YBR081C / SPT7

Subunit of the SAGA transcriptional regulatory complex, involved in proper assembly of the complex; also present as a C-terminally truncated form in the SLIK/SALSA transcriptional regulatory complex

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR081C / SPT7

Click on Significant Values for Screen Details ID:SGTC_14|Compound:0354-0009|FD-Score:4.77|P-value:1.67E-5 ID:SGTC_29|Compound:0299-0004|FD-Score:4.04|P-value:2.38E-4 ID:SGTC_31|Compound:0508-1974|FD-Score:3.76|P-value:5.76E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:6.86|P-value:9.60E-10 ID:SGTC_109|Compound:0132-0036|FD-Score:5.27|P-value:2.18E-6 ID:SGTC_117|Compound:lucigenin|FD-Score:-3.80|P-value:2.54E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:3.63|P-value:8.64E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:-5.12|P-value:1.68E-6 ID:SGTC_137|Compound:0438-0332|FD-Score:-5.21|P-value:1.16E-6 ID:SGTC_207|Compound:4185-0010|FD-Score:3.73|P-value:6.41E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:4.66|P-value:2.56E-5 ID:SGTC_483|Compound:fpl-64176|FD-Score:3.61|P-value:9.20E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:4.38|P-value:7.24E-5 ID:SGTC_661|Compound:1304-0007|FD-Score:4.13|P-value:1.71E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:4.39|P-value:7.06E-5 ID:SGTC_989|Compound:1501-0895|FD-Score:-4.35|P-value:3.68E-5 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.77|P-value:5.66E-4 ID:SGTC_1141|Compound:3253-0389|FD-Score:5.91|P-value:1.25E-7 ID:SGTC_1154|Compound:4088-0362|FD-Score:4.30|P-value:9.53E-5 ID:SGTC_1228|Compound:0124-0032|FD-Score:4.02|P-value:2.50E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:4.27|P-value:1.08E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:4.55|P-value:3.89E-5 ID:SGTC_1369|Compound:1866-0067|FD-Score:3.74|P-value:6.18E-4 ID:SGTC_1375|Compound:2910-0797|FD-Score:4.09|P-value:1.98E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-4.93|P-value:3.78E-6 ID:SGTC_1877|Compound:wortmannin|FD-Score:5.06|P-value:5.31E-6 ID:SGTC_1902|Compound:st060212|FD-Score:3.76|P-value:5.77E-4 ID:SGTC_1923|Compound:st058458|FD-Score:4.10|P-value:1.93E-4 ID:SGTC_1953|Compound:st076800|FD-Score:-3.60|P-value:4.96E-4 ID:SGTC_2011|Compound:4012611|FD-Score:4.02|P-value:2.52E-4 ID:SGTC_2081|Compound:5214970|FD-Score:4.48|P-value:5.02E-5 ID:SGTC_2089|Compound:5281248|FD-Score:-4.24|P-value:5.58E-5 ID:SGTC_2219|Compound:9098279|FD-Score:-3.74|P-value:3.14E-4 ID:SGTC_2292|Compound:7671323|FD-Score:4.22|P-value:1.28E-4 ID:SGTC_2310|Compound:7668677|FD-Score:3.64|P-value:8.36E-4 ID:SGTC_2470|Compound:5664817|FD-Score:6.66|P-value:2.87E-9 ID:SGTC_2475|Compound:5812728|FD-Score:6.04|P-value:6.67E-8 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:4.34|P-value:8.48E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:-3.92|P-value:1.73E-4 ID:SGTC_2570|Compound:licareol|FD-Score:5.31|P-value:1.88E-6 ID:SGTC_2575|Compound:plumbagin|FD-Score:4.16|P-value:1.58E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:-3.38|P-value:9.58E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:5.86|P-value:1.55E-7 ID:SGTC_2752|Compound:diclazuril|FD-Score:5.57|P-value:5.82E-7 ID:SGTC_2756|Compound:carbadox|FD-Score:-3.93|P-value:1.64E-4 ID:SGTC_2795|Compound:7780010|FD-Score:-4.41|P-value:2.90E-5 ID:SGTC_2801|Compound:7907800|FD-Score:-5.87|P-value:5.37E-8 ID:SGTC_2803|Compound:7707263|FD-Score:-4.46|P-value:2.43E-5 ID:SGTC_2836|Compound:9010338|FD-Score:4.61|P-value:3.12E-5 ID:SGTC_2851|Compound:9015922|FD-Score:5.65|P-value:4.05E-7 ID:SGTC_2854|Compound:9024559|FD-Score:-3.68|P-value:3.80E-4 ID:SGTC_2858|Compound:9025781|FD-Score:4.27|P-value:1.08E-4 ID:SGTC_2911|Compound:7942208|FD-Score:4.77|P-value:1.70E-5 ID:SGTC_2930|Compound:9013230|FD-Score:-5.33|P-value:6.68E-7 ID:SGTC_3339|Compound:9145883|FD-Score:-3.60|P-value:4.95E-4 ID:SGTC_3342|Compound:9147791|FD-Score:5.09|P-value:4.63E-6 ID:SGTC_14|Compound:0354-0009|FD-Score:4.77|P-value:1.67E-5 ID:SGTC_29|Compound:0299-0004|FD-Score:4.04|P-value:2.38E-4 ID:SGTC_31|Compound:0508-1974|FD-Score:3.76|P-value:5.76E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:6.86|P-value:9.60E-10 ID:SGTC_109|Compound:0132-0036|FD-Score:5.27|P-value:2.18E-6 ID:SGTC_117|Compound:lucigenin|FD-Score:-3.80|P-value:2.54E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:3.63|P-value:8.64E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:-5.12|P-value:1.68E-6 ID:SGTC_137|Compound:0438-0332|FD-Score:-5.21|P-value:1.16E-6 ID:SGTC_207|Compound:4185-0010|FD-Score:3.73|P-value:6.41E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:4.66|P-value:2.56E-5 ID:SGTC_483|Compound:fpl-64176|FD-Score:3.61|P-value:9.20E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:4.38|P-value:7.24E-5 ID:SGTC_661|Compound:1304-0007|FD-Score:4.13|P-value:1.71E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:4.39|P-value:7.06E-5 ID:SGTC_989|Compound:1501-0895|FD-Score:-4.35|P-value:3.68E-5 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.77|P-value:5.66E-4 ID:SGTC_1141|Compound:3253-0389|FD-Score:5.91|P-value:1.25E-7 ID:SGTC_1154|Compound:4088-0362|FD-Score:4.30|P-value:9.53E-5 ID:SGTC_1228|Compound:0124-0032|FD-Score:4.02|P-value:2.50E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:4.27|P-value:1.08E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:4.55|P-value:3.89E-5 ID:SGTC_1369|Compound:1866-0067|FD-Score:3.74|P-value:6.18E-4 ID:SGTC_1375|Compound:2910-0797|FD-Score:4.09|P-value:1.98E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-4.93|P-value:3.78E-6 ID:SGTC_1877|Compound:wortmannin|FD-Score:5.06|P-value:5.31E-6 ID:SGTC_1902|Compound:st060212|FD-Score:3.76|P-value:5.77E-4 ID:SGTC_1923|Compound:st058458|FD-Score:4.10|P-value:1.93E-4 ID:SGTC_1953|Compound:st076800|FD-Score:-3.60|P-value:4.96E-4 ID:SGTC_2011|Compound:4012611|FD-Score:4.02|P-value:2.52E-4 ID:SGTC_2081|Compound:5214970|FD-Score:4.48|P-value:5.02E-5 ID:SGTC_2089|Compound:5281248|FD-Score:-4.24|P-value:5.58E-5 ID:SGTC_2219|Compound:9098279|FD-Score:-3.74|P-value:3.14E-4 ID:SGTC_2292|Compound:7671323|FD-Score:4.22|P-value:1.28E-4 ID:SGTC_2310|Compound:7668677|FD-Score:3.64|P-value:8.36E-4 ID:SGTC_2470|Compound:5664817|FD-Score:6.66|P-value:2.87E-9 ID:SGTC_2475|Compound:5812728|FD-Score:6.04|P-value:6.67E-8 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:4.34|P-value:8.48E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:-3.92|P-value:1.73E-4 ID:SGTC_2570|Compound:licareol|FD-Score:5.31|P-value:1.88E-6 ID:SGTC_2575|Compound:plumbagin|FD-Score:4.16|P-value:1.58E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:-3.38|P-value:9.58E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:5.86|P-value:1.55E-7 ID:SGTC_2752|Compound:diclazuril|FD-Score:5.57|P-value:5.82E-7 ID:SGTC_2756|Compound:carbadox|FD-Score:-3.93|P-value:1.64E-4 ID:SGTC_2795|Compound:7780010|FD-Score:-4.41|P-value:2.90E-5 ID:SGTC_2801|Compound:7907800|FD-Score:-5.87|P-value:5.37E-8 ID:SGTC_2803|Compound:7707263|FD-Score:-4.46|P-value:2.43E-5 ID:SGTC_2836|Compound:9010338|FD-Score:4.61|P-value:3.12E-5 ID:SGTC_2851|Compound:9015922|FD-Score:5.65|P-value:4.05E-7 ID:SGTC_2854|Compound:9024559|FD-Score:-3.68|P-value:3.80E-4 ID:SGTC_2858|Compound:9025781|FD-Score:4.27|P-value:1.08E-4 ID:SGTC_2911|Compound:7942208|FD-Score:4.77|P-value:1.70E-5 ID:SGTC_2930|Compound:9013230|FD-Score:-5.33|P-value:6.68E-7 ID:SGTC_3339|Compound:9145883|FD-Score:-3.60|P-value:4.95E-4 ID:SGTC_3342|Compound:9147791|FD-Score:5.09|P-value:4.63E-6

Top fitness defect scores for YBR081C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_43 0570-0105 6.86 72.5 µM 9.60E-10 ERG2 23 3.45E-12
2 SGTC_2470 5664817 6.66 21.7 µM 2.87E-9 1 1.40E-11
3 SGTC_2475 5812728 6.04 15.0 µM 6.67E-8 mitochondrial processes 5 7.78E-10
4 SGTC_1141 3253-0389 5.91 52.6 µM 1.25E-7 2 1.74E-9
5 SGTC_2603 homopterocarpin 5.86 100.0 µM 1.55E-7 6 2.29E-9
6 SGTC_2851 9015922 5.65 71.4 µM 4.05E-7 10 7.81E-9
7 SGTC_2752 diclazuril 5.57 33.1 µM 5.82E-7 66 1.24E-8
8 SGTC_2570 licareol 5.31 100.0 µM 1.88E-6 10 5.56E-8
9 SGTC_109 0132-0036 5.27 33.7 µM 2.18E-6 13 6.70E-8
10 SGTC_3342 9147791 5.09 14.5 µM 4.63E-6 2 1.76E-7
11 SGTC_1877 wortmannin 5.06 25.0 µM 5.31E-6 62 2.10E-7
12 SGTC_14 0354-0009 4.77 295.0 µM 1.67E-5 15 9.04E-7
13 SGTC_2911 7942208 4.77 15.6 µM 1.70E-5 mitochondrial response to ROS 7 9.26E-7
14 SGTC_422 cantharidin 4.66 155.0 µM 2.56E-5 cell wall signaling 41 1.56E-6
15 SGTC_2836 9010338 4.61 19.5 µM 3.12E-5 RPP1 & pyrimidine depletion 16 2.02E-6
16 SGTC_1365 1672-3266 4.55 55.4 µM 3.89E-5 5 2.68E-6
17 SGTC_2081 5214970 4.48 32.3 µM 5.02E-5 13 3.70E-6
18 SGTC_905 2-aminofluorene 4.39 215.0 µM 7.06E-5 cell wall signaling 19 5.74E-6
19 SGTC_562 3772-2733 4.38 112.0 µM 7.24E-5 ERG2 67 5.92E-6
20 SGTC_2536 dehydroabietamide 4.34 32.0 µM 8.48E-5 26 7.25E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.110 1.47E-10 YDR120C TRM1 hom tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments
0.110 1.66E-10 YNL140C_p YNL140C_p hom Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps THO2/YNL139C
0.099 1.04E-8 YDR392W SPT3 hom Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
0.097 1.99E-8 YBL079W NUP170 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication
0.092 1.08E-7 YML062C MFT1 hom Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance
0.091 1.44E-7 YPL254W HFI1 hom Adaptor protein required for structural integrity of the SAGA complex, a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions
0.088 3.75E-7 YMR015C ERG5 hom C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs
0.086 6.89E-7 YLR087C CSF1 hom Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.084 9.85E-7 YGR178C PBP1 hom Component of glucose deprivation induced stress granules; involved in P-body-dependent granule assembly; similar to human ataxin-2; interacts with Pab1p to regulate mRNA polyadenylation; interacts with Mkt1p to regulate HO translation; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress
0.084 1.24E-6 YLR172C DPH5 hom Methyltransferase required for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); not essential for viability; GFP-Dph5p fusion protein localizes to the cytoplasm
0.083 1.33E-6 YOL001W PHO80 hom Cyclin, interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling
0.082 1.92E-6 YHR167W THP2 hom Subunit of the THO complex, which connects transcription elongation and mitotic recombination, and of the TREX complex, which is recruited to activated genes and couples transcription to mRNA export; involved in telomere maintenance
0.082 2.12E-6 YGR245C SDA1 het Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis
0.080 3.24E-6 YOL050C_d YOL050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.079 4.78E-6 YJR088C EMC2 hom Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm Y57G7A.10/EMC-2, fly CG17556, human TTC35