:4.37|P-value:2.58E-6 ID:SGTC_754|Compound:3474-0146|FD-Score:3.39|P-value:2.05E-4 ID:SGTC_862|Compound:0452-0056|FD-Score:4.15|P-value:7.47E-6 ID:SGTC_895|Compound:0964-0006|FD-Score:3.63|P-value:7.76E-5 ID:SGTC_902|Compound:1120-0002|FD-Score:8.68|P-value:6.35E-20 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.01|P-value:8.66E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:5.05|P-value:6.90E-8 ID:SGTC_1055|Compound:3448-0672|FD-Score:5.62|P-value:2.21E-9 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.37|P-value:2.21E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:4.32|P-value:3.36E-6 ID:SGTC_1290|Compound:0986-0249|FD-Score:4.69|P-value:5.05E-7 ID:SGTC_1310|Compound:1188-0297|FD-Score:3.57|P-value:9.71E-5 ID:SGTC_1335|Compound:1486-0900|FD-Score:-5.36|P-value:9.58E-9 ID:SGTC_1339|Compound:1486-1321|FD-Score:-3.55|P-value:1.00E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.22|P-value:3.96E-4 ID:SGTC_1366|Compound:1683-0113|FD-Score:-3.06|P-value:6.71E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.27|P-value:3.27E-4 ID:SGTC_1501|Compound:4491-0275|FD-Score:4.07|P-value:1.11E-5 ID:SGTC_1635|Compound:st007035|FD-Score:4.37|P-value:2.52E-6 ID:SGTC_1660|Compound:st012960|FD-Score:5.31|P-value:1.45E-8 ID:SGTC_1672|Compound:st016598|FD-Score:3.93|P-value:2.10E-5 ID:SGTC_1674|Compound:st016616|FD-Score:-3.43|P-value:1.61E-4 ID:SGTC_1676|Compound:st018489|FD-Score:7.85|P-value:1.19E-16 ID:SGTC_1991|Compound:st073000|FD-Score:3.92|P-value:2.14E-5 ID:SGTC_2054|Compound:5233173|FD-Score:3.04|P-value:7.54E-4 ID:SGTC_2102|Compound:5377816|FD-Score:3.41|P-value:1.89E-4 ID:SGTC_2326|Compound:6164455|FD-Score:3.30|P-value:2.96E-4 ID:SGTC_2353|Compound:9059630|FD-Score:3.29|P-value:3.02E-4 ID:SGTC_2355|Compound:9061122|FD-Score:3.42|P-value:1.83E-4 ID:SGTC_2356|Compound:9061756|FD-Score:4.69|P-value:4.90E-7 ID:SGTC_2364|Compound:9055074|FD-Score:3.99|P-value:1.60E-5 ID:SGTC_2399|Compound:5884133|FD-Score:3.39|P-value:2.07E-4 ID:SGTC_2526|Compound:patulin|FD-Score:4.11|P-value:9.12E-6 ID:SGTC_2785|Compound:7756463|FD-Score:3.30|P-value:2.94E-4 ID:SGTC_2797|Compound:7859098|FD-Score:3.40|P-value:1.93E-4 ID:SGTC_2874|Compound:9043904|FD-Score:-3.31|P-value:2.59E-4 ID:SGTC_2878|Compound:9043973|FD-Score:-3.54|P-value:1.04E-4 ID:SGTC_2880|Compound:9042983|FD-Score:3.94|P-value:1.97E-5 ID:SGTC_2927|Compound:9011802|FD-Score:-3.07|P-value:6.46E-4 ID:SGTC_2939|Compound:9044578|FD-Score:-3.14|P-value:4.96E-4 ID:SGTC_2954|Compound:9074818|FD-Score:-3.21|P-value:3.83E-4 ID:SGTC_2969|Compound:9091408|FD-Score:3.80|P-value:3.69E-5 ID:SGTC_2975|Compound:9084847|FD-Score:3.52|P-value:1.22E-4 ID:SGTC_3012|Compound:9080433|FD-Score:3.31|P-value:2.84E-4 ID:SGTC_3074|Compound:9116018|FD-Score:-3.14|P-value:5.01E-4 ID:SGTC_3081|Compound:9117243|FD-Score:4.41|P-value:2.12E-6 ID:SGTC_3098|Compound:9119039|FD-Score:3.18|P-value:4.63E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-3.53|P-value:1.07E-4 ID:SGTC_3322|Compound:9139058|FD-Score:3.55|P-value:1.08E-4

Top fitness defect scores for YBR035C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_171 k064-0041 15.50 9.7 µM 3.98E-59 heme requiring 1 2.56E-54
2 SGTC_73 0327-0325 13.40 16.2 µM 5.36E-45 DNA damage response 2 2.21E-41
3 SGTC_902 1120-0002 8.68 2.1 µM 6.35E-20 azole & statin 7 2.04E-18
4 SGTC_236 1509-0011 8.56 5.3 µM 1.85E-19 235 5.43E-18
5 SGTC_438 sphingosine 8.22 6.7 µM 4.65E-18 2 1.05E-16
6 SGTC_1676 st018489 7.85 23.4 µM 1.19E-16 60S ribosome export 1 2.05E-15
7 SGTC_547 1120-0019 7.35 610.0 nM 8.52E-15 azole & statin 4 1.02E-13
8 SGTC_227 fluconazole 6.61 33.5 µM 2.48E-12 azole & statin 35 1.86E-11
9 SGTC_1055 3448-0672 5.62 86.0 µM 2.21E-9 13 9.51E-9
10 SGTC_1660 st012960 5.31 28.1 µM 1.45E-8 iron homeostasis 14 5.36E-8
11 SGTC_623 k072-0108 5.28 16.9 µM 1.74E-8 heme biosynthesis & mitochondrial translocase 4 6.33E-8
12 SGTC_660 4031-1742 5.23 102.0 µM 2.43E-8 redox potentiating 17 8.58E-8
13 SGTC_556 4058-0063 5.19 51.5 µM 3.11E-8 13 1.08E-7
14 SGTC_350 k064-0020 5.17 19.8 µM 3.36E-8 heme requiring 9 1.16E-7
15 SGTC_156 3474-0145 5.05 5.6 µM 6.69E-8 endomembrane recycling 32 2.18E-7
16 SGTC_1044 1222-0021 5.05 1.8 µM 6.90E-8 heme biosynthesis & mitochondrial translocase 22 2.24E-7
17 SGTC_2356 9061756 4.69 189.0 µM 4.90E-7 6 1.36E-6
18 SGTC_1290 0986-0249 4.69 10.2 µM 5.05E-7 DNA intercalators 12 1.40E-6
19 SGTC_157 1348-1695 4.43 65.8 µM 1.88E-6 iron homeostasis 47 4.67E-6
20 SGTC_3081 9117243 4.41 49.5 µM 2.12E-6 fatty acid desaturase (OLE1) 14 5.22E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.302 1.26E-71 YDL118W_d YDL118W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps almost completely with YDL119C; mutations that would affect both YDL118W and YDL119C confer defective telomere maintenance and are synthetically sick or lethal with alpha-synuclein
0.272 4.55E-58 YDL119C_p YDL119C_p hom Putative mitochondrial transport protein; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in purified mitochondria
0.230 1.24E-41 YER061C CEM1 hom Mitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis; required for mitochondrial respiration
0.212 2.87E-35 YJL046W AIM22 hom Putative lipoate-protein ligase, required along with Lip2 and Lip5 for lipoylation of Lat1p and Kgd2p; similar to E. coli LplA; null mutant displays reduced frequency of mitochondrial genome loss
0.203 1.62E-32 YKL109W HAP4 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
0.198 4.93E-31 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.197 1.36E-30 YDR232W HEM1 het 5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p
0.193 1.95E-29 YBR227C MCX1 hom Mitochondrial matrix protein; putative ATP-binding chaperone with non-proteolytic function; similar to bacterial ClpX proteins
0.190 1.08E-28 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.189 2.22E-28 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.189 2.51E-28 YBL021C HAP3 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding
0.180 7.97E-26 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.177 4.75E-25 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.168 1.22E-22 YHR045W_p YHR045W_p hom Putative protein of unknown function; possible role in iron metabolism and/or amino acid and carbohydrate metabolism; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum
0.164 1.01E-21 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases