YBR088C / POL30

Proliferating cell nuclear antigen (PCNA), functions as the sliding clamp for DNA polymerase delta; may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair

Zygosity: Heterozygous strain
fixedexpanded
Profile for YBR088C / POL30

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:7.93|P-value:8.39E-17 ID:SGTC_38|Compound:0929-0051|FD-Score:-3.56|P-value:1.20E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:-3.14|P-value:6.00E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:3.01|P-value:8.53E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-6.22|P-value:5.95E-11 ID:SGTC_142|Compound:0335-0849|FD-Score:3.64|P-value:7.31E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:3.17|P-value:4.66E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:5.13|P-value:4.73E-8 ID:SGTC_184|Compound:1494-0393|FD-Score:5.07|P-value:6.73E-8 ID:SGTC_217|Compound:ketoconazole|FD-Score:-4.01|P-value:1.68E-5 ID:SGTC_233|Compound:rapamycin|FD-Score:4.56|P-value:1.02E-6 ID:SGTC_248|Compound:streptozotocin|FD-Score:5.65|P-value:2.14E-9 ID:SGTC_341|Compound:1486-1430|FD-Score:4.80|P-value:2.96E-7 ID:SGTC_399|Compound:oxolinic acid|FD-Score:3.32|P-value:2.65E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:3.18|P-value:4.54E-4 ID:SGTC_491|Compound:tetrandrine|FD-Score:3.16|P-value:4.93E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:5.65|P-value:2.08E-9 ID:SGTC_786|Compound:4544-0069|FD-Score:4.46|P-value:1.74E-6 ID:SGTC_869|Compound:0564-0080|FD-Score:-4.38|P-value:2.95E-6 ID:SGTC_931|Compound:2812-0076|FD-Score:-4.21|P-value:6.89E-6 ID:SGTC_1120|Compound:ficusin|FD-Score:6.73|P-value:1.29E-12 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.16|P-value:4.95E-4 ID:SGTC_1146|Compound:3579-1023|FD-Score:4.07|P-value:1.10E-5 ID:SGTC_1222|Compound:0366-0074|FD-Score:3.18|P-value:4.62E-4 ID:SGTC_1530|Compound:rhein|FD-Score:-3.15|P-value:5.64E-4 ID:SGTC_1636|Compound:st007707|FD-Score:4.09|P-value:1.04E-5 ID:SGTC_1637|Compound:st007924|FD-Score:-3.19|P-value:4.93E-4 ID:SGTC_1690|Compound:st023502|FD-Score:-3.37|P-value:2.51E-4 ID:SGTC_1703|Compound:st026983|FD-Score:3.08|P-value:6.57E-4 ID:SGTC_1710|Compound:st031758|FD-Score:3.15|P-value:5.18E-4 ID:SGTC_2178|Compound:5812956|FD-Score:3.19|P-value:4.39E-4 ID:SGTC_2284|Compound:7945075|FD-Score:3.34|P-value:2.45E-4 ID:SGTC_2386|Compound:9075165|FD-Score:3.18|P-value:4.59E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-4.07|P-value:1.32E-5 ID:SGTC_2404|Compound:5161160|FD-Score:5.80|P-value:8.12E-10 ID:SGTC_2436|Compound:5633522|FD-Score:3.97|P-value:1.76E-5 ID:SGTC_2504|Compound:purpurogallin|FD-Score:-3.60|P-value:1.01E-4 ID:SGTC_2505|Compound:galangin|FD-Score:-3.20|P-value:4.69E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.06|P-value:7.21E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.37|P-value:2.19E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:4.13|P-value:8.59E-6 ID:SGTC_2769|Compound:toremifene|FD-Score:4.00|P-value:1.56E-5 ID:SGTC_2774|Compound:tamoxifen|FD-Score:4.57|P-value:9.76E-7 ID:SGTC_2818|Compound:7996756|FD-Score:3.07|P-value:6.81E-4 ID:SGTC_2917|Compound:7979103|FD-Score:3.56|P-value:1.05E-4 ID:SGTC_2960|Compound:9079389|FD-Score:-3.82|P-value:3.90E-5 ID:SGTC_2993|Compound:9054257|FD-Score:3.30|P-value:2.92E-4 ID:SGTC_2996|Compound:9066192|FD-Score:5.63|P-value:2.29E-9 ID:SGTC_2997|Compound:9067075|FD-Score:4.04|P-value:1.32E-5 ID:SGTC_3031|Compound:9088762|FD-Score:-3.24|P-value:4.11E-4 ID:SGTC_3157|Compound:9099274|FD-Score:-4.17|P-value:8.29E-6 ID:SGTC_36|Compound:0335-0881|FD-Score:7.93|P-value:8.39E-17 ID:SGTC_38|Compound:0929-0051|FD-Score:-3.56|P-value:1.20E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:-3.14|P-value:6.00E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:3.01|P-value:8.53E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-6.22|P-value:5.95E-11 ID:SGTC_142|Compound:0335-0849|FD-Score:3.64|P-value:7.31E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:3.17|P-value:4.66E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:5.13|P-value:4.73E-8 ID:SGTC_184|Compound:1494-0393|FD-Score:5.07|P-value:6.73E-8 ID:SGTC_217|Compound:ketoconazole|FD-Score:-4.01|P-value:1.68E-5 ID:SGTC_233|Compound:rapamycin|FD-Score:4.56|P-value:1.02E-6 ID:SGTC_248|Compound:streptozotocin|FD-Score:5.65|P-value:2.14E-9 ID:SGTC_341|Compound:1486-1430|FD-Score:4.80|P-value:2.96E-7 ID:SGTC_399|Compound:oxolinic acid|FD-Score:3.32|P-value:2.65E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:3.18|P-value:4.54E-4 ID:SGTC_491|Compound:tetrandrine|FD-Score:3.16|P-value:4.93E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:5.65|P-value:2.08E-9 ID:SGTC_786|Compound:4544-0069|FD-Score:4.46|P-value:1.74E-6 ID:SGTC_869|Compound:0564-0080|FD-Score:-4.38|P-value:2.95E-6 ID:SGTC_931|Compound:2812-0076|FD-Score:-4.21|P-value:6.89E-6 ID:SGTC_1120|Compound:ficusin|FD-Score:6.73|P-value:1.29E-12 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.16|P-value:4.95E-4 ID:SGTC_1146|Compound:3579-1023|FD-Score:4.07|P-value:1.10E-5 ID:SGTC_1222|Compound:0366-0074|FD-Score:3.18|P-value:4.62E-4 ID:SGTC_1530|Compound:rhein|FD-Score:-3.15|P-value:5.64E-4 ID:SGTC_1636|Compound:st007707|FD-Score:4.09|P-value:1.04E-5 ID:SGTC_1637|Compound:st007924|FD-Score:-3.19|P-value:4.93E-4 ID:SGTC_1690|Compound:st023502|FD-Score:-3.37|P-value:2.51E-4 ID:SGTC_1703|Compound:st026983|FD-Score:3.08|P-value:6.57E-4 ID:SGTC_1710|Compound:st031758|FD-Score:3.15|P-value:5.18E-4 ID:SGTC_2178|Compound:5812956|FD-Score:3.19|P-value:4.39E-4 ID:SGTC_2284|Compound:7945075|FD-Score:3.34|P-value:2.45E-4 ID:SGTC_2386|Compound:9075165|FD-Score:3.18|P-value:4.59E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-4.07|P-value:1.32E-5 ID:SGTC_2404|Compound:5161160|FD-Score:5.80|P-value:8.12E-10 ID:SGTC_2436|Compound:5633522|FD-Score:3.97|P-value:1.76E-5 ID:SGTC_2504|Compound:purpurogallin|FD-Score:-3.60|P-value:1.01E-4 ID:SGTC_2505|Compound:galangin|FD-Score:-3.20|P-value:4.69E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.06|P-value:7.21E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.37|P-value:2.19E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:4.13|P-value:8.59E-6 ID:SGTC_2769|Compound:toremifene|FD-Score:4.00|P-value:1.56E-5 ID:SGTC_2774|Compound:tamoxifen|FD-Score:4.57|P-value:9.76E-7 ID:SGTC_2818|Compound:7996756|FD-Score:3.07|P-value:6.81E-4 ID:SGTC_2917|Compound:7979103|FD-Score:3.56|P-value:1.05E-4 ID:SGTC_2960|Compound:9079389|FD-Score:-3.82|P-value:3.90E-5 ID:SGTC_2993|Compound:9054257|FD-Score:3.30|P-value:2.92E-4 ID:SGTC_2996|Compound:9066192|FD-Score:5.63|P-value:2.29E-9 ID:SGTC_2997|Compound:9067075|FD-Score:4.04|P-value:1.32E-5 ID:SGTC_3031|Compound:9088762|FD-Score:-3.24|P-value:4.11E-4 ID:SGTC_3157|Compound:9099274|FD-Score:-4.17|P-value:8.29E-6

Top fitness defect scores for YBR088C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_36 0335-0881 7.93 14.2 µM 8.39E-17 ubiquinone biosynthesis & proteasome 8 1.10E-15 0.33
2 SGTC_1120 ficusin 6.73 1.8 µM 1.29E-12 1 8.45E-12 2.30
3 SGTC_2404 5161160 5.80 200.0 µM 8.12E-10 3 3.36E-9 0.73
4 SGTC_783 0848-0141 5.65 92.7 µM 2.08E-9 RSC & ERG11 8 8.05E-9 0.42
5 SGTC_248 streptozotocin 5.65 5.2 mM 2.14E-9 DNA damage response 11 8.26E-9 0.88
6 SGTC_2996 9066192 5.63 71.4 µM 2.29E-9 1 8.82E-9 0.60
7 SGTC_158 k038-0087 5.13 26.4 µM 4.73E-8 ubiquinone biosynthesis & proteasome 19 1.46E-7 0.19
8 SGTC_184 1494-0393 5.07 24.7 µM 6.73E-8 17 2.03E-7 0.13
9 SGTC_341 1486-1430 4.80 230.0 µM 2.96E-7 16 8.04E-7 0.02
10 SGTC_2774 tamoxifen 4.57 10.9 µM 9.76E-7 5 2.43E-6 0.41
11 SGTC_233 rapamycin 4.56 362.0 pM 1.02E-6 2 2.54E-6 1.14
12 SGTC_786 4544-0069 4.46 423.0 µM 1.74E-6 6 4.15E-6 0.31
13 SGTC_2729 fluphenazine 4.13 10.7 µM 8.59E-6 7 1.83E-5 0.26
14 SGTC_1636 st007707 4.09 68.9 µM 1.04E-5 7 2.18E-5 0.22
15 SGTC_1146 3579-1023 4.07 7.0 µM 1.10E-5 3 2.31E-5 0.00
16 SGTC_2997 9067075 4.04 71.4 µM 1.32E-5 unfolded protein response 21 2.72E-5 0.10
17 SGTC_2769 toremifene 4.00 3.7 µM 1.56E-5 5 3.19E-5 0.06
18 SGTC_2436 5633522 3.97 8.1 µM 1.76E-5 10 3.58E-5 0.06
19 SGTC_142 0335-0849 3.64 62.7 µM 7.31E-5 ubiquinone biosynthesis & proteasome 21 1.34E-4 0.06
20 SGTC_2917 7979103 3.56 53.8 µM 1.05E-4 9 1.87E-4 0.26

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.190 1.76E-28 YJL072C PSF2 het Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
0.188 6.36E-28 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.177 5.66E-25 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.171 1.48E-23 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.167 1.62E-22 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)
0.166 3.04E-22 YML110C COQ5 hom 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes
0.159 2.13E-20 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.154 2.93E-19 YOL096C COQ3 hom O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein
0.150 2.12E-18 YER048W-A ISD11 het Cysteine desulfurase (Nfs1p) activator; essential for the formation of the persulfide intermediate at the desulfurase active site during pyridoxal phosphate-dependent desulfuration of cysteine; required for mitochondrial iron-sulfur cluster biosynthesis
0.146 2.06E-17 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.145 3.66E-17 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.142 1.59E-16 YOL008W COQ10 hom Coenzyme Q (ubiquinone) binding protein, functions in the delivery of Q6 to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes
0.135 4.85E-15 YER019C-A SBH2 hom Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
0.133 1.27E-14 YDR537C_d YDR537C_d hom Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W
0.131 3.21E-14 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect