YBR069C / TAT1

Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR069C / TAT1

Click on Significant Values for Screen Details ID:SGTC_129|Compound:0088-0017|FD-Score:8.87|P-value:6.44E-7 ID:SGTC_147|Compound:4466-0538|FD-Score:9.26|P-value:2.11E-7 ID:SGTC_161|Compound:4065-0411|FD-Score:6.81|P-value:1.12E-4 ID:SGTC_257|Compound:daunorubicin|FD-Score:7.71|P-value:1.38E-5 ID:SGTC_272|Compound:doxorubicin|FD-Score:10.60|P-value:3.57E-9 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:7.28|P-value:3.84E-5 ID:SGTC_450|Compound:aminopyrene|FD-Score:6.09|P-value:5.04E-4 ID:SGTC_486|Compound:niguldipine|FD-Score:7.93|P-value:7.91E-6 ID:SGTC_538|Compound:2922-0838|FD-Score:6.48|P-value:2.27E-4 ID:SGTC_554|Compound:4483-2211|FD-Score:9.13|P-value:3.03E-7 ID:SGTC_590|Compound:k048-0076|FD-Score:-5.89|P-value:3.31E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:5.97|P-value:6.30E-4 ID:SGTC_608|Compound:k048-0125|FD-Score:-5.75|P-value:4.36E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:7.51|P-value:2.20E-5 ID:SGTC_670|Compound:4204-0025|FD-Score:-5.78|P-value:4.12E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:11.10|P-value:6.56E-10 ID:SGTC_679|Compound:0422-0091|FD-Score:6.29|P-value:3.36E-4 ID:SGTC_849|Compound:0386-0493|FD-Score:6.81|P-value:1.12E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:-6.00|P-value:2.60E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:15.90|P-value:7.64E-19 ID:SGTC_946|Compound:3434-1334|FD-Score:7.35|P-value:3.27E-5 ID:SGTC_947|Compound:3447-0010|FD-Score:6.86|P-value:1.00E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:6.95|P-value:8.21E-5 ID:SGTC_1013|Compound:4112-3890|FD-Score:10.90|P-value:1.09E-9 ID:SGTC_1023|Compound:4482-3888|FD-Score:-7.32|P-value:1.31E-5 ID:SGTC_1025|Compound:k007-0731|FD-Score:13.50|P-value:5.42E-14 ID:SGTC_1034|Compound:k072-0165|FD-Score:7.13|P-value:5.46E-5 ID:SGTC_1044|Compound:1222-0021|FD-Score:-6.25|P-value:1.56E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:7.22|P-value:4.36E-5 ID:SGTC_1111|Compound:tnp00062|FD-Score:8.35|P-value:2.62E-6 ID:SGTC_1225|Compound:1216-0074|FD-Score:7.55|P-value:2.04E-5 ID:SGTC_1240|Compound:0356-0016|FD-Score:-6.18|P-value:1.78E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:6.24|P-value:3.68E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:6.89|P-value:9.26E-5 ID:SGTC_1360|Compound:1598-0022|FD-Score:7.23|P-value:4.33E-5 ID:SGTC_1478|Compound:0453-0656|FD-Score:6.80|P-value:1.13E-4 ID:SGTC_1508|Compound:1080-0625|FD-Score:14.90|P-value:1.20E-16 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:6.41|P-value:2.62E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:-8.48|P-value:6.05E-7 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:5.80|P-value:8.74E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:5.86|P-value:7.84E-4 ID:SGTC_1613|Compound:st002381|FD-Score:8.26|P-value:3.39E-6 ID:SGTC_1614|Compound:st002383|FD-Score:7.02|P-value:6.99E-5 ID:SGTC_1616|Compound:st002734|FD-Score:-8.47|P-value:6.19E-7 ID:SGTC_1619|Compound:st003326|FD-Score:-8.88|P-value:1.91E-7 ID:SGTC_1671|Compound:st016596|FD-Score:6.76|P-value:1.24E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:-5.94|P-value:2.96E-4 ID:SGTC_1724|Compound:st037281|FD-Score:5.77|P-value:9.34E-4 ID:SGTC_1731|Compound:st035964|FD-Score:-5.40|P-value:8.65E-4 ID:SGTC_1961|Compound:st076550|FD-Score:5.75|P-value:9.70E-4 ID:SGTC_1962|Compound:st076595|FD-Score:-5.78|P-value:4.12E-4 ID:SGTC_2063|Compound:5246145|FD-Score:7.79|P-value:1.11E-5 ID:SGTC_2064|Compound:5220758|FD-Score:6.81|P-value:1.12E-4 ID:SGTC_2068|Compound:5226020|FD-Score:-5.59|P-value:5.99E-4 ID:SGTC_2080|Compound:5212524|FD-Score:-6.00|P-value:2.62E-4 ID:SGTC_2150|Compound:5556613|FD-Score:7.82|P-value:1.05E-5 ID:SGTC_2255|Compound:7941087|FD-Score:5.88|P-value:7.60E-4 ID:SGTC_2330|Compound:7979373|FD-Score:5.77|P-value:9.29E-4 ID:SGTC_2332|Compound:7982454|FD-Score:9.42|P-value:1.30E-7 ID:SGTC_2335|Compound:9018011|FD-Score:6.80|P-value:1.13E-4 ID:SGTC_2344|Compound:7990960|FD-Score:-8.02|P-value:2.16E-6 ID:SGTC_2363|Compound:9053361|FD-Score:-6.43|P-value:1.03E-4 ID:SGTC_2394|Compound:5221648|FD-Score:-5.70|P-value:4.85E-4 ID:SGTC_2398|Compound:5228213|FD-Score:-9.68|P-value:1.65E-8 ID:SGTC_2399|Compound:5884133|FD-Score:-6.86|P-value:3.95E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:-6.16|P-value:1.88E-4 ID:SGTC_2424|Compound:5537928|FD-Score:6.93|P-value:8.45E-5 ID:SGTC_2432|Compound:5630864|FD-Score:5.95|P-value:6.67E-4 ID:SGTC_2460|Compound:5552655|FD-Score:9.63|P-value:6.94E-8 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:8.15|P-value:4.48E-6 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:11.80|P-value:4.50E-11 ID:SGTC_2666|Compound:tannic acid|FD-Score:-5.91|P-value:3.17E-4 ID:SGTC_2727|Compound:riluzole|FD-Score:6.87|P-value:9.81E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:-7.25|P-value:1.54E-5 ID:SGTC_2845|Compound:9003024|FD-Score:7.41|P-value:2.84E-5 ID:SGTC_2926|Compound:9010726|FD-Score:-5.43|P-value:8.14E-4 ID:SGTC_2983|Compound:9022671|FD-Score:-5.69|P-value:4.95E-4 ID:SGTC_3004|Compound:9076122|FD-Score:11.40|P-value:1.95E-10 ID:SGTC_3008|Compound:9078912|FD-Score:5.78|P-value:9.24E-4 ID:SGTC_3009|Compound:9080819|FD-Score:9.05|P-value:3.81E-7 ID:SGTC_3039|Compound:9090270|FD-Score:-5.60|P-value:5.90E-4 ID:SGTC_3101|Compound:9120531|FD-Score:6.41|P-value:2.64E-4 ID:SGTC_3204|Compound:9114183|FD-Score:-10.70|P-value:5.72E-10 ID:SGTC_3219|Compound:9131112|FD-Score:-6.43|P-value:1.04E-4 ID:SGTC_3225|Compound:9130819|FD-Score:7.28|P-value:3.87E-5 ID:SGTC_3337|Compound:9144342|FD-Score:6.20|P-value:4.06E-4 ID:SGTC_3351|Compound:9150312|FD-Score:6.02|P-value:5.71E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:8.87|P-value:6.44E-7 ID:SGTC_147|Compound:4466-0538|FD-Score:9.26|P-value:2.11E-7 ID:SGTC_161|Compound:4065-0411|FD-Score:6.81|P-value:1.12E-4 ID:SGTC_257|Compound:daunorubicin|FD-Score:7.71|P-value:1.38E-5 ID:SGTC_272|Compound:doxorubicin|FD-Score:10.60|P-value:3.57E-9 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:7.28|P-value:3.84E-5 ID:SGTC_450|Compound:aminopyrene|FD-Score:6.09|P-value:5.04E-4 ID:SGTC_486|Compound:niguldipine|FD-Score:7.93|P-value:7.91E-6 ID:SGTC_538|Compound:2922-0838|FD-Score:6.48|P-value:2.27E-4 ID:SGTC_554|Compound:4483-2211|FD-Score:9.13|P-value:3.03E-7 ID:SGTC_590|Compound:k048-0076|FD-Score:-5.89|P-value:3.31E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:5.97|P-value:6.30E-4 ID:SGTC_608|Compound:k048-0125|FD-Score:-5.75|P-value:4.36E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:7.51|P-value:2.20E-5 ID:SGTC_670|Compound:4204-0025|FD-Score:-5.78|P-value:4.12E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:11.10|P-value:6.56E-10 ID:SGTC_679|Compound:0422-0091|FD-Score:6.29|P-value:3.36E-4 ID:SGTC_849|Compound:0386-0493|FD-Score:6.81|P-value:1.12E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:-6.00|P-value:2.60E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:15.90|P-value:7.64E-19 ID:SGTC_946|Compound:3434-1334|FD-Score:7.35|P-value:3.27E-5 ID:SGTC_947|Compound:3447-0010|FD-Score:6.86|P-value:1.00E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:6.95|P-value:8.21E-5 ID:SGTC_1013|Compound:4112-3890|FD-Score:10.90|P-value:1.09E-9 ID:SGTC_1023|Compound:4482-3888|FD-Score:-7.32|P-value:1.31E-5 ID:SGTC_1025|Compound:k007-0731|FD-Score:13.50|P-value:5.42E-14 ID:SGTC_1034|Compound:k072-0165|FD-Score:7.13|P-value:5.46E-5 ID:SGTC_1044|Compound:1222-0021|FD-Score:-6.25|P-value:1.56E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:7.22|P-value:4.36E-5 ID:SGTC_1111|Compound:tnp00062|FD-Score:8.35|P-value:2.62E-6 ID:SGTC_1225|Compound:1216-0074|FD-Score:7.55|P-value:2.04E-5 ID:SGTC_1240|Compound:0356-0016|FD-Score:-6.18|P-value:1.78E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:6.24|P-value:3.68E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:6.89|P-value:9.26E-5 ID:SGTC_1360|Compound:1598-0022|FD-Score:7.23|P-value:4.33E-5 ID:SGTC_1478|Compound:0453-0656|FD-Score:6.80|P-value:1.13E-4 ID:SGTC_1508|Compound:1080-0625|FD-Score:14.90|P-value:1.20E-16 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:6.41|P-value:2.62E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:-8.48|P-value:6.05E-7 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:5.80|P-value:8.74E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:5.86|P-value:7.84E-4 ID:SGTC_1613|Compound:st002381|FD-Score:8.26|P-value:3.39E-6 ID:SGTC_1614|Compound:st002383|FD-Score:7.02|P-value:6.99E-5 ID:SGTC_1616|Compound:st002734|FD-Score:-8.47|P-value:6.19E-7 ID:SGTC_1619|Compound:st003326|FD-Score:-8.88|P-value:1.91E-7 ID:SGTC_1671|Compound:st016596|FD-Score:6.76|P-value:1.24E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:-5.94|P-value:2.96E-4 ID:SGTC_1724|Compound:st037281|FD-Score:5.77|P-value:9.34E-4 ID:SGTC_1731|Compound:st035964|FD-Score:-5.40|P-value:8.65E-4 ID:SGTC_1961|Compound:st076550|FD-Score:5.75|P-value:9.70E-4 ID:SGTC_1962|Compound:st076595|FD-Score:-5.78|P-value:4.12E-4 ID:SGTC_2063|Compound:5246145|FD-Score:7.79|P-value:1.11E-5 ID:SGTC_2064|Compound:5220758|FD-Score:6.81|P-value:1.12E-4 ID:SGTC_2068|Compound:5226020|FD-Score:-5.59|P-value:5.99E-4 ID:SGTC_2080|Compound:5212524|FD-Score:-6.00|P-value:2.62E-4 ID:SGTC_2150|Compound:5556613|FD-Score:7.82|P-value:1.05E-5 ID:SGTC_2255|Compound:7941087|FD-Score:5.88|P-value:7.60E-4 ID:SGTC_2330|Compound:7979373|FD-Score:5.77|P-value:9.29E-4 ID:SGTC_2332|Compound:7982454|FD-Score:9.42|P-value:1.30E-7 ID:SGTC_2335|Compound:9018011|FD-Score:6.80|P-value:1.13E-4 ID:SGTC_2344|Compound:7990960|FD-Score:-8.02|P-value:2.16E-6 ID:SGTC_2363|Compound:9053361|FD-Score:-6.43|P-value:1.03E-4 ID:SGTC_2394|Compound:5221648|FD-Score:-5.70|P-value:4.85E-4 ID:SGTC_2398|Compound:5228213|FD-Score:-9.68|P-value:1.65E-8 ID:SGTC_2399|Compound:5884133|FD-Score:-6.86|P-value:3.95E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:-6.16|P-value:1.88E-4 ID:SGTC_2424|Compound:5537928|FD-Score:6.93|P-value:8.45E-5 ID:SGTC_2432|Compound:5630864|FD-Score:5.95|P-value:6.67E-4 ID:SGTC_2460|Compound:5552655|FD-Score:9.63|P-value:6.94E-8 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:8.15|P-value:4.48E-6 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:11.80|P-value:4.50E-11 ID:SGTC_2666|Compound:tannic acid|FD-Score:-5.91|P-value:3.17E-4 ID:SGTC_2727|Compound:riluzole|FD-Score:6.87|P-value:9.81E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:-7.25|P-value:1.54E-5 ID:SGTC_2845|Compound:9003024|FD-Score:7.41|P-value:2.84E-5 ID:SGTC_2926|Compound:9010726|FD-Score:-5.43|P-value:8.14E-4 ID:SGTC_2983|Compound:9022671|FD-Score:-5.69|P-value:4.95E-4 ID:SGTC_3004|Compound:9076122|FD-Score:11.40|P-value:1.95E-10 ID:SGTC_3008|Compound:9078912|FD-Score:5.78|P-value:9.24E-4 ID:SGTC_3009|Compound:9080819|FD-Score:9.05|P-value:3.81E-7 ID:SGTC_3039|Compound:9090270|FD-Score:-5.60|P-value:5.90E-4 ID:SGTC_3101|Compound:9120531|FD-Score:6.41|P-value:2.64E-4 ID:SGTC_3204|Compound:9114183|FD-Score:-10.70|P-value:5.72E-10 ID:SGTC_3219|Compound:9131112|FD-Score:-6.43|P-value:1.04E-4 ID:SGTC_3225|Compound:9130819|FD-Score:7.28|P-value:3.87E-5 ID:SGTC_3337|Compound:9144342|FD-Score:6.20|P-value:4.06E-4 ID:SGTC_3351|Compound:9150312|FD-Score:6.02|P-value:5.71E-4

Top fitness defect scores for YBR069C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_933 2914-0560 15.90 114.0 µM 7.64E-19 2 2.10E-57
2 SGTC_1508 1080-0625 14.90 72.9 µM 1.20E-16 1 2.37E-50
3 SGTC_1025 k007-0731 13.50 70.0 µM 5.42E-14 1 8.07E-42
4 SGTC_2636 apigenin dimethyl ether 11.80 100.0 µM 4.50E-11 3 1.89E-32
5 SGTC_3004 9076122 11.40 71.4 µM 1.95E-10 1 2.09E-30
6 SGTC_673 1082-0474 11.10 110.0 µM 6.56E-10 RSC complex & mRNA processing 5 1.02E-28
7 SGTC_1013 4112-3890 10.90 241.0 µM 1.09E-9 TSC3-RPN4 3 5.12E-28
8 SGTC_272 doxorubicin 10.60 8.1 µM 3.57E-9 anthracycline transcription coupled DNA repair 1 2.31E-26
9 SGTC_2460 5552655 9.63 174.2 µM 6.94E-8 amide catabolism 4 3.07E-22
10 SGTC_2332 7982454 9.42 138.9 µM 1.30E-7 3 2.30E-21
11 SGTC_147 4466-0538 9.26 29.2 µM 2.11E-7 ergosterol biosynthesis 1 1.07E-20
12 SGTC_554 4483-2211 9.13 187.0 µM 3.03E-7 1 3.39E-20
13 SGTC_3009 9080819 9.05 71.4 µM 3.81E-7 1 7.04E-20
14 SGTC_129 0088-0017 8.87 176.6 µM 6.44E-7 13 3.77E-19
15 SGTC_1111 tnp00062 8.35 510.7 nM 2.62E-6 1 3.31E-17
16 SGTC_1613 st002381 8.26 52.1 µM 3.39E-6 1 7.55E-17
17 SGTC_2634 4'-methoxyflavone 8.15 100.0 µM 4.48E-6 1 1.83E-16
18 SGTC_486 niguldipine 7.93 82.0 µM 7.91E-6 amide catabolism 5 1.11E-15
19 SGTC_2150 5556613 7.82 200.0 µM 1.05E-5 1 2.73E-15
20 SGTC_2063 5246145 7.79 200.0 µM 1.11E-5 1 3.30E-15

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.338 8.73E-90 YIR023W DAL81 hom Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism
0.288 1.17E-64 YDR463W STP1 hom Transcription factor; undergoes proteolytic processing by SPS (Ssy1p-Ptr3p-Ssy5p)-sensor component Ssy5p in response to extracellular amino acids; activates transcription of amino acid permease genes and may have a role in tRNA processing; STP1 has a paralog, STP2, that arose from the whole genome duplication
0.150 3.86E-18 YER090W TRP2 hom Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p
0.149 6.92E-18 YDR354W TRP4 hom Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis
0.141 3.56E-16 YKR019C IRS4 hom EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication
0.134 9.36E-15 YKL211C TRP3 hom Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p
0.126 2.48E-13 YDR008C_d YDR008C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.117 1.27E-11 YML123C PHO84 hom High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p; cells overexpressing Pho84p accumulate heavy metals but do not develop symptoms of metal toxicity
0.115 3.14E-11 YHR062C RPP1 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
0.114 4.33E-11 YIL143C SSL2 het Component of RNA polymerase transcription factor TFIIH holoenzyme; has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA; interacts functionally with TFIIB and has roles in transcription start site selection and in gene looping to juxtapose initiation and termination regions; involved in DNA repair; homolog of human ERCC3
0.099 9.15E-9 YDR007W TRP1 hom Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA)
0.093 8.96E-8 YOL018C TLG2 hom Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation; homologous to mammalian SNARE protein syntaxin 16 (Sx16)
0.086 5.62E-7 YHR066W SSF1 hom Constituent of 66S pre-ribosomal particles; required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family; SSF1 has a paralog, SSF2, that arose from the whole genome duplication
0.086 5.57E-7 YGL026C TRP5 hom Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis
0.081 2.74E-6 YMR202W ERG2 hom C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis