YBR047W_p / FMP23

Putative protein of unknown function; proposed to be involved in iron or copper homeostasis; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR047W / FMP23

Click on Significant Values for Screen Details ID:SGTC_419|Compound:nsc-638432|FD-Score:3.33|P-value:3.27E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:3.51|P-value:1.62E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:3.28|P-value:3.89E-4 ID:SGTC_615|Compound:k087-0205|FD-Score:3.30|P-value:3.66E-4 ID:SGTC_636|Compound:0kpi-0074|FD-Score:3.29|P-value:3.82E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:3.73|P-value:6.74E-5 ID:SGTC_764|Compound:1951-2361|FD-Score:4.05|P-value:1.67E-5 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.22|P-value:4.95E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:-3.26|P-value:4.33E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.26|P-value:4.18E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:4.26|P-value:6.63E-6 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.55|P-value:1.40E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:5.80|P-value:1.48E-9 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:4.31|P-value:5.23E-6 ID:SGTC_1312|Compound:1218-2183|FD-Score:4.40|P-value:3.35E-6 ID:SGTC_1317|Compound:1273-0028|FD-Score:-4.37|P-value:3.82E-6 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:3.52|P-value:1.60E-4 ID:SGTC_1827|Compound:berberine|FD-Score:4.57|P-value:1.46E-6 ID:SGTC_1865|Compound:st057639|FD-Score:3.63|P-value:9.94E-5 ID:SGTC_1914|Compound:st062367|FD-Score:3.37|P-value:2.83E-4 ID:SGTC_1923|Compound:st058458|FD-Score:3.07|P-value:8.43E-4 ID:SGTC_1927|Compound:st060202|FD-Score:3.98|P-value:2.33E-5 ID:SGTC_2001|Compound:4023502|FD-Score:7.06|P-value:2.39E-13 ID:SGTC_2002|Compound:4023503|FD-Score:4.52|P-value:1.83E-6 ID:SGTC_2017|Compound:5132927|FD-Score:4.87|P-value:3.14E-7 ID:SGTC_2024|Compound:5144227|FD-Score:-3.02|P-value:9.96E-4 ID:SGTC_2047|Compound:4141938|FD-Score:3.07|P-value:8.30E-4 ID:SGTC_2049|Compound:5262831|FD-Score:5.50|P-value:8.98E-9 ID:SGTC_2104|Compound:5389443|FD-Score:4.94|P-value:2.18E-7 ID:SGTC_2108|Compound:5365811|FD-Score:-4.12|P-value:1.26E-5 ID:SGTC_2113|Compound:5491891|FD-Score:4.42|P-value:3.01E-6 ID:SGTC_2188|Compound:6126565|FD-Score:3.03|P-value:9.74E-4 ID:SGTC_2222|Compound:6885208|FD-Score:4.26|P-value:6.47E-6 ID:SGTC_2404|Compound:5161160|FD-Score:3.20|P-value:5.27E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:4.57|P-value:1.42E-6 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.17|P-value:5.88E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:-3.04|P-value:9.22E-4 ID:SGTC_2792|Compound:7535235|FD-Score:-4.06|P-value:1.65E-5 ID:SGTC_2950|Compound:9072895|FD-Score:3.33|P-value:3.20E-4 ID:SGTC_2953|Compound:9074162|FD-Score:3.16|P-value:6.12E-4 ID:SGTC_3164|Compound:9100705|FD-Score:-3.21|P-value:5.10E-4 ID:SGTC_3269|Compound:9137823|FD-Score:3.36|P-value:2.95E-4 ID:SGTC_3340|Compound:9146634|FD-Score:3.54|P-value:1.46E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:3.33|P-value:3.27E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:3.51|P-value:1.62E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:3.28|P-value:3.89E-4 ID:SGTC_615|Compound:k087-0205|FD-Score:3.30|P-value:3.66E-4 ID:SGTC_636|Compound:0kpi-0074|FD-Score:3.29|P-value:3.82E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:3.73|P-value:6.74E-5 ID:SGTC_764|Compound:1951-2361|FD-Score:4.05|P-value:1.67E-5 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.22|P-value:4.95E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:-3.26|P-value:4.33E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.26|P-value:4.18E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:4.26|P-value:6.63E-6 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.55|P-value:1.40E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:5.80|P-value:1.48E-9 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:4.31|P-value:5.23E-6 ID:SGTC_1312|Compound:1218-2183|FD-Score:4.40|P-value:3.35E-6 ID:SGTC_1317|Compound:1273-0028|FD-Score:-4.37|P-value:3.82E-6 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:3.52|P-value:1.60E-4 ID:SGTC_1827|Compound:berberine|FD-Score:4.57|P-value:1.46E-6 ID:SGTC_1865|Compound:st057639|FD-Score:3.63|P-value:9.94E-5 ID:SGTC_1914|Compound:st062367|FD-Score:3.37|P-value:2.83E-4 ID:SGTC_1923|Compound:st058458|FD-Score:3.07|P-value:8.43E-4 ID:SGTC_1927|Compound:st060202|FD-Score:3.98|P-value:2.33E-5 ID:SGTC_2001|Compound:4023502|FD-Score:7.06|P-value:2.39E-13 ID:SGTC_2002|Compound:4023503|FD-Score:4.52|P-value:1.83E-6 ID:SGTC_2017|Compound:5132927|FD-Score:4.87|P-value:3.14E-7 ID:SGTC_2024|Compound:5144227|FD-Score:-3.02|P-value:9.96E-4 ID:SGTC_2047|Compound:4141938|FD-Score:3.07|P-value:8.30E-4 ID:SGTC_2049|Compound:5262831|FD-Score:5.50|P-value:8.98E-9 ID:SGTC_2104|Compound:5389443|FD-Score:4.94|P-value:2.18E-7 ID:SGTC_2108|Compound:5365811|FD-Score:-4.12|P-value:1.26E-5 ID:SGTC_2113|Compound:5491891|FD-Score:4.42|P-value:3.01E-6 ID:SGTC_2188|Compound:6126565|FD-Score:3.03|P-value:9.74E-4 ID:SGTC_2222|Compound:6885208|FD-Score:4.26|P-value:6.47E-6 ID:SGTC_2404|Compound:5161160|FD-Score:3.20|P-value:5.27E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:4.57|P-value:1.42E-6 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.17|P-value:5.88E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:-3.04|P-value:9.22E-4 ID:SGTC_2792|Compound:7535235|FD-Score:-4.06|P-value:1.65E-5 ID:SGTC_2950|Compound:9072895|FD-Score:3.33|P-value:3.20E-4 ID:SGTC_2953|Compound:9074162|FD-Score:3.16|P-value:6.12E-4 ID:SGTC_3164|Compound:9100705|FD-Score:-3.21|P-value:5.10E-4 ID:SGTC_3269|Compound:9137823|FD-Score:3.36|P-value:2.95E-4 ID:SGTC_3340|Compound:9146634|FD-Score:3.54|P-value:1.46E-4

Top fitness defect scores for YBR047W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2001 4023502 7.06 57.7 µM 2.39E-13 mitochondrial processes 1 8.04E-13
2 SGTC_1297 1068-0111 5.80 14.1 µM 1.48E-9 2 3.38E-9
3 SGTC_2049 5262831 5.50 67.2 µM 8.98E-9 7 1.89E-8
4 SGTC_2104 5389443 4.94 200.0 µM 2.18E-7 4 3.99E-7
5 SGTC_2017 5132927 4.87 60.6 µM 3.14E-7 13 5.66E-7
6 SGTC_2566 crystal violet carbinol 4.57 226.0 nM 1.42E-6 26 2.40E-6
7 SGTC_1827 berberine 4.57 7.2 µM 1.46E-6 60S ribosome export 11 2.46E-6
8 SGTC_2002 4023503 4.52 131.0 µM 1.83E-6 mitochondrial processes 19 3.05E-6
9 SGTC_2113 5491891 4.42 107.0 µM 3.01E-6 TSC3-RPN4 11 4.91E-6
10 SGTC_1312 1218-2183 4.40 165.0 µM 3.35E-6 5 5.45E-6
11 SGTC_1301 naphtanilide LB 4.31 4.8 µM 5.23E-6 heme requiring 5 8.33E-6
12 SGTC_2222 6885208 4.26 172.1 µM 6.47E-6 1 1.02E-5
13 SGTC_1080 nisoldipine 4.26 24.4 µM 6.63E-6 TSC3-RPN4 20 1.05E-5
14 SGTC_764 1951-2361 4.05 146.0 µM 1.67E-5 33 2.53E-5
15 SGTC_1927 st060202 3.98 13.8 µM 2.33E-5 18 3.49E-5
16 SGTC_757 1066-0008 3.73 322.0 µM 6.74E-5 Golgi 24 9.61E-5
17 SGTC_1865 st057639 3.63 52.2 µM 9.94E-5 22 1.39E-4
18 SGTC_1293 1000-1278 3.55 195.0 µM 1.40E-4 22 1.93E-4
19 SGTC_3340 9146634 3.54 11.1 µM 1.46E-4 23 2.01E-4
20 SGTC_1532 4',5'-dihydroxyflavone 3.52 78.7 µM 1.60E-4 Golgi 29 2.20E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.153 4.72E-19 YPR151C SUE1 hom Mitochondrial protein required for degradation of unstable forms of cytochrome c
0.121 2.13E-12 YJR023C_d YJR023C_d het Putative protein of unknown function; open reading frame overlaps LSM8/YJR022W encoding an essential snRNP protein required for RNA processing and splicing
0.111 1.01E-10 YOR233W KIN4 hom Serine/threonine protein kinase; inhibits the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex, spindle pole body and bud neck; KIN4 has a paralog, FRK1, that arose from the whole genome duplication
0.103 2.04E-9 YBR076W ECM8 hom Non-essential protein of unknown function
0.094 4.90E-8 YMR253C_p YMR253C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene
0.090 2.04E-7 YER005W YND1 hom Apyrase with wide substrate specificity, helps prevent inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates that inhibit glycotransferases; partially redundant with Gda1p; mediates adenovirus E4orf4-induced toxicity
0.089 2.80E-7 YBR203W COS111 hom Protein required for resistance to the antifungal drug ciclopirox olamine; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.087 4.39E-7 YJR068W RFC2 het Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
0.081 2.98E-6 YDL225W SHS1 hom Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins; undergoes sumoylation and phosphorylation during mitosis; protein abundance increases in response to DNA replication stress
0.076 9.38E-6 YEL027W VMA3 hom Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c; dicyclohexylcarbodiimide binding subunit); required for vacuolar acidification and important for copper and iron metal ion homeostasis
0.076 1.15E-5 YDR355C_d YDR355C_d het Dubious: Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified essential ORF SPC110/YDR356W
0.076 1.15E-5 YDR277C MTH1 hom Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
0.073 2.45E-5 YMR311C GLC8 hom Regulatory subunit of protein phosphatase 1 (Glc7p); involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2; protein abundance increases in response to DNA replication stress
0.072 2.68E-5 YPL221W FLC1 hom Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance
0.071 3.58E-5 YJR061W_p YJR061W_p hom Putative protein of unknown function; non-essential gene; transcription repressed by Rm101p; YJR061W has a paralog, MNN4, that arose from the whole genome duplication