YBR062C_p

Protein of unknown function that interacts with Msb2p; may play a role in activation of the filamentous growth pathway.

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR062C / YBR062C

Click on Significant Values for Screen Details ID:SGTC_46|Compound:0329-0187a|FD-Score:3.22|P-value:2.09E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:2.96|P-value:5.90E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:3.18|P-value:2.46E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:4.11|P-value:3.37E-6 ID:SGTC_442|Compound:cape|FD-Score:-3.21|P-value:1.98E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.80|P-value:7.26E-8 ID:SGTC_472|Compound:calcifediol|FD-Score:3.04|P-value:4.39E-4 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:3.18|P-value:2.48E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:3.89|P-value:9.97E-6 ID:SGTC_834|Compound:0312-0008|FD-Score:3.82|P-value:1.45E-5 ID:SGTC_857|Compound:0438-0306|FD-Score:-3.33|P-value:1.20E-4 ID:SGTC_862|Compound:0452-0056|FD-Score:3.53|P-value:5.62E-5 ID:SGTC_957|Compound:1187-1561|FD-Score:-3.61|P-value:3.40E-5 ID:SGTC_1020|Compound:4335-0961|FD-Score:-3.44|P-value:7.44E-5 ID:SGTC_1022|Compound:4477-0945|FD-Score:-3.82|P-value:1.28E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.01|P-value:4.92E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:2.98|P-value:5.54E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-3.84|P-value:1.16E-5 ID:SGTC_1194|Compound:1488-0194|FD-Score:-2.89|P-value:7.06E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:3.38|P-value:1.07E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:3.10|P-value:3.40E-4 ID:SGTC_1328|Compound:1441-0025|FD-Score:-2.98|P-value:5.16E-4 ID:SGTC_1352|Compound:1496-0991|FD-Score:-2.96|P-value:5.51E-4 ID:SGTC_1361|Compound:1608-0041|FD-Score:-4.57|P-value:2.41E-7 ID:SGTC_1362|Compound:1611-0397|FD-Score:3.23|P-value:2.04E-4 ID:SGTC_1391|Compound:3442-0225|FD-Score:-3.52|P-value:5.32E-5 ID:SGTC_1400|Compound:3771-8998|FD-Score:-3.30|P-value:1.38E-4 ID:SGTC_1625|Compound:st003711|FD-Score:2.88|P-value:8.04E-4 ID:SGTC_1630|Compound:st005209|FD-Score:4.47|P-value:4.83E-7 ID:SGTC_1634|Compound:st006576|FD-Score:5.62|P-value:3.65E-10 ID:SGTC_1717|Compound:st033143|FD-Score:3.13|P-value:3.08E-4 ID:SGTC_1723|Compound:st034307|FD-Score:4.19|P-value:2.18E-6 ID:SGTC_1904|Compound:st060225|FD-Score:-3.68|P-value:2.50E-5 ID:SGTC_1979|Compound:st071809|FD-Score:5.31|P-value:3.00E-9 ID:SGTC_1989|Compound:st071868|FD-Score:5.65|P-value:2.85E-10 ID:SGTC_2090|Compound:5301565|FD-Score:-3.64|P-value:3.05E-5 ID:SGTC_2127|Compound:5253358|FD-Score:4.89|P-value:4.27E-8 ID:SGTC_2239|Compound:6685329|FD-Score:2.99|P-value:5.42E-4 ID:SGTC_2437|Compound:5741531|FD-Score:3.22|P-value:2.14E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:-3.15|P-value:2.54E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:-3.35|P-value:1.10E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-3.52|P-value:5.10E-5 ID:SGTC_2728|Compound:chlorpromazine|FD-Score:-3.04|P-value:4.04E-4 ID:SGTC_2868|Compound:9035608|FD-Score:-2.99|P-value:4.85E-4 ID:SGTC_2987|Compound:9018338|FD-Score:-3.04|P-value:4.00E-4 ID:SGTC_3058|Compound:9093861|FD-Score:3.26|P-value:1.79E-4 ID:SGTC_3211|Compound:9128781|FD-Score:3.79|P-value:1.62E-5 ID:SGTC_3212|Compound:9128307|FD-Score:-4.99|P-value:1.98E-8 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.22|P-value:2.09E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:2.96|P-value:5.90E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:3.18|P-value:2.46E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:4.11|P-value:3.37E-6 ID:SGTC_442|Compound:cape|FD-Score:-3.21|P-value:1.98E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.80|P-value:7.26E-8 ID:SGTC_472|Compound:calcifediol|FD-Score:3.04|P-value:4.39E-4 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:3.18|P-value:2.48E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:3.89|P-value:9.97E-6 ID:SGTC_834|Compound:0312-0008|FD-Score:3.82|P-value:1.45E-5 ID:SGTC_857|Compound:0438-0306|FD-Score:-3.33|P-value:1.20E-4 ID:SGTC_862|Compound:0452-0056|FD-Score:3.53|P-value:5.62E-5 ID:SGTC_957|Compound:1187-1561|FD-Score:-3.61|P-value:3.40E-5 ID:SGTC_1020|Compound:4335-0961|FD-Score:-3.44|P-value:7.44E-5 ID:SGTC_1022|Compound:4477-0945|FD-Score:-3.82|P-value:1.28E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.01|P-value:4.92E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:2.98|P-value:5.54E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-3.84|P-value:1.16E-5 ID:SGTC_1194|Compound:1488-0194|FD-Score:-2.89|P-value:7.06E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:3.38|P-value:1.07E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:3.10|P-value:3.40E-4 ID:SGTC_1328|Compound:1441-0025|FD-Score:-2.98|P-value:5.16E-4 ID:SGTC_1352|Compound:1496-0991|FD-Score:-2.96|P-value:5.51E-4 ID:SGTC_1361|Compound:1608-0041|FD-Score:-4.57|P-value:2.41E-7 ID:SGTC_1362|Compound:1611-0397|FD-Score:3.23|P-value:2.04E-4 ID:SGTC_1391|Compound:3442-0225|FD-Score:-3.52|P-value:5.32E-5 ID:SGTC_1400|Compound:3771-8998|FD-Score:-3.30|P-value:1.38E-4 ID:SGTC_1625|Compound:st003711|FD-Score:2.88|P-value:8.04E-4 ID:SGTC_1630|Compound:st005209|FD-Score:4.47|P-value:4.83E-7 ID:SGTC_1634|Compound:st006576|FD-Score:5.62|P-value:3.65E-10 ID:SGTC_1717|Compound:st033143|FD-Score:3.13|P-value:3.08E-4 ID:SGTC_1723|Compound:st034307|FD-Score:4.19|P-value:2.18E-6 ID:SGTC_1904|Compound:st060225|FD-Score:-3.68|P-value:2.50E-5 ID:SGTC_1979|Compound:st071809|FD-Score:5.31|P-value:3.00E-9 ID:SGTC_1989|Compound:st071868|FD-Score:5.65|P-value:2.85E-10 ID:SGTC_2090|Compound:5301565|FD-Score:-3.64|P-value:3.05E-5 ID:SGTC_2127|Compound:5253358|FD-Score:4.89|P-value:4.27E-8 ID:SGTC_2239|Compound:6685329|FD-Score:2.99|P-value:5.42E-4 ID:SGTC_2437|Compound:5741531|FD-Score:3.22|P-value:2.14E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:-3.15|P-value:2.54E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:-3.35|P-value:1.10E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-3.52|P-value:5.10E-5 ID:SGTC_2728|Compound:chlorpromazine|FD-Score:-3.04|P-value:4.04E-4 ID:SGTC_2868|Compound:9035608|FD-Score:-2.99|P-value:4.85E-4 ID:SGTC_2987|Compound:9018338|FD-Score:-3.04|P-value:4.00E-4 ID:SGTC_3058|Compound:9093861|FD-Score:3.26|P-value:1.79E-4 ID:SGTC_3211|Compound:9128781|FD-Score:3.79|P-value:1.62E-5 ID:SGTC_3212|Compound:9128307|FD-Score:-4.99|P-value:1.98E-8

Top fitness defect scores for YBR062C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1989 st071868 5.65 50.2 µM 2.85E-10 1 7.83E-9
2 SGTC_1634 st006576 5.62 41.0 µM 3.65E-10 TSC3-RPN4 7 9.63E-9
3 SGTC_1979 st071809 5.31 45.3 µM 3.00E-9 RPP1 & pyrimidine depletion 3 5.57E-8
4 SGTC_2127 5253358 4.89 187.9 µM 4.27E-8 7 5.13E-7
5 SGTC_453 enantio-paf c16 4.80 10.0 µM 7.26E-8 96 7.99E-7
6 SGTC_1630 st005209 4.47 31.3 µM 4.83E-7 15 3.90E-6
7 SGTC_1723 st034307 4.19 2.5 µM 2.18E-6 mitochondrial processes 25 1.37E-5
8 SGTC_212 3807-4682 4.11 38.8 µM 3.37E-6 tubulin folding & SWR complex 62 1.98E-5
9 SGTC_662 k832-1615 3.89 104.0 µM 9.97E-6 18 4.91E-5
10 SGTC_834 0312-0008 3.82 75.7 µM 1.45E-5 NEO1 43 6.74E-5
11 SGTC_3211 9128781 3.79 49.5 µM 1.62E-5 67 7.40E-5
12 SGTC_862 0452-0056 3.53 10.2 µM 5.62E-5 azole & statin 42 2.10E-4
13 SGTC_1202 1988-0068 3.38 29.6 µM 1.07E-4 RNA processing & uracil transport 47 3.61E-4
14 SGTC_3058 9093861 3.26 49.5 µM 1.79E-4 44 5.55E-4
15 SGTC_1362 1611-0397 3.23 101.0 µM 2.04E-4 43 6.19E-4
16 SGTC_46 0329-0187a 3.22 2.2 µM 2.09E-4 111 6.32E-4
17 SGTC_2437 5741531 3.22 144.2 µM 2.14E-4 71 6.46E-4
18 SGTC_188 3229-0966 3.18 278.5 µM 2.46E-4 68 7.25E-4
19 SGTC_494 Boc-Gly-Val-Val-CHO 3.18 140.0 µM 2.48E-4 23 7.31E-4
20 SGTC_1717 st033143 3.13 58.0 µM 3.08E-4 87 8.77E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.168 1.40E-22 YER069W ARG5,6 hom Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine
0.127 1.38E-13 YMR195W ICY1 hom Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation
0.123 7.39E-13 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.111 1.01E-10 YBR232C_d YBR232C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.108 3.57E-10 YBL034C STU1 het Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles
0.104 1.61E-9 YGR161W-C_p YGR161W-C_p hom Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species
0.103 2.05E-9 YDL146W LDB17 hom Protein involved in the regulation of endocytosis; transiently recruited to actin cortical patches in a SLA1-dependent manner after late coat component assembly; GFP-fusion protein localizes to the periphery, cytoplasm, bud, and bud neck
0.098 1.13E-8 YMR214W SCJ1 hom One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins
0.097 1.66E-8 YER043C SAH1 het S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor
0.097 1.95E-8 YOL140W ARG8 hom Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine
0.095 3.58E-8 YDL188C PPH22 hom Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; protein abundance increases in response to DNA replication stress; PPH22 has a paralog, PPH21, that arose from the whole genome duplication
0.093 7.16E-8 YLL020C_d YLL020C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KNS1
0.092 1.08E-7 YLR298C YHC1 het Component of the U1 snRNP complex required for pre-mRNA splicing; putative ortholog of human U1C protein, which is involved in formation of a complex between U1 snRNP and the pre-mRNA 5' splice site
0.091 1.34E-7 YBL005W PDR3 hom Transcriptional activator of the pleiotropic drug resistance network; regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements); post-translationally up-regulated in cells lacking a functional mitochondrial genome; PDR3 has a paralog, PDR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.091 1.39E-7 YLR042C_p YLR042C_p hom Protein of unknown function; localizes to the cytoplasm; YLL042C is not an essential gene