YBR056W-A_p

Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the dubious ORF YBR056C-B

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR056W-A / YBR056W-A

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:6.07|P-value:9.79E-9 ID:SGTC_134|Compound:0269-0018|FD-Score:6.58|P-value:5.53E-10 ID:SGTC_164|Compound:4100-3994|FD-Score:4.00|P-value:1.16E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:4.19|P-value:5.81E-5 ID:SGTC_274|Compound:sirtinol|FD-Score:3.58|P-value:5.04E-4 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:-3.46|P-value:5.08E-4 ID:SGTC_501|Compound:nsc-95397|FD-Score:3.56|P-value:5.32E-4 ID:SGTC_564|Compound:3555-0129|FD-Score:3.56|P-value:5.35E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:5.53|P-value:1.63E-7 ID:SGTC_566|Compound:0958-0068|FD-Score:7.28|P-value:7.43E-12 ID:SGTC_629|Compound:3448-6466|FD-Score:3.70|P-value:3.35E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:-3.54|P-value:3.86E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:-3.26|P-value:9.58E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:-3.66|P-value:2.56E-4 ID:SGTC_861|Compound:0443-0273|FD-Score:3.90|P-value:1.65E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:5.35|P-value:3.88E-7 ID:SGTC_1013|Compound:4112-3890|FD-Score:-4.00|P-value:7.45E-5 ID:SGTC_1091|Compound:telmisartan|FD-Score:3.59|P-value:4.84E-4 ID:SGTC_1172|Compound:0370-0043|FD-Score:5.75|P-value:5.38E-8 ID:SGTC_1364|Compound:1653-0028|FD-Score:4.51|P-value:1.63E-5 ID:SGTC_1438|Compound:4092-1045|FD-Score:3.41|P-value:8.69E-4 ID:SGTC_1602|Compound:st001878|FD-Score:5.39|P-value:3.15E-7 ID:SGTC_1657|Compound:st012939|FD-Score:3.54|P-value:5.79E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.90|P-value:1.69E-4 ID:SGTC_1683|Compound:st010134|FD-Score:3.73|P-value:3.03E-4 ID:SGTC_1720|Compound:st037298|FD-Score:-3.32|P-value:7.96E-4 ID:SGTC_1725|Compound:st036284|FD-Score:4.37|P-value:2.84E-5 ID:SGTC_1779|Compound:st039427|FD-Score:3.41|P-value:8.66E-4 ID:SGTC_1868|Compound:st057644|FD-Score:4.50|P-value:1.70E-5 ID:SGTC_1921|Compound:5740136|FD-Score:-4.06|P-value:5.88E-5 ID:SGTC_1932|Compound:st074806|FD-Score:5.52|P-value:1.66E-7 ID:SGTC_1936|Compound:st074407|FD-Score:4.39|P-value:2.58E-5 ID:SGTC_1937|Compound:st074714|FD-Score:5.95|P-value:1.86E-8 ID:SGTC_1942|Compound:st076330|FD-Score:4.21|P-value:5.38E-5 ID:SGTC_2012|Compound:4023501|FD-Score:3.46|P-value:7.39E-4 ID:SGTC_2104|Compound:5389443|FD-Score:3.59|P-value:4.92E-4 ID:SGTC_2118|Compound:5526350|FD-Score:3.42|P-value:8.61E-4 ID:SGTC_2172|Compound:5754775|FD-Score:5.19|P-value:8.41E-7 ID:SGTC_2352|Compound:9027995|FD-Score:3.58|P-value:5.11E-4 ID:SGTC_2358|Compound:9037157|FD-Score:3.84|P-value:2.04E-4 ID:SGTC_2360|Compound:9040895|FD-Score:3.64|P-value:4.10E-4 ID:SGTC_2390|Compound:9097792|FD-Score:3.41|P-value:8.67E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.90|P-value:1.07E-4 ID:SGTC_2486|Compound:5283202|FD-Score:-3.98|P-value:8.08E-5 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-3.45|P-value:5.20E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-3.79|P-value:1.59E-4 ID:SGTC_2820|Compound:7989630|FD-Score:3.38|P-value:9.73E-4 ID:SGTC_2833|Compound:9001315|FD-Score:4.36|P-value:2.96E-5 ID:SGTC_2956|Compound:9076196|FD-Score:3.68|P-value:3.65E-4 ID:SGTC_2966|Compound:9084041|FD-Score:3.43|P-value:8.32E-4 ID:SGTC_3045|Compound:9092950|FD-Score:4.44|P-value:2.15E-5 ID:SGTC_3348|Compound:9149464|FD-Score:3.38|P-value:9.51E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:6.07|P-value:9.79E-9 ID:SGTC_134|Compound:0269-0018|FD-Score:6.58|P-value:5.53E-10 ID:SGTC_164|Compound:4100-3994|FD-Score:4.00|P-value:1.16E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:4.19|P-value:5.81E-5 ID:SGTC_274|Compound:sirtinol|FD-Score:3.58|P-value:5.04E-4 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:-3.46|P-value:5.08E-4 ID:SGTC_501|Compound:nsc-95397|FD-Score:3.56|P-value:5.32E-4 ID:SGTC_564|Compound:3555-0129|FD-Score:3.56|P-value:5.35E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:5.53|P-value:1.63E-7 ID:SGTC_566|Compound:0958-0068|FD-Score:7.28|P-value:7.43E-12 ID:SGTC_629|Compound:3448-6466|FD-Score:3.70|P-value:3.35E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:-3.54|P-value:3.86E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:-3.26|P-value:9.58E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:-3.66|P-value:2.56E-4 ID:SGTC_861|Compound:0443-0273|FD-Score:3.90|P-value:1.65E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:5.35|P-value:3.88E-7 ID:SGTC_1013|Compound:4112-3890|FD-Score:-4.00|P-value:7.45E-5 ID:SGTC_1091|Compound:telmisartan|FD-Score:3.59|P-value:4.84E-4 ID:SGTC_1172|Compound:0370-0043|FD-Score:5.75|P-value:5.38E-8 ID:SGTC_1364|Compound:1653-0028|FD-Score:4.51|P-value:1.63E-5 ID:SGTC_1438|Compound:4092-1045|FD-Score:3.41|P-value:8.69E-4 ID:SGTC_1602|Compound:st001878|FD-Score:5.39|P-value:3.15E-7 ID:SGTC_1657|Compound:st012939|FD-Score:3.54|P-value:5.79E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.90|P-value:1.69E-4 ID:SGTC_1683|Compound:st010134|FD-Score:3.73|P-value:3.03E-4 ID:SGTC_1720|Compound:st037298|FD-Score:-3.32|P-value:7.96E-4 ID:SGTC_1725|Compound:st036284|FD-Score:4.37|P-value:2.84E-5 ID:SGTC_1779|Compound:st039427|FD-Score:3.41|P-value:8.66E-4 ID:SGTC_1868|Compound:st057644|FD-Score:4.50|P-value:1.70E-5 ID:SGTC_1921|Compound:5740136|FD-Score:-4.06|P-value:5.88E-5 ID:SGTC_1932|Compound:st074806|FD-Score:5.52|P-value:1.66E-7 ID:SGTC_1936|Compound:st074407|FD-Score:4.39|P-value:2.58E-5 ID:SGTC_1937|Compound:st074714|FD-Score:5.95|P-value:1.86E-8 ID:SGTC_1942|Compound:st076330|FD-Score:4.21|P-value:5.38E-5 ID:SGTC_2012|Compound:4023501|FD-Score:3.46|P-value:7.39E-4 ID:SGTC_2104|Compound:5389443|FD-Score:3.59|P-value:4.92E-4 ID:SGTC_2118|Compound:5526350|FD-Score:3.42|P-value:8.61E-4 ID:SGTC_2172|Compound:5754775|FD-Score:5.19|P-value:8.41E-7 ID:SGTC_2352|Compound:9027995|FD-Score:3.58|P-value:5.11E-4 ID:SGTC_2358|Compound:9037157|FD-Score:3.84|P-value:2.04E-4 ID:SGTC_2360|Compound:9040895|FD-Score:3.64|P-value:4.10E-4 ID:SGTC_2390|Compound:9097792|FD-Score:3.41|P-value:8.67E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.90|P-value:1.07E-4 ID:SGTC_2486|Compound:5283202|FD-Score:-3.98|P-value:8.08E-5 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-3.45|P-value:5.20E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-3.79|P-value:1.59E-4 ID:SGTC_2820|Compound:7989630|FD-Score:3.38|P-value:9.73E-4 ID:SGTC_2833|Compound:9001315|FD-Score:4.36|P-value:2.96E-5 ID:SGTC_2956|Compound:9076196|FD-Score:3.68|P-value:3.65E-4 ID:SGTC_2966|Compound:9084041|FD-Score:3.43|P-value:8.32E-4 ID:SGTC_3045|Compound:9092950|FD-Score:4.44|P-value:2.15E-5 ID:SGTC_3348|Compound:9149464|FD-Score:3.38|P-value:9.51E-4

Top fitness defect scores for YBR056W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_566 0958-0068 7.28 16.5 µM 7.43E-12 RSC & ERG11 1 1.62E-13
2 SGTC_134 0269-0018 6.58 6.9 µM 5.53E-10 73 2.32E-11
3 SGTC_58 0957-0393 6.07 9.0 µM 9.79E-9 cell wall 211 6.36E-10
4 SGTC_1937 st074714 5.95 47.2 µM 1.86E-8 15 1.33E-9
5 SGTC_1172 0370-0043 5.75 85.0 µM 5.38E-8 4 4.53E-9
6 SGTC_565 1418-0001 5.53 44.5 µM 1.63E-7 2 1.63E-8
7 SGTC_1932 st074806 5.52 40.9 µM 1.66E-7 2 1.66E-8
8 SGTC_1602 st001878 5.39 87.6 µM 3.15E-7 9 3.48E-8
9 SGTC_953 1188-0045 5.35 9.7 µM 3.88E-7 60S ribosome export 4 4.41E-8
10 SGTC_2172 5754775 5.19 163.9 µM 8.41E-7 5 1.08E-7
11 SGTC_1364 1653-0028 4.51 37.6 µM 1.63E-5 11 3.29E-6
12 SGTC_1868 st057644 4.50 42.7 µM 1.70E-5 22 3.44E-6
13 SGTC_3045 9092950 4.44 49.5 µM 2.15E-5 11 4.52E-6
14 SGTC_1936 st074407 4.39 74.3 µM 2.58E-5 DNA damage response 21 5.57E-6
15 SGTC_1725 st036284 4.37 20.6 µM 2.84E-5 22 6.24E-6
16 SGTC_2833 9001315 4.36 45.5 µM 2.96E-5 amide catabolism 41 6.55E-6
17 SGTC_1942 st076330 4.21 65.2 µM 5.38E-5 24 1.30E-5
18 SGTC_236 1509-0011 4.19 5.3 µM 5.81E-5 370 1.42E-5
19 SGTC_164 4100-3994 4.00 89.6 µM 1.16E-4 30 3.15E-5
20 SGTC_861 0443-0273 3.90 110.0 µM 1.65E-4 12 4.75E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.179 1.22E-25 YML129C COX14 hom Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes
0.166 4.90E-22 YDR231C COX20 hom Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
0.157 7.74E-20 YDL107W MSS2 hom Peripherally bound inner membrane protein of the mitochondrial matrix involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p
0.151 1.18E-18 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.147 9.72E-18 YGL107C RMD9 hom Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes
0.143 6.83E-17 YHL038C CBP2 hom Required for splicing of the group I intron bI5 of the COB pre-mRNA; nuclear-encoded mitochondrial protein that binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene
0.142 1.32E-16 YNR045W PET494 hom Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane
0.141 2.88E-16 YJL062W-A COA3 hom Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly
0.139 7.01E-16 YMR316W DIA1 hom Protein of unknown function, involved in invasive and pseudohyphal growth; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.136 2.22E-15 YER058W PET117 hom Protein required for assembly of cytochrome c oxidase
0.136 2.98E-15 YDR082W STN1 het Telomere end-binding and capping protein, plays a key role with Pol12p in linking telomerase action with completion of lagging strand synthesis, and in a regulatory step required for telomere capping
0.135 3.76E-15 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.129 7.65E-14 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.121 1.77E-12 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.121 1.76E-12 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p