YBR059C / AKL1

Ser-Thr protein kinase, member (with Ark1p and Prk1p) of the Ark kinase family; involved in endocytosis and actin cytoskeleton organization

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR059C / AKL1

Click on Significant Values for Screen Details ID:SGTC_349|Compound:k015-0014|FD-Score:5.25|P-value:1.21E-7 ID:SGTC_354|Compound:2783-3500|FD-Score:3.55|P-value:2.42E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:-3.33|P-value:5.22E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:-3.21|P-value:7.76E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:3.16|P-value:9.24E-4 ID:SGTC_699|Compound:0375-0592|FD-Score:-3.35|P-value:4.88E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:3.98|P-value:4.51E-5 ID:SGTC_809|Compound:3998-0021|FD-Score:3.36|P-value:4.77E-4 ID:SGTC_810|Compound:3825-7150|FD-Score:-3.18|P-value:8.73E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:4.12|P-value:2.52E-5 ID:SGTC_1122|Compound:capsaicin|FD-Score:3.95|P-value:5.09E-5 ID:SGTC_1136|Compound:pergolide|FD-Score:3.60|P-value:2.02E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.20|P-value:8.08E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:3.87|P-value:6.88E-5 ID:SGTC_1243|Compound:0416-0003|FD-Score:-3.15|P-value:9.60E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:3.31|P-value:5.67E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.95|P-value:5.01E-5 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:-4.11|P-value:2.59E-5 ID:SGTC_1556|Compound:plumbagin|FD-Score:-4.63|P-value:2.50E-6 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.52|P-value:2.63E-4 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:6.65|P-value:2.90E-11 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:6.75|P-value:1.49E-11 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:-5.75|P-value:7.52E-9 ID:SGTC_1630|Compound:st005209|FD-Score:3.33|P-value:5.32E-4 ID:SGTC_1641|Compound:st009299|FD-Score:-3.41|P-value:3.91E-4 ID:SGTC_1733|Compound:st037357|FD-Score:-3.85|P-value:7.54E-5 ID:SGTC_2043|Compound:5101342|FD-Score:3.22|P-value:7.73E-4 ID:SGTC_2060|Compound:5238662|FD-Score:4.07|P-value:3.11E-5 ID:SGTC_2395|Compound:5646831|FD-Score:-3.42|P-value:3.78E-4 ID:SGTC_2414|Compound:st077232|FD-Score:3.17|P-value:8.94E-4 ID:SGTC_2833|Compound:9001315|FD-Score:6.29|P-value:2.95E-10 ID:SGTC_2942|Compound:9052777|FD-Score:3.55|P-value:2.36E-4 ID:SGTC_2973|Compound:9094665|FD-Score:-3.26|P-value:6.50E-4 ID:SGTC_2976|Compound:9009005|FD-Score:3.46|P-value:3.35E-4 ID:SGTC_2983|Compound:9022671|FD-Score:-3.32|P-value:5.28E-4 ID:SGTC_3025|Compound:9087895|FD-Score:4.02|P-value:3.86E-5 ID:SGTC_3026|Compound:9090633|FD-Score:6.56|P-value:5.50E-11 ID:SGTC_3082|Compound:9117008|FD-Score:3.35|P-value:4.98E-4 ID:SGTC_3143|Compound:9086658|FD-Score:4.53|P-value:4.21E-6 ID:SGTC_3202|Compound:9113761|FD-Score:-3.51|P-value:2.74E-4 ID:SGTC_3294|Compound:9122953|FD-Score:3.21|P-value:7.94E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:5.25|P-value:1.21E-7 ID:SGTC_354|Compound:2783-3500|FD-Score:3.55|P-value:2.42E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:-3.33|P-value:5.22E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:-3.21|P-value:7.76E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:3.16|P-value:9.24E-4 ID:SGTC_699|Compound:0375-0592|FD-Score:-3.35|P-value:4.88E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:3.98|P-value:4.51E-5 ID:SGTC_809|Compound:3998-0021|FD-Score:3.36|P-value:4.77E-4 ID:SGTC_810|Compound:3825-7150|FD-Score:-3.18|P-value:8.73E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:4.12|P-value:2.52E-5 ID:SGTC_1122|Compound:capsaicin|FD-Score:3.95|P-value:5.09E-5 ID:SGTC_1136|Compound:pergolide|FD-Score:3.60|P-value:2.02E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.20|P-value:8.08E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:3.87|P-value:6.88E-5 ID:SGTC_1243|Compound:0416-0003|FD-Score:-3.15|P-value:9.60E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:3.31|P-value:5.67E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.95|P-value:5.01E-5 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:-4.11|P-value:2.59E-5 ID:SGTC_1556|Compound:plumbagin|FD-Score:-4.63|P-value:2.50E-6 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.52|P-value:2.63E-4 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:6.65|P-value:2.90E-11 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:6.75|P-value:1.49E-11 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:-5.75|P-value:7.52E-9 ID:SGTC_1630|Compound:st005209|FD-Score:3.33|P-value:5.32E-4 ID:SGTC_1641|Compound:st009299|FD-Score:-3.41|P-value:3.91E-4 ID:SGTC_1733|Compound:st037357|FD-Score:-3.85|P-value:7.54E-5 ID:SGTC_2043|Compound:5101342|FD-Score:3.22|P-value:7.73E-4 ID:SGTC_2060|Compound:5238662|FD-Score:4.07|P-value:3.11E-5 ID:SGTC_2395|Compound:5646831|FD-Score:-3.42|P-value:3.78E-4 ID:SGTC_2414|Compound:st077232|FD-Score:3.17|P-value:8.94E-4 ID:SGTC_2833|Compound:9001315|FD-Score:6.29|P-value:2.95E-10 ID:SGTC_2942|Compound:9052777|FD-Score:3.55|P-value:2.36E-4 ID:SGTC_2973|Compound:9094665|FD-Score:-3.26|P-value:6.50E-4 ID:SGTC_2976|Compound:9009005|FD-Score:3.46|P-value:3.35E-4 ID:SGTC_2983|Compound:9022671|FD-Score:-3.32|P-value:5.28E-4 ID:SGTC_3025|Compound:9087895|FD-Score:4.02|P-value:3.86E-5 ID:SGTC_3026|Compound:9090633|FD-Score:6.56|P-value:5.50E-11 ID:SGTC_3082|Compound:9117008|FD-Score:3.35|P-value:4.98E-4 ID:SGTC_3143|Compound:9086658|FD-Score:4.53|P-value:4.21E-6 ID:SGTC_3202|Compound:9113761|FD-Score:-3.51|P-value:2.74E-4 ID:SGTC_3294|Compound:9122953|FD-Score:3.21|P-value:7.94E-4

Top fitness defect scores for YBR059C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1585 2',4'-dihydroxychalcone 6.75 10.4 µM 1.49E-11 7 7.23E-12
2 SGTC_1582 3',3',6'-trihydroxyflavone 6.65 74.0 µM 2.90E-11 1 1.43E-11
3 SGTC_3026 9090633 6.56 49.5 µM 5.50E-11 1 2.78E-11
4 SGTC_2833 9001315 6.29 45.5 µM 2.95E-10 amide catabolism 15 1.57E-10
5 SGTC_349 k015-0014 5.25 24.0 µM 1.21E-7 6 7.75E-8
6 SGTC_3143 9086658 4.53 49.5 µM 4.21E-6 28 3.01E-6
7 SGTC_823 0417-1665 4.12 178.0 µM 2.52E-5 36 1.90E-5
8 SGTC_2060 5238662 4.07 140.0 µM 3.11E-5 25 2.36E-5
9 SGTC_3025 9087895 4.02 49.5 µM 3.86E-5 PDR1 37 2.95E-5
10 SGTC_757 1066-0008 3.98 322.0 µM 4.51E-5 Golgi 16 3.46E-5
11 SGTC_1280 0880-0253 3.95 10.1 µM 5.01E-5 17 3.86E-5
12 SGTC_1122 capsaicin 3.95 818.6 nM 5.09E-5 27 3.93E-5
13 SGTC_1181 1222-0449 3.87 220.0 µM 6.88E-5 29 5.35E-5
14 SGTC_1136 pergolide 3.60 1.1 µM 2.02E-4 54 1.62E-4
15 SGTC_2942 9052777 3.55 62.2 µM 2.36E-4 49 1.90E-4
16 SGTC_354 2783-3500 3.55 4.9 µM 2.42E-4 cell wall 62 1.95E-4
17 SGTC_1580 hydrocortisone 21-hemisuccinate 3.52 43.2 µM 2.63E-4 31 2.13E-4
18 SGTC_2976 9009005 3.46 19.5 µM 3.35E-4 42 2.73E-4
19 SGTC_809 3998-0021 3.36 90.0 µM 4.77E-4 RNA processing & uracil transport 20 3.93E-4
20 SGTC_3082 9117008 3.35 49.5 µM 4.98E-4 35 4.11E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.112 6.49E-11 YNR028W CPR8 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; similarity to Cpr4p suggests a potential role in the secretory pathway
0.107 4.21E-10 YHR117W TOM71 hom Mitochondrial outer membrane protein; probable minor component of the TOM (translocase of outer membrane) complex responsible for recognition and import of mitochondrially directed proteins; TOM71 has a paralog, TOM70, that arose from the whole genome duplication
0.088 3.46E-7 YMR106C YKU80 hom Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
0.085 8.26E-7 YLR089C ALT1 hom Alanine transaminase (glutamic pyruvic transaminase); involved in alanine biosynthetic and catabolic processes; expression is induced in the presence of alanine; repression is mediated by Nrg1p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; paralogous gene ALT2 is catalytically inactive
0.084 1.15E-6 YKL021C MAK11 het Protein involved in an early, nucleolar step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats
0.080 3.38E-6 YBR148W YSW1 hom Protein required for normal prospore membrane formation; interacts with Gip1p, which is the meiosis-specific regulatory subunit of the Glc7p protein phosphatase; expressed specifically in spores and localizes to the prospore membrane
0.080 3.49E-6 YOR058C ASE1 hom Mitotic spindle midzone localized protein; microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate; relative distribution to microtubules decreases upon DNA replication stress
0.080 4.04E-6 YLR314C CDC3 het Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble with other septins into rod-like complexes that can associate with other rods to form filament polymers; septin rings at the mother-bud neck act as scaffolds for recruiting factors needed for cell division and as barriers to prevent diffusion of specific proteins between mother and daughter cells
0.079 4.54E-6 YER176W ECM32 hom DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes
0.079 5.20E-6 YBL029C-A YBL029C-A hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; protein abundance increases in response to DNA replication stress; has potential orthologs in Saccharomyces species and in Yarrowia lipolytica
0.078 6.46E-6 YLR332W MID2 hom O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p
0.077 7.05E-6 YBL099W ATP1 hom Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
0.077 8.38E-6 YDR532C KRE28 hom Subunit of a kinetochore-microtubule binding complex with Spc105p that bridges centromeric heterochromatin and kinetochore MAPs and motors, and is also required for sister chromatid bi-orientation and kinetochore binding of SAC components
0.077 9.05E-6 YOR057W SGT1 het Cochaperone protein; regulates activity of adenylyl cyclase Cyr1p; involved in kinetochore complex assembly; associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex; acts as a linker between Skp1p and HSP90 complexes; protein abundance increases in response to DNA replication stress
0.075 1.43E-5 YDR215C_d YDR215C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein