HIPHOP chemogenomics database

YBR074W_p

Putative metalloprotease

Zygosity: Homozygous strain

fixedexpanded
Profile for YBR074W / YBR074W

Click on Significant Values for Screen Details

Top fitness defect scores for YBR074W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2832	7992762	6.01	52.0 µM	7.81E-9		6	9.39E-10
2	SGTC_3149	9097855	5.76	49.5 µM	2.95E-8	Golgi	6	4.19E-9
3	SGTC_2326	6164455	5.09	177.6 µM	8.47E-7	mitochondrial processes	6	1.82E-7
4	SGTC_864	0469-0573	5.04	172.0 µM	1.07E-6		4	2.36E-7
5	SGTC_2786	7743617	4.72	45.5 µM	4.40E-6		13	1.15E-6
6	SGTC_556	4058-0063	4.67	51.5 µM	5.54E-6		17	1.50E-6
7	SGTC_2841	9004761	4.31	39.0 µM	2.54E-5	amide catabolism	19	8.24E-6
8	SGTC_3181	9108277	4.22	49.5 µM	3.55E-5	iron homeostasis	10	1.20E-5
9	SGTC_627	1391-0720	4.20	175.0 µM	3.88E-5		10	1.33E-5
10	SGTC_2159	5658611	4.16	73.8 µM	4.64E-5		7	1.62E-5
11	SGTC_2853	9015042	4.16	58.4 µM	4.65E-5		19	1.63E-5
12	SGTC_2477	5967686	4.05	25.2 µM	6.88E-5		23	2.53E-5
13	SGTC_2037	5169046	4.04	200.0 µM	7.25E-5	60S ribosome export	12	2.68E-5
14	SGTC_3151	9099821	4.04	49.5 µM	7.29E-5		19	2.69E-5
15	SGTC_724	3910-0327	3.96	137.0 µM	9.85E-5	ERG2	18	3.78E-5
16	SGTC_2675	theaflavin digallate	3.89	100.0 µM	1.27E-4	iron homeostasis	33	5.00E-5
17	SGTC_1660	st012960	3.83	28.1 µM	1.60E-4	iron homeostasis	42	6.49E-5
18	SGTC_571	k831-0106	3.82	44.2 µM	1.63E-4		16	6.62E-5
19	SGTC_2779	methotrexate	3.76	400.0 µM	2.01E-4		33	8.40E-5
20	SGTC_2842	9000675	3.73	19.5 µM	2.27E-4		27	9.64E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.136	2.54E-15	YGR267C	FOL2	het	GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway
0.102	3.36E-9	YGR034W	RPL26B	hom	Ribosomal 60S subunit protein L26B; binds to 5.8S rRNA; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26B has a paralog, RPL26A, that arose from the whole genome duplication
0.100	7.47E-9	YJR035W	RAD26	hom	Protein involved in transcription-coupled nucleotide excision repair of UV-induced DNA lesions; recruitment to DNA lesions is dependent on an elongating RNA polymerase II; homolog of human CSB protein
0.086	6.41E-7	YDL137W	ARF2	hom	ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; ARF2 has a paralog, ARF1, that arose from the whole genome duplication
0.085	8.54E-7	YPL099C	AIM43	hom	Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss
0.081	2.82E-6	YNR028W	CPR8	hom	Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; similarity to Cpr4p suggests a potential role in the secretory pathway
0.080	3.65E-6	YPR193C	HPA2	hom	Tetrameric histone acetyltransferase with similarity to Gcn5p, Hat1p, Elp3p, and Hpa3p; acetylates histones H3 and H4 in vitro and exhibits autoacetylation activity
0.080	3.64E-6	YJL215C_d	YJL215C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.079	4.32E-6	YPR078C_p	YPR078C_p	hom	Putative protein of unknown function; possible role in DNA metabolism and/or in genome stability; expression is heat-inducible
0.079	4.40E-6	YLR145W	RMP1	het	Subunit of RNase MRP, which processes pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; unlike most subunits, not shared between RNase MRP and nuclear RNase P
0.077	8.31E-6	YOR074C	CDC21	het	Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S
0.077	8.71E-6	YER176W	ECM32	hom	DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes
0.076	1.10E-5	YLL048C	YBT1	hom	Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates the release of lumenal Ca2+ stores; similar to mammalian bile transporters
0.074	1.60E-5	YIL102C_p	YIL102C_p	hom	Putative protein of unknown function
0.073	2.17E-5	YMR041C	ARA2	hom	NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase