YBR076W / ECM8

Non-essential protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR076W / ECM8

Click on Significant Values for Screen Details ID:SGTC_38|Compound:0929-0051|FD-Score:-3.70|P-value:1.06E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:-3.24|P-value:5.90E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:-3.56|P-value:1.83E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:3.14|P-value:9.85E-4 ID:SGTC_480|Compound:am 92016|FD-Score:3.25|P-value:6.60E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:-3.59|P-value:1.59E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:3.45|P-value:3.25E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:3.22|P-value:7.47E-4 ID:SGTC_906|Compound:1165-0455|FD-Score:3.77|P-value:9.88E-5 ID:SGTC_1063|Compound:disulfiram|FD-Score:4.32|P-value:9.73E-6 ID:SGTC_1074|Compound:carmofur|FD-Score:5.01|P-value:3.51E-7 ID:SGTC_1140|Compound:3229-1848|FD-Score:3.72|P-value:1.18E-4 ID:SGTC_1328|Compound:1441-0025|FD-Score:3.68|P-value:1.37E-4 ID:SGTC_1423|Compound:4048-0112|FD-Score:3.80|P-value:8.73E-5 ID:SGTC_1481|Compound:3346-2004|FD-Score:3.20|P-value:7.83E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.74|P-value:1.09E-4 ID:SGTC_1667|Compound:st014849|FD-Score:3.99|P-value:4.06E-5 ID:SGTC_1958|Compound:st076513|FD-Score:5.47|P-value:3.05E-8 ID:SGTC_2010|Compound:4012422|FD-Score:-3.75|P-value:8.56E-5 ID:SGTC_2049|Compound:5262831|FD-Score:7.16|P-value:6.63E-13 ID:SGTC_2092|Compound:5303694|FD-Score:3.28|P-value:6.14E-4 ID:SGTC_2244|Compound:6635614|FD-Score:3.46|P-value:3.23E-4 ID:SGTC_2280|Compound:7785178|FD-Score:3.86|P-value:6.82E-5 ID:SGTC_2330|Compound:7979373|FD-Score:-4.34|P-value:6.95E-6 ID:SGTC_2332|Compound:7982454|FD-Score:6.02|P-value:1.25E-9 ID:SGTC_2334|Compound:9017922|FD-Score:5.84|P-value:3.58E-9 ID:SGTC_2335|Compound:9018011|FD-Score:-4.05|P-value:2.48E-5 ID:SGTC_2378|Compound:9074213|FD-Score:3.25|P-value:6.71E-4 ID:SGTC_2380|Compound:9035439|FD-Score:-3.31|P-value:4.56E-4 ID:SGTC_2394|Compound:5221648|FD-Score:3.19|P-value:8.20E-4 ID:SGTC_2397|Compound:5161689|FD-Score:3.32|P-value:5.20E-4 ID:SGTC_2404|Compound:5161160|FD-Score:4.91|P-value:5.98E-7 ID:SGTC_2782|Compound:7736369|FD-Score:-4.41|P-value:5.21E-6 ID:SGTC_2783|Compound:7738165|FD-Score:5.39|P-value:4.73E-8 ID:SGTC_2794|Compound:7785382|FD-Score:-3.26|P-value:5.37E-4 ID:SGTC_2801|Compound:7907800|FD-Score:-3.37|P-value:3.61E-4 ID:SGTC_2990|Compound:9074105|FD-Score:3.35|P-value:4.69E-4 ID:SGTC_3300|Compound:9124615|FD-Score:3.29|P-value:5.93E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:-3.70|P-value:1.06E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:-3.24|P-value:5.90E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:-3.56|P-value:1.83E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:3.14|P-value:9.85E-4 ID:SGTC_480|Compound:am 92016|FD-Score:3.25|P-value:6.60E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:-3.59|P-value:1.59E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:3.45|P-value:3.25E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:3.22|P-value:7.47E-4 ID:SGTC_906|Compound:1165-0455|FD-Score:3.77|P-value:9.88E-5 ID:SGTC_1063|Compound:disulfiram|FD-Score:4.32|P-value:9.73E-6 ID:SGTC_1074|Compound:carmofur|FD-Score:5.01|P-value:3.51E-7 ID:SGTC_1140|Compound:3229-1848|FD-Score:3.72|P-value:1.18E-4 ID:SGTC_1328|Compound:1441-0025|FD-Score:3.68|P-value:1.37E-4 ID:SGTC_1423|Compound:4048-0112|FD-Score:3.80|P-value:8.73E-5 ID:SGTC_1481|Compound:3346-2004|FD-Score:3.20|P-value:7.83E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.74|P-value:1.09E-4 ID:SGTC_1667|Compound:st014849|FD-Score:3.99|P-value:4.06E-5 ID:SGTC_1958|Compound:st076513|FD-Score:5.47|P-value:3.05E-8 ID:SGTC_2010|Compound:4012422|FD-Score:-3.75|P-value:8.56E-5 ID:SGTC_2049|Compound:5262831|FD-Score:7.16|P-value:6.63E-13 ID:SGTC_2092|Compound:5303694|FD-Score:3.28|P-value:6.14E-4 ID:SGTC_2244|Compound:6635614|FD-Score:3.46|P-value:3.23E-4 ID:SGTC_2280|Compound:7785178|FD-Score:3.86|P-value:6.82E-5 ID:SGTC_2330|Compound:7979373|FD-Score:-4.34|P-value:6.95E-6 ID:SGTC_2332|Compound:7982454|FD-Score:6.02|P-value:1.25E-9 ID:SGTC_2334|Compound:9017922|FD-Score:5.84|P-value:3.58E-9 ID:SGTC_2335|Compound:9018011|FD-Score:-4.05|P-value:2.48E-5 ID:SGTC_2378|Compound:9074213|FD-Score:3.25|P-value:6.71E-4 ID:SGTC_2380|Compound:9035439|FD-Score:-3.31|P-value:4.56E-4 ID:SGTC_2394|Compound:5221648|FD-Score:3.19|P-value:8.20E-4 ID:SGTC_2397|Compound:5161689|FD-Score:3.32|P-value:5.20E-4 ID:SGTC_2404|Compound:5161160|FD-Score:4.91|P-value:5.98E-7 ID:SGTC_2782|Compound:7736369|FD-Score:-4.41|P-value:5.21E-6 ID:SGTC_2783|Compound:7738165|FD-Score:5.39|P-value:4.73E-8 ID:SGTC_2794|Compound:7785382|FD-Score:-3.26|P-value:5.37E-4 ID:SGTC_2801|Compound:7907800|FD-Score:-3.37|P-value:3.61E-4 ID:SGTC_2990|Compound:9074105|FD-Score:3.35|P-value:4.69E-4 ID:SGTC_3300|Compound:9124615|FD-Score:3.29|P-value:5.93E-4

Top fitness defect scores for YBR076W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2049 5262831 7.16 67.2 µM 6.63E-13 2 4.17E-13
2 SGTC_2332 7982454 6.02 138.9 µM 1.25E-9 16 8.74E-10
3 SGTC_2334 9017922 5.84 200.0 µM 3.58E-9 2 2.55E-9
4 SGTC_1958 st076513 5.47 41.9 µM 3.05E-8 60S ribosome export 12 2.24E-8
5 SGTC_2783 7738165 5.39 71.4 µM 4.73E-8 8 3.50E-8
6 SGTC_1074 carmofur 5.01 3.8 µM 3.51E-7 exosome 7 2.67E-7
7 SGTC_2404 5161160 4.91 200.0 µM 5.98E-7 7 4.60E-7
8 SGTC_1063 disulfiram 4.32 1.8 µM 9.73E-6 15 7.81E-6
9 SGTC_1667 st014849 3.99 34.6 µM 4.06E-5 Golgi 7 3.33E-5
10 SGTC_2280 7785178 3.86 200.0 µM 6.82E-5 11 5.65E-5
11 SGTC_1423 4048-0112 3.80 5.6 µM 8.73E-5 26 7.26E-5
12 SGTC_906 1165-0455 3.77 526.0 µM 9.88E-5 14 8.24E-5
13 SGTC_1635 st007035 3.74 42.4 µM 1.09E-4 226 9.06E-5
14 SGTC_1140 3229-1848 3.72 3.0 µM 1.18E-4 13 9.84E-5
15 SGTC_1328 1441-0025 3.68 69.2 µM 1.37E-4 12 1.15E-4
16 SGTC_2244 6635614 3.46 200.0 µM 3.23E-4 10 2.75E-4
17 SGTC_733 4069-0007 3.45 56.1 µM 3.25E-4 ERAD & cell cycle 112 2.76E-4
18 SGTC_2990 9074105 3.35 71.4 µM 4.69E-4 17 4.01E-4
19 SGTC_2397 5161689 3.32 200.0 µM 5.20E-4 63 4.45E-4
20 SGTC_3300 9124615 3.29 50.5 µM 5.93E-4 41 5.09E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.117 1.20E-11 YNR018W RCF2 hom Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast
0.111 1.40E-10 YPL249C GYP5 hom GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.106 6.83E-10 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.103 2.04E-9 YBR047W_p FMP23_p hom Putative protein of unknown function; proposed to be involved in iron or copper homeostasis; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.097 1.58E-8 YKR102W FLO10 hom Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth
0.097 1.60E-8 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.096 2.15E-8 YPR076W_d YPR076W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.093 7.56E-8 YGR066C_p YGR066C_p hom Putative protein of unknown function
0.091 1.42E-7 YLR314C CDC3 het Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble with other septins into rod-like complexes that can associate with other rods to form filament polymers; septin rings at the mother-bud neck act as scaffolds for recruiting factors needed for cell division and as barriers to prevent diffusion of specific proteins between mother and daughter cells
0.089 2.57E-7 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.086 5.58E-7 YGL191W COX13 hom Subunit VIa of cytochrome c oxidase; present in a subclass of cytochrome c oxidase complexes that may have a role in mimimizing generation of reactive oxygen species; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP; required for assembly of Rcf2p into cytochrome c oxidase - cytochrome bc1 supercomplexes
0.086 6.20E-7 YBL029W_p YBL029W_p hom Non-essential protein of unknown function
0.084 9.99E-7 YKR089C TGL4 hom Multifunctional triacylglycerol lipase, steryl ester hydrolase, and Ca2+-independent phospholipase A2; catalyzes acyl-CoA dependent acylation of LPA to PA; required with Tgl3p for timely bud formation; phosphorylated and activated by Cdc28p
0.084 1.20E-6 YOR239W ABP140 hom AdoMet-dependent tRNA methyltransferase and actin binding protein; C-terminal domain is responsible for 3-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA-Thr and tRNA-Ser and contains an S-adenosylmethionine (AdoMet) binding motif; N-terminal actin binding sequence interacts with actin filaments and localizes to actin patches and cables; N- and C-terminal domains are encoded in separate ORFs that are translated into one protein via a +1 frameshift
0.083 1.47E-6 YOR220W RCN2 hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; phosphorylated in response to alpha factor; protein abundance increases in response to DNA replication stress