YBR073W / RDH54

DNA-dependent ATPase; stimulates strand exchange by modifying the topology of double-stranded DNA; involved in recombinational repair of DNA double-strand breaks during mitosis and meiosis; proposed to be involved in crossover interference; interacts with Dmc1p; stimulates Dmc1p and Rad51p

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR073W / RDH54

Click on Significant Values for Screen Details ID:SGTC_209|Compound:4077-0173|FD-Score:3.25|P-value:7.38E-4 ID:SGTC_324|Compound:1315-0088|FD-Score:3.52|P-value:2.79E-4 ID:SGTC_330|Compound:1488-0319|FD-Score:-3.45|P-value:1.89E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:3.33|P-value:5.57E-4 ID:SGTC_493|Compound:zm226600|FD-Score:3.21|P-value:8.33E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:3.63|P-value:1.80E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:-3.25|P-value:3.96E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:4.73|P-value:1.47E-6 ID:SGTC_604|Compound:1000-0114|FD-Score:3.22|P-value:8.23E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:3.27|P-value:6.90E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:3.32|P-value:5.72E-4 ID:SGTC_877|Compound:0771-0151|FD-Score:4.74|P-value:1.42E-6 ID:SGTC_907|Compound:3448-6986|FD-Score:-3.42|P-value:2.14E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:-3.51|P-value:1.48E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.17|P-value:9.59E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:-3.20|P-value:4.76E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:4.64|P-value:2.32E-6 ID:SGTC_1004|Compound:4084-0029|FD-Score:-3.04|P-value:8.45E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:4.33|P-value:9.77E-6 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.31|P-value:5.90E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:3.68|P-value:1.53E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.21|P-value:8.44E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:3.36|P-value:4.89E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:3.30|P-value:6.04E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:3.39|P-value:4.40E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:3.20|P-value:8.81E-4 ID:SGTC_1555|Compound:citronellol|FD-Score:3.76|P-value:1.11E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.64|P-value:1.76E-4 ID:SGTC_1659|Compound:st012954|FD-Score:8.32|P-value:6.19E-17 ID:SGTC_1673|Compound:st016611|FD-Score:3.62|P-value:1.87E-4 ID:SGTC_1707|Compound:st032323|FD-Score:4.13|P-value:2.35E-5 ID:SGTC_1726|Compound:st035556|FD-Score:3.89|P-value:6.52E-5 ID:SGTC_1738|Compound:st035555|FD-Score:4.09|P-value:2.82E-5 ID:SGTC_1958|Compound:st076513|FD-Score:3.19|P-value:9.00E-4 ID:SGTC_1964|Compound:st076914|FD-Score:3.19|P-value:8.86E-4 ID:SGTC_1966|Compound:st070145|FD-Score:4.36|P-value:8.49E-6 ID:SGTC_2188|Compound:6126565|FD-Score:3.53|P-value:2.66E-4 ID:SGTC_2206|Compound:7254556|FD-Score:3.69|P-value:1.45E-4 ID:SGTC_2213|Compound:7173844|FD-Score:-3.09|P-value:7.01E-4 ID:SGTC_2214|Compound:7179297|FD-Score:3.20|P-value:8.59E-4 ID:SGTC_2432|Compound:5630864|FD-Score:-3.92|P-value:2.79E-5 ID:SGTC_2433|Compound:5607874|FD-Score:-3.22|P-value:4.42E-4 ID:SGTC_2457|Compound:5731572|FD-Score:3.61|P-value:1.99E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-4.31|P-value:4.91E-6 ID:SGTC_2788|Compound:5282734|FD-Score:3.17|P-value:9.75E-4 ID:SGTC_2792|Compound:7535235|FD-Score:3.64|P-value:1.77E-4 ID:SGTC_2838|Compound:9002687|FD-Score:3.70|P-value:1.40E-4 ID:SGTC_3293|Compound:9120939|FD-Score:4.48|P-value:4.88E-6 ID:SGTC_209|Compound:4077-0173|FD-Score:3.25|P-value:7.38E-4 ID:SGTC_324|Compound:1315-0088|FD-Score:3.52|P-value:2.79E-4 ID:SGTC_330|Compound:1488-0319|FD-Score:-3.45|P-value:1.89E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:3.33|P-value:5.57E-4 ID:SGTC_493|Compound:zm226600|FD-Score:3.21|P-value:8.33E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:3.63|P-value:1.80E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:-3.25|P-value:3.96E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:4.73|P-value:1.47E-6 ID:SGTC_604|Compound:1000-0114|FD-Score:3.22|P-value:8.23E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:3.27|P-value:6.90E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:3.32|P-value:5.72E-4 ID:SGTC_877|Compound:0771-0151|FD-Score:4.74|P-value:1.42E-6 ID:SGTC_907|Compound:3448-6986|FD-Score:-3.42|P-value:2.14E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:-3.51|P-value:1.48E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.17|P-value:9.59E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:-3.20|P-value:4.76E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:4.64|P-value:2.32E-6 ID:SGTC_1004|Compound:4084-0029|FD-Score:-3.04|P-value:8.45E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:4.33|P-value:9.77E-6 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.31|P-value:5.90E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:3.68|P-value:1.53E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.21|P-value:8.44E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:3.36|P-value:4.89E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:3.30|P-value:6.04E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:3.39|P-value:4.40E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:3.20|P-value:8.81E-4 ID:SGTC_1555|Compound:citronellol|FD-Score:3.76|P-value:1.11E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.64|P-value:1.76E-4 ID:SGTC_1659|Compound:st012954|FD-Score:8.32|P-value:6.19E-17 ID:SGTC_1673|Compound:st016611|FD-Score:3.62|P-value:1.87E-4 ID:SGTC_1707|Compound:st032323|FD-Score:4.13|P-value:2.35E-5 ID:SGTC_1726|Compound:st035556|FD-Score:3.89|P-value:6.52E-5 ID:SGTC_1738|Compound:st035555|FD-Score:4.09|P-value:2.82E-5 ID:SGTC_1958|Compound:st076513|FD-Score:3.19|P-value:9.00E-4 ID:SGTC_1964|Compound:st076914|FD-Score:3.19|P-value:8.86E-4 ID:SGTC_1966|Compound:st070145|FD-Score:4.36|P-value:8.49E-6 ID:SGTC_2188|Compound:6126565|FD-Score:3.53|P-value:2.66E-4 ID:SGTC_2206|Compound:7254556|FD-Score:3.69|P-value:1.45E-4 ID:SGTC_2213|Compound:7173844|FD-Score:-3.09|P-value:7.01E-4 ID:SGTC_2214|Compound:7179297|FD-Score:3.20|P-value:8.59E-4 ID:SGTC_2432|Compound:5630864|FD-Score:-3.92|P-value:2.79E-5 ID:SGTC_2433|Compound:5607874|FD-Score:-3.22|P-value:4.42E-4 ID:SGTC_2457|Compound:5731572|FD-Score:3.61|P-value:1.99E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-4.31|P-value:4.91E-6 ID:SGTC_2788|Compound:5282734|FD-Score:3.17|P-value:9.75E-4 ID:SGTC_2792|Compound:7535235|FD-Score:3.64|P-value:1.77E-4 ID:SGTC_2838|Compound:9002687|FD-Score:3.70|P-value:1.40E-4 ID:SGTC_3293|Compound:9120939|FD-Score:4.48|P-value:4.88E-6

Top fitness defect scores for YBR073W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1659 st012954 8.32 42.1 µM 6.19E-17 2 4.48E-17
2 SGTC_877 0771-0151 4.74 33.1 µM 1.42E-6 8 1.06E-6
3 SGTC_518 1021-0119 4.73 62.6 µM 1.47E-6 ERG2 19 1.10E-6
4 SGTC_996 3970-0799 4.64 1.8 µM 2.32E-6 61 1.74E-6
5 SGTC_3293 9120939 4.48 62.0 µM 4.88E-6 8 3.67E-6
6 SGTC_1966 st070145 4.36 16.1 µM 8.49E-6 19 6.42E-6
7 SGTC_1022 4477-0945 4.33 21.3 µM 9.77E-6 13 7.40E-6
8 SGTC_1707 st032323 4.13 6.3 µM 2.35E-5 DNA damage response 50 1.79E-5
9 SGTC_1738 st035555 4.09 74.0 µM 2.82E-5 TSC3-RPN4 29 2.15E-5
10 SGTC_1726 st035556 3.89 14.6 µM 6.52E-5 36 5.01E-5
11 SGTC_1555 citronellol 3.76 128.0 µM 1.11E-4 4 8.57E-5
12 SGTC_2838 9002687 3.70 71.4 µM 1.40E-4 fatty acid desaturase (OLE1) 24 1.09E-4
13 SGTC_2206 7254556 3.69 147.0 µM 1.45E-4 60S ribosome export 4 1.12E-4
14 SGTC_1071 trifluoperazine 3.68 6.3 µM 1.53E-4 34 1.19E-4
15 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 3.64 85.4 µM 1.76E-4 31 1.37E-4
16 SGTC_2792 7535235 3.64 81.8 µM 1.77E-4 fatty acid desaturase (OLE1) 44 1.37E-4
17 SGTC_513 4245-1575 3.63 41.7 µM 1.80E-4 unfolded protein response 128 1.40E-4
18 SGTC_1673 st016611 3.62 27.3 µM 1.87E-4 59 1.45E-4
19 SGTC_2457 5731572 3.61 11.7 µM 1.99E-4 21 1.54E-4
20 SGTC_2188 6126565 3.53 140.7 µM 2.66E-4 mitochondrial processes 18 2.07E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.158 3.17E-20 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.129 6.94E-14 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.129 7.04E-14 YDR386W MUS81 hom Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p
0.125 3.11E-13 YDL059C RAD59 hom Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p
0.124 5.49E-13 YGL040C HEM2 het Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.120 3.59E-12 YGL205W POX1 hom Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.112 8.66E-11 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.108 3.35E-10 YJR014W TMA22 hom Protein of unknown function; associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1; protein abundance increases in response to DNA replication stress
0.107 5.40E-10 YDL177C_p YDL177C_p hom Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene
0.105 9.10E-10 YDR294C DPL1 hom Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate
0.103 2.11E-9 YNL273W TOF1 hom Subunit of a replication-pausing checkpoint complex (Tof1p-Mrc1p-Csm3p) that acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase
0.101 4.49E-9 YGL096W TOS8 hom Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication
0.101 4.76E-9 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.099 8.92E-9 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.099 1.07E-8 YJR117W STE24 hom Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans