YBR040W / FIG1

Integral membrane protein required for efficient mating; may participate in or regulate the low affinity Ca2+ influx system, which affects intracellular signaling and cell-cell fusion during mating

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR040W / FIG1

Click on Significant Values for Screen Details ID:SGTC_68|Compound:0986-0284|FD-Score:7.55|P-value:7.78E-16 ID:SGTC_85|Compound:0868-0259|FD-Score:5.35|P-value:7.82E-9 ID:SGTC_96|Compound:0929-0093|FD-Score:-3.12|P-value:4.88E-4 ID:SGTC_259|Compound:usnic acid|FD-Score:-3.06|P-value:6.13E-4 ID:SGTC_333|Compound:3486-0131|FD-Score:3.29|P-value:2.59E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:3.98|P-value:1.34E-5 ID:SGTC_617|Compound:3770-0098|FD-Score:3.26|P-value:2.91E-4 ID:SGTC_776|Compound:4476-4378|FD-Score:5.78|P-value:5.16E-10 ID:SGTC_785|Compound:1270-0111|FD-Score:-3.73|P-value:4.03E-5 ID:SGTC_787|Compound:4152-0075|FD-Score:-3.88|P-value:2.05E-5 ID:SGTC_854|Compound:0422-0053|FD-Score:3.04|P-value:6.63E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:-4.24|P-value:3.82E-6 ID:SGTC_871|Compound:0574-0004|FD-Score:3.67|P-value:5.22E-5 ID:SGTC_877|Compound:0771-0151|FD-Score:5.28|P-value:1.27E-8 ID:SGTC_970|Compound:1315-0089|FD-Score:-4.03|P-value:1.03E-5 ID:SGTC_972|Compound:1319-0219|FD-Score:3.12|P-value:4.99E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:6.94|P-value:1.13E-13 ID:SGTC_988|Compound:1497-1057|FD-Score:3.70|P-value:4.70E-5 ID:SGTC_1136|Compound:pergolide|FD-Score:4.02|P-value:1.11E-5 ID:SGTC_1213|Compound:1315-0166|FD-Score:-3.37|P-value:1.87E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:-3.08|P-value:5.82E-4 ID:SGTC_1413|Compound:3910-0535|FD-Score:3.99|P-value:1.24E-5 ID:SGTC_1422|Compound:4031-0024|FD-Score:3.39|P-value:1.70E-4 ID:SGTC_1728|Compound:st035614|FD-Score:3.39|P-value:1.75E-4 ID:SGTC_1746|Compound:st038117|FD-Score:2.96|P-value:8.88E-4 ID:SGTC_1851|Compound:st056236|FD-Score:3.19|P-value:3.83E-4 ID:SGTC_1861|Compound:st057647|FD-Score:2.98|P-value:8.22E-4 ID:SGTC_1868|Compound:st057644|FD-Score:3.12|P-value:4.89E-4 ID:SGTC_1878|Compound:temozolomide|FD-Score:3.30|P-value:2.42E-4 ID:SGTC_2137|Compound:5261020|FD-Score:3.28|P-value:2.69E-4 ID:SGTC_2191|Compound:5911152|FD-Score:3.39|P-value:1.71E-4 ID:SGTC_2299|Compound:7976368|FD-Score:4.22|P-value:4.26E-6 ID:SGTC_2302|Compound:7771753|FD-Score:3.38|P-value:1.76E-4 ID:SGTC_2383|Compound:9036125|FD-Score:3.20|P-value:3.62E-4 ID:SGTC_2394|Compound:5221648|FD-Score:-5.02|P-value:5.62E-8 ID:SGTC_2403|Compound:6032726|FD-Score:-2.97|P-value:8.58E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:5.33|P-value:9.03E-9 ID:SGTC_2563|Compound:tomatine|FD-Score:-5.29|P-value:1.20E-8 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.07|P-value:5.96E-4 ID:SGTC_2623|Compound:humulene|FD-Score:3.14|P-value:4.50E-4 ID:SGTC_2717|Compound:st081029|FD-Score:3.08|P-value:5.63E-4 ID:SGTC_2781|Compound:5567276|FD-Score:3.43|P-value:1.43E-4 ID:SGTC_2906|Compound:7926292|FD-Score:3.07|P-value:5.94E-4 ID:SGTC_2915|Compound:7971052|FD-Score:3.10|P-value:5.39E-4 ID:SGTC_2932|Compound:9016711|FD-Score:3.11|P-value:5.12E-4 ID:SGTC_3012|Compound:9080433|FD-Score:3.67|P-value:5.25E-5 ID:SGTC_3208|Compound:9114115|FD-Score:3.93|P-value:1.64E-5 ID:SGTC_3211|Compound:9128781|FD-Score:-3.26|P-value:2.90E-4 ID:SGTC_3352|Compound:9151559|FD-Score:3.17|P-value:4.15E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:7.55|P-value:7.78E-16 ID:SGTC_85|Compound:0868-0259|FD-Score:5.35|P-value:7.82E-9 ID:SGTC_96|Compound:0929-0093|FD-Score:-3.12|P-value:4.88E-4 ID:SGTC_259|Compound:usnic acid|FD-Score:-3.06|P-value:6.13E-4 ID:SGTC_333|Compound:3486-0131|FD-Score:3.29|P-value:2.59E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:3.98|P-value:1.34E-5 ID:SGTC_617|Compound:3770-0098|FD-Score:3.26|P-value:2.91E-4 ID:SGTC_776|Compound:4476-4378|FD-Score:5.78|P-value:5.16E-10 ID:SGTC_785|Compound:1270-0111|FD-Score:-3.73|P-value:4.03E-5 ID:SGTC_787|Compound:4152-0075|FD-Score:-3.88|P-value:2.05E-5 ID:SGTC_854|Compound:0422-0053|FD-Score:3.04|P-value:6.63E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:-4.24|P-value:3.82E-6 ID:SGTC_871|Compound:0574-0004|FD-Score:3.67|P-value:5.22E-5 ID:SGTC_877|Compound:0771-0151|FD-Score:5.28|P-value:1.27E-8 ID:SGTC_970|Compound:1315-0089|FD-Score:-4.03|P-value:1.03E-5 ID:SGTC_972|Compound:1319-0219|FD-Score:3.12|P-value:4.99E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:6.94|P-value:1.13E-13 ID:SGTC_988|Compound:1497-1057|FD-Score:3.70|P-value:4.70E-5 ID:SGTC_1136|Compound:pergolide|FD-Score:4.02|P-value:1.11E-5 ID:SGTC_1213|Compound:1315-0166|FD-Score:-3.37|P-value:1.87E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:-3.08|P-value:5.82E-4 ID:SGTC_1413|Compound:3910-0535|FD-Score:3.99|P-value:1.24E-5 ID:SGTC_1422|Compound:4031-0024|FD-Score:3.39|P-value:1.70E-4 ID:SGTC_1728|Compound:st035614|FD-Score:3.39|P-value:1.75E-4 ID:SGTC_1746|Compound:st038117|FD-Score:2.96|P-value:8.88E-4 ID:SGTC_1851|Compound:st056236|FD-Score:3.19|P-value:3.83E-4 ID:SGTC_1861|Compound:st057647|FD-Score:2.98|P-value:8.22E-4 ID:SGTC_1868|Compound:st057644|FD-Score:3.12|P-value:4.89E-4 ID:SGTC_1878|Compound:temozolomide|FD-Score:3.30|P-value:2.42E-4 ID:SGTC_2137|Compound:5261020|FD-Score:3.28|P-value:2.69E-4 ID:SGTC_2191|Compound:5911152|FD-Score:3.39|P-value:1.71E-4 ID:SGTC_2299|Compound:7976368|FD-Score:4.22|P-value:4.26E-6 ID:SGTC_2302|Compound:7771753|FD-Score:3.38|P-value:1.76E-4 ID:SGTC_2383|Compound:9036125|FD-Score:3.20|P-value:3.62E-4 ID:SGTC_2394|Compound:5221648|FD-Score:-5.02|P-value:5.62E-8 ID:SGTC_2403|Compound:6032726|FD-Score:-2.97|P-value:8.58E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:5.33|P-value:9.03E-9 ID:SGTC_2563|Compound:tomatine|FD-Score:-5.29|P-value:1.20E-8 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.07|P-value:5.96E-4 ID:SGTC_2623|Compound:humulene|FD-Score:3.14|P-value:4.50E-4 ID:SGTC_2717|Compound:st081029|FD-Score:3.08|P-value:5.63E-4 ID:SGTC_2781|Compound:5567276|FD-Score:3.43|P-value:1.43E-4 ID:SGTC_2906|Compound:7926292|FD-Score:3.07|P-value:5.94E-4 ID:SGTC_2915|Compound:7971052|FD-Score:3.10|P-value:5.39E-4 ID:SGTC_2932|Compound:9016711|FD-Score:3.11|P-value:5.12E-4 ID:SGTC_3012|Compound:9080433|FD-Score:3.67|P-value:5.25E-5 ID:SGTC_3208|Compound:9114115|FD-Score:3.93|P-value:1.64E-5 ID:SGTC_3211|Compound:9128781|FD-Score:-3.26|P-value:2.90E-4 ID:SGTC_3352|Compound:9151559|FD-Score:3.17|P-value:4.15E-4

Top fitness defect scores for YBR040W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_68 0986-0284 7.55 82.8 µM 7.78E-16 8 2.18E-14
2 SGTC_976 1348-1067 6.94 47.6 µM 1.13E-13 60S ribosome export 2 1.91E-12
3 SGTC_776 4476-4378 5.78 112.0 µM 5.16E-10 ERG2 8 3.72E-9
4 SGTC_85 0868-0259 5.35 160.1 µM 7.82E-9 60S ribosome export 3 4.29E-8
5 SGTC_2405 ticlatone 5.33 3.5 µM 9.03E-9 34 4.88E-8
6 SGTC_877 0771-0151 5.28 33.1 µM 1.27E-8 3 6.62E-8
7 SGTC_2299 7976368 4.22 114.9 µM 4.26E-6 22 1.25E-5
8 SGTC_1136 pergolide 4.02 1.1 µM 1.11E-5 36 2.96E-5
9 SGTC_1413 3910-0535 3.99 34.4 µM 1.24E-5 11 3.25E-5
10 SGTC_594 1487-1584 3.98 10.8 µM 1.34E-5 22 3.50E-5
11 SGTC_3208 9114115 3.93 49.5 µM 1.64E-5 35 4.20E-5
12 SGTC_988 1497-1057 3.70 103.0 µM 4.70E-5 14 1.08E-4
13 SGTC_871 0574-0004 3.67 149.0 µM 5.22E-5 56 1.19E-4
14 SGTC_3012 9080433 3.67 71.4 µM 5.25E-5 17 1.20E-4
15 SGTC_2781 5567276 3.43 71.4 µM 1.43E-4 79 2.97E-4
16 SGTC_1422 4031-0024 3.39 15.5 µM 1.70E-4 iron homeostasis 33 3.45E-4
17 SGTC_2191 5911152 3.39 200.0 µM 1.71E-4 30 3.49E-4
18 SGTC_1728 st035614 3.39 33.8 µM 1.75E-4 85 3.55E-4
19 SGTC_2302 7771753 3.38 200.0 µM 1.76E-4 62 3.58E-4
20 SGTC_1878 temozolomide 3.30 1.0 mM 2.42E-4 23 4.76E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.201 5.97E-32 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.128 8.46E-14 YDR329C PEX3 hom Peroxisomal membrane protein (PMP) required for proper localization and stability of PMPs; anchors peroxisome retention factor Inp1p at the peroxisomal membrane; interacts with Pex19p
0.116 1.63E-11 YAL024C LTE1 hom Protein similar to GDP/GTP exchange factors but without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures
0.112 7.34E-11 YDR412W RRP17 het Component of the pre-60S pre-ribosomal particle; required for cell viability under standard (aerobic) conditions but not under anaerobic conditions; exonuclease required for 5′ end processing of pre-60S ribosomal RNA
0.106 6.36E-10 YBR205W KTR3 hom Putative alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; Svp26p mediates uptake of Ktr3p into COPII vesicles; relocalizes from nucleus to vacuole upon DNA replication stress
0.100 6.63E-9 YER074W RPS24A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24A has a paralog, RPS24B, that arose from the whole genome duplication
0.098 1.25E-8 YNL298W CLA4 hom Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p
0.093 6.65E-8 YGL135W RPL1B hom Ribosomal 60S subunit protein L1B; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1B has a paralog, RPL1A, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal
0.093 6.88E-8 YDR164C SEC1 het Sm-like protein involved in docking and fusion of exocytic vesicles; binds to assembled SNARE complexes at the membrane and stimulates membrane fusion; localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function
0.086 5.96E-7 YJL047C-A_p YJL047C-A_p hom Putative protein of unknown function
0.086 6.28E-7 YGR134W CAF130 hom Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation
0.086 6.59E-7 YPL010W RET3 het Zeta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER
0.085 9.27E-7 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.084 1.12E-6 YML028W TSA1 hom Thioredoxin peroxidase; acts as both a ribosome-associated and free cytoplasmic antioxidant; self-associates to form a high-molecular weight chaperone complex under oxidative stress; deletion results in mutator phenotype; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress
0.083 1.47E-6 YDR219C MFB1 hom Mitochondria-associated F-box protein involved in maintenance of normal mitochondrial morphology; interacts with Skp1p through the F-box motif; preferentially localizes to the mother cell during budding