HIPHOP chemogenomics database
YBR046C / ZTA1 
NADPH-dependent quinone reductase, GFP-tagged protein localizes to the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YBR046C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.102 | 3.50E-9 | YLR262C-A | TMA7 | hom | Protein of unknown that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin; protein abundance increases in response to DNA replication stress |
| 0.091 | 1.13E-7 | YNL338W_d | YNL338W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps TEL14L-XC, which is Telomeric X element Core sequence on the left arm of Chromosome XIV |
| 0.089 | 2.64E-7 | YBR057C | MUM2 | hom | Cytoplasmic protein essential for meiotic DNA replication and sporulation; interacts with Orc2p, which is a component of the origin recognition complex |
| 0.083 | 1.28E-6 | YNL046W_p | YNL046W_p | hom | Putative protein of unknown function; expression depends on Swi5p; GFP-fusion protein localizes to the endoplasmic reticulum; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) |
| 0.082 | 1.88E-6 | YNL123W | NMA111 | hom | Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases |
| 0.079 | 4.85E-6 | YEL060C | PRB1 | hom | Vacuolar proteinase B (yscB); serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation; activity inhibited by Pbi2p; protein abundance increases in response to DNA replication stress |
| 0.076 | 1.05E-5 | YNL152W | INN1 | het | Essential protein that associates with contractile actomyosin ring; required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function; activates chitin synthase activity of Chs2p during cytokinesis |
| 0.074 | 1.58E-5 | YGL177W_d | YGL177W_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.073 | 2.15E-5 | YPL243W | SRP68 | het | Core component of the signal recognition particle (SRP) complex; SRP complex functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress |
| 0.069 | 6.41E-5 | YNL109W_d | YNL109W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YNL108C |
| 0.069 | 6.74E-5 | YJR057W | CDC8 | het | Thymidylate and uridylate kinase, functions in de novo biosynthesis of pyrimidine deoxyribonucleotides; converts dTMP to dTDP and dUMP to dUTP; essential for mitotic and meiotic DNA replication; homologous to S. pombe Tmp1p |
| 0.068 | 7.84E-5 | YER115C | SPR6 | hom | Protein of unknown function, expressed during sporulation; not required for sporulation, but gene exhibits genetic interactions with other genes required for sporulation |
| 0.068 | 8.09E-5 | YLL008W | DRS1 | het | Nucleolar DEAD-box protein required for ribosome assembly and function, including synthesis of 60S ribosomal subunits; constituent of 66S pre-ribosomal particles |
| 0.067 | 9.90E-5 | YDR102C_d | YDR102C_d | hom | Dubious open reading frame; homozygous diploid deletion strain exhibits high budding index |
| 0.067 | 9.92E-5 | YDL084W | SUB2 | het | Component of the TREX complex required for nuclear mRNA export; member of the DEAD-box RNA helicase superfamily and is involved in early and late steps of spliceosome assembly; homolog of the human splicing factor hUAP56; relocalizes from nucleus to cytoplasm upon DNA replication stress |