HIPHOP chemogenomics database
YBR056W-A_p 
Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the dubious ORF YBR056C-B
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YBR056W-A deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.179 | 1.22E-25 | YML129C | COX14 | hom | Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes |
| 0.166 | 4.90E-22 | YDR231C | COX20 | hom | Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase |
| 0.157 | 7.74E-20 | YDL107W | MSS2 | hom | Peripherally bound inner membrane protein of the mitochondrial matrix involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p |
| 0.151 | 1.18E-18 | YPL132W | COX11 | hom | Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p |
| 0.147 | 9.72E-18 | YGL107C | RMD9 | hom | Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes |
| 0.143 | 6.83E-17 | YHL038C | CBP2 | hom | Required for splicing of the group I intron bI5 of the COB pre-mRNA; nuclear-encoded mitochondrial protein that binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene |
| 0.142 | 1.32E-16 | YNR045W | PET494 | hom | Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane |
| 0.141 | 2.88E-16 | YJL062W-A | COA3 | hom | Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly |
| 0.139 | 7.01E-16 | YMR316W | DIA1 | hom | Protein of unknown function, involved in invasive and pseudohyphal growth; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern |
| 0.136 | 2.22E-15 | YER058W | PET117 | hom | Protein required for assembly of cytochrome c oxidase |
| 0.136 | 2.98E-15 | YDR082W | STN1 | het | Telomere end-binding and capping protein, plays a key role with Pol12p in linking telomerase action with completion of lagging strand synthesis, and in a regulatory step required for telomere capping |
| 0.135 | 3.76E-15 | YDR205W | MSC2 | hom | Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids |
| 0.129 | 7.65E-14 | YMR035W | IMP2 | hom | Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p |
| 0.121 | 1.77E-12 | YGR183C | QCR9 | hom | Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex |
| 0.121 | 1.76E-12 | YJL166W | QCR8 | hom | Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p |