YBR067C / TIP1

Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR067C / TIP1

Click on Significant Values for Screen Details ID:SGTC_120|Compound:rhodamine 6G|FD-Score:-3.10|P-value:3.19E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:2.96|P-value:7.84E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:2.92|P-value:9.09E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:4.58|P-value:4.39E-7 ID:SGTC_208|Compound:k072-0098|FD-Score:4.18|P-value:3.67E-6 ID:SGTC_357|Compound:1325-0123|FD-Score:3.32|P-value:1.92E-4 ID:SGTC_442|Compound:cape|FD-Score:3.84|P-value:1.89E-5 ID:SGTC_455|Compound:paf C-16|FD-Score:3.15|P-value:3.76E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:3.26|P-value:2.41E-4 ID:SGTC_645|Compound:0845-0943|FD-Score:4.21|P-value:3.15E-6 ID:SGTC_668|Compound:1682-0499|FD-Score:3.87|P-value:1.69E-5 ID:SGTC_826|Compound:1683-5028|FD-Score:3.06|P-value:5.45E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:3.45|P-value:1.10E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:12.00|P-value:6.22E-39 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:3.39|P-value:1.40E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.50|P-value:8.75E-5 ID:SGTC_1127|Compound:asiatic acid|FD-Score:4.81|P-value:1.18E-7 ID:SGTC_1148|Compound:3909-7663|FD-Score:-3.44|P-value:7.82E-5 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.75|P-value:2.91E-5 ID:SGTC_1198|Compound:1612-1005|FD-Score:4.60|P-value:3.92E-7 ID:SGTC_1200|Compound:1643-0193|FD-Score:3.13|P-value:4.01E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:3.16|P-value:3.61E-4 ID:SGTC_1407|Compound:3909-7909|FD-Score:4.25|P-value:2.59E-6 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.16|P-value:3.60E-4 ID:SGTC_1765|Compound:st044815|FD-Score:3.48|P-value:9.55E-5 ID:SGTC_1972|Compound:st070201|FD-Score:3.70|P-value:3.61E-5 ID:SGTC_2044|Compound:5102272|FD-Score:2.96|P-value:7.73E-4 ID:SGTC_2063|Compound:5246145|FD-Score:2.97|P-value:7.43E-4 ID:SGTC_2127|Compound:5253358|FD-Score:2.99|P-value:7.12E-4 ID:SGTC_2211|Compound:7117706|FD-Score:3.15|P-value:3.81E-4 ID:SGTC_2239|Compound:6685329|FD-Score:3.19|P-value:3.22E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.77|P-value:1.71E-5 ID:SGTC_2245|Compound:6637752|FD-Score:3.96|P-value:1.06E-5 ID:SGTC_2450|Compound:5739737|FD-Score:-3.22|P-value:1.98E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-2.87|P-value:7.84E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:-4.23|P-value:1.72E-6 ID:SGTC_2586|Compound:curcumin|FD-Score:3.96|P-value:1.09E-5 ID:SGTC_2740|Compound:felodipine|FD-Score:3.31|P-value:1.96E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.01|P-value:6.57E-4 ID:SGTC_3124|Compound:9127567|FD-Score:3.40|P-value:1.37E-4 ID:SGTC_3136|Compound:9095672|FD-Score:3.68|P-value:4.09E-5 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:-3.10|P-value:3.19E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:2.96|P-value:7.84E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:2.92|P-value:9.09E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:4.58|P-value:4.39E-7 ID:SGTC_208|Compound:k072-0098|FD-Score:4.18|P-value:3.67E-6 ID:SGTC_357|Compound:1325-0123|FD-Score:3.32|P-value:1.92E-4 ID:SGTC_442|Compound:cape|FD-Score:3.84|P-value:1.89E-5 ID:SGTC_455|Compound:paf C-16|FD-Score:3.15|P-value:3.76E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:3.26|P-value:2.41E-4 ID:SGTC_645|Compound:0845-0943|FD-Score:4.21|P-value:3.15E-6 ID:SGTC_668|Compound:1682-0499|FD-Score:3.87|P-value:1.69E-5 ID:SGTC_826|Compound:1683-5028|FD-Score:3.06|P-value:5.45E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:3.45|P-value:1.10E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:12.00|P-value:6.22E-39 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:3.39|P-value:1.40E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.50|P-value:8.75E-5 ID:SGTC_1127|Compound:asiatic acid|FD-Score:4.81|P-value:1.18E-7 ID:SGTC_1148|Compound:3909-7663|FD-Score:-3.44|P-value:7.82E-5 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.75|P-value:2.91E-5 ID:SGTC_1198|Compound:1612-1005|FD-Score:4.60|P-value:3.92E-7 ID:SGTC_1200|Compound:1643-0193|FD-Score:3.13|P-value:4.01E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:3.16|P-value:3.61E-4 ID:SGTC_1407|Compound:3909-7909|FD-Score:4.25|P-value:2.59E-6 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.16|P-value:3.60E-4 ID:SGTC_1765|Compound:st044815|FD-Score:3.48|P-value:9.55E-5 ID:SGTC_1972|Compound:st070201|FD-Score:3.70|P-value:3.61E-5 ID:SGTC_2044|Compound:5102272|FD-Score:2.96|P-value:7.73E-4 ID:SGTC_2063|Compound:5246145|FD-Score:2.97|P-value:7.43E-4 ID:SGTC_2127|Compound:5253358|FD-Score:2.99|P-value:7.12E-4 ID:SGTC_2211|Compound:7117706|FD-Score:3.15|P-value:3.81E-4 ID:SGTC_2239|Compound:6685329|FD-Score:3.19|P-value:3.22E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.77|P-value:1.71E-5 ID:SGTC_2245|Compound:6637752|FD-Score:3.96|P-value:1.06E-5 ID:SGTC_2450|Compound:5739737|FD-Score:-3.22|P-value:1.98E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-2.87|P-value:7.84E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:-4.23|P-value:1.72E-6 ID:SGTC_2586|Compound:curcumin|FD-Score:3.96|P-value:1.09E-5 ID:SGTC_2740|Compound:felodipine|FD-Score:3.31|P-value:1.96E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.01|P-value:6.57E-4 ID:SGTC_3124|Compound:9127567|FD-Score:3.40|P-value:1.37E-4 ID:SGTC_3136|Compound:9095672|FD-Score:3.68|P-value:4.09E-5

Top fitness defect scores for YBR067C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_996 3970-0799 12.00 1.8 µM 6.22E-39 9 1.35E-33
2 SGTC_1127 asiatic acid 4.81 681.4 nM 1.18E-7 9 7.58E-7
3 SGTC_1198 1612-1005 4.60 86.7 µM 3.92E-7 2 2.14E-6
4 SGTC_183 3914-0051 4.58 30.6 µM 4.39E-7 60S ribosome export 9 2.36E-6
5 SGTC_1407 3909-7909 4.25 12.3 µM 2.59E-6 60S ribosome export 8 1.09E-5
6 SGTC_645 0845-0943 4.21 5.4 µM 3.15E-6 60S ribosome export 7 1.29E-5
7 SGTC_208 k072-0098 4.18 12.4 µM 3.67E-6 heme biosynthesis & mitochondrial translocase 36 1.47E-5
8 SGTC_2245 6637752 3.96 200.0 µM 1.06E-5 17 3.68E-5
9 SGTC_2586 curcumin 3.96 80.0 µM 1.09E-5 iron homeostasis 49 3.77E-5
10 SGTC_668 1682-0499 3.87 62.6 µM 1.69E-5 22 5.51E-5
11 SGTC_442 cape 3.84 100.0 µM 1.89E-5 19 6.08E-5
12 SGTC_1194 1488-0194 3.75 225.0 µM 2.91E-5 36 8.84E-5
13 SGTC_1972 st070201 3.70 17.4 µM 3.61E-5 31 1.07E-4
14 SGTC_3136 9095672 3.68 49.5 µM 4.09E-5 32 1.19E-4
15 SGTC_1125 tnp00248 3.50 1.3 µM 8.75E-5 51 2.29E-4
16 SGTC_1765 st044815 3.48 90.4 µM 9.55E-5 39 2.47E-4
17 SGTC_891 0929-0073 3.45 133.0 µM 1.10E-4 39 2.79E-4
18 SGTC_3124 9127567 3.40 49.5 µM 1.37E-4 DNA damage response 31 3.38E-4
19 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 3.39 15.5 µM 1.40E-4 45 3.44E-4
20 SGTC_357 1325-0123 3.32 420.0 µM 1.92E-4 20 4.54E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.454 6.74E-170 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.351 5.43E-98 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.342 8.97E-93 YGL040C HEM2 het Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.313 7.12E-77 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.286 3.82E-64 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.280 2.30E-61 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.249 1.80E-48 YGL205W POX1 hom Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.244 1.41E-46 YNR033W ABZ1 hom Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress
0.242 7.08E-46 YDL086W_p YDL086W_p hom Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene
0.238 2.60E-44 YGR035C_p YGR035C_p hom Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
0.232 2.55E-42 YGL083W SCY1 hom Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase
0.226 6.90E-40 YDL186W_p YDL186W_p hom Putative protein of unknown function; YDL186W is not an essential gene
0.225 1.31E-39 YJR014W TMA22 hom Protein of unknown function; associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1; protein abundance increases in response to DNA replication stress
0.216 8.05E-37 YJL149W DAS1 hom Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C
0.215 2.15E-36 YGL096W TOS8 hom Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication