YBR043C / QDR3

Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; has a role in polyamine homeostasis; expression is upregulated under polyamine stress; required for resistance to quinidine, barban, cisplatin, and bleomycin

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR043C / QDR3

Click on Significant Values for Screen Details ID:SGTC_45|Compound:0kpi-0036|FD-Score:2.92|P-value:9.46E-4 ID:SGTC_72|Compound:0744-0168|FD-Score:4.51|P-value:9.16E-7 ID:SGTC_74|Compound:000s-0487|FD-Score:4.47|P-value:1.13E-6 ID:SGTC_108|Compound:0509-0257|FD-Score:-3.93|P-value:2.49E-5 ID:SGTC_150|Compound:3970-0969|FD-Score:3.63|P-value:5.79E-5 ID:SGTC_174|Compound:3553-0389|FD-Score:-3.65|P-value:8.15E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:3.93|P-value:1.56E-5 ID:SGTC_316|Compound:k060-0003|FD-Score:5.20|P-value:1.94E-8 ID:SGTC_326|Compound:k292-0812|FD-Score:3.24|P-value:2.83E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:3.76|P-value:3.40E-5 ID:SGTC_529|Compound:4076-0302|FD-Score:3.77|P-value:3.12E-5 ID:SGTC_786|Compound:4544-0069|FD-Score:3.42|P-value:1.39E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:3.18|P-value:3.61E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:3.73|P-value:3.74E-5 ID:SGTC_975|Compound:1335-0046|FD-Score:3.48|P-value:1.11E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:-4.28|P-value:4.75E-6 ID:SGTC_1012|Compound:4112-3522|FD-Score:3.50|P-value:1.01E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:5.30|P-value:1.10E-8 ID:SGTC_1020|Compound:4335-0961|FD-Score:4.59|P-value:5.84E-7 ID:SGTC_1203|Compound:3992-3522|FD-Score:-5.55|P-value:4.37E-9 ID:SGTC_1261|Compound:0712-0010|FD-Score:2.98|P-value:7.53E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.64|P-value:5.71E-5 ID:SGTC_1502|Compound:4534-4282|FD-Score:-3.84|P-value:3.68E-5 ID:SGTC_1567|Compound:st069303|FD-Score:4.23|P-value:3.82E-6 ID:SGTC_1779|Compound:st039427|FD-Score:3.26|P-value:2.65E-4 ID:SGTC_1799|Compound:st045822|FD-Score:3.19|P-value:3.48E-4 ID:SGTC_1893|Compound:st059353|FD-Score:-3.02|P-value:9.48E-4 ID:SGTC_1895|Compound:st058434|FD-Score:-3.22|P-value:4.48E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.58|P-value:7.22E-5 ID:SGTC_2094|Compound:5332512|FD-Score:3.31|P-value:2.15E-4 ID:SGTC_2095|Compound:5432005|FD-Score:-3.54|P-value:1.32E-4 ID:SGTC_2109|Compound:5483026|FD-Score:-3.49|P-value:1.58E-4 ID:SGTC_2151|Compound:5563267|FD-Score:3.65|P-value:5.31E-5 ID:SGTC_2155|Compound:5570423|FD-Score:2.98|P-value:7.58E-4 ID:SGTC_2267|Compound:7931562|FD-Score:-4.63|P-value:8.40E-7 ID:SGTC_2304|Compound:7443016|FD-Score:-5.09|P-value:6.55E-8 ID:SGTC_2307|Compound:7538926|FD-Score:7.15|P-value:2.51E-14 ID:SGTC_2308|Compound:7584454|FD-Score:3.17|P-value:3.72E-4 ID:SGTC_2311|Compound:7694451|FD-Score:4.37|P-value:1.89E-6 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:2.91|P-value:9.64E-4 ID:SGTC_3009|Compound:9080819|FD-Score:3.01|P-value:6.81E-4 ID:SGTC_3014|Compound:9081533|FD-Score:4.20|P-value:4.39E-6 ID:SGTC_3212|Compound:9128307|FD-Score:-7.65|P-value:9.02E-16 ID:SGTC_45|Compound:0kpi-0036|FD-Score:2.92|P-value:9.46E-4 ID:SGTC_72|Compound:0744-0168|FD-Score:4.51|P-value:9.16E-7 ID:SGTC_74|Compound:000s-0487|FD-Score:4.47|P-value:1.13E-6 ID:SGTC_108|Compound:0509-0257|FD-Score:-3.93|P-value:2.49E-5 ID:SGTC_150|Compound:3970-0969|FD-Score:3.63|P-value:5.79E-5 ID:SGTC_174|Compound:3553-0389|FD-Score:-3.65|P-value:8.15E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:3.93|P-value:1.56E-5 ID:SGTC_316|Compound:k060-0003|FD-Score:5.20|P-value:1.94E-8 ID:SGTC_326|Compound:k292-0812|FD-Score:3.24|P-value:2.83E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:3.76|P-value:3.40E-5 ID:SGTC_529|Compound:4076-0302|FD-Score:3.77|P-value:3.12E-5 ID:SGTC_786|Compound:4544-0069|FD-Score:3.42|P-value:1.39E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:3.18|P-value:3.61E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:3.73|P-value:3.74E-5 ID:SGTC_975|Compound:1335-0046|FD-Score:3.48|P-value:1.11E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:-4.28|P-value:4.75E-6 ID:SGTC_1012|Compound:4112-3522|FD-Score:3.50|P-value:1.01E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:5.30|P-value:1.10E-8 ID:SGTC_1020|Compound:4335-0961|FD-Score:4.59|P-value:5.84E-7 ID:SGTC_1203|Compound:3992-3522|FD-Score:-5.55|P-value:4.37E-9 ID:SGTC_1261|Compound:0712-0010|FD-Score:2.98|P-value:7.53E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.64|P-value:5.71E-5 ID:SGTC_1502|Compound:4534-4282|FD-Score:-3.84|P-value:3.68E-5 ID:SGTC_1567|Compound:st069303|FD-Score:4.23|P-value:3.82E-6 ID:SGTC_1779|Compound:st039427|FD-Score:3.26|P-value:2.65E-4 ID:SGTC_1799|Compound:st045822|FD-Score:3.19|P-value:3.48E-4 ID:SGTC_1893|Compound:st059353|FD-Score:-3.02|P-value:9.48E-4 ID:SGTC_1895|Compound:st058434|FD-Score:-3.22|P-value:4.48E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.58|P-value:7.22E-5 ID:SGTC_2094|Compound:5332512|FD-Score:3.31|P-value:2.15E-4 ID:SGTC_2095|Compound:5432005|FD-Score:-3.54|P-value:1.32E-4 ID:SGTC_2109|Compound:5483026|FD-Score:-3.49|P-value:1.58E-4 ID:SGTC_2151|Compound:5563267|FD-Score:3.65|P-value:5.31E-5 ID:SGTC_2155|Compound:5570423|FD-Score:2.98|P-value:7.58E-4 ID:SGTC_2267|Compound:7931562|FD-Score:-4.63|P-value:8.40E-7 ID:SGTC_2304|Compound:7443016|FD-Score:-5.09|P-value:6.55E-8 ID:SGTC_2307|Compound:7538926|FD-Score:7.15|P-value:2.51E-14 ID:SGTC_2308|Compound:7584454|FD-Score:3.17|P-value:3.72E-4 ID:SGTC_2311|Compound:7694451|FD-Score:4.37|P-value:1.89E-6 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:2.91|P-value:9.64E-4 ID:SGTC_3009|Compound:9080819|FD-Score:3.01|P-value:6.81E-4 ID:SGTC_3014|Compound:9081533|FD-Score:4.20|P-value:4.39E-6 ID:SGTC_3212|Compound:9128307|FD-Score:-7.65|P-value:9.02E-16

Top fitness defect scores for YBR043C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2307 7538926 7.15 6.3 µM 2.51E-14 5 4.49E-13
2 SGTC_1013 4112-3890 5.30 241.0 µM 1.10E-8 TSC3-RPN4 14 5.95E-8
3 SGTC_316 k060-0003 5.20 58.6 µM 1.94E-8 3 9.91E-8
4 SGTC_1020 4335-0961 4.59 93.3 µM 5.84E-7 5 2.18E-6
5 SGTC_72 0744-0168 4.51 198.4 µM 9.16E-7 RPP1 & pyrimidine depletion 21 3.27E-6
6 SGTC_74 000s-0487 4.47 160.3 µM 1.13E-6 17 3.96E-6
7 SGTC_2311 7694451 4.37 200.0 µM 1.89E-6 10 6.30E-6
8 SGTC_1567 st069303 4.23 68.4 µM 3.82E-6 mitochondrial processes 14 1.19E-5
9 SGTC_3014 9081533 4.20 49.5 µM 4.39E-6 7 1.35E-5
10 SGTC_184 1494-0393 3.93 24.7 µM 1.56E-5 61 4.28E-5
11 SGTC_529 4076-0302 3.77 30.3 µM 3.12E-5 mitochondrial processes 22 8.02E-5
12 SGTC_507 nimesulide 3.76 162.0 µM 3.40E-5 20 8.65E-5
13 SGTC_911 3456-4043 3.73 236.0 µM 3.74E-5 mitochondrial processes 34 9.43E-5
14 SGTC_2151 5563267 3.65 85.4 µM 5.31E-5 29 1.30E-4
15 SGTC_1475 4092-1048 3.64 11.7 µM 5.71E-5 plasma membrane duress 39 1.38E-4
16 SGTC_150 3970-0969 3.63 77.2 µM 5.79E-5 79 1.40E-4
17 SGTC_2002 4023503 3.58 131.0 µM 7.22E-5 mitochondrial processes 50 1.71E-4
18 SGTC_1012 4112-3522 3.50 18.0 µM 1.01E-4 33 2.32E-4
19 SGTC_975 1335-0046 3.48 28.5 µM 1.11E-4 RPP1 & pyrimidine depletion 55 2.52E-4
20 SGTC_786 4544-0069 3.42 423.0 µM 1.39E-4 55 3.11E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.137 1.58E-15 YPL035C_d YPL035C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene
0.117 1.14E-11 YJR016C ILV3 het Dihydroxyacid dehydratase, catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids
0.117 1.31E-11 YGL042C_d YGL042C_d hom Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene DST1
0.111 1.33E-10 YJL097W PHS1 het Essential 3-hydroxyacyl-CoA dehydratase of the ER membrane, involved in elongation of very long-chain fatty acids; evolutionarily conserved, similar to mammalian PTPLA and PTPLB; involved in sphingolipid biosynthesis and protein trafficking
0.100 5.67E-9 YKL162C-A_d YKL162C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.099 7.78E-9 YHR179W OYE2 hom Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); responsible for geraniol reduction into citronellol during fermentation; homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death; protein abundance increases in response to DNA replication stress
0.098 1.33E-8 YNL286W CUS2 hom Protein that binds to U2 snRNA and Prp11p, may be involved in U2 snRNA folding; contains two RNA recognition motifs (RRMs)
0.097 1.63E-8 YDL108W KIN28 het Serine/threonine protein kinase, subunit of the transcription factor TFIIH; involved in transcription initiation at RNA polymerase II promoters
0.097 1.72E-8 YER157W COG3 het Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.097 1.75E-8 YHR195W NVJ1 hom Nuclear envelope protein, anchored to the nuclear inner membrane, that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN)
0.095 3.50E-8 YPL095C EEB1 hom Acyl-coenzymeA:ethanol O-acyltransferase; responsible for the major part of medium-chain fatty acid ethyl ester biosynthesis during fermentation; possesses short-chain esterase activity; may be involved in lipid metabolism and detoxification; EEB1 has a paralog, EHT1, that arose from the whole genome duplication
0.095 3.69E-8 YNL207W RIO2 het Essential serine kinase involved in the processing of the 20S pre-rRNA into mature 18S rRNA; has similarity to Rio1p
0.089 2.13E-7 YDL218W_p YDL218W_p hom Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions; expression also induced in cells treated with the mycotoxin patulin
0.087 4.23E-7 YIL096C_p YIL096C_p hom Putative S-adenosylmethionine-dependent methyltransferase; associates with precursors of the 60S ribosomal subunit; predicted to be involved in ribosome biogenesis
0.087 4.29E-7 YNL203C_d YNL203C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data