YBR089W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene POL30

Zygosity: Heterozygous strain
fixedexpanded
Profile for YBR089W / YBR089W

Click on Significant Values for Screen Details ID:SGTC_137|Compound:0438-0332|FD-Score:3.30|P-value:9.64E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:-3.07|P-value:2.43E-4 ID:SGTC_162|Compound:k030-0015|FD-Score:2.78|P-value:8.47E-4 ID:SGTC_248|Compound:streptozotocin|FD-Score:2.80|P-value:7.85E-4 ID:SGTC_599|Compound:1935-0052|FD-Score:2.99|P-value:3.69E-4 ID:SGTC_718|Compound:1130-0073|FD-Score:-2.91|P-value:4.74E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:2.81|P-value:7.49E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.36|P-value:6.77E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.34|P-value:7.98E-5 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.15|P-value:1.92E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:2.93|P-value:4.64E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:-2.82|P-value:6.91E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.40|P-value:5.76E-5 ID:SGTC_1526|Compound:st051518|FD-Score:-2.72|P-value:9.98E-4 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:3.03|P-value:3.09E-4 ID:SGTC_1674|Compound:st016616|FD-Score:-3.62|P-value:2.03E-5 ID:SGTC_1691|Compound:st019933|FD-Score:3.06|P-value:2.82E-4 ID:SGTC_1740|Compound:st038286|FD-Score:-2.86|P-value:5.78E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.65|P-value:1.86E-5 ID:SGTC_2365|Compound:9042475|FD-Score:3.12|P-value:2.13E-4 ID:SGTC_2391|Compound:6285546|FD-Score:-2.83|P-value:6.47E-4 ID:SGTC_2482|Compound:5981709|FD-Score:3.44|P-value:5.18E-5 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:2.78|P-value:8.69E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.23|P-value:1.32E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:2.85|P-value:6.57E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:-2.86|P-value:5.97E-4 ID:SGTC_2696|Compound:st077691|FD-Score:3.08|P-value:2.53E-4 ID:SGTC_2817|Compound:7995342|FD-Score:3.71|P-value:1.38E-5 ID:SGTC_2833|Compound:9001315|FD-Score:2.91|P-value:5.05E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-4.42|P-value:2.72E-7 ID:SGTC_2974|Compound:9094440|FD-Score:-3.00|P-value:3.31E-4 ID:SGTC_2997|Compound:9067075|FD-Score:3.05|P-value:2.85E-4 ID:SGTC_3085|Compound:9117376|FD-Score:-3.82|P-value:7.50E-6 ID:SGTC_3196|Compound:9111891|FD-Score:-3.79|P-value:8.55E-6 ID:SGTC_3263|Compound:9137018|FD-Score:-3.93|P-value:4.26E-6 ID:SGTC_3275|Compound:9138069|FD-Score:-3.41|P-value:5.43E-5 ID:SGTC_3281|Compound:9140613|FD-Score:-6.05|P-value:3.58E-12 ID:SGTC_137|Compound:0438-0332|FD-Score:3.30|P-value:9.64E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:-3.07|P-value:2.43E-4 ID:SGTC_162|Compound:k030-0015|FD-Score:2.78|P-value:8.47E-4 ID:SGTC_248|Compound:streptozotocin|FD-Score:2.80|P-value:7.85E-4 ID:SGTC_599|Compound:1935-0052|FD-Score:2.99|P-value:3.69E-4 ID:SGTC_718|Compound:1130-0073|FD-Score:-2.91|P-value:4.74E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:2.81|P-value:7.49E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.36|P-value:6.77E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.34|P-value:7.98E-5 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.15|P-value:1.92E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:2.93|P-value:4.64E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:-2.82|P-value:6.91E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.40|P-value:5.76E-5 ID:SGTC_1526|Compound:st051518|FD-Score:-2.72|P-value:9.98E-4 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:3.03|P-value:3.09E-4 ID:SGTC_1674|Compound:st016616|FD-Score:-3.62|P-value:2.03E-5 ID:SGTC_1691|Compound:st019933|FD-Score:3.06|P-value:2.82E-4 ID:SGTC_1740|Compound:st038286|FD-Score:-2.86|P-value:5.78E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.65|P-value:1.86E-5 ID:SGTC_2365|Compound:9042475|FD-Score:3.12|P-value:2.13E-4 ID:SGTC_2391|Compound:6285546|FD-Score:-2.83|P-value:6.47E-4 ID:SGTC_2482|Compound:5981709|FD-Score:3.44|P-value:5.18E-5 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:2.78|P-value:8.69E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.23|P-value:1.32E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:2.85|P-value:6.57E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:-2.86|P-value:5.97E-4 ID:SGTC_2696|Compound:st077691|FD-Score:3.08|P-value:2.53E-4 ID:SGTC_2817|Compound:7995342|FD-Score:3.71|P-value:1.38E-5 ID:SGTC_2833|Compound:9001315|FD-Score:2.91|P-value:5.05E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-4.42|P-value:2.72E-7 ID:SGTC_2974|Compound:9094440|FD-Score:-3.00|P-value:3.31E-4 ID:SGTC_2997|Compound:9067075|FD-Score:3.05|P-value:2.85E-4 ID:SGTC_3085|Compound:9117376|FD-Score:-3.82|P-value:7.50E-6 ID:SGTC_3196|Compound:9111891|FD-Score:-3.79|P-value:8.55E-6 ID:SGTC_3263|Compound:9137018|FD-Score:-3.93|P-value:4.26E-6 ID:SGTC_3275|Compound:9138069|FD-Score:-3.41|P-value:5.43E-5 ID:SGTC_3281|Compound:9140613|FD-Score:-6.05|P-value:3.58E-12

Top fitness defect scores for YBR089W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2817 7995342 3.71 71.4 µM 1.38E-5 10 1.02E-4 0.17
2 SGTC_2247 cerulenin 3.65 830.0 nM 1.86E-5 7 1.30E-4 0.06
3 SGTC_2482 5981709 3.44 142.7 µM 5.18E-5 PDR1 20 2.92E-4 0.10
4 SGTC_1161 k007-0610 3.34 110.0 µM 7.98E-5 ERAD & cell cycle 48 4.12E-4 0.00
5 SGTC_137 0438-0332 3.30 85.4 µM 9.64E-5 ubiquinone biosynthesis & proteasome 54 4.78E-4 0.06
6 SGTC_2564 betulinic acid 3.23 100.0 µM 1.32E-4 14 6.16E-4 0.16
7 SGTC_1282 0886-0010 3.15 32.4 µM 1.92E-4 endomembrane recycling 23 8.28E-4 0.02
8 SGTC_2365 9042475 3.12 200.0 µM 2.13E-4 13 8.97E-4 0.03
9 SGTC_2696 st077691 3.08 74.3 µM 2.53E-4 21 0.00103 0.07
10 SGTC_1691 st019933 3.06 84.6 µM 2.82E-4 6 0.00112 0.06
11 SGTC_2997 9067075 3.05 71.4 µM 2.85E-4 unfolded protein response 36 0.00113 0.01
12 SGTC_1587 estradiol valerate 3.03 56.1 µM 3.09E-4 8 0.00121 0.14
13 SGTC_599 1935-0052 2.99 86.5 µM 3.69E-4 9 0.00139 0.01
14 SGTC_1283 0922-0125 2.93 16.4 µM 4.64E-4 9 0.00167 0.09
15 SGTC_2833 9001315 2.91 45.5 µM 5.05E-4 amide catabolism 19 0.00179 0.05
16 SGTC_2597 laccaic acid a 2.85 100.0 µM 6.57E-4 23 0.00220 0.02
17 SGTC_969 1313-0238 2.81 134.0 µM 7.49E-4 mitochondrial processes 51 0.00245 0.05
18 SGTC_248 streptozotocin 2.80 5.2 mM 7.85E-4 DNA damage response 32 0.00254 0.03
19 SGTC_162 k030-0015 2.78 37.8 µM 8.47E-4 iron homeostasis 15 0.00270 0.00
20 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 2.78 100.0 µM 8.69E-4 19 0.00276 0.08

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.174 2.74E-24 YDR048C_d YDR048C_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.149 3.52E-18 YLR223C IFH1 het Coactivator that regulates transcription of ribosomal protein (RP) genes; recruited to RP gene promoters during optimal growth conditions via Fhl1p; subunit of CURI, a complex that coordinates RP production and pre-rRNA processing
0.147 8.86E-18 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.142 1.64E-16 YMR308C PSE1 het Karyopherin/importin that interacts with the nuclear pore complex; acts as the nuclear import receptor for specific proteins, including Pdr1p, Yap1p, Ste12p, and Aft1p
0.140 4.52E-16 YBR262C AIM5 hom Mitochondrial inner membrane protein; subunit of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture
0.135 3.95E-15 YDL007W RPT2 het One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle
0.132 1.61E-14 YER012W PRE1 het Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle
0.132 1.82E-14 YBL015W ACH1 hom Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
0.131 2.40E-14 YLL010C PSR1 hom Plasma membrane associated protein phosphatase involved in the general stress response; required along with binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p
0.131 2.73E-14 YJR127C RSF2 hom Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.130 5.00E-14 YDL110C TMA17 hom Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion
0.130 4.71E-14 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.130 4.95E-14 YKL196C YKT6 het Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and within the Golgi, endocytic trafficking to the vacuole, and vacuolar fusion; membrane localization due to prenylation at the carboxy-terminus
0.127 1.56E-13 YDR499W LCD1 het Essential protein required for the DNA integrity checkpoint pathways; interacts physically with Mec1p; putative homolog of S. pombe Rad26 and human ATRIP; forms nuclear foci upon DNA replication stress
0.125 3.92E-13 YCL035C GRX1 hom Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress