YBR072C-A_p

Putative protein of unknown function; identified by fungal homology and RT-PCR

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR072C-A / YBR072C-A

Click on Significant Values for Screen Details ID:SGTC_90|Compound:0870-0863|FD-Score:4.83|P-value:3.23E-7 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.28|P-value:3.53E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:3.87|P-value:3.33E-5 ID:SGTC_232|Compound:clozapine|FD-Score:3.27|P-value:3.88E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:9.09|P-value:3.92E-21 ID:SGTC_249|Compound:wiskostatin|FD-Score:3.02|P-value:9.39E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:3.32|P-value:3.13E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:3.12|P-value:6.63E-4 ID:SGTC_418|Compound:lividomycin a|FD-Score:3.45|P-value:1.96E-4 ID:SGTC_529|Compound:4076-0302|FD-Score:3.09|P-value:7.28E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:-3.34|P-value:2.74E-4 ID:SGTC_647|Compound:0140-0236|FD-Score:-3.11|P-value:6.48E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:3.57|P-value:1.20E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.20|P-value:4.94E-4 ID:SGTC_1229|Compound:0139-0193|FD-Score:3.27|P-value:3.79E-4 ID:SGTC_1324|Compound:1418-0026|FD-Score:-3.00|P-value:9.69E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:4.13|P-value:1.04E-5 ID:SGTC_1449|Compound:4112-4002|FD-Score:3.25|P-value:4.11E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.22|P-value:4.35E-4 ID:SGTC_1635|Compound:st007035|FD-Score:6.14|P-value:1.31E-10 ID:SGTC_1694|Compound:st024011|FD-Score:3.95|P-value:2.41E-5 ID:SGTC_1722|Compound:st034304|FD-Score:5.07|P-value:8.76E-8 ID:SGTC_1811|Compound:st050069|FD-Score:-3.00|P-value:9.55E-4 ID:SGTC_1836|Compound:st055642|FD-Score:3.16|P-value:5.68E-4 ID:SGTC_1837|Compound:st055472|FD-Score:4.13|P-value:1.07E-5 ID:SGTC_1838|Compound:st055369|FD-Score:-3.09|P-value:7.08E-4 ID:SGTC_1856|Compound:st057054|FD-Score:3.41|P-value:2.24E-4 ID:SGTC_2032|Compound:5185112|FD-Score:3.29|P-value:3.62E-4 ID:SGTC_2045|Compound:5106652|FD-Score:3.37|P-value:2.63E-4 ID:SGTC_2052|Compound:5265182|FD-Score:3.43|P-value:2.08E-4 ID:SGTC_2055|Compound:5235184|FD-Score:6.16|P-value:1.10E-10 ID:SGTC_2056|Compound:5235370|FD-Score:3.76|P-value:5.42E-5 ID:SGTC_2122|Compound:5258151|FD-Score:-3.37|P-value:2.52E-4 ID:SGTC_2132|Compound:5317594|FD-Score:-3.34|P-value:2.80E-4 ID:SGTC_2134|Compound:5324836|FD-Score:-3.80|P-value:4.27E-5 ID:SGTC_2320|Compound:7373003|FD-Score:3.91|P-value:2.92E-5 ID:SGTC_2328|Compound:6201408|FD-Score:-3.91|P-value:2.65E-5 ID:SGTC_2379|Compound:9035213|FD-Score:3.65|P-value:8.79E-5 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.39|P-value:2.45E-4 ID:SGTC_2505|Compound:galangin|FD-Score:3.35|P-value:2.87E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-3.05|P-value:8.17E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:5.23|P-value:3.56E-8 ID:SGTC_2927|Compound:9011802|FD-Score:5.38|P-value:1.50E-8 ID:SGTC_3007|Compound:9078383|FD-Score:3.73|P-value:6.09E-5 ID:SGTC_3011|Compound:9081274|FD-Score:3.01|P-value:9.76E-4 ID:SGTC_3012|Compound:9080433|FD-Score:3.08|P-value:7.76E-4 ID:SGTC_3050|Compound:9093513|FD-Score:3.98|P-value:2.05E-5 ID:SGTC_3123|Compound:9126162|FD-Score:-3.12|P-value:6.31E-4 ID:SGTC_3134|Compound:9127454|FD-Score:-4.68|P-value:6.66E-7 ID:SGTC_3180|Compound:9109287|FD-Score:3.26|P-value:3.91E-4 ID:SGTC_3311|Compound:9131146|FD-Score:-3.50|P-value:1.52E-4 ID:SGTC_3353|Compound:9151644|FD-Score:3.09|P-value:7.30E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:4.83|P-value:3.23E-7 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.28|P-value:3.53E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:3.87|P-value:3.33E-5 ID:SGTC_232|Compound:clozapine|FD-Score:3.27|P-value:3.88E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:9.09|P-value:3.92E-21 ID:SGTC_249|Compound:wiskostatin|FD-Score:3.02|P-value:9.39E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:3.32|P-value:3.13E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:3.12|P-value:6.63E-4 ID:SGTC_418|Compound:lividomycin a|FD-Score:3.45|P-value:1.96E-4 ID:SGTC_529|Compound:4076-0302|FD-Score:3.09|P-value:7.28E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:-3.34|P-value:2.74E-4 ID:SGTC_647|Compound:0140-0236|FD-Score:-3.11|P-value:6.48E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:3.57|P-value:1.20E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.20|P-value:4.94E-4 ID:SGTC_1229|Compound:0139-0193|FD-Score:3.27|P-value:3.79E-4 ID:SGTC_1324|Compound:1418-0026|FD-Score:-3.00|P-value:9.69E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:4.13|P-value:1.04E-5 ID:SGTC_1449|Compound:4112-4002|FD-Score:3.25|P-value:4.11E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.22|P-value:4.35E-4 ID:SGTC_1635|Compound:st007035|FD-Score:6.14|P-value:1.31E-10 ID:SGTC_1694|Compound:st024011|FD-Score:3.95|P-value:2.41E-5 ID:SGTC_1722|Compound:st034304|FD-Score:5.07|P-value:8.76E-8 ID:SGTC_1811|Compound:st050069|FD-Score:-3.00|P-value:9.55E-4 ID:SGTC_1836|Compound:st055642|FD-Score:3.16|P-value:5.68E-4 ID:SGTC_1837|Compound:st055472|FD-Score:4.13|P-value:1.07E-5 ID:SGTC_1838|Compound:st055369|FD-Score:-3.09|P-value:7.08E-4 ID:SGTC_1856|Compound:st057054|FD-Score:3.41|P-value:2.24E-4 ID:SGTC_2032|Compound:5185112|FD-Score:3.29|P-value:3.62E-4 ID:SGTC_2045|Compound:5106652|FD-Score:3.37|P-value:2.63E-4 ID:SGTC_2052|Compound:5265182|FD-Score:3.43|P-value:2.08E-4 ID:SGTC_2055|Compound:5235184|FD-Score:6.16|P-value:1.10E-10 ID:SGTC_2056|Compound:5235370|FD-Score:3.76|P-value:5.42E-5 ID:SGTC_2122|Compound:5258151|FD-Score:-3.37|P-value:2.52E-4 ID:SGTC_2132|Compound:5317594|FD-Score:-3.34|P-value:2.80E-4 ID:SGTC_2134|Compound:5324836|FD-Score:-3.80|P-value:4.27E-5 ID:SGTC_2320|Compound:7373003|FD-Score:3.91|P-value:2.92E-5 ID:SGTC_2328|Compound:6201408|FD-Score:-3.91|P-value:2.65E-5 ID:SGTC_2379|Compound:9035213|FD-Score:3.65|P-value:8.79E-5 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.39|P-value:2.45E-4 ID:SGTC_2505|Compound:galangin|FD-Score:3.35|P-value:2.87E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-3.05|P-value:8.17E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:5.23|P-value:3.56E-8 ID:SGTC_2927|Compound:9011802|FD-Score:5.38|P-value:1.50E-8 ID:SGTC_3007|Compound:9078383|FD-Score:3.73|P-value:6.09E-5 ID:SGTC_3011|Compound:9081274|FD-Score:3.01|P-value:9.76E-4 ID:SGTC_3012|Compound:9080433|FD-Score:3.08|P-value:7.76E-4 ID:SGTC_3050|Compound:9093513|FD-Score:3.98|P-value:2.05E-5 ID:SGTC_3123|Compound:9126162|FD-Score:-3.12|P-value:6.31E-4 ID:SGTC_3134|Compound:9127454|FD-Score:-4.68|P-value:6.66E-7 ID:SGTC_3180|Compound:9109287|FD-Score:3.26|P-value:3.91E-4 ID:SGTC_3311|Compound:9131146|FD-Score:-3.50|P-value:1.52E-4 ID:SGTC_3353|Compound:9151644|FD-Score:3.09|P-value:7.30E-4

Top fitness defect scores for YBR072C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 9.09 5.3 µM 3.92E-21 215 5.12E-20
2 SGTC_2055 5235184 6.16 200.0 µM 1.10E-10 ERG2 6 3.57E-10
3 SGTC_1635 st007035 6.14 42.4 µM 1.31E-10 135 4.24E-10
4 SGTC_2927 9011802 5.38 47.9 µM 1.50E-8 8 3.70E-8
5 SGTC_2689 tacrolimus 5.23 100.0 µM 3.56E-8 18 8.37E-8
6 SGTC_1722 st034304 5.07 3.6 µM 8.76E-8 mitochondrial processes 10 1.96E-7
7 SGTC_90 0870-0863 4.83 4.6 µM 3.23E-7 26 6.71E-7
8 SGTC_1340 1486-1359 4.13 257.0 µM 1.04E-5 19 1.78E-5
9 SGTC_1837 st055472 4.13 66.5 µM 1.07E-5 16 1.83E-5
10 SGTC_3050 9093513 3.98 49.5 µM 2.05E-5 17 3.38E-5
11 SGTC_1694 st024011 3.95 44.9 µM 2.41E-5 ERG2 39 3.94E-5
12 SGTC_2320 7373003 3.91 200.0 µM 2.92E-5 28 4.71E-5
13 SGTC_137 0438-0332 3.87 85.4 µM 3.33E-5 ubiquinone biosynthesis & proteasome 130 5.33E-5
14 SGTC_2056 5235370 3.76 200.0 µM 5.42E-5 50 8.46E-5
15 SGTC_3007 9078383 3.73 71.4 µM 6.09E-5 21 9.44E-5
16 SGTC_2379 9035213 3.65 200.0 µM 8.79E-5 33 1.34E-4
17 SGTC_1011 4112-3381 3.57 17.4 µM 1.20E-4 55 1.79E-4
18 SGTC_418 lividomycin a 3.45 100.0 µM 1.96E-4 23 2.84E-4
19 SGTC_2052 5265182 3.43 7.1 µM 2.08E-4 47 3.01E-4
20 SGTC_1856 st057054 3.41 55.7 µM 2.24E-4 40 3.24E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.349 9.45E-97 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.338 2.61E-90 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.331 2.05E-86 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.321 2.11E-81 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.309 4.13E-75 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.306 9.82E-74 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.304 1.78E-72 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.303 4.63E-72 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.298 6.22E-70 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.297 2.63E-69 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.295 2.22E-68 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.292 6.91E-67 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.292 7.10E-67 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.290 7.65E-66 YKL087C CYT2 hom Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1
0.289 1.13E-65 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex