YBR072W / HSP26

Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires heat-induced conformational change; also has mRNA binding activity

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR072W / HSP26

Click on Significant Values for Screen Details ID:SGTC_173|Compound:1273-0061|FD-Score:3.97|P-value:1.84E-5 ID:SGTC_231|Compound:b-estradiol|FD-Score:2.97|P-value:9.93E-4 ID:SGTC_259|Compound:usnic acid|FD-Score:-3.22|P-value:4.09E-4 ID:SGTC_271|Compound:rotenone|FD-Score:4.86|P-value:2.10E-7 ID:SGTC_362|Compound:0310-0100|FD-Score:3.90|P-value:2.50E-5 ID:SGTC_428|Compound:3448-4153|FD-Score:-3.65|P-value:7.59E-5 ID:SGTC_466|Compound:geldanamycin|FD-Score:4.38|P-value:2.55E-6 ID:SGTC_513|Compound:4245-1575|FD-Score:4.06|P-value:1.20E-5 ID:SGTC_556|Compound:4058-0063|FD-Score:3.92|P-value:2.25E-5 ID:SGTC_577|Compound:r071-0003|FD-Score:3.91|P-value:2.35E-5 ID:SGTC_615|Compound:k087-0205|FD-Score:7.80|P-value:2.45E-16 ID:SGTC_652|Compound:0437-0092|FD-Score:4.00|P-value:1.59E-5 ID:SGTC_735|Compound:3076-0345|FD-Score:3.15|P-value:5.21E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:3.26|P-value:3.51E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:-3.29|P-value:3.20E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:4.13|P-value:8.56E-6 ID:SGTC_1090|Compound:efavirenz|FD-Score:3.12|P-value:5.75E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:4.31|P-value:3.58E-6 ID:SGTC_1284|Compound:0929-0043|FD-Score:3.02|P-value:8.46E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:4.31|P-value:3.73E-6 ID:SGTC_1403|Compound:3909-7815|FD-Score:4.94|P-value:1.36E-7 ID:SGTC_1562|Compound:morin hydrate|FD-Score:3.13|P-value:5.60E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.07|P-value:6.92E-4 ID:SGTC_1688|Compound:st021091|FD-Score:4.69|P-value:5.25E-7 ID:SGTC_1747|Compound:st037496|FD-Score:-3.25|P-value:3.66E-4 ID:SGTC_1768|Compound:st044301|FD-Score:3.00|P-value:8.85E-4 ID:SGTC_1776|Compound:st049249|FD-Score:4.42|P-value:2.12E-6 ID:SGTC_1799|Compound:st045822|FD-Score:3.88|P-value:2.74E-5 ID:SGTC_1912|Compound:st060209|FD-Score:3.13|P-value:5.60E-4 ID:SGTC_1994|Compound:st072947|FD-Score:3.33|P-value:2.66E-4 ID:SGTC_2019|Compound:4016004|FD-Score:4.28|P-value:4.14E-6 ID:SGTC_2034|Compound:5197015|FD-Score:3.01|P-value:8.60E-4 ID:SGTC_2204|Compound:7233102|FD-Score:2.97|P-value:9.95E-4 ID:SGTC_2240|Compound:6690706|FD-Score:-3.15|P-value:5.40E-4 ID:SGTC_2258|Compound:7960471|FD-Score:-3.00|P-value:9.28E-4 ID:SGTC_2297|Compound:7971671|FD-Score:3.24|P-value:3.74E-4 ID:SGTC_2427|Compound:5545055|FD-Score:-3.76|P-value:4.69E-5 ID:SGTC_2483|Compound:5729050|FD-Score:3.67|P-value:6.73E-5 ID:SGTC_2485|Compound:5633444|FD-Score:4.08|P-value:1.11E-5 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:8.18|P-value:8.60E-18 ID:SGTC_3329|Compound:9141233|FD-Score:3.34|P-value:2.49E-4 ID:SGTC_3340|Compound:9146634|FD-Score:3.36|P-value:2.33E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:3.97|P-value:1.84E-5 ID:SGTC_231|Compound:b-estradiol|FD-Score:2.97|P-value:9.93E-4 ID:SGTC_259|Compound:usnic acid|FD-Score:-3.22|P-value:4.09E-4 ID:SGTC_271|Compound:rotenone|FD-Score:4.86|P-value:2.10E-7 ID:SGTC_362|Compound:0310-0100|FD-Score:3.90|P-value:2.50E-5 ID:SGTC_428|Compound:3448-4153|FD-Score:-3.65|P-value:7.59E-5 ID:SGTC_466|Compound:geldanamycin|FD-Score:4.38|P-value:2.55E-6 ID:SGTC_513|Compound:4245-1575|FD-Score:4.06|P-value:1.20E-5 ID:SGTC_556|Compound:4058-0063|FD-Score:3.92|P-value:2.25E-5 ID:SGTC_577|Compound:r071-0003|FD-Score:3.91|P-value:2.35E-5 ID:SGTC_615|Compound:k087-0205|FD-Score:7.80|P-value:2.45E-16 ID:SGTC_652|Compound:0437-0092|FD-Score:4.00|P-value:1.59E-5 ID:SGTC_735|Compound:3076-0345|FD-Score:3.15|P-value:5.21E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:3.26|P-value:3.51E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:-3.29|P-value:3.20E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:4.13|P-value:8.56E-6 ID:SGTC_1090|Compound:efavirenz|FD-Score:3.12|P-value:5.75E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:4.31|P-value:3.58E-6 ID:SGTC_1284|Compound:0929-0043|FD-Score:3.02|P-value:8.46E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:4.31|P-value:3.73E-6 ID:SGTC_1403|Compound:3909-7815|FD-Score:4.94|P-value:1.36E-7 ID:SGTC_1562|Compound:morin hydrate|FD-Score:3.13|P-value:5.60E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.07|P-value:6.92E-4 ID:SGTC_1688|Compound:st021091|FD-Score:4.69|P-value:5.25E-7 ID:SGTC_1747|Compound:st037496|FD-Score:-3.25|P-value:3.66E-4 ID:SGTC_1768|Compound:st044301|FD-Score:3.00|P-value:8.85E-4 ID:SGTC_1776|Compound:st049249|FD-Score:4.42|P-value:2.12E-6 ID:SGTC_1799|Compound:st045822|FD-Score:3.88|P-value:2.74E-5 ID:SGTC_1912|Compound:st060209|FD-Score:3.13|P-value:5.60E-4 ID:SGTC_1994|Compound:st072947|FD-Score:3.33|P-value:2.66E-4 ID:SGTC_2019|Compound:4016004|FD-Score:4.28|P-value:4.14E-6 ID:SGTC_2034|Compound:5197015|FD-Score:3.01|P-value:8.60E-4 ID:SGTC_2204|Compound:7233102|FD-Score:2.97|P-value:9.95E-4 ID:SGTC_2240|Compound:6690706|FD-Score:-3.15|P-value:5.40E-4 ID:SGTC_2258|Compound:7960471|FD-Score:-3.00|P-value:9.28E-4 ID:SGTC_2297|Compound:7971671|FD-Score:3.24|P-value:3.74E-4 ID:SGTC_2427|Compound:5545055|FD-Score:-3.76|P-value:4.69E-5 ID:SGTC_2483|Compound:5729050|FD-Score:3.67|P-value:6.73E-5 ID:SGTC_2485|Compound:5633444|FD-Score:4.08|P-value:1.11E-5 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:8.18|P-value:8.60E-18 ID:SGTC_3329|Compound:9141233|FD-Score:3.34|P-value:2.49E-4 ID:SGTC_3340|Compound:9146634|FD-Score:3.36|P-value:2.33E-4

Top fitness defect scores for YBR072W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 8.18 100.0 µM 8.60E-18 60S ribosome export 1 1.38E-16
2 SGTC_615 k087-0205 7.80 167.0 µM 2.45E-16 1 3.07E-15
3 SGTC_1403 3909-7815 4.94 62.9 µM 1.36E-7 8 3.87E-7
4 SGTC_271 rotenone 4.86 740.0 µM 2.10E-7 9 5.79E-7
5 SGTC_1688 st021091 4.69 57.6 µM 5.25E-7 2 1.35E-6
6 SGTC_1776 st049249 4.42 45.9 µM 2.12E-6 11 4.94E-6
7 SGTC_466 geldanamycin 4.38 89.2 µM 2.55E-6 RPP1 & pyrimidine depletion 4 5.86E-6
8 SGTC_1188 1403-0014 4.31 4.6 µM 3.58E-6 mitochondrial stress 41 8.03E-6
9 SGTC_1390 3413-2614 4.31 145.0 µM 3.73E-6 fatty acid desaturase (OLE1) 16 8.33E-6
10 SGTC_2019 4016004 4.28 108.0 µM 4.14E-6 21 9.17E-6
11 SGTC_1060 3448-7350 4.13 82.0 µM 8.56E-6 Golgi 31 1.80E-5
12 SGTC_2485 5633444 4.08 17.8 µM 1.11E-5 redox potentiating 37 2.29E-5
13 SGTC_513 4245-1575 4.06 41.7 µM 1.20E-5 unfolded protein response 109 2.46E-5
14 SGTC_652 0437-0092 4.00 114.0 µM 1.59E-5 14 3.19E-5
15 SGTC_173 1273-0061 3.97 2.7 µM 1.84E-5 mitochondrial stress 185 3.66E-5
16 SGTC_556 4058-0063 3.92 51.5 µM 2.25E-5 26 4.42E-5
17 SGTC_577 r071-0003 3.91 38.6 µM 2.35E-5 fatty acid desaturase (OLE1) 58 4.60E-5
18 SGTC_362 0310-0100 3.90 9.0 µM 2.50E-5 RPP1 & pyrimidine depletion 36 4.86E-5
19 SGTC_1799 st045822 3.88 46.1 µM 2.74E-5 15 5.30E-5
20 SGTC_2483 5729050 3.67 27.2 µM 6.73E-5 32 1.22E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.123 7.91E-13 YNL182C IPI3 het Component of the Rix1 complex (Rix1p-Ipi1p-Ipi3p) and pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; highly conserved protein which contains several WD40 motifs; IPI3 is an essential gene
0.120 3.59E-12 YNL054W VAC7 hom Integral vacuolar membrane protein involved in vacuole inheritance and morphology; activates Fab1p kinase activity under basal conditions and also after hyperosmotic shock
0.108 3.28E-10 YNL082W PMS1 hom ATP-binding protein required for mismatch repair in mitosis and meiosis; functions as a heterodimer with Mlh1p, binds double- and single-stranded DNA via its N-terminal domain, similar to E. coli MutL
0.101 5.59E-9 YJL051W IRC8 hom Bud tip localized protein of unknown function; mRNA is targeted to the bud by a She2p dependent transport system; mRNA is cell cycle regulated via Fkh2p, peaking in G2/M phase; null mutant displays increased levels of spontaneous Rad52p foc
0.096 2.16E-8 YKR058W GLG1 hom Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG1 has a paralog, GLG2, that arose from the whole genome duplication
0.094 4.31E-8 YLR283W_p YLR283W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR283W is not an essential gene
0.093 5.86E-8 YNR021W_p YNR021W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNR021W is not an essential gene
0.085 7.73E-7 YIL042C PKP1 hom Mitochondrial protein kinase involved in negative regulation of pyruvate dehydrogenase complex activity by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp2p and phosphatases Ptc5p and Ptc6p
0.083 1.37E-6 YLR072W_p YLR072W_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YLR072W is not an esssential gene
0.083 1.55E-6 YDL198C GGC1 hom Mitochondrial GTP/GDP transporter, essential for mitochondrial genome maintenance; has a role in mitochondrial iron transport; member of the mitochondrial carrier family
0.083 1.69E-6 YHR085W IPI1 het Component of the Rix1 complex (Rix1p-Ipi1p-Ipi3p) and possibly pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; IPI1 is an essential gene
0.082 1.72E-6 YKR053C YSR3 hom Dihydrosphingosine 1-phosphate phosphatase; membrane protein involved in sphingolipid metabolism; YSR3 has a paralog, LCB3, that arose from the whole genome duplication
0.082 1.77E-6 YJR117W STE24 hom Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans
0.079 4.51E-6 YKL111C_d YKL111C_d het Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified essential gene ABF1
0.078 6.10E-6 YCR075C ERS1 hom Protein with similarity to human cystinosin, which is a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains