HIPHOP chemogenomics database
YBR064W_d 
Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YBR063C
Zygosity: Homozygous strain
fixedexpanded
  Click on Significant Values for Screen Details |
Top fitness defect scores for YBR064W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.112 | 6.70E-11 | YGL039W | YGL039W | hom | Oxidoreductase shown to reduce carbonyl compounds to chiral alcohols |
| 0.105 | 1.02E-9 | YLR421C | RPN13 | hom | Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome; null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; protein abundance increases in response to DNA replication stress |
| 0.092 | 8.46E-8 | YGL096W | TOS8 | hom | Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication |
| 0.087 | 4.83E-7 | YDR181C | SAS4 | hom | Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p |
| 0.085 | 7.05E-7 | YJR094C | IME1 | hom | Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p |
| 0.082 | 2.27E-6 | YBR093C | PHO5 | hom | Repressible acid phosphatase (1 of 3) that also mediates extracellular nucleotide-derived phosphate hydrolysis; secretory pathway derived cell surface glycoprotein; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2 |
| 0.081 | 2.90E-6 | YHR114W | BZZ1 | hom | SH3 domain protein implicated in the regulation of actin polymerization, able to recruit actin polymerization machinery through its SH3 domains, colocalizes with cortical actin patches and Las17p, interacts with type I myosins |
| 0.078 | 5.82E-6 | YDR048C_d | YDR048C_d | hom | Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.078 | 6.30E-6 | YHR039C | MSC7 | hom | Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids |
| 0.076 | 1.11E-5 | YKL221W | MCH2 | hom | Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport |
| 0.075 | 1.24E-5 | YKL106C-A_p | YKL106C-A_p | hom | Putative protein of unknown function; identified by homology to uncharacterized proteins in other fungi |
| 0.075 | 1.37E-5 | YMR230W-A_p | YMR230W-A_p | hom | Putative protein of unknown function |
| 0.075 | 1.43E-5 | YMR240C | CUS1 | het | Protein required for assembly of U2 snRNP into the spliceosome, forms a complex with Hsh49p and Hsh155p |
| 0.074 | 1.58E-5 | YDR315C | IPK1 | hom | Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable |
| 0.070 | 5.24E-5 | YER063W | THO1 | hom | Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation |