YBR079C / RPG1

eIF3a subunit of the core complex of translation initiation factor 3 (eIF3), essential for translation; part of a Prt1p-Rpg1p-Nip1p subcomplex that stimulates binding of mRNA and tRNA(i)Met to ribosomes; involved in translation reinitiation

Zygosity: Heterozygous strain
fixedexpanded
Profile for YBR079C / RPG1

Click on Significant Values for Screen Details ID:SGTC_234|Compound:nsc-17383|FD-Score:-3.77|P-value:1.57E-5 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:5.64|P-value:2.41E-10 ID:SGTC_385|Compound:1494-0393|FD-Score:3.45|P-value:6.79E-5 ID:SGTC_403|Compound:arphamenine a|FD-Score:3.20|P-value:2.08E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:3.03|P-value:4.07E-4 ID:SGTC_809|Compound:3998-0021|FD-Score:3.35|P-value:1.07E-4 ID:SGTC_904|Compound:1141-0088|FD-Score:2.99|P-value:4.72E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:3.60|P-value:3.53E-5 ID:SGTC_1090|Compound:efavirenz|FD-Score:2.93|P-value:6.17E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:3.59|P-value:3.59E-5 ID:SGTC_1184|Compound:1269-1718|FD-Score:2.85|P-value:8.08E-4 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.45|P-value:6.93E-5 ID:SGTC_1306|Compound:1185-0270|FD-Score:2.87|P-value:7.75E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:3.99|P-value:5.24E-6 ID:SGTC_1600|Compound:coumarin 106|FD-Score:-3.33|P-value:1.21E-4 ID:SGTC_1618|Compound:st003135|FD-Score:3.77|P-value:1.59E-5 ID:SGTC_1675|Compound:st018485|FD-Score:3.02|P-value:4.22E-4 ID:SGTC_1871|Compound:st057448|FD-Score:-4.24|P-value:1.47E-6 ID:SGTC_1912|Compound:st060209|FD-Score:5.25|P-value:3.41E-9 ID:SGTC_1966|Compound:st070145|FD-Score:-3.14|P-value:2.65E-4 ID:SGTC_1968|Compound:st069590|FD-Score:3.18|P-value:2.22E-4 ID:SGTC_2056|Compound:5235370|FD-Score:3.35|P-value:1.08E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-2.99|P-value:4.90E-4 ID:SGTC_2271|Compound:7849410|FD-Score:3.35|P-value:1.09E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-3.96|P-value:6.19E-6 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:-3.96|P-value:6.05E-6 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-2.87|P-value:7.56E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:-3.38|P-value:9.48E-5 ID:SGTC_2686|Compound:alizarin|FD-Score:-2.80|P-value:9.88E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:-4.32|P-value:9.56E-7 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:-3.58|P-value:3.84E-5 ID:SGTC_2776|Compound:terbinafine|FD-Score:-4.18|P-value:1.93E-6 ID:SGTC_2781|Compound:5567276|FD-Score:3.11|P-value:2.97E-4 ID:SGTC_2798|Compound:7813637|FD-Score:5.00|P-value:1.72E-8 ID:SGTC_2821|Compound:7996764|FD-Score:-3.52|P-value:5.15E-5 ID:SGTC_2825|Compound:7998094|FD-Score:2.87|P-value:7.75E-4 ID:SGTC_2835|Compound:9006588|FD-Score:-3.32|P-value:1.26E-4 ID:SGTC_2944|Compound:9067346|FD-Score:-3.92|P-value:7.54E-6 ID:SGTC_2947|Compound:9072639|FD-Score:-2.98|P-value:4.99E-4 ID:SGTC_3072|Compound:9116419|FD-Score:-3.53|P-value:4.81E-5 ID:SGTC_3150|Compound:9097574|FD-Score:3.69|P-value:2.35E-5 ID:SGTC_3159|Compound:9100096|FD-Score:-2.88|P-value:7.55E-4 ID:SGTC_3326|Compound:9140064|FD-Score:4.18|P-value:1.97E-6 ID:SGTC_3350|Compound:9150499|FD-Score:-2.97|P-value:5.15E-4 ID:SGTC_234|Compound:nsc-17383|FD-Score:-3.77|P-value:1.57E-5 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:5.64|P-value:2.41E-10 ID:SGTC_385|Compound:1494-0393|FD-Score:3.45|P-value:6.79E-5 ID:SGTC_403|Compound:arphamenine a|FD-Score:3.20|P-value:2.08E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:3.03|P-value:4.07E-4 ID:SGTC_809|Compound:3998-0021|FD-Score:3.35|P-value:1.07E-4 ID:SGTC_904|Compound:1141-0088|FD-Score:2.99|P-value:4.72E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:3.60|P-value:3.53E-5 ID:SGTC_1090|Compound:efavirenz|FD-Score:2.93|P-value:6.17E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:3.59|P-value:3.59E-5 ID:SGTC_1184|Compound:1269-1718|FD-Score:2.85|P-value:8.08E-4 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.45|P-value:6.93E-5 ID:SGTC_1306|Compound:1185-0270|FD-Score:2.87|P-value:7.75E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:3.99|P-value:5.24E-6 ID:SGTC_1600|Compound:coumarin 106|FD-Score:-3.33|P-value:1.21E-4 ID:SGTC_1618|Compound:st003135|FD-Score:3.77|P-value:1.59E-5 ID:SGTC_1675|Compound:st018485|FD-Score:3.02|P-value:4.22E-4 ID:SGTC_1871|Compound:st057448|FD-Score:-4.24|P-value:1.47E-6 ID:SGTC_1912|Compound:st060209|FD-Score:5.25|P-value:3.41E-9 ID:SGTC_1966|Compound:st070145|FD-Score:-3.14|P-value:2.65E-4 ID:SGTC_1968|Compound:st069590|FD-Score:3.18|P-value:2.22E-4 ID:SGTC_2056|Compound:5235370|FD-Score:3.35|P-value:1.08E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-2.99|P-value:4.90E-4 ID:SGTC_2271|Compound:7849410|FD-Score:3.35|P-value:1.09E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-3.96|P-value:6.19E-6 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:-3.96|P-value:6.05E-6 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-2.87|P-value:7.56E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:-3.38|P-value:9.48E-5 ID:SGTC_2686|Compound:alizarin|FD-Score:-2.80|P-value:9.88E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:-4.32|P-value:9.56E-7 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:-3.58|P-value:3.84E-5 ID:SGTC_2776|Compound:terbinafine|FD-Score:-4.18|P-value:1.93E-6 ID:SGTC_2781|Compound:5567276|FD-Score:3.11|P-value:2.97E-4 ID:SGTC_2798|Compound:7813637|FD-Score:5.00|P-value:1.72E-8 ID:SGTC_2821|Compound:7996764|FD-Score:-3.52|P-value:5.15E-5 ID:SGTC_2825|Compound:7998094|FD-Score:2.87|P-value:7.75E-4 ID:SGTC_2835|Compound:9006588|FD-Score:-3.32|P-value:1.26E-4 ID:SGTC_2944|Compound:9067346|FD-Score:-3.92|P-value:7.54E-6 ID:SGTC_2947|Compound:9072639|FD-Score:-2.98|P-value:4.99E-4 ID:SGTC_3072|Compound:9116419|FD-Score:-3.53|P-value:4.81E-5 ID:SGTC_3150|Compound:9097574|FD-Score:3.69|P-value:2.35E-5 ID:SGTC_3159|Compound:9100096|FD-Score:-2.88|P-value:7.55E-4 ID:SGTC_3326|Compound:9140064|FD-Score:4.18|P-value:1.97E-6 ID:SGTC_3350|Compound:9150499|FD-Score:-2.97|P-value:5.15E-4

Top fitness defect scores for YBR079C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_243 5hr heat shock (37°C) + splitomicin 5.64 1.0 µM 2.41E-10 heat shock/prefoldin 1 8.66E-9 1.00
2 SGTC_1912 st060209 5.25 90.8 µM 3.41E-9 4 7.70E-8 0.16
3 SGTC_2798 7813637 5.00 45.5 µM 1.72E-8 7 2.93E-7 0.17
4 SGTC_3326 9140064 4.18 16.4 µM 1.97E-6 5 1.47E-5 0.36
5 SGTC_1465 k213-0056 3.99 144.0 µM 5.24E-6 DNA intercalators 9 3.30E-5 0.02
6 SGTC_1618 st003135 3.77 44.5 µM 1.59E-5 4 8.26E-5 0.10
7 SGTC_3150 9097574 3.69 49.5 µM 2.35E-5 5 1.14E-4 0.13
8 SGTC_962 1254-0300 3.60 21.5 µM 3.53E-5 3 1.60E-4 0.05
9 SGTC_1130 3454-2858 3.59 15.9 µM 3.59E-5 NEO1 14 1.62E-4 0.02
10 SGTC_385 1494-0393 3.45 12.4 µM 6.79E-5 7 2.76E-4 0.17
11 SGTC_1199 1638-0010 3.45 4.5 µM 6.93E-5 endomembrane recycling 5 2.80E-4 0.01
12 SGTC_809 3998-0021 3.35 90.0 µM 1.07E-4 RNA processing & uracil transport 14 4.01E-4 0.01
13 SGTC_2056 5235370 3.35 200.0 µM 1.08E-4 10 4.04E-4 0.08
14 SGTC_2271 7849410 3.35 118.6 µM 1.09E-4 3 4.08E-4 0.09
15 SGTC_403 arphamenine a 3.20 50.0 µM 2.08E-4 60S ribosome export 13 6.98E-4 0.12
16 SGTC_1968 st069590 3.18 43.6 µM 2.22E-4 25 7.36E-4 0.11
17 SGTC_2781 5567276 3.11 71.4 µM 2.97E-4 20 9.39E-4 0.07
18 SGTC_532 1548-0774 3.03 215.0 µM 4.07E-4 15 0.00122 0.03
19 SGTC_1675 st018485 3.02 24.5 µM 4.22E-4 60S ribosome export 20 0.00126 0.00
20 SGTC_904 1141-0088 2.99 396.0 µM 4.72E-4 10 0.00138 0.03

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.112 7.18E-11 YER075C PTP3 hom Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the cytoplasm
0.103 2.50E-9 YDR260C SWM1 hom Subunit of the anaphase-promoting complex, which is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation
0.102 3.48E-9 YHR101C BIG1 het Integral membrane protein of the endoplasmic reticulum, required for normal content of cell wall beta-1,6-glucan
0.091 1.46E-7 YGL051W MST27 hom Putative integral membrane protein, involved in vesicle formation; forms complex with Mst28p; member of DUP240 gene family; binds COPI and COPII vesicles
0.088 3.49E-7 YDL078C MDH3 hom Peroxisomal malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the glyoxylate cycle
0.086 5.31E-7 YAL030W SNC1 hom Vesicle membrane receptor protein (v-SNARE); involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; proposed to be involved in endocytosis; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; SNC1 has a paralog, SNC2, that arose from the whole genome duplication
0.086 5.69E-7 YLR027C AAT2 hom Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells
0.081 2.92E-6 YLR200W YKE2 hom Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin
0.080 3.49E-6 YNL338W_d YNL338W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps TEL14L-XC, which is Telomeric X element Core sequence on the left arm of Chromosome XIV
0.080 3.66E-6 YMR240C CUS1 het Protein required for assembly of U2 snRNP into the spliceosome, forms a complex with Hsh49p and Hsh155p
0.079 5.08E-6 YAL016C-B_d YAL016C-B_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.077 8.21E-6 YKL133C_p YKL133C_p hom Putative protein of unknown function; has similarity to Mgr3p, but unlike MGR3, is not required for growth of cells lacking the mitochondrial genome (null mutation does not confer a petite-negative phenotype)
0.076 1.08E-5 YGR052W_p FMP48_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation
0.074 1.83E-5 YHR106W TRR2 hom Mitochondrial thioredoxin reductase; involved in protection against oxidative stress, required with Glr1p to maintain the redox state of Trx3p; contains active-site motif (CAVC) present in prokaryotic orthologs; binds NADPH and FAD; TRR2 has a paralog, TRR1, that arose from the whole genome duplication
0.071 3.50E-5 YHL036W MUP3 hom Low affinity methionine permease, similar to Mup1p