YBR057C / MUM2

Cytoplasmic protein essential for meiotic DNA replication and sporulation; interacts with Orc2p, which is a component of the origin recognition complex

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR057C / MUM2

Click on Significant Values for Screen Details ID:SGTC_53|Compound:0973-0023|FD-Score:-4.00|P-value:2.86E-5 ID:SGTC_350|Compound:k064-0020|FD-Score:-4.41|P-value:4.71E-6 ID:SGTC_357|Compound:1325-0123|FD-Score:3.35|P-value:4.70E-4 ID:SGTC_570|Compound:0987-0065|FD-Score:-3.27|P-value:4.88E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:3.87|P-value:6.50E-5 ID:SGTC_726|Compound:3448-4391|FD-Score:-4.40|P-value:4.89E-6 ID:SGTC_867|Compound:0518-0118|FD-Score:3.60|P-value:1.83E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:3.20|P-value:7.86E-4 ID:SGTC_1725|Compound:st036284|FD-Score:-3.42|P-value:2.89E-4 ID:SGTC_1726|Compound:st035556|FD-Score:4.83|P-value:8.27E-7 ID:SGTC_1730|Compound:st033808|FD-Score:-4.52|P-value:2.85E-6 ID:SGTC_1736|Compound:st036774|FD-Score:-5.40|P-value:3.02E-8 ID:SGTC_1754|Compound:st042065|FD-Score:-3.64|P-value:1.27E-4 ID:SGTC_1760|Compound:st045453|FD-Score:-3.44|P-value:2.66E-4 ID:SGTC_1782|Compound:st039423|FD-Score:5.17|P-value:1.45E-7 ID:SGTC_1910|Compound:st062352|FD-Score:3.22|P-value:7.35E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:4.55|P-value:3.34E-6 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-4.10|P-value:1.85E-5 ID:SGTC_2857|Compound:9024691|FD-Score:3.79|P-value:8.90E-5 ID:SGTC_2938|Compound:9059746|FD-Score:-3.67|P-value:1.12E-4 ID:SGTC_2943|Compound:9068529|FD-Score:4.43|P-value:5.58E-6 ID:SGTC_2944|Compound:9067346|FD-Score:6.48|P-value:6.39E-11 ID:SGTC_2977|Compound:9011197|FD-Score:6.44|P-value:8.23E-11 ID:SGTC_2980|Compound:9014342|FD-Score:4.10|P-value:2.43E-5 ID:SGTC_3062|Compound:9077494|FD-Score:3.33|P-value:5.01E-4 ID:SGTC_3175|Compound:9106517|FD-Score:3.82|P-value:7.87E-5 ID:SGTC_3179|Compound:9107801|FD-Score:4.28|P-value:1.10E-5 ID:SGTC_3284|Compound:9108171|FD-Score:3.19|P-value:8.23E-4 ID:SGTC_3286|Compound:9117135|FD-Score:3.83|P-value:7.47E-5 ID:SGTC_3304|Compound:9125678|FD-Score:3.57|P-value:2.09E-4 ID:SGTC_3336|Compound:9143619|FD-Score:-3.09|P-value:9.26E-4 ID:SGTC_3342|Compound:9147791|FD-Score:-3.83|P-value:5.91E-5 ID:SGTC_53|Compound:0973-0023|FD-Score:-4.00|P-value:2.86E-5 ID:SGTC_350|Compound:k064-0020|FD-Score:-4.41|P-value:4.71E-6 ID:SGTC_357|Compound:1325-0123|FD-Score:3.35|P-value:4.70E-4 ID:SGTC_570|Compound:0987-0065|FD-Score:-3.27|P-value:4.88E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:3.87|P-value:6.50E-5 ID:SGTC_726|Compound:3448-4391|FD-Score:-4.40|P-value:4.89E-6 ID:SGTC_867|Compound:0518-0118|FD-Score:3.60|P-value:1.83E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:3.20|P-value:7.86E-4 ID:SGTC_1725|Compound:st036284|FD-Score:-3.42|P-value:2.89E-4 ID:SGTC_1726|Compound:st035556|FD-Score:4.83|P-value:8.27E-7 ID:SGTC_1730|Compound:st033808|FD-Score:-4.52|P-value:2.85E-6 ID:SGTC_1736|Compound:st036774|FD-Score:-5.40|P-value:3.02E-8 ID:SGTC_1754|Compound:st042065|FD-Score:-3.64|P-value:1.27E-4 ID:SGTC_1760|Compound:st045453|FD-Score:-3.44|P-value:2.66E-4 ID:SGTC_1782|Compound:st039423|FD-Score:5.17|P-value:1.45E-7 ID:SGTC_1910|Compound:st062352|FD-Score:3.22|P-value:7.35E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:4.55|P-value:3.34E-6 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-4.10|P-value:1.85E-5 ID:SGTC_2857|Compound:9024691|FD-Score:3.79|P-value:8.90E-5 ID:SGTC_2938|Compound:9059746|FD-Score:-3.67|P-value:1.12E-4 ID:SGTC_2943|Compound:9068529|FD-Score:4.43|P-value:5.58E-6 ID:SGTC_2944|Compound:9067346|FD-Score:6.48|P-value:6.39E-11 ID:SGTC_2977|Compound:9011197|FD-Score:6.44|P-value:8.23E-11 ID:SGTC_2980|Compound:9014342|FD-Score:4.10|P-value:2.43E-5 ID:SGTC_3062|Compound:9077494|FD-Score:3.33|P-value:5.01E-4 ID:SGTC_3175|Compound:9106517|FD-Score:3.82|P-value:7.87E-5 ID:SGTC_3179|Compound:9107801|FD-Score:4.28|P-value:1.10E-5 ID:SGTC_3284|Compound:9108171|FD-Score:3.19|P-value:8.23E-4 ID:SGTC_3286|Compound:9117135|FD-Score:3.83|P-value:7.47E-5 ID:SGTC_3304|Compound:9125678|FD-Score:3.57|P-value:2.09E-4 ID:SGTC_3336|Compound:9143619|FD-Score:-3.09|P-value:9.26E-4 ID:SGTC_3342|Compound:9147791|FD-Score:-3.83|P-value:5.91E-5

Top fitness defect scores for YBR057C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2944 9067346 6.48 25.6 µM 6.39E-11 3 4.71E-11
2 SGTC_2977 9011197 6.44 71.4 µM 8.23E-11 4 6.09E-11
3 SGTC_1782 st039423 5.17 80.6 µM 1.45E-7 3 1.15E-7
4 SGTC_1726 st035556 4.83 14.6 µM 8.27E-7 19 6.69E-7
5 SGTC_2535 4',4'-dimethoxydalbergione 4.55 51.2 µM 3.34E-6 DNA damage response 9 2.75E-6
6 SGTC_2943 9068529 4.43 45.3 µM 5.58E-6 9 4.61E-6
7 SGTC_3179 9107801 4.28 49.5 µM 1.10E-5 4 9.17E-6
8 SGTC_2980 9014342 4.10 25.3 µM 2.43E-5 24 2.04E-5
9 SGTC_720 r052-1644 3.87 49.9 µM 6.50E-5 TSC3-RPN4 25 5.52E-5
10 SGTC_3286 9117135 3.83 37.2 µM 7.47E-5 14 6.36E-5
11 SGTC_3175 9106517 3.82 49.5 µM 7.87E-5 iron homeostasis 19 6.70E-5
12 SGTC_2857 9024691 3.79 58.4 µM 8.90E-5 26 7.58E-5
13 SGTC_867 0518-0118 3.60 155.0 µM 1.83E-4 DNA intercalators 30 1.57E-4
14 SGTC_3304 9125678 3.57 46.1 µM 2.09E-4 67 1.80E-4
15 SGTC_357 1325-0123 3.35 420.0 µM 4.70E-4 19 4.09E-4
16 SGTC_3062 9077494 3.33 49.5 µM 5.01E-4 mitochondrial response to ROS 51 4.36E-4
17 SGTC_1910 st062352 3.22 60.4 µM 7.35E-4 62 6.43E-4
18 SGTC_1459 k035-0031 3.20 35.7 µM 7.86E-4 DNA intercalators 46 6.88E-4
19 SGTC_3284 9108171 3.19 64.9 µM 8.23E-4 49 7.21E-4
20 SGTC_302 1094-0063 3.11 18.9 µM 0.00106 32 9.33E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.137 1.75E-15 YLR262C-A TMA7 hom Protein of unknown that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin; protein abundance increases in response to DNA replication stress
0.121 2.05E-12 YNL274C GOR1 hom Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress
0.116 1.85E-11 YPR013C_p CMR3_p hom Putative zinc finger protein; YPR013C is not an essential gene
0.104 1.58E-9 YOR056C NOB1 het Protein involved in proteasomal and 40S ribosomal subunit biogenesis; required for cleavage of the 20S pre-rRNA to generate the mature 18S rRNA; cleavage is activated by Fun12p, a GTPase and translation initiation factor; relocalizes from nucleus to nucleolus upon DNA replication stress
0.103 1.94E-9 YKL019W RAM2 het Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor
0.103 2.34E-9 YLR153C ACS2 het Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions
0.101 4.48E-9 YLR229C CDC42 het Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins
0.096 2.83E-8 YGL155W CDC43 het Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis
0.094 4.44E-8 YGL224C SDT1 hom Pyrimidine nucleotidase; overexpression suppresses the 6-AU sensitivity of transcription elongation factor S-II, as well as resistance to other pyrimidine derivatives
0.090 1.85E-7 YKL058W TOA2 het TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIA; protein abundance increases in response to DNA replication stress
0.089 2.64E-7 YBR046C ZTA1 hom NADPH-dependent quinone reductase, GFP-tagged protein localizes to the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin
0.086 6.57E-7 YOR144C ELG1 hom Subunit of an alternative replication factor C complex important for DNA replication and genome integrity; suppresses spontaneous DNA damage; involved in homologous recombination-mediated repair and telomere homeostasis; required for PCNA (Pol30p) unloading during DNA replication
0.084 1.12E-6 YDR362C TFC6 het One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; cooperates with Tfc3p in DNA binding; human homolog is TFIIIC-110
0.084 1.10E-6 YPL220W RPL1A hom Ribosomal 60S subunit protein L1A; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1A has a paralog, RPL1B, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal
0.083 1.59E-6 YNL120C_d YNL120C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; deletion enhances replication of Brome mosaic virus in S. cerevisiae, but likely due to effects on the overlapping gene