YBR037C / SCO1

Copper-binding protein of mitochondrial inner membrane; required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; similar to thioredoxins; SCO1 has a paralog, SCO2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR037C / SCO1

Click on Significant Values for Screen Details ID:SGTC_40|Compound:0327-0103|FD-Score:4.18|P-value:3.29E-5 ID:SGTC_144|Compound:4161-2749|FD-Score:3.80|P-value:1.40E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.38|P-value:5.87E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:-4.01|P-value:5.84E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:9.44|P-value:8.36E-20 ID:SGTC_314|Compound:1671-0008|FD-Score:4.22|P-value:2.75E-5 ID:SGTC_324|Compound:1315-0088|FD-Score:5.08|P-value:5.90E-7 ID:SGTC_371|Compound:0195-0006|FD-Score:3.48|P-value:4.48E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:3.52|P-value:3.82E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:3.52|P-value:3.87E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:3.34|P-value:7.13E-4 ID:SGTC_657|Compound:3534-0529|FD-Score:3.79|P-value:1.48E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:3.87|P-value:1.08E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:3.45|P-value:4.86E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:3.28|P-value:8.79E-4 ID:SGTC_1067|Compound:clotrimazole|FD-Score:4.24|P-value:2.58E-5 ID:SGTC_1068|Compound:loratadine|FD-Score:3.45|P-value:4.94E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:-3.32|P-value:7.03E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.43|P-value:5.17E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.39|P-value:6.01E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.24|P-value:9.78E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:4.08|P-value:4.81E-5 ID:SGTC_1291|Compound:0993-0025|FD-Score:3.84|P-value:1.19E-4 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:4.53|P-value:7.55E-6 ID:SGTC_1394|Compound:3474-0001|FD-Score:4.12|P-value:4.07E-5 ID:SGTC_1480|Compound:1070-0044|FD-Score:3.60|P-value:2.90E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.49|P-value:4.33E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.61|P-value:2.84E-4 ID:SGTC_1689|Compound:st020265|FD-Score:3.37|P-value:6.53E-4 ID:SGTC_1744|Compound:st037937|FD-Score:-3.61|P-value:2.64E-4 ID:SGTC_1764|Compound:st044502|FD-Score:4.26|P-value:2.34E-5 ID:SGTC_1923|Compound:st058458|FD-Score:3.60|P-value:2.87E-4 ID:SGTC_1946|Compound:st076057|FD-Score:-3.25|P-value:8.82E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:3.32|P-value:7.53E-4 ID:SGTC_2016|Compound:5121758|FD-Score:3.38|P-value:6.29E-4 ID:SGTC_2079|Compound:5212404|FD-Score:6.00|P-value:4.63E-9 ID:SGTC_2120|Compound:5538279|FD-Score:3.44|P-value:5.07E-4 ID:SGTC_2438|Compound:5259590|FD-Score:4.41|P-value:1.23E-5 ID:SGTC_2607|Compound:solasodine|FD-Score:3.56|P-value:3.36E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.38|P-value:6.23E-4 ID:SGTC_2728|Compound:chlorpromazine|FD-Score:3.69|P-value:2.10E-4 ID:SGTC_2821|Compound:7996764|FD-Score:3.44|P-value:5.03E-4 ID:SGTC_2948|Compound:9070189|FD-Score:3.51|P-value:3.98E-4 ID:SGTC_3301|Compound:9125354|FD-Score:3.36|P-value:6.67E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:4.18|P-value:3.29E-5 ID:SGTC_144|Compound:4161-2749|FD-Score:3.80|P-value:1.40E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.38|P-value:5.87E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:-4.01|P-value:5.84E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:9.44|P-value:8.36E-20 ID:SGTC_314|Compound:1671-0008|FD-Score:4.22|P-value:2.75E-5 ID:SGTC_324|Compound:1315-0088|FD-Score:5.08|P-value:5.90E-7 ID:SGTC_371|Compound:0195-0006|FD-Score:3.48|P-value:4.48E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:3.52|P-value:3.82E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:3.52|P-value:3.87E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:3.34|P-value:7.13E-4 ID:SGTC_657|Compound:3534-0529|FD-Score:3.79|P-value:1.48E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:3.87|P-value:1.08E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:3.45|P-value:4.86E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:3.28|P-value:8.79E-4 ID:SGTC_1067|Compound:clotrimazole|FD-Score:4.24|P-value:2.58E-5 ID:SGTC_1068|Compound:loratadine|FD-Score:3.45|P-value:4.94E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:-3.32|P-value:7.03E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.43|P-value:5.17E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.39|P-value:6.01E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.24|P-value:9.78E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:4.08|P-value:4.81E-5 ID:SGTC_1291|Compound:0993-0025|FD-Score:3.84|P-value:1.19E-4 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:4.53|P-value:7.55E-6 ID:SGTC_1394|Compound:3474-0001|FD-Score:4.12|P-value:4.07E-5 ID:SGTC_1480|Compound:1070-0044|FD-Score:3.60|P-value:2.90E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.49|P-value:4.33E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.61|P-value:2.84E-4 ID:SGTC_1689|Compound:st020265|FD-Score:3.37|P-value:6.53E-4 ID:SGTC_1744|Compound:st037937|FD-Score:-3.61|P-value:2.64E-4 ID:SGTC_1764|Compound:st044502|FD-Score:4.26|P-value:2.34E-5 ID:SGTC_1923|Compound:st058458|FD-Score:3.60|P-value:2.87E-4 ID:SGTC_1946|Compound:st076057|FD-Score:-3.25|P-value:8.82E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:3.32|P-value:7.53E-4 ID:SGTC_2016|Compound:5121758|FD-Score:3.38|P-value:6.29E-4 ID:SGTC_2079|Compound:5212404|FD-Score:6.00|P-value:4.63E-9 ID:SGTC_2120|Compound:5538279|FD-Score:3.44|P-value:5.07E-4 ID:SGTC_2438|Compound:5259590|FD-Score:4.41|P-value:1.23E-5 ID:SGTC_2607|Compound:solasodine|FD-Score:3.56|P-value:3.36E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.38|P-value:6.23E-4 ID:SGTC_2728|Compound:chlorpromazine|FD-Score:3.69|P-value:2.10E-4 ID:SGTC_2821|Compound:7996764|FD-Score:3.44|P-value:5.03E-4 ID:SGTC_2948|Compound:9070189|FD-Score:3.51|P-value:3.98E-4 ID:SGTC_3301|Compound:9125354|FD-Score:3.36|P-value:6.67E-4

Top fitness defect scores for YBR037C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 9.44 5.3 µM 8.36E-20 206 1.93E-21
2 SGTC_2079 5212404 6.00 121.0 µM 4.63E-9 1 9.61E-10
3 SGTC_324 1315-0088 5.08 19.6 µM 5.90E-7 RSC & ERG11 2 1.88E-7
4 SGTC_1301 naphtanilide LB 4.53 4.8 µM 7.55E-6 heme requiring 4 3.00E-6
5 SGTC_2438 5259590 4.41 200.0 µM 1.23E-5 13 5.11E-6
6 SGTC_1764 st044502 4.26 93.5 µM 2.34E-5 26 1.03E-5
7 SGTC_1067 clotrimazole 4.24 1.4 µM 2.58E-5 azole & statin 33 1.14E-5
8 SGTC_314 1671-0008 4.22 2.7 µM 2.75E-5 42 1.22E-5
9 SGTC_40 0327-0103 4.18 19.8 µM 3.29E-5 24 1.49E-5
10 SGTC_1394 3474-0001 4.12 65.7 µM 4.07E-5 endomembrane recycling 38 1.88E-5
11 SGTC_1264 0783-0040 4.08 158.0 µM 4.81E-5 24 2.25E-5
12 SGTC_777 1315-0167 3.87 517.0 µM 1.08E-4 Golgi 26 5.41E-5
13 SGTC_1291 0993-0025 3.84 5.8 µM 1.19E-4 13 6.04E-5
14 SGTC_144 4161-2749 3.80 112.4 µM 1.40E-4 DNA intercalators 26 7.18E-5
15 SGTC_657 3534-0529 3.79 86.7 µM 1.48E-4 15 7.64E-5
16 SGTC_2728 chlorpromazine 3.69 9.2 µM 2.10E-4 4 1.11E-4
17 SGTC_1534 6-azauridine 3.61 81.6 µM 2.84E-4 RNA pol III & RNase P/MRP 36 1.55E-4
18 SGTC_1923 st058458 3.60 19.1 µM 2.87E-4 44 1.57E-4
19 SGTC_1480 1070-0044 3.60 41.2 µM 2.90E-4 27 1.58E-4
20 SGTC_2607 solasodine 3.56 47.4 µM 3.36E-4 73 1.86E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.282 1.24E-62 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.280 1.37E-61 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.278 9.68E-61 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.277 2.85E-60 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.268 2.28E-56 YMR286W MRPL33 hom Mitochondrial ribosomal protein of the large subunit
0.268 4.85E-56 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.263 5.17E-54 YJL022W_d YJL022W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.258 5.91E-52 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.257 8.01E-52 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.252 7.67E-50 YHR116W COX23 hom Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs
0.247 4.93E-48 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.246 3.08E-47 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.243 1.82E-46 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.240 3.62E-45 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.238 1.34E-44 YML129C COX14 hom Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes