YBR056W

Putative glycoside hydrolase of the mitochondrial intermembrane space

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR056W / YBR056W

Click on Significant Values for Screen Details

Top fitness defect scores for YBR056W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2567 aureobasidin a 8.46 60.0 nM 3.52E-18 18 1.32E-17
2 SGTC_184 1494-0393 6.10 24.7 µM 2.51E-10 16 5.42E-10
3 SGTC_873 0591-4978 5.56 488.0 µM 6.93E-9 4 1.35E-8
4 SGTC_1305 1181-0477 5.39 144.0 µM 1.83E-8 7 3.46E-8
5 SGTC_94 0334-0113 5.35 514.8 µM 2.35E-8 4 4.39E-8
6 SGTC_2627 acetyl isogambogic acid 5.27 100.0 µM 3.76E-8 TSC3-RPN4 24 6.92E-8
7 SGTC_382 3229-0966 4.63 23.2 µM 1.11E-6 8 1.83E-6
8 SGTC_1346 1488-2224 4.53 62.4 µM 1.83E-6 16 2.96E-6
9 SGTC_3259 9138485 4.16 49.5 µM 1.03E-5 9 1.58E-5
10 SGTC_718 1130-0073 4.15 349.0 µM 1.09E-5 16 1.66E-5
11 SGTC_115 0527-0192 4.00 112.0 µM 2.10E-5 67 3.14E-5
12 SGTC_126 0417-1624 3.95 672.5 µM 2.67E-5 DNA intercalators 34 3.97E-5
13 SGTC_2523 spermine 3.86 47.7 µM 3.92E-5 calcium & mitochondrial duress 31 5.73E-5
14 SGTC_874 0599-0792 3.70 117.0 µM 7.61E-5 35 1.09E-4
15 SGTC_400 oxethazaine 3.69 37.5 µM 7.94E-5 calcium & mitochondrial duress 26 1.14E-4
16 SGTC_833 3852-0053 3.67 558.0 µM 8.40E-5 21 1.20E-4
17 SGTC_1233 0325-0408 3.67 14.2 µM 8.51E-5 26 1.21E-4
18 SGTC_1368 1852-0141 3.66 284.0 µM 8.99E-5 ERG2 46 1.28E-4
19 SGTC_376 3970-0862 3.60 59.1 µM 1.13E-4 29 1.59E-4
20 SGTC_2286 7945697 3.60 125.0 µM 1.14E-4 69 1.61E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.255 1.10E-50 YKL004W AUR1 het Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
0.174 3.99E-24 YDR367W KEI1 het Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene
0.153 5.25E-19 YMR211W DML1 het Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family
0.149 3.81E-18 YBR110W ALG1 het Mannosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability, mutation is functionally complemented by human ortholog
0.142 1.26E-16 YEL064C AVT2 hom Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.135 4.25E-15 YPL035C_d YPL035C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene
0.124 5.65E-13 YGL002W ERP6 hom Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; ERP6 has a paralog, ERP1, that arose from the whole genome duplication
0.117 1.03E-11 YPL262W FUM1 hom Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria
0.111 1.25E-10 YHR149C SKG6 hom Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
0.110 1.64E-10 YDR155C CPR1 hom Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A; protein abundance increases in response to DNA replication stress
0.109 2.29E-10 YLR037C PAU23 hom Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth
0.107 5.94E-10 YDR118W APC4 het Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to the nucleus increases upon DNA replication stress
0.106 6.97E-10 YMR044W IOC4 hom Member of a complex (Isw1b) with Isw1p and Ioc2p; interacts directly with H3K36me3 nucleosomes through its PWWP domain to recruit the Isw1b complex to open reading frames in a Set2p-dependent manner; Isw1b exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing
0.105 1.15E-9 YPL038W MET31 hom Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; MET31 has a paralog, MET32, that arose from the whole genome duplication
0.103 2.40E-9 YCR057C PWP2 het Conserved 90S pre-ribosomal component essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites; contains eight WD-repeats; PWP2 deletion leads to defects in cell cycle and bud morphogenesis