YBR048W / RPS11B

Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11B has a paralog, RPS11A, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR048W / RPS11B

Click on Significant Values for Screen Details ID:SGTC_118|Compound:0083-0097|FD-Score:4.90|P-value:1.28E-6 ID:SGTC_217|Compound:ketoconazole|FD-Score:-3.59|P-value:2.79E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:-4.14|P-value:3.43E-5 ID:SGTC_350|Compound:k064-0020|FD-Score:3.28|P-value:8.18E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:5.73|P-value:1.88E-8 ID:SGTC_365|Compound:0121-0052|FD-Score:3.60|P-value:2.79E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:3.69|P-value:2.02E-4 ID:SGTC_490|Compound:phenamil|FD-Score:5.10|P-value:4.86E-7 ID:SGTC_620|Compound:0109-0052|FD-Score:4.30|P-value:1.83E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:5.56|P-value:4.74E-8 ID:SGTC_648|Compound:0375-0473|FD-Score:3.32|P-value:7.17E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:5.11|P-value:4.82E-7 ID:SGTC_665|Compound:3914-0008|FD-Score:4.51|P-value:7.61E-6 ID:SGTC_774|Compound:k060-0086|FD-Score:3.55|P-value:3.33E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:-4.83|P-value:1.78E-6 ID:SGTC_1150|Compound:3909-7983|FD-Score:3.82|P-value:1.25E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:3.39|P-value:5.69E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:4.48|P-value:8.57E-6 ID:SGTC_1348|Compound:1493-0373|FD-Score:4.01|P-value:5.96E-5 ID:SGTC_1370|Compound:2001-0092|FD-Score:-4.95|P-value:9.99E-7 ID:SGTC_1381|Compound:2324-0066|FD-Score:-5.17|P-value:3.43E-7 ID:SGTC_1438|Compound:4092-1045|FD-Score:-3.66|P-value:2.15E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:3.95|P-value:7.47E-5 ID:SGTC_1518|Compound:st038567|FD-Score:6.02|P-value:3.89E-9 ID:SGTC_1726|Compound:st035556|FD-Score:4.26|P-value:2.18E-5 ID:SGTC_1767|Compound:st044992|FD-Score:3.74|P-value:1.64E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-3.89|P-value:9.44E-5 ID:SGTC_1788|Compound:fluconazole|FD-Score:-3.22|P-value:9.93E-4 ID:SGTC_1826|Compound:st055655|FD-Score:3.34|P-value:6.82E-4 ID:SGTC_1885|Compound:st057546|FD-Score:4.92|P-value:1.16E-6 ID:SGTC_1961|Compound:st076550|FD-Score:3.73|P-value:1.71E-4 ID:SGTC_2018|Compound:5133068|FD-Score:3.34|P-value:6.73E-4 ID:SGTC_2284|Compound:7945075|FD-Score:3.95|P-value:7.45E-5 ID:SGTC_2305|Compound:7443522|FD-Score:3.31|P-value:7.55E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.48|P-value:4.23E-4 ID:SGTC_2311|Compound:7694451|FD-Score:-5.41|P-value:9.94E-8 ID:SGTC_2582|Compound:agaric acid|FD-Score:-6.29|P-value:7.85E-10 ID:SGTC_2584|Compound:androsterone|FD-Score:-4.89|P-value:1.34E-6 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:-4.03|P-value:5.49E-5 ID:SGTC_2610|Compound:ononetin|FD-Score:5.27|P-value:2.09E-7 ID:SGTC_2612|Compound:dictamnine|FD-Score:-3.48|P-value:4.15E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-3.94|P-value:7.59E-5 ID:SGTC_2629|Compound:bisabolol|FD-Score:-3.54|P-value:3.33E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:10.80|P-value:1.24E-25 ID:SGTC_2694|Compound:st077685|FD-Score:4.65|P-value:4.05E-6 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.26|P-value:8.92E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:4.27|P-value:2.14E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.60|P-value:2.72E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:-6.16|P-value:1.65E-9 ID:SGTC_2844|Compound:9010103|FD-Score:3.30|P-value:7.78E-4 ID:SGTC_2845|Compound:9003024|FD-Score:6.65|P-value:8.84E-11 ID:SGTC_2911|Compound:7942208|FD-Score:4.47|P-value:8.99E-6 ID:SGTC_2927|Compound:9011802|FD-Score:3.83|P-value:1.20E-4 ID:SGTC_2965|Compound:9082772|FD-Score:3.29|P-value:8.10E-4 ID:SGTC_2977|Compound:9011197|FD-Score:7.61|P-value:1.40E-13 ID:SGTC_2978|Compound:9011784|FD-Score:-5.89|P-value:7.52E-9 ID:SGTC_3018|Compound:9082602|FD-Score:-3.59|P-value:2.80E-4 ID:SGTC_3201|Compound:9113999|FD-Score:3.36|P-value:6.39E-4 ID:SGTC_3315|Compound:9136395|FD-Score:3.66|P-value:2.21E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.90|P-value:1.28E-6 ID:SGTC_217|Compound:ketoconazole|FD-Score:-3.59|P-value:2.79E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:-4.14|P-value:3.43E-5 ID:SGTC_350|Compound:k064-0020|FD-Score:3.28|P-value:8.18E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:5.73|P-value:1.88E-8 ID:SGTC_365|Compound:0121-0052|FD-Score:3.60|P-value:2.79E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:3.69|P-value:2.02E-4 ID:SGTC_490|Compound:phenamil|FD-Score:5.10|P-value:4.86E-7 ID:SGTC_620|Compound:0109-0052|FD-Score:4.30|P-value:1.83E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:5.56|P-value:4.74E-8 ID:SGTC_648|Compound:0375-0473|FD-Score:3.32|P-value:7.17E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:5.11|P-value:4.82E-7 ID:SGTC_665|Compound:3914-0008|FD-Score:4.51|P-value:7.61E-6 ID:SGTC_774|Compound:k060-0086|FD-Score:3.55|P-value:3.33E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:-4.83|P-value:1.78E-6 ID:SGTC_1150|Compound:3909-7983|FD-Score:3.82|P-value:1.25E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:3.39|P-value:5.69E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:4.48|P-value:8.57E-6 ID:SGTC_1348|Compound:1493-0373|FD-Score:4.01|P-value:5.96E-5 ID:SGTC_1370|Compound:2001-0092|FD-Score:-4.95|P-value:9.99E-7 ID:SGTC_1381|Compound:2324-0066|FD-Score:-5.17|P-value:3.43E-7 ID:SGTC_1438|Compound:4092-1045|FD-Score:-3.66|P-value:2.15E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:3.95|P-value:7.47E-5 ID:SGTC_1518|Compound:st038567|FD-Score:6.02|P-value:3.89E-9 ID:SGTC_1726|Compound:st035556|FD-Score:4.26|P-value:2.18E-5 ID:SGTC_1767|Compound:st044992|FD-Score:3.74|P-value:1.64E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-3.89|P-value:9.44E-5 ID:SGTC_1788|Compound:fluconazole|FD-Score:-3.22|P-value:9.93E-4 ID:SGTC_1826|Compound:st055655|FD-Score:3.34|P-value:6.82E-4 ID:SGTC_1885|Compound:st057546|FD-Score:4.92|P-value:1.16E-6 ID:SGTC_1961|Compound:st076550|FD-Score:3.73|P-value:1.71E-4 ID:SGTC_2018|Compound:5133068|FD-Score:3.34|P-value:6.73E-4 ID:SGTC_2284|Compound:7945075|FD-Score:3.95|P-value:7.45E-5 ID:SGTC_2305|Compound:7443522|FD-Score:3.31|P-value:7.55E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.48|P-value:4.23E-4 ID:SGTC_2311|Compound:7694451|FD-Score:-5.41|P-value:9.94E-8 ID:SGTC_2582|Compound:agaric acid|FD-Score:-6.29|P-value:7.85E-10 ID:SGTC_2584|Compound:androsterone|FD-Score:-4.89|P-value:1.34E-6 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:-4.03|P-value:5.49E-5 ID:SGTC_2610|Compound:ononetin|FD-Score:5.27|P-value:2.09E-7 ID:SGTC_2612|Compound:dictamnine|FD-Score:-3.48|P-value:4.15E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-3.94|P-value:7.59E-5 ID:SGTC_2629|Compound:bisabolol|FD-Score:-3.54|P-value:3.33E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:10.80|P-value:1.24E-25 ID:SGTC_2694|Compound:st077685|FD-Score:4.65|P-value:4.05E-6 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.26|P-value:8.92E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:4.27|P-value:2.14E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.60|P-value:2.72E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:-6.16|P-value:1.65E-9 ID:SGTC_2844|Compound:9010103|FD-Score:3.30|P-value:7.78E-4 ID:SGTC_2845|Compound:9003024|FD-Score:6.65|P-value:8.84E-11 ID:SGTC_2911|Compound:7942208|FD-Score:4.47|P-value:8.99E-6 ID:SGTC_2927|Compound:9011802|FD-Score:3.83|P-value:1.20E-4 ID:SGTC_2965|Compound:9082772|FD-Score:3.29|P-value:8.10E-4 ID:SGTC_2977|Compound:9011197|FD-Score:7.61|P-value:1.40E-13 ID:SGTC_2978|Compound:9011784|FD-Score:-5.89|P-value:7.52E-9 ID:SGTC_3018|Compound:9082602|FD-Score:-3.59|P-value:2.80E-4 ID:SGTC_3201|Compound:9113999|FD-Score:3.36|P-value:6.39E-4 ID:SGTC_3315|Compound:9136395|FD-Score:3.66|P-value:2.21E-4

Top fitness defect scores for YBR048W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2688 kanamycin b 10.80 96.7 µM 1.24E-25 calcium & mitochondrial duress 18 1.16E-27
2 SGTC_2977 9011197 7.61 71.4 µM 1.40E-13 1 1.36E-14
3 SGTC_2845 9003024 6.65 43.0 µM 8.84E-11 amide catabolism 14 1.47E-11
4 SGTC_1518 st038567 6.02 90.8 µM 3.89E-9 3 8.91E-10
5 SGTC_358 0075-0058 5.73 9.4 µM 1.88E-8 20 4.90E-9
6 SGTC_625 k213-0058 5.56 121.0 µM 4.74E-8 translation 46 1.34E-8
7 SGTC_2610 ononetin 5.27 44.2 µM 2.09E-7 12 6.65E-8
8 SGTC_656 4090-1979 5.11 187.0 µM 4.82E-7 5 1.65E-7
9 SGTC_490 phenamil 5.10 164.0 µM 4.86E-7 heme requiring 4 1.66E-7
10 SGTC_1885 st057546 4.92 99.9 µM 1.16E-6 6 4.28E-7
11 SGTC_118 0083-0097 4.90 135.3 µM 1.28E-6 translation 64 4.75E-7
12 SGTC_2694 st077685 4.65 81.9 µM 4.05E-6 endomembrane recycling 16 1.65E-6
13 SGTC_665 3914-0008 4.51 307.0 µM 7.61E-6 11 3.26E-6
14 SGTC_1347 1493-0251 4.48 600.0 nM 8.57E-6 mitochondrial response to ROS 10 3.71E-6
15 SGTC_2911 7942208 4.47 15.6 µM 8.99E-6 mitochondrial response to ROS 11 3.91E-6
16 SGTC_620 0109-0052 4.30 432.0 µM 1.83E-5 10 8.42E-6
17 SGTC_2750 bromebric acid 4.27 70.2 µM 2.14E-5 21 9.98E-6
18 SGTC_1726 st035556 4.26 14.6 µM 2.18E-5 30 1.02E-5
19 SGTC_1348 1493-0373 4.01 93.8 µM 5.96E-5 12 3.02E-5
20 SGTC_2284 7945075 3.95 39.2 µM 7.45E-5 mitochondrial processes 26 3.85E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.202 3.73E-32 YLR367W RPS22B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication
0.196 2.52E-30 YDR447C RPS17B hom Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17B has a paralog, RPS17A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.195 4.36E-30 YLL045C RPL8B hom Ribosomal 60S subunit protein L8B; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8B has a paralog, RPL8A, that arose from the whole genome duplication
0.164 1.20E-21 YFL036W RPO41 hom Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.157 6.17E-20 YCR046C IMG1 hom Mitochondrial ribosomal protein of the large subunit, required for respiration and for maintenance of the mitochondrial genome
0.153 4.10E-19 YDR101C ARX1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.148 7.03E-18 YGR214W RPS0A hom Ribosomal 40S subunit protein S0A; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2; RPS0A has a paralog, RPS0B, that arose from the whole genome duplication;
0.148 8.47E-18 YDL052C SLC1 hom 1-acyl-sn-glycerol-3-phosphate acyltransferase, catalyzes the acylation of lysophosphatidic acid to form phosphatidic acid, a key intermediate in lipid metabolism; enzymatic activity detected in lipid particles and microsomes
0.143 7.05E-17 YBR191W RPL21A hom Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication
0.138 9.41E-16 YNL227C JJJ1 hom Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis
0.131 3.20E-14 YER048C CAJ1 hom Nuclear type II J heat shock protein of the E. coli dnaJ family, contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly
0.129 7.64E-14 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.128 1.18E-13 YGR118W RPS23A hom Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23A has a paralog, RPS23B, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal
0.124 6.96E-13 YLR402W_d YLR402W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.123 8.81E-13 YNL067W RPL9B hom Ribosomal 60S subunit protein L9B; nearly identical to paralog Rpl9Ap; homologous to mammalian ribosomal protein L9 and bacterial L6