YBR053C_p

Putative protein of unknown function; induced by cell wall perturbation

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR053C / YBR053C

Click on Significant Values for Screen Details ID:SGTC_69|Compound:0096-0274|FD-Score:3.86|P-value:1.11E-5 ID:SGTC_382|Compound:3229-0966|FD-Score:-3.54|P-value:5.34E-5 ID:SGTC_394|Compound:menadione|FD-Score:3.86|P-value:1.15E-5 ID:SGTC_396|Compound:dithiazanine|FD-Score:3.31|P-value:1.41E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:2.87|P-value:8.11E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.07|P-value:3.73E-4 ID:SGTC_482|Compound:fipronil|FD-Score:3.33|P-value:1.28E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:-3.87|P-value:1.15E-5 ID:SGTC_511|Compound:blebbistatin|FD-Score:-2.90|P-value:7.43E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:-2.89|P-value:7.76E-4 ID:SGTC_732|Compound:3970-1727|FD-Score:3.33|P-value:1.25E-4 ID:SGTC_766|Compound:1391-0721|FD-Score:4.30|P-value:1.16E-6 ID:SGTC_828|Compound:2074-0507|FD-Score:2.93|P-value:6.53E-4 ID:SGTC_833|Compound:3852-0053|FD-Score:3.11|P-value:3.19E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:-3.24|P-value:1.95E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.86|P-value:1.11E-5 ID:SGTC_1012|Compound:4112-3522|FD-Score:4.40|P-value:6.62E-7 ID:SGTC_1105|Compound:epirubicin|FD-Score:3.43|P-value:8.26E-5 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.06|P-value:3.81E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.17|P-value:2.47E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:2.98|P-value:5.31E-4 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:2.91|P-value:6.88E-4 ID:SGTC_1808|Compound:st050063|FD-Score:2.84|P-value:8.98E-4 ID:SGTC_1825|Compound:st052143|FD-Score:3.96|P-value:7.01E-6 ID:SGTC_1908|Compound:st060353|FD-Score:2.98|P-value:5.41E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.03|P-value:4.33E-4 ID:SGTC_2268|Compound:7933382|FD-Score:4.30|P-value:1.18E-6 ID:SGTC_2350|Compound:9023895|FD-Score:2.99|P-value:5.20E-4 ID:SGTC_2421|Compound:5690543|FD-Score:3.26|P-value:1.73E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:3.01|P-value:4.73E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.61|P-value:3.68E-5 ID:SGTC_2607|Compound:solasodine|FD-Score:-3.54|P-value:5.22E-5 ID:SGTC_2610|Compound:ononetin|FD-Score:2.99|P-value:5.03E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.35|P-value:1.17E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:4.08|P-value:3.80E-6 ID:SGTC_2900|Compound:5328528|FD-Score:3.23|P-value:1.96E-4 ID:SGTC_3157|Compound:9099274|FD-Score:3.86|P-value:1.14E-5 ID:SGTC_3333|Compound:9141820|FD-Score:5.06|P-value:1.43E-8 ID:SGTC_3344|Compound:9148862|FD-Score:2.91|P-value:7.05E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:3.86|P-value:1.11E-5 ID:SGTC_382|Compound:3229-0966|FD-Score:-3.54|P-value:5.34E-5 ID:SGTC_394|Compound:menadione|FD-Score:3.86|P-value:1.15E-5 ID:SGTC_396|Compound:dithiazanine|FD-Score:3.31|P-value:1.41E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:2.87|P-value:8.11E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.07|P-value:3.73E-4 ID:SGTC_482|Compound:fipronil|FD-Score:3.33|P-value:1.28E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:-3.87|P-value:1.15E-5 ID:SGTC_511|Compound:blebbistatin|FD-Score:-2.90|P-value:7.43E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:-2.89|P-value:7.76E-4 ID:SGTC_732|Compound:3970-1727|FD-Score:3.33|P-value:1.25E-4 ID:SGTC_766|Compound:1391-0721|FD-Score:4.30|P-value:1.16E-6 ID:SGTC_828|Compound:2074-0507|FD-Score:2.93|P-value:6.53E-4 ID:SGTC_833|Compound:3852-0053|FD-Score:3.11|P-value:3.19E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:-3.24|P-value:1.95E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.86|P-value:1.11E-5 ID:SGTC_1012|Compound:4112-3522|FD-Score:4.40|P-value:6.62E-7 ID:SGTC_1105|Compound:epirubicin|FD-Score:3.43|P-value:8.26E-5 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.06|P-value:3.81E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.17|P-value:2.47E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:2.98|P-value:5.31E-4 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:2.91|P-value:6.88E-4 ID:SGTC_1808|Compound:st050063|FD-Score:2.84|P-value:8.98E-4 ID:SGTC_1825|Compound:st052143|FD-Score:3.96|P-value:7.01E-6 ID:SGTC_1908|Compound:st060353|FD-Score:2.98|P-value:5.41E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.03|P-value:4.33E-4 ID:SGTC_2268|Compound:7933382|FD-Score:4.30|P-value:1.18E-6 ID:SGTC_2350|Compound:9023895|FD-Score:2.99|P-value:5.20E-4 ID:SGTC_2421|Compound:5690543|FD-Score:3.26|P-value:1.73E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:3.01|P-value:4.73E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.61|P-value:3.68E-5 ID:SGTC_2607|Compound:solasodine|FD-Score:-3.54|P-value:5.22E-5 ID:SGTC_2610|Compound:ononetin|FD-Score:2.99|P-value:5.03E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.35|P-value:1.17E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:4.08|P-value:3.80E-6 ID:SGTC_2900|Compound:5328528|FD-Score:3.23|P-value:1.96E-4 ID:SGTC_3157|Compound:9099274|FD-Score:3.86|P-value:1.14E-5 ID:SGTC_3333|Compound:9141820|FD-Score:5.06|P-value:1.43E-8 ID:SGTC_3344|Compound:9148862|FD-Score:2.91|P-value:7.05E-4

Top fitness defect scores for YBR053C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3333 9141820 5.06 12.1 µM 1.43E-8 8 2.14E-7
2 SGTC_1012 4112-3522 4.40 18.0 µM 6.62E-7 18 5.29E-6
3 SGTC_766 1391-0721 4.30 126.0 µM 1.16E-6 8 8.45E-6
4 SGTC_2268 7933382 4.30 153.8 µM 1.18E-6 31 8.57E-6
5 SGTC_2778 tioconazole 4.08 65.1 nM 3.80E-6 ergosterol depletion effects on membrane 57 2.28E-5
6 SGTC_1825 st052143 3.96 62.6 µM 7.01E-6 13 3.82E-5
7 SGTC_1003 4049-0218 3.86 100.0 µM 1.11E-5 19 5.59E-5
8 SGTC_69 0096-0274 3.86 206.7 µM 1.11E-5 mitochondrial processes 45 5.60E-5
9 SGTC_3157 9099274 3.86 49.5 µM 1.14E-5 22 5.75E-5
10 SGTC_394 menadione 3.86 8.3 µM 1.15E-5 superoxide 35 5.77E-5
11 SGTC_2595 hexamethylquercetagetin 3.61 100.0 µM 3.68E-5 35 1.53E-4
12 SGTC_1105 epirubicin 3.43 18.1 µM 8.26E-5 anthracycline transcription coupled DNA repair 35 3.02E-4
13 SGTC_2751 anetholtrithion 3.35 17.2 µM 1.17E-4 45 4.05E-4
14 SGTC_732 3970-1727 3.33 52.7 µM 1.25E-4 18 4.27E-4
15 SGTC_482 fipronil 3.33 114.0 µM 1.28E-4 7 4.36E-4
16 SGTC_396 dithiazanine 3.31 1.2 µM 1.41E-4 21 4.72E-4
17 SGTC_2421 5690543 3.26 90.7 µM 1.73E-4 42 5.62E-4
18 SGTC_2900 5328528 3.23 85.3 µM 1.96E-4 Golgi 58 6.23E-4
19 SGTC_1370 2001-0092 3.17 44.6 µM 2.47E-4 75 7.57E-4
20 SGTC_833 3852-0053 3.11 558.0 µM 3.19E-4 49 9.39E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.135 4.09E-15 YKR041W YKR041W hom Protein of unknown function; localizes to the mitotic spindle; overexpression of YKR041W affects endocytic protein trafficking
0.106 6.58E-10 YHL034C SBP1 hom Protein that binds eIF4G and has a role in repression of translation; has an RGG motif; found in cytoplasmic P bodies; found associated with small nucleolar RNAs snR10 and snR11
0.106 7.01E-10 YIL155C GUT2 hom Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner
0.105 1.18E-9 YNL152W INN1 het Essential protein that associates with contractile actomyosin ring; required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function; activates chitin synthase activity of Chs2p during cytokinesis
0.102 3.28E-9 YOR273C TPO4 hom Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane
0.095 3.71E-8 YLR274W MCM5 het Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase
0.091 1.35E-7 YOR257W CDC31 het Calcium-binding component of the spindle pole body (SPB) half-bridge, required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; binds multiubiquitinated proteins and is involved in proteasomal protein degradation
0.089 2.55E-7 YBL023C MCM2 het Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex; relative distribution to the nucleus increases upon DNA replication stress
0.088 3.43E-7 YNR065C_p YNR065C_p hom Protein of unknown function; protein-protein interactions suggest a possible role in actin patch formation; YNR065C is not an essential gene
0.088 3.59E-7 YPL094C SEC62 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.088 3.63E-7 YBL075C SSA3 hom ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm; SSA3 has a paralog, SSA4, that arose from the whole genome duplication
0.085 7.53E-7 YMR199W CLN1 hom G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
0.080 3.42E-6 YNL038W GPI15 het Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-H protein
0.079 4.75E-6 YER104W RTT105 het Protein with a role in regulation of Ty1 transposition
0.074 1.67E-5 YML070W DAK1 hom Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation