YBR064W_d

Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YBR063C

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR064W / YBR064W

Click on Significant Values for Screen Details ID:SGTC_44|Compound:0929-0055|FD-Score:3.15|P-value:4.07E-4 ID:SGTC_48|Compound:0382-0018|FD-Score:4.22|P-value:3.72E-6 ID:SGTC_61|Compound:0978-8327|FD-Score:-3.39|P-value:1.85E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:2.95|P-value:8.53E-4 ID:SGTC_297|Compound:0986-0032|FD-Score:3.07|P-value:5.40E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.43|P-value:1.55E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:-6.22|P-value:2.85E-11 ID:SGTC_638|Compound:3970-0837|FD-Score:-2.97|P-value:9.28E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:3.89|P-value:1.78E-5 ID:SGTC_666|Compound:0272-0154|FD-Score:-3.25|P-value:3.19E-4 ID:SGTC_735|Compound:3076-0345|FD-Score:3.35|P-value:1.85E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:3.52|P-value:9.01E-5 ID:SGTC_937|Compound:3122-0005|FD-Score:3.43|P-value:1.33E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:4.45|P-value:1.13E-6 ID:SGTC_958|Compound:1222-0007|FD-Score:3.06|P-value:5.67E-4 ID:SGTC_1042|Compound:0350-0096|FD-Score:6.31|P-value:1.13E-11 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.09|P-value:4.94E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:3.65|P-value:5.18E-5 ID:SGTC_1145|Compound:3546-0597|FD-Score:3.21|P-value:3.23E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:2.97|P-value:7.89E-4 ID:SGTC_1267|Compound:0828-0272|FD-Score:-3.50|P-value:1.16E-4 ID:SGTC_1307|Compound:1187-1599|FD-Score:-3.83|P-value:2.84E-5 ID:SGTC_1480|Compound:1070-0044|FD-Score:4.82|P-value:1.52E-7 ID:SGTC_1501|Compound:4491-0275|FD-Score:3.84|P-value:2.24E-5 ID:SGTC_1605|Compound:st000082|FD-Score:4.50|P-value:8.83E-7 ID:SGTC_1661|Compound:st013063|FD-Score:2.94|P-value:8.82E-4 ID:SGTC_1836|Compound:st055642|FD-Score:-3.27|P-value:3.00E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.26|P-value:2.62E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:-3.67|P-value:5.82E-5 ID:SGTC_1919|Compound:st067113|FD-Score:3.09|P-value:5.12E-4 ID:SGTC_1921|Compound:5740136|FD-Score:-3.02|P-value:7.74E-4 ID:SGTC_1961|Compound:st076550|FD-Score:-3.37|P-value:2.00E-4 ID:SGTC_2057|Compound:5236571|FD-Score:-3.38|P-value:1.89E-4 ID:SGTC_2172|Compound:5754775|FD-Score:-3.26|P-value:3.06E-4 ID:SGTC_2176|Compound:5809774|FD-Score:-3.06|P-value:6.52E-4 ID:SGTC_2180|Compound:6301957|FD-Score:3.28|P-value:2.46E-4 ID:SGTC_2269|Compound:7935389|FD-Score:-3.38|P-value:1.94E-4 ID:SGTC_2278|Compound:7948257|FD-Score:-3.02|P-value:7.71E-4 ID:SGTC_2288|Compound:7946289|FD-Score:-4.54|P-value:8.84E-7 ID:SGTC_2299|Compound:7976368|FD-Score:4.16|P-value:4.99E-6 ID:SGTC_2313|Compound:7726885|FD-Score:-3.23|P-value:3.53E-4 ID:SGTC_2320|Compound:7373003|FD-Score:-3.91|P-value:1.93E-5 ID:SGTC_2328|Compound:6201408|FD-Score:5.46|P-value:3.54E-9 ID:SGTC_2400|Compound:5203494|FD-Score:-3.14|P-value:4.88E-4 ID:SGTC_2447|Compound:5741742|FD-Score:3.52|P-value:8.93E-5 ID:SGTC_2504|Compound:purpurogallin|FD-Score:-4.99|P-value:7.54E-8 ID:SGTC_2699|Compound:st077704|FD-Score:3.43|P-value:1.34E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:-3.34|P-value:2.29E-4 ID:SGTC_2865|Compound:9030313|FD-Score:3.17|P-value:3.78E-4 ID:SGTC_2868|Compound:9035608|FD-Score:2.94|P-value:8.77E-4 ID:SGTC_2872|Compound:9044037|FD-Score:3.87|P-value:1.99E-5 ID:SGTC_2876|Compound:9059903|FD-Score:2.99|P-value:7.39E-4 ID:SGTC_2877|Compound:9040724|FD-Score:3.48|P-value:1.07E-4 ID:SGTC_2962|Compound:9082311|FD-Score:3.00|P-value:7.03E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.17|P-value:3.74E-4 ID:SGTC_2992|Compound:9074591|FD-Score:-3.94|P-value:1.75E-5 ID:SGTC_3000|Compound:9075062|FD-Score:3.63|P-value:5.62E-5 ID:SGTC_3007|Compound:9078383|FD-Score:-3.47|P-value:1.36E-4 ID:SGTC_3008|Compound:9078912|FD-Score:3.85|P-value:2.14E-5 ID:SGTC_3011|Compound:9081274|FD-Score:-7.31|P-value:6.76E-15 ID:SGTC_3137|Compound:9097352|FD-Score:-7.91|P-value:3.80E-17 ID:SGTC_3138|Compound:9097216|FD-Score:-3.88|P-value:2.22E-5 ID:SGTC_3139|Compound:9095020|FD-Score:3.79|P-value:2.81E-5 ID:SGTC_3161|Compound:9100388|FD-Score:-3.00|P-value:8.25E-4 ID:SGTC_3255|Compound:9139072|FD-Score:4.23|P-value:3.53E-6 ID:SGTC_3278|Compound:9139605|FD-Score:-3.20|P-value:3.93E-4 ID:SGTC_3281|Compound:9140613|FD-Score:-4.67|P-value:4.45E-7 ID:SGTC_3300|Compound:9124615|FD-Score:2.93|P-value:9.15E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:3.15|P-value:4.07E-4 ID:SGTC_48|Compound:0382-0018|FD-Score:4.22|P-value:3.72E-6 ID:SGTC_61|Compound:0978-8327|FD-Score:-3.39|P-value:1.85E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:2.95|P-value:8.53E-4 ID:SGTC_297|Compound:0986-0032|FD-Score:3.07|P-value:5.40E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.43|P-value:1.55E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:-6.22|P-value:2.85E-11 ID:SGTC_638|Compound:3970-0837|FD-Score:-2.97|P-value:9.28E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:3.89|P-value:1.78E-5 ID:SGTC_666|Compound:0272-0154|FD-Score:-3.25|P-value:3.19E-4 ID:SGTC_735|Compound:3076-0345|FD-Score:3.35|P-value:1.85E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:3.52|P-value:9.01E-5 ID:SGTC_937|Compound:3122-0005|FD-Score:3.43|P-value:1.33E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:4.45|P-value:1.13E-6 ID:SGTC_958|Compound:1222-0007|FD-Score:3.06|P-value:5.67E-4 ID:SGTC_1042|Compound:0350-0096|FD-Score:6.31|P-value:1.13E-11 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.09|P-value:4.94E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:3.65|P-value:5.18E-5 ID:SGTC_1145|Compound:3546-0597|FD-Score:3.21|P-value:3.23E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:2.97|P-value:7.89E-4 ID:SGTC_1267|Compound:0828-0272|FD-Score:-3.50|P-value:1.16E-4 ID:SGTC_1307|Compound:1187-1599|FD-Score:-3.83|P-value:2.84E-5 ID:SGTC_1480|Compound:1070-0044|FD-Score:4.82|P-value:1.52E-7 ID:SGTC_1501|Compound:4491-0275|FD-Score:3.84|P-value:2.24E-5 ID:SGTC_1605|Compound:st000082|FD-Score:4.50|P-value:8.83E-7 ID:SGTC_1661|Compound:st013063|FD-Score:2.94|P-value:8.82E-4 ID:SGTC_1836|Compound:st055642|FD-Score:-3.27|P-value:3.00E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.26|P-value:2.62E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:-3.67|P-value:5.82E-5 ID:SGTC_1919|Compound:st067113|FD-Score:3.09|P-value:5.12E-4 ID:SGTC_1921|Compound:5740136|FD-Score:-3.02|P-value:7.74E-4 ID:SGTC_1961|Compound:st076550|FD-Score:-3.37|P-value:2.00E-4 ID:SGTC_2057|Compound:5236571|FD-Score:-3.38|P-value:1.89E-4 ID:SGTC_2172|Compound:5754775|FD-Score:-3.26|P-value:3.06E-4 ID:SGTC_2176|Compound:5809774|FD-Score:-3.06|P-value:6.52E-4 ID:SGTC_2180|Compound:6301957|FD-Score:3.28|P-value:2.46E-4 ID:SGTC_2269|Compound:7935389|FD-Score:-3.38|P-value:1.94E-4 ID:SGTC_2278|Compound:7948257|FD-Score:-3.02|P-value:7.71E-4 ID:SGTC_2288|Compound:7946289|FD-Score:-4.54|P-value:8.84E-7 ID:SGTC_2299|Compound:7976368|FD-Score:4.16|P-value:4.99E-6 ID:SGTC_2313|Compound:7726885|FD-Score:-3.23|P-value:3.53E-4 ID:SGTC_2320|Compound:7373003|FD-Score:-3.91|P-value:1.93E-5 ID:SGTC_2328|Compound:6201408|FD-Score:5.46|P-value:3.54E-9 ID:SGTC_2400|Compound:5203494|FD-Score:-3.14|P-value:4.88E-4 ID:SGTC_2447|Compound:5741742|FD-Score:3.52|P-value:8.93E-5 ID:SGTC_2504|Compound:purpurogallin|FD-Score:-4.99|P-value:7.54E-8 ID:SGTC_2699|Compound:st077704|FD-Score:3.43|P-value:1.34E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:-3.34|P-value:2.29E-4 ID:SGTC_2865|Compound:9030313|FD-Score:3.17|P-value:3.78E-4 ID:SGTC_2868|Compound:9035608|FD-Score:2.94|P-value:8.77E-4 ID:SGTC_2872|Compound:9044037|FD-Score:3.87|P-value:1.99E-5 ID:SGTC_2876|Compound:9059903|FD-Score:2.99|P-value:7.39E-4 ID:SGTC_2877|Compound:9040724|FD-Score:3.48|P-value:1.07E-4 ID:SGTC_2962|Compound:9082311|FD-Score:3.00|P-value:7.03E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.17|P-value:3.74E-4 ID:SGTC_2992|Compound:9074591|FD-Score:-3.94|P-value:1.75E-5 ID:SGTC_3000|Compound:9075062|FD-Score:3.63|P-value:5.62E-5 ID:SGTC_3007|Compound:9078383|FD-Score:-3.47|P-value:1.36E-4 ID:SGTC_3008|Compound:9078912|FD-Score:3.85|P-value:2.14E-5 ID:SGTC_3011|Compound:9081274|FD-Score:-7.31|P-value:6.76E-15 ID:SGTC_3137|Compound:9097352|FD-Score:-7.91|P-value:3.80E-17 ID:SGTC_3138|Compound:9097216|FD-Score:-3.88|P-value:2.22E-5 ID:SGTC_3139|Compound:9095020|FD-Score:3.79|P-value:2.81E-5 ID:SGTC_3161|Compound:9100388|FD-Score:-3.00|P-value:8.25E-4 ID:SGTC_3255|Compound:9139072|FD-Score:4.23|P-value:3.53E-6 ID:SGTC_3278|Compound:9139605|FD-Score:-3.20|P-value:3.93E-4 ID:SGTC_3281|Compound:9140613|FD-Score:-4.67|P-value:4.45E-7 ID:SGTC_3300|Compound:9124615|FD-Score:2.93|P-value:9.15E-4

Top fitness defect scores for YBR064W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1042 0350-0096 6.31 82.0 µM 1.13E-11 TSC3-RPN4 5 1.43E-10
2 SGTC_2328 6201408 5.46 200.0 µM 3.54E-9 5 2.45E-8
3 SGTC_1480 1070-0044 4.82 41.2 µM 1.52E-7 4 7.07E-7
4 SGTC_1605 st000082 4.50 49.1 µM 8.83E-7 60S ribosome export 6 3.41E-6
5 SGTC_953 1188-0045 4.45 9.7 µM 1.13E-6 60S ribosome export 17 4.24E-6
6 SGTC_3255 9139072 4.23 49.5 µM 3.53E-6 8 1.18E-5
7 SGTC_48 0382-0018 4.22 55.0 µM 3.72E-6 3 1.23E-5
8 SGTC_2299 7976368 4.16 114.9 µM 4.99E-6 23 1.60E-5
9 SGTC_659 k018-0002 3.89 107.0 µM 1.78E-5 18 5.00E-5
10 SGTC_2872 9044037 3.87 26.0 µM 1.99E-5 5 5.54E-5
11 SGTC_3008 9078912 3.85 71.4 µM 2.14E-5 22 5.91E-5
12 SGTC_1501 4491-0275 3.84 38.4 µM 2.24E-5 11 6.15E-5
13 SGTC_3139 9095020 3.79 49.5 µM 2.81E-5 10 7.55E-5
14 SGTC_1121 fusaric acid 3.65 630.5 nM 5.18E-5 42 1.30E-4
15 SGTC_3000 9075062 3.63 71.4 µM 5.62E-5 32 1.40E-4
16 SGTC_2447 5741742 3.52 33.8 µM 8.93E-5 33 2.12E-4
17 SGTC_762 1165-0429 3.52 115.0 µM 9.01E-5 TSC3-RPN4 30 2.14E-4
18 SGTC_2877 9040724 3.48 71.4 µM 1.07E-4 27 2.49E-4
19 SGTC_937 3122-0005 3.43 46.7 µM 1.33E-4 41 3.03E-4
20 SGTC_2699 st077704 3.43 54.6 µM 1.34E-4 endomembrane recycling 71 3.07E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.112 6.70E-11 YGL039W YGL039W hom Oxidoreductase shown to reduce carbonyl compounds to chiral alcohols
0.105 1.02E-9 YLR421C RPN13 hom Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome; null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; protein abundance increases in response to DNA replication stress
0.092 8.46E-8 YGL096W TOS8 hom Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication
0.087 4.83E-7 YDR181C SAS4 hom Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p
0.085 7.05E-7 YJR094C IME1 hom Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p
0.082 2.27E-6 YBR093C PHO5 hom Repressible acid phosphatase (1 of 3) that also mediates extracellular nucleotide-derived phosphate hydrolysis; secretory pathway derived cell surface glycoprotein; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2
0.081 2.90E-6 YHR114W BZZ1 hom SH3 domain protein implicated in the regulation of actin polymerization, able to recruit actin polymerization machinery through its SH3 domains, colocalizes with cortical actin patches and Las17p, interacts with type I myosins
0.078 5.82E-6 YDR048C_d YDR048C_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.078 6.30E-6 YHR039C MSC7 hom Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids
0.076 1.11E-5 YKL221W MCH2 hom Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
0.075 1.24E-5 YKL106C-A_p YKL106C-A_p hom Putative protein of unknown function; identified by homology to uncharacterized proteins in other fungi
0.075 1.37E-5 YMR230W-A_p YMR230W-A_p hom Putative protein of unknown function
0.075 1.43E-5 YMR240C CUS1 het Protein required for assembly of U2 snRNP into the spliceosome, forms a complex with Hsh49p and Hsh155p
0.074 1.58E-5 YDR315C IPK1 hom Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable
0.070 5.24E-5 YER063W THO1 hom Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation