YBR036C / CSG2

Endoplasmic reticulum membrane protein, required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR036C / CSG2

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:5.49|P-value:3.09E-6 ID:SGTC_41|Compound:0478-0632|FD-Score:-5.02|P-value:2.31E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:5.41|P-value:4.17E-6 ID:SGTC_121|Compound:0557-0495|FD-Score:4.66|P-value:6.06E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:8.26|P-value:5.65E-12 ID:SGTC_206|Compound:4546-0025|FD-Score:8.71|P-value:4.16E-13 ID:SGTC_208|Compound:k072-0098|FD-Score:7.32|P-value:8.67E-10 ID:SGTC_217|Compound:ketoconazole|FD-Score:-4.22|P-value:3.08E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:10.60|P-value:1.68E-18 ID:SGTC_232|Compound:clozapine|FD-Score:7.86|P-value:5.27E-11 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.76|P-value:9.58E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:12.40|P-value:1.16E-24 ID:SGTC_309|Compound:k408-0051|FD-Score:7.86|P-value:5.22E-11 ID:SGTC_312|Compound:4092-0653|FD-Score:-4.00|P-value:5.91E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:4.42|P-value:1.33E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:-4.12|P-value:4.13E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:6.92|P-value:6.39E-9 ID:SGTC_365|Compound:0121-0052|FD-Score:-4.54|P-value:1.15E-4 ID:SGTC_373|Compound:0844-0104|FD-Score:4.84|P-value:3.26E-5 ID:SGTC_384|Compound:k007-0144|FD-Score:8.46|P-value:1.83E-12 ID:SGTC_439|Compound:amiodarone|FD-Score:8.49|P-value:1.48E-12 ID:SGTC_470|Compound:aa-861|FD-Score:14.30|P-value:3.60E-32 ID:SGTC_502|Compound:l-744,832|FD-Score:4.19|P-value:2.73E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:-3.92|P-value:7.47E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:8.07|P-value:1.66E-11 ID:SGTC_637|Compound:1181-0519|FD-Score:4.48|P-value:1.10E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:9.37|P-value:7.08E-15 ID:SGTC_664|Compound:1222-0054|FD-Score:5.70|P-value:1.32E-6 ID:SGTC_700|Compound:3453-2283|FD-Score:4.17|P-value:2.86E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:9.00|P-value:7.23E-14 ID:SGTC_813|Compound:k007-0158|FD-Score:6.56|P-value:3.40E-8 ID:SGTC_823|Compound:0417-1665|FD-Score:6.32|P-value:9.72E-8 ID:SGTC_834|Compound:0312-0008|FD-Score:3.93|P-value:5.88E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:6.80|P-value:1.13E-8 ID:SGTC_940|Compound:3232-1287|FD-Score:5.30|P-value:6.31E-6 ID:SGTC_955|Compound:1216-0110|FD-Score:16.80|P-value:2.31E-43 ID:SGTC_993|Compound:3909-8757|FD-Score:6.47|P-value:5.03E-8 ID:SGTC_1026|Compound:k007-1105|FD-Score:7.93|P-value:3.54E-11 ID:SGTC_1130|Compound:3454-2858|FD-Score:4.80|P-value:3.84E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:7.51|P-value:3.29E-10 ID:SGTC_1241|Compound:0364-0022|FD-Score:6.22|P-value:1.57E-7 ID:SGTC_1344|Compound:1488-0097|FD-Score:5.35|P-value:5.32E-6 ID:SGTC_1372|Compound:2752-0194|FD-Score:3.85|P-value:7.44E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:4.24|P-value:2.36E-4 ID:SGTC_1633|Compound:st005664|FD-Score:4.01|P-value:4.67E-4 ID:SGTC_1673|Compound:st016611|FD-Score:4.96|P-value:2.17E-5 ID:SGTC_1781|Compound:st038725|FD-Score:6.27|P-value:1.22E-7 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:4.80|P-value:3.82E-5 ID:SGTC_1797|Compound:st048695|FD-Score:6.06|P-value:3.03E-7 ID:SGTC_1803|Compound:st050068|FD-Score:5.59|P-value:2.10E-6 ID:SGTC_1941|Compound:st076221|FD-Score:5.74|P-value:1.13E-6 ID:SGTC_1991|Compound:st073000|FD-Score:3.82|P-value:7.99E-4 ID:SGTC_2006|Compound:4011487|FD-Score:6.90|P-value:6.97E-9 ID:SGTC_2016|Compound:5121758|FD-Score:4.42|P-value:1.34E-4 ID:SGTC_2020|Compound:4017018|FD-Score:4.61|P-value:7.11E-5 ID:SGTC_2024|Compound:5144227|FD-Score:-3.83|P-value:9.54E-4 ID:SGTC_2036|Compound:5160441|FD-Score:9.45|P-value:4.20E-15 ID:SGTC_2055|Compound:5235184|FD-Score:3.94|P-value:5.66E-4 ID:SGTC_2120|Compound:5538279|FD-Score:4.74|P-value:4.64E-5 ID:SGTC_2208|Compound:7283366|FD-Score:3.76|P-value:9.54E-4 ID:SGTC_2211|Compound:7117706|FD-Score:5.51|P-value:2.85E-6 ID:SGTC_2220|Compound:6782180|FD-Score:3.84|P-value:7.50E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:13.80|P-value:5.58E-30 ID:SGTC_2293|Compound:7624732|FD-Score:5.54|P-value:2.50E-6 ID:SGTC_2359|Compound:9039622|FD-Score:6.47|P-value:5.14E-8 ID:SGTC_2405|Compound:ticlatone|FD-Score:-5.51|P-value:3.80E-6 ID:SGTC_2459|Compound:5811157|FD-Score:4.12|P-value:3.39E-4 ID:SGTC_2472|Compound:5377652|FD-Score:3.75|P-value:9.69E-4 ID:SGTC_2482|Compound:5981709|FD-Score:4.98|P-value:2.01E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.78|P-value:4.05E-5 ID:SGTC_2581|Compound:avocatin a|FD-Score:4.31|P-value:1.91E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:8.09|P-value:1.49E-11 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.76|P-value:9.47E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:-4.04|P-value:5.28E-4 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:14.50|P-value:5.83E-33 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:4.59|P-value:7.74E-5 ID:SGTC_2736|Compound:butenafine|FD-Score:6.72|P-value:1.60E-8 ID:SGTC_2776|Compound:terbinafine|FD-Score:11.70|P-value:5.34E-22 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.90|P-value:7.94E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:-3.91|P-value:7.59E-4 ID:SGTC_2858|Compound:9025781|FD-Score:5.08|P-value:1.41E-5 ID:SGTC_2867|Compound:9039098|FD-Score:14.00|P-value:1.23E-30 ID:SGTC_2873|Compound:9040596|FD-Score:19.40|P-value:2.83E-57 ID:SGTC_2882|Compound:9058044|FD-Score:4.38|P-value:1.49E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-8.05|P-value:2.72E-11 ID:SGTC_2934|Compound:9036370|FD-Score:5.49|P-value:3.03E-6 ID:SGTC_2954|Compound:9074818|FD-Score:9.61|P-value:1.47E-15 ID:SGTC_2968|Compound:9090663|FD-Score:4.12|P-value:3.32E-4 ID:SGTC_3152|Compound:9099253|FD-Score:4.20|P-value:2.66E-4 ID:SGTC_3166|Compound:9102297|FD-Score:4.27|P-value:2.10E-4 ID:SGTC_3188|Compound:9110789|FD-Score:5.59|P-value:2.06E-6 ID:SGTC_3189|Compound:9110682|FD-Score:6.72|P-value:1.61E-8 ID:SGTC_3220|Compound:9131269|FD-Score:3.83|P-value:7.88E-4 ID:SGTC_3311|Compound:9131146|FD-Score:8.13|P-value:1.16E-11 ID:SGTC_15|Compound:0266-0086|FD-Score:5.49|P-value:3.09E-6 ID:SGTC_41|Compound:0478-0632|FD-Score:-5.02|P-value:2.31E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:5.41|P-value:4.17E-6 ID:SGTC_121|Compound:0557-0495|FD-Score:4.66|P-value:6.06E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:8.26|P-value:5.65E-12 ID:SGTC_206|Compound:4546-0025|FD-Score:8.71|P-value:4.16E-13 ID:SGTC_208|Compound:k072-0098|FD-Score:7.32|P-value:8.67E-10 ID:SGTC_217|Compound:ketoconazole|FD-Score:-4.22|P-value:3.08E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:10.60|P-value:1.68E-18 ID:SGTC_232|Compound:clozapine|FD-Score:7.86|P-value:5.27E-11 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.76|P-value:9.58E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:12.40|P-value:1.16E-24 ID:SGTC_309|Compound:k408-0051|FD-Score:7.86|P-value:5.22E-11 ID:SGTC_312|Compound:4092-0653|FD-Score:-4.00|P-value:5.91E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:4.42|P-value:1.33E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:-4.12|P-value:4.13E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:6.92|P-value:6.39E-9 ID:SGTC_365|Compound:0121-0052|FD-Score:-4.54|P-value:1.15E-4 ID:SGTC_373|Compound:0844-0104|FD-Score:4.84|P-value:3.26E-5 ID:SGTC_384|Compound:k007-0144|FD-Score:8.46|P-value:1.83E-12 ID:SGTC_439|Compound:amiodarone|FD-Score:8.49|P-value:1.48E-12 ID:SGTC_470|Compound:aa-861|FD-Score:14.30|P-value:3.60E-32 ID:SGTC_502|Compound:l-744,832|FD-Score:4.19|P-value:2.73E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:-3.92|P-value:7.47E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:8.07|P-value:1.66E-11 ID:SGTC_637|Compound:1181-0519|FD-Score:4.48|P-value:1.10E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:9.37|P-value:7.08E-15 ID:SGTC_664|Compound:1222-0054|FD-Score:5.70|P-value:1.32E-6 ID:SGTC_700|Compound:3453-2283|FD-Score:4.17|P-value:2.86E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:9.00|P-value:7.23E-14 ID:SGTC_813|Compound:k007-0158|FD-Score:6.56|P-value:3.40E-8 ID:SGTC_823|Compound:0417-1665|FD-Score:6.32|P-value:9.72E-8 ID:SGTC_834|Compound:0312-0008|FD-Score:3.93|P-value:5.88E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:6.80|P-value:1.13E-8 ID:SGTC_940|Compound:3232-1287|FD-Score:5.30|P-value:6.31E-6 ID:SGTC_955|Compound:1216-0110|FD-Score:16.80|P-value:2.31E-43 ID:SGTC_993|Compound:3909-8757|FD-Score:6.47|P-value:5.03E-8 ID:SGTC_1026|Compound:k007-1105|FD-Score:7.93|P-value:3.54E-11 ID:SGTC_1130|Compound:3454-2858|FD-Score:4.80|P-value:3.84E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:7.51|P-value:3.29E-10 ID:SGTC_1241|Compound:0364-0022|FD-Score:6.22|P-value:1.57E-7 ID:SGTC_1344|Compound:1488-0097|FD-Score:5.35|P-value:5.32E-6 ID:SGTC_1372|Compound:2752-0194|FD-Score:3.85|P-value:7.44E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:4.24|P-value:2.36E-4 ID:SGTC_1633|Compound:st005664|FD-Score:4.01|P-value:4.67E-4 ID:SGTC_1673|Compound:st016611|FD-Score:4.96|P-value:2.17E-5 ID:SGTC_1781|Compound:st038725|FD-Score:6.27|P-value:1.22E-7 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:4.80|P-value:3.82E-5 ID:SGTC_1797|Compound:st048695|FD-Score:6.06|P-value:3.03E-7 ID:SGTC_1803|Compound:st050068|FD-Score:5.59|P-value:2.10E-6 ID:SGTC_1941|Compound:st076221|FD-Score:5.74|P-value:1.13E-6 ID:SGTC_1991|Compound:st073000|FD-Score:3.82|P-value:7.99E-4 ID:SGTC_2006|Compound:4011487|FD-Score:6.90|P-value:6.97E-9 ID:SGTC_2016|Compound:5121758|FD-Score:4.42|P-value:1.34E-4 ID:SGTC_2020|Compound:4017018|FD-Score:4.61|P-value:7.11E-5 ID:SGTC_2024|Compound:5144227|FD-Score:-3.83|P-value:9.54E-4 ID:SGTC_2036|Compound:5160441|FD-Score:9.45|P-value:4.20E-15 ID:SGTC_2055|Compound:5235184|FD-Score:3.94|P-value:5.66E-4 ID:SGTC_2120|Compound:5538279|FD-Score:4.74|P-value:4.64E-5 ID:SGTC_2208|Compound:7283366|FD-Score:3.76|P-value:9.54E-4 ID:SGTC_2211|Compound:7117706|FD-Score:5.51|P-value:2.85E-6 ID:SGTC_2220|Compound:6782180|FD-Score:3.84|P-value:7.50E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:13.80|P-value:5.58E-30 ID:SGTC_2293|Compound:7624732|FD-Score:5.54|P-value:2.50E-6 ID:SGTC_2359|Compound:9039622|FD-Score:6.47|P-value:5.14E-8 ID:SGTC_2405|Compound:ticlatone|FD-Score:-5.51|P-value:3.80E-6 ID:SGTC_2459|Compound:5811157|FD-Score:4.12|P-value:3.39E-4 ID:SGTC_2472|Compound:5377652|FD-Score:3.75|P-value:9.69E-4 ID:SGTC_2482|Compound:5981709|FD-Score:4.98|P-value:2.01E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.78|P-value:4.05E-5 ID:SGTC_2581|Compound:avocatin a|FD-Score:4.31|P-value:1.91E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:8.09|P-value:1.49E-11 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.76|P-value:9.47E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:-4.04|P-value:5.28E-4 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:14.50|P-value:5.83E-33 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:4.59|P-value:7.74E-5 ID:SGTC_2736|Compound:butenafine|FD-Score:6.72|P-value:1.60E-8 ID:SGTC_2776|Compound:terbinafine|FD-Score:11.70|P-value:5.34E-22 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.90|P-value:7.94E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:-3.91|P-value:7.59E-4 ID:SGTC_2858|Compound:9025781|FD-Score:5.08|P-value:1.41E-5 ID:SGTC_2867|Compound:9039098|FD-Score:14.00|P-value:1.23E-30 ID:SGTC_2873|Compound:9040596|FD-Score:19.40|P-value:2.83E-57 ID:SGTC_2882|Compound:9058044|FD-Score:4.38|P-value:1.49E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-8.05|P-value:2.72E-11 ID:SGTC_2934|Compound:9036370|FD-Score:5.49|P-value:3.03E-6 ID:SGTC_2954|Compound:9074818|FD-Score:9.61|P-value:1.47E-15 ID:SGTC_2968|Compound:9090663|FD-Score:4.12|P-value:3.32E-4 ID:SGTC_3152|Compound:9099253|FD-Score:4.20|P-value:2.66E-4 ID:SGTC_3166|Compound:9102297|FD-Score:4.27|P-value:2.10E-4 ID:SGTC_3188|Compound:9110789|FD-Score:5.59|P-value:2.06E-6 ID:SGTC_3189|Compound:9110682|FD-Score:6.72|P-value:1.61E-8 ID:SGTC_3220|Compound:9131269|FD-Score:3.83|P-value:7.88E-4 ID:SGTC_3311|Compound:9131146|FD-Score:8.13|P-value:1.16E-11

Top fitness defect scores for YBR036C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2873 9040596 19.40 71.4 µM 2.83E-57 1 3.31E-84
2 SGTC_955 1216-0110 16.80 33.0 µM 2.31E-43 sphingolipid biosynthesis & PDR1 6 1.72E-63
3 SGTC_2658 polymyxin b sulfate 14.50 77.0 µM 5.83E-33 NEO1 4 5.15E-48
4 SGTC_470 aa-861 14.30 153.0 µM 3.60E-32 sphingolipid biosynthesis & PDR1 3 7.72E-47
5 SGTC_2867 9039098 14.00 71.4 µM 1.23E-30 iron homeostasis 1 1.47E-44
6 SGTC_2232 chlorophetanol 13.80 41.5 µM 5.58E-30 TRP & mitochondrial translation 6 1.39E-43
7 SGTC_266 formosanin C 12.40 406.0 nM 1.16E-24 sphingolipid biosynthesis & PDR1 10 1.11E-35
8 SGTC_2776 terbinafine 11.70 19.9 µM 5.34E-22 cell wall signaling 7 1.00E-31
9 SGTC_221 trifluoperazine 10.60 10.3 µM 1.68E-18 NEO1-PIK1 53 1.55E-26
10 SGTC_2954 9074818 9.61 52.7 µM 1.47E-15 2 3.56E-22
11 SGTC_2036 5160441 9.45 105.0 µM 4.20E-15 NEO1 20 1.68E-21
12 SGTC_658 3253-0951 9.37 102.0 µM 7.08E-15 calcium & mitochondrial duress 5 3.65E-21
13 SGTC_733 4069-0007 9.00 56.1 µM 7.23E-14 ERAD & cell cycle 20 1.14E-19
14 SGTC_206 4546-0025 8.71 72.0 µM 4.16E-13 NEO1 16 1.52E-18
15 SGTC_439 amiodarone 8.49 34.4 µM 1.48E-12 NEO1-PIK1 19 9.91E-18
16 SGTC_384 k007-0144 8.46 5.2 µM 1.83E-12 ERAD & cell cycle 13 1.35E-17
17 SGTC_146 3448-8650 8.26 53.1 µM 5.65E-12 NEO1-PIK1 25 7.19E-17
18 SGTC_3311 9131146 8.13 2.9 µM 1.16E-11 cell wall 33 2.07E-16
19 SGTC_2582 agaric acid 8.09 100.0 µM 1.49E-11 redox potentiating 102 3.02E-16
20 SGTC_568 1193-0097 8.07 7.5 µM 1.66E-11 ERAD & cell cycle 36 3.54E-16

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.500 5.38E-212 YPL057C SUR1 hom Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication
0.469 1.48E-183 YDR072C IPT1 hom Inositolphosphotransferase, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid; can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin
0.358 3.48E-102 YDR372C VPS74 hom Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33
0.305 1.87E-73 YIL048W NEO1 het Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus
0.302 9.52E-72 YDR456W NHX1 hom Na+/H+ and K+/H+ exchanger, required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion
0.262 1.43E-53 YHR004C NEM1 hom Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation; homolog of the human protein Dullard
0.248 2.59E-48 YDR455C_d YDR455C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W
0.247 5.15E-48 YIL030C SSM4 hom Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.246 2.33E-47 YAL009W SPO7 hom Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology, premeiotic replication, and sporulation
0.239 6.09E-45 YOR039W CKB2 hom Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase
0.237 4.79E-44 YPL002C SNF8 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression
0.236 6.73E-44 YLR057W MNL2 hom Putative mannosidase involved in ER-associated protein degradation; localizes to the endoplasmic reticulum; sequence similarity with seven-hairpin glycosidase (GH47) family members, such as Mns1p and Mnl1p, that hydrolyze 1,2-linked alpha-D-mannose residues; non-essential gene
0.233 1.04E-42 YMR102C_p YMR102C_p hom Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
0.229 5.55E-41 YDL090C RAM1 hom Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit
0.228 8.67E-41 YOL002C IZH2 hom Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc