YBR046C / ZTA1

NADPH-dependent quinone reductase, GFP-tagged protein localizes to the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR046C / ZTA1

Click on Significant Values for Screen Details ID:SGTC_69|Compound:0096-0274|FD-Score:5.35|P-value:5.68E-8 ID:SGTC_143|Compound:4032-1194|FD-Score:-3.13|P-value:8.92E-4 ID:SGTC_254|Compound:nsc-64875|FD-Score:3.43|P-value:3.46E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:-3.85|P-value:6.31E-5 ID:SGTC_308|Compound:4092-1169|FD-Score:4.32|P-value:9.43E-6 ID:SGTC_329|Compound:k048-0121|FD-Score:-4.31|P-value:8.78E-6 ID:SGTC_331|Compound:k048-0133|FD-Score:-4.27|P-value:1.04E-5 ID:SGTC_333|Compound:3486-0131|FD-Score:-4.08|P-value:2.46E-5 ID:SGTC_550|Compound:4123-0385|FD-Score:3.18|P-value:8.38E-4 ID:SGTC_626|Compound:0214-0009|FD-Score:4.08|P-value:2.67E-5 ID:SGTC_652|Compound:0437-0092|FD-Score:3.12|P-value:9.92E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:3.27|P-value:6.12E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:4.09|P-value:2.58E-5 ID:SGTC_761|Compound:k216-0224|FD-Score:3.22|P-value:7.25E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:-3.68|P-value:1.21E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:3.71|P-value:1.20E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:3.18|P-value:8.23E-4 ID:SGTC_1182|Compound:1222-0449|FD-Score:4.55|P-value:3.29E-6 ID:SGTC_1221|Compound:2958-7315|FD-Score:3.24|P-value:6.70E-4 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.39|P-value:3.90E-4 ID:SGTC_1738|Compound:st035555|FD-Score:-4.93|P-value:4.66E-7 ID:SGTC_1782|Compound:st039423|FD-Score:3.77|P-value:9.42E-5 ID:SGTC_1856|Compound:st057054|FD-Score:3.72|P-value:1.14E-4 ID:SGTC_1864|Compound:st057645|FD-Score:3.28|P-value:5.88E-4 ID:SGTC_1868|Compound:st057644|FD-Score:-4.06|P-value:2.60E-5 ID:SGTC_1871|Compound:st057448|FD-Score:-3.43|P-value:3.11E-4 ID:SGTC_1889|Compound:st059080|FD-Score:4.62|P-value:2.35E-6 ID:SGTC_1904|Compound:st060225|FD-Score:-4.37|P-value:6.76E-6 ID:SGTC_1921|Compound:5740136|FD-Score:4.15|P-value:1.96E-5 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:3.95|P-value:4.58E-5 ID:SGTC_2131|Compound:toluylene red|FD-Score:-3.20|P-value:7.14E-4 ID:SGTC_2347|Compound:9049783|FD-Score:-3.52|P-value:2.22E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.27|P-value:6.04E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-3.63|P-value:1.52E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-3.18|P-value:7.71E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:4.14|P-value:2.09E-5 ID:SGTC_2823|Compound:7987624|FD-Score:3.32|P-value:5.14E-4 ID:SGTC_2882|Compound:9058044|FD-Score:3.44|P-value:3.25E-4 ID:SGTC_2944|Compound:9067346|FD-Score:5.26|P-value:9.14E-8 ID:SGTC_3027|Compound:9089541|FD-Score:3.44|P-value:3.31E-4 ID:SGTC_3032|Compound:9089427|FD-Score:3.29|P-value:5.62E-4 ID:SGTC_3054|Compound:9094397|FD-Score:3.33|P-value:4.86E-4 ID:SGTC_3106|Compound:9121286|FD-Score:4.80|P-value:1.01E-6 ID:SGTC_69|Compound:0096-0274|FD-Score:5.35|P-value:5.68E-8 ID:SGTC_143|Compound:4032-1194|FD-Score:-3.13|P-value:8.92E-4 ID:SGTC_254|Compound:nsc-64875|FD-Score:3.43|P-value:3.46E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:-3.85|P-value:6.31E-5 ID:SGTC_308|Compound:4092-1169|FD-Score:4.32|P-value:9.43E-6 ID:SGTC_329|Compound:k048-0121|FD-Score:-4.31|P-value:8.78E-6 ID:SGTC_331|Compound:k048-0133|FD-Score:-4.27|P-value:1.04E-5 ID:SGTC_333|Compound:3486-0131|FD-Score:-4.08|P-value:2.46E-5 ID:SGTC_550|Compound:4123-0385|FD-Score:3.18|P-value:8.38E-4 ID:SGTC_626|Compound:0214-0009|FD-Score:4.08|P-value:2.67E-5 ID:SGTC_652|Compound:0437-0092|FD-Score:3.12|P-value:9.92E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:3.27|P-value:6.12E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:4.09|P-value:2.58E-5 ID:SGTC_761|Compound:k216-0224|FD-Score:3.22|P-value:7.25E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:-3.68|P-value:1.21E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:3.71|P-value:1.20E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:3.18|P-value:8.23E-4 ID:SGTC_1182|Compound:1222-0449|FD-Score:4.55|P-value:3.29E-6 ID:SGTC_1221|Compound:2958-7315|FD-Score:3.24|P-value:6.70E-4 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.39|P-value:3.90E-4 ID:SGTC_1738|Compound:st035555|FD-Score:-4.93|P-value:4.66E-7 ID:SGTC_1782|Compound:st039423|FD-Score:3.77|P-value:9.42E-5 ID:SGTC_1856|Compound:st057054|FD-Score:3.72|P-value:1.14E-4 ID:SGTC_1864|Compound:st057645|FD-Score:3.28|P-value:5.88E-4 ID:SGTC_1868|Compound:st057644|FD-Score:-4.06|P-value:2.60E-5 ID:SGTC_1871|Compound:st057448|FD-Score:-3.43|P-value:3.11E-4 ID:SGTC_1889|Compound:st059080|FD-Score:4.62|P-value:2.35E-6 ID:SGTC_1904|Compound:st060225|FD-Score:-4.37|P-value:6.76E-6 ID:SGTC_1921|Compound:5740136|FD-Score:4.15|P-value:1.96E-5 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:3.95|P-value:4.58E-5 ID:SGTC_2131|Compound:toluylene red|FD-Score:-3.20|P-value:7.14E-4 ID:SGTC_2347|Compound:9049783|FD-Score:-3.52|P-value:2.22E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.27|P-value:6.04E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-3.63|P-value:1.52E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-3.18|P-value:7.71E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:4.14|P-value:2.09E-5 ID:SGTC_2823|Compound:7987624|FD-Score:3.32|P-value:5.14E-4 ID:SGTC_2882|Compound:9058044|FD-Score:3.44|P-value:3.25E-4 ID:SGTC_2944|Compound:9067346|FD-Score:5.26|P-value:9.14E-8 ID:SGTC_3027|Compound:9089541|FD-Score:3.44|P-value:3.31E-4 ID:SGTC_3032|Compound:9089427|FD-Score:3.29|P-value:5.62E-4 ID:SGTC_3054|Compound:9094397|FD-Score:3.33|P-value:4.86E-4 ID:SGTC_3106|Compound:9121286|FD-Score:4.80|P-value:1.01E-6

Top fitness defect scores for YBR046C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_69 0096-0274 5.35 206.7 µM 5.68E-8 mitochondrial processes 13 4.38E-8
2 SGTC_2944 9067346 5.26 25.6 µM 9.14E-8 8 7.10E-8
3 SGTC_3106 9121286 4.80 49.5 µM 1.01E-6 4 8.13E-7
4 SGTC_1889 st059080 4.62 5.2 µM 2.35E-6 10 1.92E-6
5 SGTC_1182 1222-0449 4.55 220.0 µM 3.29E-6 10 2.70E-6
6 SGTC_308 4092-1169 4.32 104.0 µM 9.43E-6 plasma membrane duress 43 7.86E-6
7 SGTC_1921 5740136 4.15 50.0 µM 1.96E-5 TRP & mitochondrial translation 49 1.65E-5
8 SGTC_2633 5,7-dihydroxyisoflavone 4.14 100.0 µM 2.09E-5 28 1.76E-5
9 SGTC_736 0958-0254 4.09 92.6 µM 2.58E-5 Golgi 28 2.19E-5
10 SGTC_626 0214-0009 4.08 33.0 µM 2.67E-5 copper-dependent oxidative stress 15 2.26E-5
11 SGTC_1965 Pectolinarigenin 3.95 58.4 µM 4.58E-5 RPP1 & pyrimidine depletion 15 3.91E-5
12 SGTC_1782 st039423 3.77 80.6 µM 9.42E-5 27 8.14E-5
13 SGTC_1856 st057054 3.72 55.7 µM 1.14E-4 32 9.92E-5
14 SGTC_1120 ficusin 3.71 1.8 µM 1.20E-4 32 1.04E-4
15 SGTC_2882 9058044 3.44 58.4 µM 3.25E-4 27 2.86E-4
16 SGTC_3027 9089541 3.44 49.5 µM 3.31E-4 fatty acid desaturase (OLE1) 35 2.92E-4
17 SGTC_254 nsc-64875 3.43 3.8 µM 3.46E-4 ergosterol depletion effects on membrane 47 3.05E-4
18 SGTC_1435 4092-0789 3.39 56.7 µM 3.90E-4 plasma membrane duress 28 3.44E-4
19 SGTC_3054 9094397 3.33 49.5 µM 4.86E-4 fatty acid desaturase (OLE1) 54 4.31E-4
20 SGTC_2823 7987624 3.32 58.4 µM 5.14E-4 63 4.56E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.102 3.50E-9 YLR262C-A TMA7 hom Protein of unknown that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin; protein abundance increases in response to DNA replication stress
0.091 1.13E-7 YNL338W_d YNL338W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps TEL14L-XC, which is Telomeric X element Core sequence on the left arm of Chromosome XIV
0.089 2.64E-7 YBR057C MUM2 hom Cytoplasmic protein essential for meiotic DNA replication and sporulation; interacts with Orc2p, which is a component of the origin recognition complex
0.083 1.28E-6 YNL046W_p YNL046W_p hom Putative protein of unknown function; expression depends on Swi5p; GFP-fusion protein localizes to the endoplasmic reticulum; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.082 1.88E-6 YNL123W NMA111 hom Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases
0.079 4.85E-6 YEL060C PRB1 hom Vacuolar proteinase B (yscB); serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation; activity inhibited by Pbi2p; protein abundance increases in response to DNA replication stress
0.076 1.05E-5 YNL152W INN1 het Essential protein that associates with contractile actomyosin ring; required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function; activates chitin synthase activity of Chs2p during cytokinesis
0.074 1.58E-5 YGL177W_d YGL177W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.073 2.15E-5 YPL243W SRP68 het Core component of the signal recognition particle (SRP) complex; SRP complex functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress
0.069 6.41E-5 YNL109W_d YNL109W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YNL108C
0.069 6.74E-5 YJR057W CDC8 het Thymidylate and uridylate kinase, functions in de novo biosynthesis of pyrimidine deoxyribonucleotides; converts dTMP to dTDP and dUMP to dUTP; essential for mitotic and meiotic DNA replication; homologous to S. pombe Tmp1p
0.068 7.84E-5 YER115C SPR6 hom Protein of unknown function, expressed during sporulation; not required for sporulation, but gene exhibits genetic interactions with other genes required for sporulation
0.068 8.09E-5 YLL008W DRS1 het Nucleolar DEAD-box protein required for ribosome assembly and function, including synthesis of 60S ribosomal subunits; constituent of 66S pre-ribosomal particles
0.067 9.90E-5 YDR102C_d YDR102C_d hom Dubious open reading frame; homozygous diploid deletion strain exhibits high budding index
0.067 9.92E-5 YDL084W SUB2 het Component of the TREX complex required for nuclear mRNA export; member of the DEAD-box RNA helicase superfamily and is involved in early and late steps of spliceosome assembly; homolog of the human splicing factor hUAP56; relocalizes from nucleus to cytoplasm upon DNA replication stress