HIPHOP chemogenomics database

YBR054W / YRO2

Protein of unknown function with similarity to archaeal rhodopsins; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; transcriptionally regulated by Haa1p; YRO2 has a paralog, MRH1, that arose from the whole genome duplication

Zygosity: Homozygous strain

fixedexpanded
Profile for YBR054W / YRO2

Click on Significant Values for Screen Details

Top fitness defect scores for YBR054W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2604	4'-hydroxychalcone	5.33	11.3 µM	1.02E-9		10	4.95E-8
2	SGTC_2483	5729050	5.13	27.2 µM	3.90E-9		9	1.43E-7
3	SGTC_2919	7978188	4.70	46.4 µM	6.30E-8		10	1.29E-6
4	SGTC_1475	4092-1048	4.23	11.7 µM	1.01E-6	plasma membrane duress	27	1.17E-5
5	SGTC_2572	astragaloside iv	3.84	100.0 µM	8.20E-6		29	6.14E-5
6	SGTC_1182	1222-0449	3.83	220.0 µM	8.75E-6		23	6.46E-5
7	SGTC_2703	st077852	3.78	53.4 µM	1.14E-5		29	7.97E-5
8	SGTC_1836	st055642	3.54	81.0 µM	3.69E-5		32	2.03E-4
9	SGTC_1314	1222-0010	3.52	41.1 µM	4.00E-5		21	2.17E-4
10	SGTC_1464	k208-0027	3.40	110.0 µM	6.89E-5		38	3.34E-4
11	SGTC_1156	4092-0367	3.24	4.9 µM	1.41E-4		56	5.92E-4
12	SGTC_940	3232-1287	3.22	54.8 µM	1.54E-4	NEO1	69	6.37E-4
13	SGTC_2258	7960471	3.19	200.0 µM	1.77E-4		33	7.11E-4
14	SGTC_259	usnic acid	3.05	108.9 µM	3.20E-4		52	0.00114
15	SGTC_1004	4084-0029	3.01	199.0 µM	3.82E-4		60	0.00131
16	SGTC_2123	5259487	2.97	200.0 µM	4.52E-4		59	0.00150
17	SGTC_2287	7945887	2.96	168.8 µM	4.65E-4		38	0.00154
18	SGTC_1693	xanthone	2.91	101.9 µM	5.61E-4	DNA damage response	51	0.00179
19	SGTC_1718	roemerine	2.91	11.9 µM	5.68E-4	redox potentiating	126	0.00181
20	SGTC_704	1310-0270	2.90	142.0 µM	5.80E-4		90	0.00184

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.127	1.80E-13	YNL034W_p	YNL034W_p	hom	Putative protein of unknown function; YNL034W is not an essential gene
0.111	1.18E-10	YMR271C	URA10	hom	Minor orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA10 has a paralog, URA5, that arose from the whole genome duplication
0.111	1.26E-10	YOL068C	HST1	hom	NAD(+)-dependent histone deacetylase; essential subunit of the Sum1p/Rfm1p/Hst1p complex required for ORC-dependent silencing and mitotic repression; non-essential subunit of the Set3C deacetylase complex; involved in telomere maintenance
0.095	3.44E-8	YKL067W	YNK1	hom	Nucleoside diphosphate kinase; catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate; protein abundance increases in response to DNA replication stress
0.094	4.43E-8	YJR037W_d	YJR037W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene HUL4/YJR036C; deletion mutant has decreased spore survival in Drosophila feces
0.094	5.68E-8	YOR098C	NUP1	het	FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC; both NUP1 and NUP60 are homologous to human NUP153
0.090	1.99E-7	YPL116W	HOS3	hom	Trichostatin A-insensitive homodimeric histone deacetylase (HDAC) with specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeats
0.084	9.77E-7	YGR044C	RME1	hom	Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-alpha2 regulator; mediates cell type control of sporulation; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.080	3.42E-6	YMR075W	RCO1	hom	Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p
0.077	7.35E-6	YKL179C	COY1	hom	Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.077	7.42E-6	YBL107C	MIC23	hom	Mitochondrial intermembrane space protein of unknown function; imported via the MIA import machinery; contains an unusual twin cysteine motif (CX13C CX14C)
0.077	7.59E-6	YMR274C	RCE1	hom	Type II CAAX prenyl protease involved in the proteolysis and maturation of Ras and the a-factor mating pheromone
0.077	8.46E-6	YBR128C	ATG14	hom	Autophagy-specific subunit of phosphatidylinositol 3-kinase complex I (with Vps34/15/30p); Atg14p targets complex I to the phagophore assembly site (PAS); required for localizing additional ATG proteins to the PAS; required for overflow degradation of misfolded proteins when ERAD is saturated; homolog of human Barkor
0.076	1.15E-5	YLR001C_p	YLR001C_p	hom	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; predicted to be palmitoylated
0.075	1.52E-5	YJR107W_p	YJR107W_p	hom	Putative lipase