YBR042C / CST26

Putative transferase involved in phospholipid biosynthesis; required for incorporation of stearic acid into phosphatidylinositol; affects chromosome stability when overexpressed; CST26 has a paralog, YDR018C, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR042C / CST26

Click on Significant Values for Screen Details ID:SGTC_119|Compound:0121-0043|FD-Score:-3.14|P-value:8.43E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:3.10|P-value:7.70E-4 ID:SGTC_200|Compound:k038-0079|FD-Score:-3.23|P-value:6.14E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:5.99|P-value:5.78E-10 ID:SGTC_310|Compound:1273-0058|FD-Score:7.97|P-value:3.14E-16 ID:SGTC_451|Compound:chloral hydrate|FD-Score:-3.29|P-value:4.98E-4 ID:SGTC_480|Compound:am 92016|FD-Score:-3.86|P-value:5.54E-5 ID:SGTC_698|Compound:k064-0052|FD-Score:-3.30|P-value:4.94E-4 ID:SGTC_702|Compound:1488-0190|FD-Score:4.09|P-value:1.52E-5 ID:SGTC_885|Compound:0865-0106|FD-Score:3.22|P-value:5.05E-4 ID:SGTC_890|Compound:0929-0006|FD-Score:3.04|P-value:9.53E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:3.52|P-value:1.62E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:-3.13|P-value:8.71E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:3.55|P-value:1.47E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:3.24|P-value:4.61E-4 ID:SGTC_1140|Compound:3229-1848|FD-Score:3.19|P-value:5.67E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:-3.82|P-value:6.46E-5 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.70|P-value:7.92E-5 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:4.56|P-value:1.69E-6 ID:SGTC_1685|Compound:st024049|FD-Score:-4.12|P-value:1.82E-5 ID:SGTC_1702|Compound:st027038|FD-Score:3.27|P-value:4.16E-4 ID:SGTC_1752|Compound:st044819|FD-Score:4.36|P-value:4.50E-6 ID:SGTC_1761|Compound:st044296|FD-Score:4.00|P-value:2.26E-5 ID:SGTC_1782|Compound:st039423|FD-Score:3.53|P-value:1.57E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:4.32|P-value:5.44E-6 ID:SGTC_1832|Compound:st054113|FD-Score:3.86|P-value:4.12E-5 ID:SGTC_1841|Compound:st054148|FD-Score:3.65|P-value:9.99E-5 ID:SGTC_1985|Compound:st071382|FD-Score:3.20|P-value:5.44E-4 ID:SGTC_1994|Compound:st072947|FD-Score:-4.51|P-value:3.00E-6 ID:SGTC_2139|Compound:5578692|FD-Score:3.25|P-value:4.55E-4 ID:SGTC_2281|Compound:7943571|FD-Score:-3.35|P-value:4.02E-4 ID:SGTC_2285|Compound:7945142|FD-Score:3.87|P-value:3.92E-5 ID:SGTC_2308|Compound:7584454|FD-Score:3.78|P-value:5.91E-5 ID:SGTC_2321|Compound:7390090|FD-Score:3.25|P-value:4.47E-4 ID:SGTC_2370|Compound:9071495|FD-Score:3.24|P-value:4.69E-4 ID:SGTC_2450|Compound:5739737|FD-Score:3.83|P-value:4.65E-5 ID:SGTC_2557|Compound:derrustone|FD-Score:3.38|P-value:2.85E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:-3.48|P-value:2.49E-4 ID:SGTC_2646|Compound:retinol|FD-Score:3.41|P-value:2.50E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.06|P-value:1.34E-7 ID:SGTC_2808|Compound:7946468|FD-Score:3.08|P-value:8.29E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.18|P-value:5.91E-4 ID:SGTC_2969|Compound:9091408|FD-Score:3.09|P-value:7.86E-4 ID:SGTC_3024|Compound:9090631|FD-Score:6.92|P-value:1.03E-12 ID:SGTC_3037|Compound:9091026|FD-Score:-3.29|P-value:5.04E-4 ID:SGTC_3040|Compound:9091894|FD-Score:3.06|P-value:8.81E-4 ID:SGTC_3218|Compound:9131285|FD-Score:3.03|P-value:9.76E-4 ID:SGTC_3311|Compound:9131146|FD-Score:-3.28|P-value:5.23E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:-3.14|P-value:8.43E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:3.10|P-value:7.70E-4 ID:SGTC_200|Compound:k038-0079|FD-Score:-3.23|P-value:6.14E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:5.99|P-value:5.78E-10 ID:SGTC_310|Compound:1273-0058|FD-Score:7.97|P-value:3.14E-16 ID:SGTC_451|Compound:chloral hydrate|FD-Score:-3.29|P-value:4.98E-4 ID:SGTC_480|Compound:am 92016|FD-Score:-3.86|P-value:5.54E-5 ID:SGTC_698|Compound:k064-0052|FD-Score:-3.30|P-value:4.94E-4 ID:SGTC_702|Compound:1488-0190|FD-Score:4.09|P-value:1.52E-5 ID:SGTC_885|Compound:0865-0106|FD-Score:3.22|P-value:5.05E-4 ID:SGTC_890|Compound:0929-0006|FD-Score:3.04|P-value:9.53E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:3.52|P-value:1.62E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:-3.13|P-value:8.71E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:3.55|P-value:1.47E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:3.24|P-value:4.61E-4 ID:SGTC_1140|Compound:3229-1848|FD-Score:3.19|P-value:5.67E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:-3.82|P-value:6.46E-5 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.70|P-value:7.92E-5 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:4.56|P-value:1.69E-6 ID:SGTC_1685|Compound:st024049|FD-Score:-4.12|P-value:1.82E-5 ID:SGTC_1702|Compound:st027038|FD-Score:3.27|P-value:4.16E-4 ID:SGTC_1752|Compound:st044819|FD-Score:4.36|P-value:4.50E-6 ID:SGTC_1761|Compound:st044296|FD-Score:4.00|P-value:2.26E-5 ID:SGTC_1782|Compound:st039423|FD-Score:3.53|P-value:1.57E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:4.32|P-value:5.44E-6 ID:SGTC_1832|Compound:st054113|FD-Score:3.86|P-value:4.12E-5 ID:SGTC_1841|Compound:st054148|FD-Score:3.65|P-value:9.99E-5 ID:SGTC_1985|Compound:st071382|FD-Score:3.20|P-value:5.44E-4 ID:SGTC_1994|Compound:st072947|FD-Score:-4.51|P-value:3.00E-6 ID:SGTC_2139|Compound:5578692|FD-Score:3.25|P-value:4.55E-4 ID:SGTC_2281|Compound:7943571|FD-Score:-3.35|P-value:4.02E-4 ID:SGTC_2285|Compound:7945142|FD-Score:3.87|P-value:3.92E-5 ID:SGTC_2308|Compound:7584454|FD-Score:3.78|P-value:5.91E-5 ID:SGTC_2321|Compound:7390090|FD-Score:3.25|P-value:4.47E-4 ID:SGTC_2370|Compound:9071495|FD-Score:3.24|P-value:4.69E-4 ID:SGTC_2450|Compound:5739737|FD-Score:3.83|P-value:4.65E-5 ID:SGTC_2557|Compound:derrustone|FD-Score:3.38|P-value:2.85E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:-3.48|P-value:2.49E-4 ID:SGTC_2646|Compound:retinol|FD-Score:3.41|P-value:2.50E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.06|P-value:1.34E-7 ID:SGTC_2808|Compound:7946468|FD-Score:3.08|P-value:8.29E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.18|P-value:5.91E-4 ID:SGTC_2969|Compound:9091408|FD-Score:3.09|P-value:7.86E-4 ID:SGTC_3024|Compound:9090631|FD-Score:6.92|P-value:1.03E-12 ID:SGTC_3037|Compound:9091026|FD-Score:-3.29|P-value:5.04E-4 ID:SGTC_3040|Compound:9091894|FD-Score:3.06|P-value:8.81E-4 ID:SGTC_3218|Compound:9131285|FD-Score:3.03|P-value:9.76E-4 ID:SGTC_3311|Compound:9131146|FD-Score:-3.28|P-value:5.23E-4

Top fitness defect scores for YBR042C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_310 1273-0058 7.97 1.1 µM 3.14E-16 mitochondrial stress 91 8.14E-16
2 SGTC_3024 9090631 6.92 49.5 µM 1.03E-12 1 2.20E-12
3 SGTC_299 1273-0059 5.99 1.4 µM 5.78E-10 6 1.05E-9
4 SGTC_2688 kanamycin b 5.06 96.7 µM 1.34E-7 calcium & mitochondrial duress 238 2.12E-7
5 SGTC_1565 sinapyl alcohol 4.56 95.1 µM 1.69E-6 14 2.51E-6
6 SGTC_1752 st044819 4.36 83.0 µM 4.50E-6 19 6.51E-6
7 SGTC_1787 fluconazole 4.32 80.0 µM 5.44E-6 iron homeostasis 18 7.82E-6
8 SGTC_702 1488-0190 4.09 94.0 µM 1.52E-5 amide catabolism 13 2.13E-5
9 SGTC_1761 st044296 4.00 37.0 µM 2.26E-5 14 3.13E-5
10 SGTC_2285 7945142 3.87 200.0 µM 3.92E-5 25 5.35E-5
11 SGTC_1832 st054113 3.86 55.0 µM 4.12E-5 6 5.61E-5
12 SGTC_2450 5739737 3.83 12.9 µM 4.65E-5 27 6.32E-5
13 SGTC_2308 7584454 3.78 197.6 µM 5.91E-5 23 7.98E-5
14 SGTC_1456 k015-0012 3.70 13.0 µM 7.92E-5 40 1.06E-4
15 SGTC_1841 st054148 3.65 70.0 µM 9.99E-5 16 1.33E-4
16 SGTC_956 1185-0240 3.55 191.0 µM 1.47E-4 33 1.93E-4
17 SGTC_1782 st039423 3.53 80.6 µM 1.57E-4 31 2.06E-4
18 SGTC_939 1165-0479 3.52 45.3 µM 1.62E-4 50 2.13E-4
19 SGTC_2646 retinol 3.41 96.8 µM 2.50E-4 26 3.24E-4
20 SGTC_2557 derrustone 3.38 83.8 µM 2.85E-4 60 3.68E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.141 1.87E-16 YNL073W MSK1 hom Mitochondrial lysine-tRNA synthetase, required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria and for aminoacylation of mitochondrially encoded tRNA(Lys)
0.137 2.01E-15 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.131 2.55E-14 YNL130C CPT1 hom Cholinephosphotransferase; required for phosphatidylcholine biosynthesis and for inositol-dependent regulation of EPT1 transcription; CPT1 has a paralog, EPT1, that arose from the whole genome duplication
0.121 1.93E-12 YER028C MIG3 hom Transcriptional regulator; partially nonfunctional in S288C strains but has a major role in catabolite repression and ethanol response in some other strains; involved in response to toxic agents; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes; MIG3 has a paralog, MIG2, that arose from the whole genome duplication
0.119 5.10E-12 YOR276W CAF20 hom Phosphoprotein of the mRNA cap-binding complex involved in translational control, repressor of cap-dependent translation initiation, competes with eIF4G for binding to eIF4E
0.116 1.34E-11 YDR497C ITR1 hom Myo-inositol transporter; has strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p; relative distribution to the vacuole increases upon DNA replication stress
0.115 2.75E-11 YLL033W IRC19 hom Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci
0.114 3.25E-11 YOR093C_p YOR093C_p hom Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents
0.111 1.43E-10 YNL291C MID1 hom N-glycosylated integral membrane protein of the ER membrane and plasma membrane, functions as a stretch-activated Ca2+-permeable cation channel required for Ca2+ influx stimulated by pheromone; interacts with Cch1p; forms an oligomer
0.105 8.90E-10 YPL078C ATP4 hom Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; contributes to the oligomerization of the complex; phosphorylated
0.105 1.07E-9 YGL143C MRF1 hom Mitochondrial translation release factor, involved in stop codon recognition and hydrolysis of the peptidyl-tRNA bond during mitochondrial translation; lack of MRF1 causes mitochondrial genome instability
0.104 1.29E-9 YDR519W FPR2 hom Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase); binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking; relocalizes from nucleus to vacuole upon DNA replication stress
0.103 2.00E-9 YMR267W PPA2 hom Mitochondrial inorganic pyrophosphatase, required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate
0.103 2.30E-9 YLR404W FLD1 hom Seipin protein involved in lipid droplet morphology, number, and size; proposed to be involved in lipid metabolism; related to the human BSCL2 which is associated with lipodystrophy
0.103 2.35E-9 YDR347W MRP1 hom Mitochondrial ribosomal protein of the small subunit; MRP1 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator, and with PET123, encoding a small subunit mitochondrial ribosomal protein