YBR078W / ECM33

GPI-anchored protein of unknown function, has a possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p and Pst1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR078W / ECM33

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-4.49|P-value:8.55E-5 ID:SGTC_69|Compound:0096-0274|FD-Score:4.63|P-value:1.32E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:4.96|P-value:4.58E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:4.26|P-value:4.07E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:4.86|P-value:6.45E-5 ID:SGTC_127|Compound:0180-0333|FD-Score:13.50|P-value:9.16E-28 ID:SGTC_132|Compound:0417-1715|FD-Score:-3.92|P-value:4.95E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:7.59|P-value:7.26E-10 ID:SGTC_150|Compound:3970-0969|FD-Score:7.31|P-value:2.90E-9 ID:SGTC_168|Compound:3970-0862|FD-Score:5.89|P-value:1.54E-6 ID:SGTC_184|Compound:1494-0393|FD-Score:16.00|P-value:3.74E-38 ID:SGTC_194|Compound:1486-1323|FD-Score:4.22|P-value:4.60E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:8.25|P-value:2.33E-11 ID:SGTC_252|Compound:miconazole|FD-Score:-5.47|P-value:2.62E-6 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.05|P-value:3.38E-5 ID:SGTC_282|Compound:k297-0036|FD-Score:-5.26|P-value:5.89E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:4.78|P-value:8.33E-5 ID:SGTC_332|Compound:4112-0506|FD-Score:4.74|P-value:9.29E-5 ID:SGTC_365|Compound:0121-0052|FD-Score:8.95|P-value:4.29E-13 ID:SGTC_372|Compound:0155-0182|FD-Score:5.90|P-value:1.45E-6 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.67|P-value:9.85E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:5.56|P-value:5.46E-6 ID:SGTC_383|Compound:2324-0395|FD-Score:6.52|P-value:1.14E-7 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.99|P-value:8.79E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-11.70|P-value:4.55E-22 ID:SGTC_690|Compound:glyoxal|FD-Score:5.95|P-value:1.23E-6 ID:SGTC_692|Compound:k241-0027|FD-Score:-4.46|P-value:9.57E-5 ID:SGTC_760|Compound:0568-0725|FD-Score:-5.06|P-value:1.22E-5 ID:SGTC_839|Compound:0122-0028|FD-Score:4.30|P-value:3.69E-4 ID:SGTC_889|Compound:0919-1524|FD-Score:-3.91|P-value:5.05E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:3.98|P-value:9.22E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:7.94|P-value:1.20E-10 ID:SGTC_927|Compound:2425-1185|FD-Score:-4.80|P-value:3.04E-5 ID:SGTC_933|Compound:2914-0560|FD-Score:6.42|P-value:1.73E-7 ID:SGTC_969|Compound:1313-0238|FD-Score:6.12|P-value:6.13E-7 ID:SGTC_1123|Compound:mangostin|FD-Score:15.80|P-value:1.96E-37 ID:SGTC_1240|Compound:0356-0016|FD-Score:9.05|P-value:2.38E-13 ID:SGTC_1347|Compound:1493-0251|FD-Score:6.19|P-value:4.56E-7 ID:SGTC_1398|Compound:3558-0053|FD-Score:3.97|P-value:9.27E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:-9.31|P-value:8.75E-15 ID:SGTC_1493|Compound:4348-0038|FD-Score:4.13|P-value:5.95E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:7.14|P-value:6.74E-9 ID:SGTC_1621|Compound:st003705|FD-Score:5.17|P-value:2.21E-5 ID:SGTC_1715|Compound:st032160|FD-Score:-4.53|P-value:7.58E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.83|P-value:6.32E-4 ID:SGTC_1784|Compound:st039334|FD-Score:4.37|P-value:2.96E-4 ID:SGTC_1804|Compound:st050076|FD-Score:4.02|P-value:8.26E-4 ID:SGTC_1806|Compound:st050005|FD-Score:4.60|P-value:1.47E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.26|P-value:4.10E-4 ID:SGTC_1866|Compound:st057638|FD-Score:5.28|P-value:1.52E-5 ID:SGTC_1998|Compound:st075797|FD-Score:5.66|P-value:3.74E-6 ID:SGTC_2054|Compound:5233173|FD-Score:7.45|P-value:1.50E-9 ID:SGTC_2328|Compound:6201408|FD-Score:4.73|P-value:9.90E-5 ID:SGTC_2332|Compound:7982454|FD-Score:-3.88|P-value:5.48E-4 ID:SGTC_2344|Compound:7990960|FD-Score:-3.90|P-value:5.24E-4 ID:SGTC_2348|Compound:9022543|FD-Score:6.03|P-value:8.60E-7 ID:SGTC_2396|Compound:5342950|FD-Score:4.32|P-value:3.51E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:5.93|P-value:1.31E-6 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:6.12|P-value:5.96E-7 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.53|P-value:1.85E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:6.93|P-value:1.80E-8 ID:SGTC_2612|Compound:dictamnine|FD-Score:4.56|P-value:1.68E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:4.55|P-value:1.73E-4 ID:SGTC_2641|Compound:levomentholum|FD-Score:-3.74|P-value:8.29E-4 ID:SGTC_2646|Compound:retinol|FD-Score:-3.72|P-value:8.71E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:8.26|P-value:2.23E-11 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.79|P-value:2.23E-6 ID:SGTC_2702|Compound:st077768|FD-Score:5.66|P-value:3.66E-6 ID:SGTC_2703|Compound:st077852|FD-Score:4.14|P-value:5.76E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:4.99|P-value:4.19E-5 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:-4.25|P-value:1.85E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:6.02|P-value:9.13E-7 ID:SGTC_2905|Compound:7799065|FD-Score:-8.54|P-value:9.50E-13 ID:SGTC_2911|Compound:7942208|FD-Score:7.55|P-value:9.23E-10 ID:SGTC_2925|Compound:9010536|FD-Score:4.40|P-value:2.73E-4 ID:SGTC_2930|Compound:9013230|FD-Score:4.38|P-value:2.86E-4 ID:SGTC_2937|Compound:9044753|FD-Score:4.35|P-value:3.18E-4 ID:SGTC_2965|Compound:9082772|FD-Score:8.36|P-value:1.29E-11 ID:SGTC_2980|Compound:9014342|FD-Score:-3.90|P-value:5.29E-4 ID:SGTC_3062|Compound:9077494|FD-Score:5.56|P-value:5.43E-6 ID:SGTC_3168|Compound:9103419|FD-Score:-3.89|P-value:5.37E-4 ID:SGTC_3181|Compound:9108277|FD-Score:-5.01|P-value:1.46E-5 ID:SGTC_3187|Compound:9109394|FD-Score:4.30|P-value:3.63E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.49|P-value:8.55E-5 ID:SGTC_69|Compound:0096-0274|FD-Score:4.63|P-value:1.32E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:4.96|P-value:4.58E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:4.26|P-value:4.07E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:4.86|P-value:6.45E-5 ID:SGTC_127|Compound:0180-0333|FD-Score:13.50|P-value:9.16E-28 ID:SGTC_132|Compound:0417-1715|FD-Score:-3.92|P-value:4.95E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:7.59|P-value:7.26E-10 ID:SGTC_150|Compound:3970-0969|FD-Score:7.31|P-value:2.90E-9 ID:SGTC_168|Compound:3970-0862|FD-Score:5.89|P-value:1.54E-6 ID:SGTC_184|Compound:1494-0393|FD-Score:16.00|P-value:3.74E-38 ID:SGTC_194|Compound:1486-1323|FD-Score:4.22|P-value:4.60E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:8.25|P-value:2.33E-11 ID:SGTC_252|Compound:miconazole|FD-Score:-5.47|P-value:2.62E-6 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.05|P-value:3.38E-5 ID:SGTC_282|Compound:k297-0036|FD-Score:-5.26|P-value:5.89E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:4.78|P-value:8.33E-5 ID:SGTC_332|Compound:4112-0506|FD-Score:4.74|P-value:9.29E-5 ID:SGTC_365|Compound:0121-0052|FD-Score:8.95|P-value:4.29E-13 ID:SGTC_372|Compound:0155-0182|FD-Score:5.90|P-value:1.45E-6 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.67|P-value:9.85E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:5.56|P-value:5.46E-6 ID:SGTC_383|Compound:2324-0395|FD-Score:6.52|P-value:1.14E-7 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.99|P-value:8.79E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-11.70|P-value:4.55E-22 ID:SGTC_690|Compound:glyoxal|FD-Score:5.95|P-value:1.23E-6 ID:SGTC_692|Compound:k241-0027|FD-Score:-4.46|P-value:9.57E-5 ID:SGTC_760|Compound:0568-0725|FD-Score:-5.06|P-value:1.22E-5 ID:SGTC_839|Compound:0122-0028|FD-Score:4.30|P-value:3.69E-4 ID:SGTC_889|Compound:0919-1524|FD-Score:-3.91|P-value:5.05E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:3.98|P-value:9.22E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:7.94|P-value:1.20E-10 ID:SGTC_927|Compound:2425-1185|FD-Score:-4.80|P-value:3.04E-5 ID:SGTC_933|Compound:2914-0560|FD-Score:6.42|P-value:1.73E-7 ID:SGTC_969|Compound:1313-0238|FD-Score:6.12|P-value:6.13E-7 ID:SGTC_1123|Compound:mangostin|FD-Score:15.80|P-value:1.96E-37 ID:SGTC_1240|Compound:0356-0016|FD-Score:9.05|P-value:2.38E-13 ID:SGTC_1347|Compound:1493-0251|FD-Score:6.19|P-value:4.56E-7 ID:SGTC_1398|Compound:3558-0053|FD-Score:3.97|P-value:9.27E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:-9.31|P-value:8.75E-15 ID:SGTC_1493|Compound:4348-0038|FD-Score:4.13|P-value:5.95E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:7.14|P-value:6.74E-9 ID:SGTC_1621|Compound:st003705|FD-Score:5.17|P-value:2.21E-5 ID:SGTC_1715|Compound:st032160|FD-Score:-4.53|P-value:7.58E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.83|P-value:6.32E-4 ID:SGTC_1784|Compound:st039334|FD-Score:4.37|P-value:2.96E-4 ID:SGTC_1804|Compound:st050076|FD-Score:4.02|P-value:8.26E-4 ID:SGTC_1806|Compound:st050005|FD-Score:4.60|P-value:1.47E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.26|P-value:4.10E-4 ID:SGTC_1866|Compound:st057638|FD-Score:5.28|P-value:1.52E-5 ID:SGTC_1998|Compound:st075797|FD-Score:5.66|P-value:3.74E-6 ID:SGTC_2054|Compound:5233173|FD-Score:7.45|P-value:1.50E-9 ID:SGTC_2328|Compound:6201408|FD-Score:4.73|P-value:9.90E-5 ID:SGTC_2332|Compound:7982454|FD-Score:-3.88|P-value:5.48E-4 ID:SGTC_2344|Compound:7990960|FD-Score:-3.90|P-value:5.24E-4 ID:SGTC_2348|Compound:9022543|FD-Score:6.03|P-value:8.60E-7 ID:SGTC_2396|Compound:5342950|FD-Score:4.32|P-value:3.51E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:5.93|P-value:1.31E-6 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:6.12|P-value:5.96E-7 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.53|P-value:1.85E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:6.93|P-value:1.80E-8 ID:SGTC_2612|Compound:dictamnine|FD-Score:4.56|P-value:1.68E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:4.55|P-value:1.73E-4 ID:SGTC_2641|Compound:levomentholum|FD-Score:-3.74|P-value:8.29E-4 ID:SGTC_2646|Compound:retinol|FD-Score:-3.72|P-value:8.71E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:8.26|P-value:2.23E-11 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.79|P-value:2.23E-6 ID:SGTC_2702|Compound:st077768|FD-Score:5.66|P-value:3.66E-6 ID:SGTC_2703|Compound:st077852|FD-Score:4.14|P-value:5.76E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:4.99|P-value:4.19E-5 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:-4.25|P-value:1.85E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:6.02|P-value:9.13E-7 ID:SGTC_2905|Compound:7799065|FD-Score:-8.54|P-value:9.50E-13 ID:SGTC_2911|Compound:7942208|FD-Score:7.55|P-value:9.23E-10 ID:SGTC_2925|Compound:9010536|FD-Score:4.40|P-value:2.73E-4 ID:SGTC_2930|Compound:9013230|FD-Score:4.38|P-value:2.86E-4 ID:SGTC_2937|Compound:9044753|FD-Score:4.35|P-value:3.18E-4 ID:SGTC_2965|Compound:9082772|FD-Score:8.36|P-value:1.29E-11 ID:SGTC_2980|Compound:9014342|FD-Score:-3.90|P-value:5.29E-4 ID:SGTC_3062|Compound:9077494|FD-Score:5.56|P-value:5.43E-6 ID:SGTC_3168|Compound:9103419|FD-Score:-3.89|P-value:5.37E-4 ID:SGTC_3181|Compound:9108277|FD-Score:-5.01|P-value:1.46E-5 ID:SGTC_3187|Compound:9109394|FD-Score:4.30|P-value:3.63E-4

Top fitness defect scores for YBR078W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_184 1494-0393 16.00 24.7 µM 3.74E-38 2 7.81E-58
2 SGTC_1123 mangostin 15.80 811.3 nM 1.96E-37 mitochondrial response to ROS 1 9.83E-57
3 SGTC_127 0180-0333 13.50 59.1 µM 9.16E-28 mitochondrial response to ROS 1 6.03E-42
4 SGTC_1240 0356-0016 9.05 42.1 µM 2.38E-13 mitochondrial response to ROS 3 7.09E-20
5 SGTC_365 0121-0052 8.95 13.6 µM 4.29E-13 mitochondrial response to ROS 3 1.75E-19
6 SGTC_2965 9082772 8.36 38.6 µM 1.29E-11 mitochondrial response to ROS 4 3.21E-17
7 SGTC_2679 rapamycin 8.26 1.0 nM 2.23E-11 39 7.46E-17
8 SGTC_217 ketoconazole 8.25 989.0 nM 2.33E-11 ergosterol depletion effects on membrane 1 7.94E-17
9 SGTC_908 3448-7491 7.94 47.7 µM 1.20E-10 mitochondrial stress 18 9.79E-16
10 SGTC_141 0443-0274 7.59 32.3 µM 7.26E-10 mitochondrial response to ROS 11 1.55E-14
11 SGTC_2911 7942208 7.55 15.6 µM 9.23E-10 mitochondrial response to ROS 1 2.24E-14
12 SGTC_2054 5233173 7.45 129.0 µM 1.50E-9 mitochondrial response to ROS 9 4.74E-14
13 SGTC_150 3970-0969 7.31 77.2 µM 2.90E-9 10 1.30E-13
14 SGTC_1597 7-benzyloxygramine 7.14 47.5 µM 6.74E-9 calcium & mitochondrial duress 35 4.72E-13
15 SGTC_2587 piperic acid 6.93 92.2 µM 1.80E-8 1 2.13E-12
16 SGTC_383 2324-0395 6.52 7.4 µM 1.14E-7 azole & statin 13 3.58E-11
17 SGTC_933 2914-0560 6.42 114.0 µM 1.73E-7 9 6.83E-11
18 SGTC_1347 1493-0251 6.19 600.0 nM 4.56E-7 mitochondrial response to ROS 2 3.02E-10
19 SGTC_2538 3',7'-epoxycaryophyllan-6-one 6.12 100.0 µM 5.96E-7 2 4.55E-10
20 SGTC_969 1313-0238 6.12 134.0 µM 6.13E-7 mitochondrial processes 4 4.75E-10

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.359 1.39E-102 YFL036W RPO41 hom Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.271 1.23E-57 YOR101W RAS1 hom GTPase involved in G-protein signaling in adenylate cyclase activation; plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes; relative distribution to the nucleus increases upon DNA replication stress
0.200 9.86E-32 YKL139W CTK1 hom Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I); phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity; similar to the Drosophila dCDK12 and human CDK12 and probably CDK13
0.155 2.14E-19 YHR045W_p YHR045W_p hom Putative protein of unknown function; possible role in iron metabolism and/or amino acid and carbohydrate metabolism; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum
0.152 1.05E-18 YBR110W ALG1 het Mannosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability, mutation is functionally complemented by human ortholog
0.149 4.26E-18 YGL252C RTG2 hom Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p
0.137 1.66E-15 YPL170W DAP1 hom Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis
0.137 2.22E-15 YJL101C GSH1 hom Gamma glutamylcysteine synthetase; catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury; protein abundance increases in response to DNA replication stress
0.134 7.73E-15 YDR158W HOM2 hom Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.129 5.58E-14 YGR257C MTM1 hom Mitochondrial protein of the mitochondrial carrier family, involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor
0.128 8.93E-14 YPL262W FUM1 hom Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria
0.123 8.78E-13 YNR015W SMM1 hom Dihydrouridine synthase, member of a family of dihydrouridine synthases including Dus1p, Smm1p, Dus3p, and Dus4p; modifies uridine residues at position 20 of cytoplasmic tRNAs
0.123 8.86E-13 YJL054W TIM54 het Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane
0.123 9.41E-13 YJL046W AIM22 hom Putative lipoate-protein ligase, required along with Lip2 and Lip5 for lipoylation of Lat1p and Kgd2p; similar to E. coli LplA; null mutant displays reduced frequency of mitochondrial genome loss
0.116 1.85E-11 YDR115W YDR115W hom Putative mitochondrial ribosomal protein of the large subunit; similar to E. coli L34 ribosomal protein; required for respiratory growth, as are most mitochondrial ribosomal proteins; protein increases in abundance and relocalizes to the plasma membrane upon DNA replication stress