YBR071W

Protein of unknown function found in the cytoplasm and bud neck; mRNA expression may be regulated by the cell cycle and/or cell wall stress; overexpression of YBR071W affects endocytic protein trafficking

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR071W / YBR071W

Click on Significant Values for Screen Details ID:SGTC_44|Compound:0929-0055|FD-Score:-4.89|P-value:4.81E-8 ID:SGTC_229|Compound:benomyl|FD-Score:3.18|P-value:3.15E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:3.21|P-value:2.82E-4 ID:SGTC_303|Compound:1348-1668|FD-Score:-3.53|P-value:5.61E-5 ID:SGTC_524|Compound:r073-0010|FD-Score:-2.84|P-value:9.27E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:3.64|P-value:4.54E-5 ID:SGTC_610|Compound:4215-0184|FD-Score:3.30|P-value:1.95E-4 ID:SGTC_730|Compound:1436-0052|FD-Score:-3.31|P-value:1.48E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-2.92|P-value:6.87E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:3.75|P-value:2.69E-5 ID:SGTC_927|Compound:2425-1185|FD-Score:2.94|P-value:7.90E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.19|P-value:3.00E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:7.37|P-value:8.07E-16 ID:SGTC_1123|Compound:mangostin|FD-Score:6.44|P-value:1.71E-12 ID:SGTC_1167|Compound:k781-0610|FD-Score:-2.94|P-value:6.49E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:3.39|P-value:1.33E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:2.90|P-value:9.08E-4 ID:SGTC_1915|Compound:st067105|FD-Score:-3.00|P-value:5.17E-4 ID:SGTC_2053|Compound:5265679|FD-Score:-3.60|P-value:4.24E-5 ID:SGTC_2338|Compound:7999974|FD-Score:3.44|P-value:1.09E-4 ID:SGTC_2339|Compound:9000433|FD-Score:-3.74|P-value:2.22E-5 ID:SGTC_2403|Compound:6032726|FD-Score:-3.14|P-value:3.00E-4 ID:SGTC_2453|Compound:5731132|FD-Score:3.21|P-value:2.80E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.91|P-value:1.26E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.84|P-value:1.80E-5 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-3.50|P-value:6.65E-5 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-5.65|P-value:3.57E-10 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:4.02|P-value:7.29E-6 ID:SGTC_3013|Compound:9080133|FD-Score:3.50|P-value:8.27E-5 ID:SGTC_3211|Compound:9128781|FD-Score:-3.69|P-value:2.75E-5 ID:SGTC_3354|Compound:9151612|FD-Score:3.28|P-value:2.11E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:-4.89|P-value:4.81E-8 ID:SGTC_229|Compound:benomyl|FD-Score:3.18|P-value:3.15E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:3.21|P-value:2.82E-4 ID:SGTC_303|Compound:1348-1668|FD-Score:-3.53|P-value:5.61E-5 ID:SGTC_524|Compound:r073-0010|FD-Score:-2.84|P-value:9.27E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:3.64|P-value:4.54E-5 ID:SGTC_610|Compound:4215-0184|FD-Score:3.30|P-value:1.95E-4 ID:SGTC_730|Compound:1436-0052|FD-Score:-3.31|P-value:1.48E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-2.92|P-value:6.87E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:3.75|P-value:2.69E-5 ID:SGTC_927|Compound:2425-1185|FD-Score:2.94|P-value:7.90E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.19|P-value:3.00E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:7.37|P-value:8.07E-16 ID:SGTC_1123|Compound:mangostin|FD-Score:6.44|P-value:1.71E-12 ID:SGTC_1167|Compound:k781-0610|FD-Score:-2.94|P-value:6.49E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:3.39|P-value:1.33E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:2.90|P-value:9.08E-4 ID:SGTC_1915|Compound:st067105|FD-Score:-3.00|P-value:5.17E-4 ID:SGTC_2053|Compound:5265679|FD-Score:-3.60|P-value:4.24E-5 ID:SGTC_2338|Compound:7999974|FD-Score:3.44|P-value:1.09E-4 ID:SGTC_2339|Compound:9000433|FD-Score:-3.74|P-value:2.22E-5 ID:SGTC_2403|Compound:6032726|FD-Score:-3.14|P-value:3.00E-4 ID:SGTC_2453|Compound:5731132|FD-Score:3.21|P-value:2.80E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.91|P-value:1.26E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.84|P-value:1.80E-5 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-3.50|P-value:6.65E-5 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-5.65|P-value:3.57E-10 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:4.02|P-value:7.29E-6 ID:SGTC_3013|Compound:9080133|FD-Score:3.50|P-value:8.27E-5 ID:SGTC_3211|Compound:9128781|FD-Score:-3.69|P-value:2.75E-5 ID:SGTC_3354|Compound:9151612|FD-Score:3.28|P-value:2.11E-4

Top fitness defect scores for YBR071W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1044 1222-0021 7.37 1.8 µM 8.07E-16 heme biosynthesis & mitochondrial translocase 7 8.24E-14
2 SGTC_1123 mangostin 6.44 811.3 nM 1.71E-12 mitochondrial response to ROS 9 5.80E-11
3 SGTC_2621 lithochol-11-enic acid 4.02 100.0 µM 7.29E-6 22 2.85E-5
4 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 3.91 63.6 µM 1.26E-5 44 4.55E-5
5 SGTC_2567 aureobasidin a 3.84 60.0 nM 1.80E-5 101 6.22E-5
6 SGTC_788 1182-0090 3.75 188.0 µM 2.69E-5 endomembrane recycling 85 8.78E-5
7 SGTC_548 1436-0017 3.64 110.0 µM 4.54E-5 TSC3-RPN4 47 1.38E-4
8 SGTC_3013 9080133 3.50 71.4 µM 8.27E-5 40 2.32E-4
9 SGTC_2338 7999974 3.44 200.0 µM 1.09E-4 40 2.93E-4
10 SGTC_1231 0242-0792 3.39 125.0 µM 1.33E-4 37 3.50E-4
11 SGTC_610 4215-0184 3.30 155.0 µM 1.95E-4 exosome 28 4.87E-4
12 SGTC_3354 9151612 3.28 71.4 µM 2.11E-4 35 5.20E-4
13 SGTC_2453 5731132 3.21 22.2 µM 2.80E-4 55 6.66E-4
14 SGTC_301 4119-0100 3.21 24.5 µM 2.82E-4 NEO1 121 6.69E-4
15 SGTC_1031 k035-0009 3.19 16.0 µM 3.00E-4 64 7.06E-4
16 SGTC_229 benomyl 3.18 22.9 µM 3.15E-4 tubulin folding & SWR complex 56 7.37E-4
17 SGTC_927 2425-1185 2.94 123.0 µM 7.90E-4 71 0.00163
18 SGTC_1589 2',5'-dimethoxyflavone 2.90 47.2 µM 9.08E-4 64 0.00184
19 SGTC_65 0798-0905 2.87 35.0 µM 0.00102 calcium & mitochondrial duress 177 0.00204
20 SGTC_1877 wortmannin 2.83 25.0 µM 0.00120 172 0.00235

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.187 6.76E-28 YDR224C HTB1 het Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB2; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation
0.172 1.49E-23 YKL004W AUR1 het Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
0.157 7.15E-20 YEL001C IRC22 hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci
0.130 4.36E-14 YGL255W ZRT1 hom High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor
0.124 5.58E-13 YLR417W VPS36 hom Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome
0.119 5.09E-12 YGL090W LIF1 hom Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein
0.118 6.61E-12 YKR008W RSC4 het Component of the RSC chromatin remodeling complex; found in close proximity to nucleosomal DNA; displaced from the surface of nucleosomal DNA after chromatin remodeling; acetylated (K25) by Gcn5p, altering replication stress tolerance; contains tandem bromodomains that recognize histone H3 acetylated on K14 (H3K14ac) by Gcn5p
0.115 2.75E-11 YOL125W TRM13 hom 2'-O-methyltransferase responsible for modification of tRNA at position 4; C-terminal domain has similarity to Rossmann-fold (RFM) superfamily of RNA methyltransferases
0.114 4.70E-11 YBL081W_p YBL081W_p hom Non-essential protein of unknown function; null mutation results in a decrease in plasma membrane electron transport
0.110 1.77E-10 YDR367W KEI1 het Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene
0.109 2.14E-10 YGR093W_p YGR093W_p hom Putative protein of unconfirmed function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
0.108 3.17E-10 YML028W TSA1 hom Thioredoxin peroxidase; acts as both a ribosome-associated and free cytoplasmic antioxidant; self-associates to form a high-molecular weight chaperone complex under oxidative stress; deletion results in mutator phenotype; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress
0.106 6.50E-10 YNL277W-A_p YNL277W-A_p hom Putative protein of unknown function
0.105 9.23E-10 YNL294C RIM21 hom pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH
0.100 7.45E-9 YHL045W_d YHL045W_d hom Putative protein of unknown function; not an essential gene