YBR074W_p

Putative metalloprotease

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR074W / YBR074W

Click on Significant Values for Screen Details ID:SGTC_407|Compound:eburnamonine|FD-Score:3.37|P-value:7.73E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:3.70|P-value:2.48E-4 ID:SGTC_556|Compound:4058-0063|FD-Score:4.67|P-value:5.54E-6 ID:SGTC_571|Compound:k831-0106|FD-Score:3.82|P-value:1.63E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:3.43|P-value:6.30E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:4.20|P-value:3.88E-5 ID:SGTC_724|Compound:3910-0327|FD-Score:3.96|P-value:9.85E-5 ID:SGTC_774|Compound:k060-0086|FD-Score:3.48|P-value:5.42E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:5.04|P-value:1.07E-6 ID:SGTC_973|Compound:1325-0077|FD-Score:-3.79|P-value:1.69E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.40|P-value:6.94E-4 ID:SGTC_1384|Compound:3089-0840|FD-Score:3.50|P-value:5.01E-4 ID:SGTC_1385|Compound:3091-4834|FD-Score:3.55|P-value:4.28E-4 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:3.49|P-value:5.23E-4 ID:SGTC_1660|Compound:st012960|FD-Score:3.83|P-value:1.60E-4 ID:SGTC_2037|Compound:5169046|FD-Score:4.04|P-value:7.25E-5 ID:SGTC_2159|Compound:5658611|FD-Score:4.16|P-value:4.64E-5 ID:SGTC_2253|Compound:7938677|FD-Score:3.44|P-value:6.07E-4 ID:SGTC_2326|Compound:6164455|FD-Score:5.09|P-value:8.47E-7 ID:SGTC_2477|Compound:5967686|FD-Score:4.05|P-value:6.88E-5 ID:SGTC_2511|Compound:berberine|FD-Score:3.60|P-value:3.57E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.41|P-value:6.80E-4 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:3.73|P-value:2.30E-4 ID:SGTC_2667|Compound:digitoxin|FD-Score:-3.33|P-value:8.22E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:3.89|P-value:1.27E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.32|P-value:8.88E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:3.76|P-value:2.01E-4 ID:SGTC_2786|Compound:7743617|FD-Score:4.72|P-value:4.40E-6 ID:SGTC_2832|Compound:7992762|FD-Score:6.01|P-value:7.81E-9 ID:SGTC_2841|Compound:9004761|FD-Score:4.31|P-value:2.54E-5 ID:SGTC_2842|Compound:9000675|FD-Score:3.73|P-value:2.27E-4 ID:SGTC_2853|Compound:9015042|FD-Score:4.16|P-value:4.65E-5 ID:SGTC_3149|Compound:9097855|FD-Score:5.76|P-value:2.95E-8 ID:SGTC_3151|Compound:9099821|FD-Score:4.04|P-value:7.29E-5 ID:SGTC_3181|Compound:9108277|FD-Score:4.22|P-value:3.55E-5 ID:SGTC_407|Compound:eburnamonine|FD-Score:3.37|P-value:7.73E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:3.70|P-value:2.48E-4 ID:SGTC_556|Compound:4058-0063|FD-Score:4.67|P-value:5.54E-6 ID:SGTC_571|Compound:k831-0106|FD-Score:3.82|P-value:1.63E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:3.43|P-value:6.30E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:4.20|P-value:3.88E-5 ID:SGTC_724|Compound:3910-0327|FD-Score:3.96|P-value:9.85E-5 ID:SGTC_774|Compound:k060-0086|FD-Score:3.48|P-value:5.42E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:5.04|P-value:1.07E-6 ID:SGTC_973|Compound:1325-0077|FD-Score:-3.79|P-value:1.69E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.40|P-value:6.94E-4 ID:SGTC_1384|Compound:3089-0840|FD-Score:3.50|P-value:5.01E-4 ID:SGTC_1385|Compound:3091-4834|FD-Score:3.55|P-value:4.28E-4 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:3.49|P-value:5.23E-4 ID:SGTC_1660|Compound:st012960|FD-Score:3.83|P-value:1.60E-4 ID:SGTC_2037|Compound:5169046|FD-Score:4.04|P-value:7.25E-5 ID:SGTC_2159|Compound:5658611|FD-Score:4.16|P-value:4.64E-5 ID:SGTC_2253|Compound:7938677|FD-Score:3.44|P-value:6.07E-4 ID:SGTC_2326|Compound:6164455|FD-Score:5.09|P-value:8.47E-7 ID:SGTC_2477|Compound:5967686|FD-Score:4.05|P-value:6.88E-5 ID:SGTC_2511|Compound:berberine|FD-Score:3.60|P-value:3.57E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.41|P-value:6.80E-4 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:3.73|P-value:2.30E-4 ID:SGTC_2667|Compound:digitoxin|FD-Score:-3.33|P-value:8.22E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:3.89|P-value:1.27E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.32|P-value:8.88E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:3.76|P-value:2.01E-4 ID:SGTC_2786|Compound:7743617|FD-Score:4.72|P-value:4.40E-6 ID:SGTC_2832|Compound:7992762|FD-Score:6.01|P-value:7.81E-9 ID:SGTC_2841|Compound:9004761|FD-Score:4.31|P-value:2.54E-5 ID:SGTC_2842|Compound:9000675|FD-Score:3.73|P-value:2.27E-4 ID:SGTC_2853|Compound:9015042|FD-Score:4.16|P-value:4.65E-5 ID:SGTC_3149|Compound:9097855|FD-Score:5.76|P-value:2.95E-8 ID:SGTC_3151|Compound:9099821|FD-Score:4.04|P-value:7.29E-5 ID:SGTC_3181|Compound:9108277|FD-Score:4.22|P-value:3.55E-5

Top fitness defect scores for YBR074W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2832 7992762 6.01 52.0 µM 7.81E-9 6 9.39E-10
2 SGTC_3149 9097855 5.76 49.5 µM 2.95E-8 Golgi 6 4.19E-9
3 SGTC_2326 6164455 5.09 177.6 µM 8.47E-7 mitochondrial processes 6 1.82E-7
4 SGTC_864 0469-0573 5.04 172.0 µM 1.07E-6 4 2.36E-7
5 SGTC_2786 7743617 4.72 45.5 µM 4.40E-6 13 1.15E-6
6 SGTC_556 4058-0063 4.67 51.5 µM 5.54E-6 17 1.50E-6
7 SGTC_2841 9004761 4.31 39.0 µM 2.54E-5 amide catabolism 19 8.24E-6
8 SGTC_3181 9108277 4.22 49.5 µM 3.55E-5 iron homeostasis 10 1.20E-5
9 SGTC_627 1391-0720 4.20 175.0 µM 3.88E-5 10 1.33E-5
10 SGTC_2159 5658611 4.16 73.8 µM 4.64E-5 7 1.62E-5
11 SGTC_2853 9015042 4.16 58.4 µM 4.65E-5 19 1.63E-5
12 SGTC_2477 5967686 4.05 25.2 µM 6.88E-5 23 2.53E-5
13 SGTC_2037 5169046 4.04 200.0 µM 7.25E-5 60S ribosome export 12 2.68E-5
14 SGTC_3151 9099821 4.04 49.5 µM 7.29E-5 19 2.69E-5
15 SGTC_724 3910-0327 3.96 137.0 µM 9.85E-5 ERG2 18 3.78E-5
16 SGTC_2675 theaflavin digallate 3.89 100.0 µM 1.27E-4 iron homeostasis 33 5.00E-5
17 SGTC_1660 st012960 3.83 28.1 µM 1.60E-4 iron homeostasis 42 6.49E-5
18 SGTC_571 k831-0106 3.82 44.2 µM 1.63E-4 16 6.62E-5
19 SGTC_2779 methotrexate 3.76 400.0 µM 2.01E-4 33 8.40E-5
20 SGTC_2842 9000675 3.73 19.5 µM 2.27E-4 27 9.64E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.136 2.54E-15 YGR267C FOL2 het GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway
0.102 3.36E-9 YGR034W RPL26B hom Ribosomal 60S subunit protein L26B; binds to 5.8S rRNA; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26B has a paralog, RPL26A, that arose from the whole genome duplication
0.100 7.47E-9 YJR035W RAD26 hom Protein involved in transcription-coupled nucleotide excision repair of UV-induced DNA lesions; recruitment to DNA lesions is dependent on an elongating RNA polymerase II; homolog of human CSB protein
0.086 6.41E-7 YDL137W ARF2 hom ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; ARF2 has a paralog, ARF1, that arose from the whole genome duplication
0.085 8.54E-7 YPL099C AIM43 hom Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss
0.081 2.82E-6 YNR028W CPR8 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; similarity to Cpr4p suggests a potential role in the secretory pathway
0.080 3.65E-6 YPR193C HPA2 hom Tetrameric histone acetyltransferase with similarity to Gcn5p, Hat1p, Elp3p, and Hpa3p; acetylates histones H3 and H4 in vitro and exhibits autoacetylation activity
0.080 3.64E-6 YJL215C_d YJL215C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.079 4.32E-6 YPR078C_p YPR078C_p hom Putative protein of unknown function; possible role in DNA metabolism and/or in genome stability; expression is heat-inducible
0.079 4.40E-6 YLR145W RMP1 het Subunit of RNase MRP, which processes pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; unlike most subunits, not shared between RNase MRP and nuclear RNase P
0.077 8.31E-6 YOR074C CDC21 het Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S
0.077 8.71E-6 YER176W ECM32 hom DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes
0.076 1.10E-5 YLL048C YBT1 hom Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates the release of lumenal Ca2+ stores; similar to mammalian bile transporters
0.074 1.60E-5 YIL102C_p YIL102C_p hom Putative protein of unknown function
0.073 2.17E-5 YMR041C ARA2 hom NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase