YBR055C / PRP6

Splicing factor, component of the U4/U6-U5 snRNP complex

Zygosity: Heterozygous strain
fixedexpanded
Profile for YBR055C / PRP6

Click on Significant Values for Screen Details ID:SGTC_71|Compound:0417-1750|FD-Score:3.25|P-value:4.39E-4 ID:SGTC_162|Compound:k030-0015|FD-Score:3.31|P-value:3.45E-4 ID:SGTC_289|Compound:k017-0060|FD-Score:-3.03|P-value:8.34E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:-3.07|P-value:7.09E-4 ID:SGTC_306|Compound:1672-3436|FD-Score:3.11|P-value:7.17E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:4.00|P-value:2.09E-5 ID:SGTC_727|Compound:3032-0951|FD-Score:-3.03|P-value:8.31E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:-3.33|P-value:2.70E-4 ID:SGTC_812|Compound:4251-0442|FD-Score:3.33|P-value:3.30E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:3.07|P-value:8.27E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:3.79|P-value:5.09E-5 ID:SGTC_1049|Compound:3226-0134|FD-Score:6.99|P-value:3.25E-13 ID:SGTC_1066|Compound:ketoconazole|FD-Score:-3.19|P-value:4.54E-4 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:-3.46|P-value:1.65E-4 ID:SGTC_1163|Compound:k060-0048|FD-Score:3.03|P-value:9.51E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:-5.20|P-value:3.70E-8 ID:SGTC_1626|Compound:st003712|FD-Score:-3.00|P-value:9.05E-4 ID:SGTC_1705|Compound:st027868|FD-Score:-3.54|P-value:1.18E-4 ID:SGTC_1724|Compound:st037281|FD-Score:3.78|P-value:5.37E-5 ID:SGTC_1815|Compound:st051655|FD-Score:3.14|P-value:6.62E-4 ID:SGTC_1941|Compound:st076221|FD-Score:5.05|P-value:1.08E-7 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:4.68|P-value:7.99E-7 ID:SGTC_1952|Compound:st077036|FD-Score:6.26|P-value:6.22E-11 ID:SGTC_2199|Compound:6590217|FD-Score:-3.02|P-value:8.55E-4 ID:SGTC_2240|Compound:6690706|FD-Score:4.13|P-value:1.15E-5 ID:SGTC_2258|Compound:7960471|FD-Score:3.21|P-value:4.98E-4 ID:SGTC_2441|Compound:5730946|FD-Score:3.18|P-value:5.64E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.94|P-value:2.73E-5 ID:SGTC_2516|Compound:gossypol|FD-Score:3.67|P-value:8.61E-5 ID:SGTC_2517|Compound:totarol|FD-Score:4.01|P-value:1.96E-5 ID:SGTC_2522|Compound:biochanin a|FD-Score:-3.19|P-value:4.56E-4 ID:SGTC_2525|Compound:harmine|FD-Score:-3.68|P-value:6.58E-5 ID:SGTC_2533|Compound:agelasine|FD-Score:-3.40|P-value:2.08E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:-3.06|P-value:7.36E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.31|P-value:3.46E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:-3.61|P-value:8.84E-5 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:-2.98|P-value:9.86E-4 ID:SGTC_2798|Compound:7813637|FD-Score:3.04|P-value:9.23E-4 ID:SGTC_2816|Compound:7982706|FD-Score:3.03|P-value:9.71E-4 ID:SGTC_2832|Compound:7992762|FD-Score:3.25|P-value:4.36E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-7.32|P-value:1.84E-14 ID:SGTC_2905|Compound:7799065|FD-Score:3.28|P-value:3.93E-4 ID:SGTC_2913|Compound:7966556|FD-Score:3.03|P-value:9.75E-4 ID:SGTC_2935|Compound:9038016|FD-Score:-3.22|P-value:4.05E-4 ID:SGTC_2951|Compound:9072950|FD-Score:-3.02|P-value:8.51E-4 ID:SGTC_2955|Compound:9076254|FD-Score:-3.38|P-value:2.25E-4 ID:SGTC_2958|Compound:9077254|FD-Score:-3.43|P-value:1.86E-4 ID:SGTC_3010|Compound:9080089|FD-Score:-3.12|P-value:5.86E-4 ID:SGTC_3076|Compound:9116187|FD-Score:-3.65|P-value:7.66E-5 ID:SGTC_3077|Compound:9117319|FD-Score:3.11|P-value:7.34E-4 ID:SGTC_3221|Compound:9128209|FD-Score:3.08|P-value:7.99E-4 ID:SGTC_3225|Compound:9130819|FD-Score:3.25|P-value:4.45E-4 ID:SGTC_3310|Compound:9130229|FD-Score:-3.51|P-value:1.36E-4 ID:SGTC_3314|Compound:9135860|FD-Score:-4.11|P-value:1.01E-5 ID:SGTC_3322|Compound:9139058|FD-Score:-3.81|P-value:3.88E-5 ID:SGTC_3329|Compound:9141233|FD-Score:3.11|P-value:7.36E-4 ID:SGTC_3339|Compound:9145883|FD-Score:3.11|P-value:7.29E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:3.25|P-value:4.39E-4 ID:SGTC_162|Compound:k030-0015|FD-Score:3.31|P-value:3.45E-4 ID:SGTC_289|Compound:k017-0060|FD-Score:-3.03|P-value:8.34E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:-3.07|P-value:7.09E-4 ID:SGTC_306|Compound:1672-3436|FD-Score:3.11|P-value:7.17E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:4.00|P-value:2.09E-5 ID:SGTC_727|Compound:3032-0951|FD-Score:-3.03|P-value:8.31E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:-3.33|P-value:2.70E-4 ID:SGTC_812|Compound:4251-0442|FD-Score:3.33|P-value:3.30E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:3.07|P-value:8.27E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:3.79|P-value:5.09E-5 ID:SGTC_1049|Compound:3226-0134|FD-Score:6.99|P-value:3.25E-13 ID:SGTC_1066|Compound:ketoconazole|FD-Score:-3.19|P-value:4.54E-4 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:-3.46|P-value:1.65E-4 ID:SGTC_1163|Compound:k060-0048|FD-Score:3.03|P-value:9.51E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:-5.20|P-value:3.70E-8 ID:SGTC_1626|Compound:st003712|FD-Score:-3.00|P-value:9.05E-4 ID:SGTC_1705|Compound:st027868|FD-Score:-3.54|P-value:1.18E-4 ID:SGTC_1724|Compound:st037281|FD-Score:3.78|P-value:5.37E-5 ID:SGTC_1815|Compound:st051655|FD-Score:3.14|P-value:6.62E-4 ID:SGTC_1941|Compound:st076221|FD-Score:5.05|P-value:1.08E-7 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:4.68|P-value:7.99E-7 ID:SGTC_1952|Compound:st077036|FD-Score:6.26|P-value:6.22E-11 ID:SGTC_2199|Compound:6590217|FD-Score:-3.02|P-value:8.55E-4 ID:SGTC_2240|Compound:6690706|FD-Score:4.13|P-value:1.15E-5 ID:SGTC_2258|Compound:7960471|FD-Score:3.21|P-value:4.98E-4 ID:SGTC_2441|Compound:5730946|FD-Score:3.18|P-value:5.64E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.94|P-value:2.73E-5 ID:SGTC_2516|Compound:gossypol|FD-Score:3.67|P-value:8.61E-5 ID:SGTC_2517|Compound:totarol|FD-Score:4.01|P-value:1.96E-5 ID:SGTC_2522|Compound:biochanin a|FD-Score:-3.19|P-value:4.56E-4 ID:SGTC_2525|Compound:harmine|FD-Score:-3.68|P-value:6.58E-5 ID:SGTC_2533|Compound:agelasine|FD-Score:-3.40|P-value:2.08E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:-3.06|P-value:7.36E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.31|P-value:3.46E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:-3.61|P-value:8.84E-5 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:-2.98|P-value:9.86E-4 ID:SGTC_2798|Compound:7813637|FD-Score:3.04|P-value:9.23E-4 ID:SGTC_2816|Compound:7982706|FD-Score:3.03|P-value:9.71E-4 ID:SGTC_2832|Compound:7992762|FD-Score:3.25|P-value:4.36E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-7.32|P-value:1.84E-14 ID:SGTC_2905|Compound:7799065|FD-Score:3.28|P-value:3.93E-4 ID:SGTC_2913|Compound:7966556|FD-Score:3.03|P-value:9.75E-4 ID:SGTC_2935|Compound:9038016|FD-Score:-3.22|P-value:4.05E-4 ID:SGTC_2951|Compound:9072950|FD-Score:-3.02|P-value:8.51E-4 ID:SGTC_2955|Compound:9076254|FD-Score:-3.38|P-value:2.25E-4 ID:SGTC_2958|Compound:9077254|FD-Score:-3.43|P-value:1.86E-4 ID:SGTC_3010|Compound:9080089|FD-Score:-3.12|P-value:5.86E-4 ID:SGTC_3076|Compound:9116187|FD-Score:-3.65|P-value:7.66E-5 ID:SGTC_3077|Compound:9117319|FD-Score:3.11|P-value:7.34E-4 ID:SGTC_3221|Compound:9128209|FD-Score:3.08|P-value:7.99E-4 ID:SGTC_3225|Compound:9130819|FD-Score:3.25|P-value:4.45E-4 ID:SGTC_3310|Compound:9130229|FD-Score:-3.51|P-value:1.36E-4 ID:SGTC_3314|Compound:9135860|FD-Score:-4.11|P-value:1.01E-5 ID:SGTC_3322|Compound:9139058|FD-Score:-3.81|P-value:3.88E-5 ID:SGTC_3329|Compound:9141233|FD-Score:3.11|P-value:7.36E-4 ID:SGTC_3339|Compound:9145883|FD-Score:3.11|P-value:7.29E-4

Top fitness defect scores for YBR055C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1049 3226-0134 6.99 66.0 µM 3.25E-13 1 1.33E-12 1.21
2 SGTC_1952 st077036 6.26 64.1 µM 6.22E-11 3 1.90E-10 0.55
3 SGTC_1941 st076221 5.05 61.8 µM 1.08E-7 sphingolipid biosynthesis & PDR1 4 2.20E-7 0.03
4 SGTC_1951 sophoraflavanone G 4.68 9.2 µM 7.99E-7 RNA processing & uracil transport 2 1.46E-6 0.74
5 SGTC_2240 6690706 4.13 185.9 µM 1.15E-5 6 1.83E-5 0.40
6 SGTC_2517 totarol 4.01 10.0 µM 1.96E-5 5 3.03E-5 0.06
7 SGTC_364 0083-0097 4.00 67.7 µM 2.09E-5 8 3.22E-5 0.02
8 SGTC_2514 salinomycin 3.94 42.7 µM 2.73E-5 2 4.15E-5 0.28
9 SGTC_981 1488-1094 3.79 54.9 µM 5.09E-5 3 7.49E-5 0.09
10 SGTC_1724 st037281 3.78 8.3 µM 5.37E-5 17 7.87E-5 0.01
11 SGTC_2516 gossypol 3.67 71.5 µM 8.61E-5 10 1.23E-4 0.11
12 SGTC_812 4251-0442 3.33 148.0 µM 3.30E-4 8 4.41E-4 0.07
13 SGTC_162 k030-0015 3.31 37.8 µM 3.45E-4 iron homeostasis 7 4.60E-4 0.21
14 SGTC_2592 piperlongumine 3.31 83.3 µM 3.46E-4 TSC3-RPN4 16 4.61E-4 0.01
15 SGTC_2905 7799065 3.28 20.1 µM 3.93E-4 13 5.21E-4 0.02
16 SGTC_2832 7992762 3.25 52.0 µM 4.36E-4 12 5.75E-4 0.09
17 SGTC_71 0417-1750 3.25 47.8 µM 4.39E-4 Golgi 17 5.79E-4 0.21
18 SGTC_3225 9130819 3.25 49.5 µM 4.45E-4 amide catabolism 19 5.86E-4 0.01
19 SGTC_2258 7960471 3.21 200.0 µM 4.98E-4 11 6.52E-4 0.09
20 SGTC_2441 5730946 3.18 39.1 µM 5.64E-4 10 7.34E-4 0.09

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.188 5.67E-28 YKL202W_d YKL202W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.142 1.83E-16 YNR028W CPR8 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; similarity to Cpr4p suggests a potential role in the secretory pathway
0.113 5.16E-11 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.111 1.33E-10 YFL041W FET5 hom Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport
0.109 2.99E-10 YBL086C_p YBL086C_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.108 4.07E-10 YGL254W FZF1 hom Transcription factor involved in sulfite metabolism; sole identified regulatory target is SSU1; overexpression suppresses sulfite-sensitivity of many unrelated mutants due to hyperactivation of SSU1, contains five zinc fingers; protein abundance increases in response to DNA replication stress
0.105 1.03E-9 YGL037C PNC1 hom Nicotinamidase that converts nicotinamide to nicotinic acid; part of the NAD(+) salvage pathway; required for life span extension by calorie restriction; PNC1 expression responds to all known stimuli that extend replicative life span; protein increases in abundance and relative distribution to cytoplasmic foci decreases upon DNA replication stress
0.103 2.40E-9 YCL043C PDI1 het Protein disulfide isomerase; multifunctional protein of ER lumen, essential for formation of disulfide bonds in secretory and cell-surface proteins, unscrambles non-native disulfide bonds; key regulator of Ero1p; forms complex with Mnl1p that has exomannosidase activity, processing unfolded protein-bound Man8GlcNAc2 oligosaccharides to Man7GlcNAc2, promoting degradation in unfolded protein response; PDI1 has a paralog, EUG1, that arose from the whole genome duplication
0.098 1.45E-8 YKR059W TIF1 hom Translation initiation factor eIF4A; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G; protein abundance increases in response to DNA replication stress; TIF1 has a paralog, TIF2, that arose from the whole genome duplication
0.095 4.31E-8 YPR093C ASR1 hom Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; contains a Ring/PHD finger domain similar to the mammalian rA9 protein
0.094 4.34E-8 YDR439W LRS4 hom Nucleolar protein that forms a complex with Csm1p, and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation
0.094 5.81E-8 YOL138C RTC1 hom Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; null mutation suppresses cdc13-1 temperature sensitivity; has N-terminal WD-40 repeats and a C-terminal RING motif
0.091 1.18E-7 YDR056C_p YDR056C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR056C is not an essential protein
0.090 1.76E-7 YGR036C CAX4 hom Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation
0.088 3.44E-7 YGL001C ERG26 het C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis