YBR092C / PHO3

Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR092C / PHO3

Click on Significant Values for Screen Details ID:SGTC_180|Compound:1486-1293|FD-Score:3.50|P-value:6.88E-5 ID:SGTC_183|Compound:3914-0051|FD-Score:4.56|P-value:3.34E-7 ID:SGTC_220|Compound:paclitaxel|FD-Score:-3.22|P-value:2.09E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:3.04|P-value:4.68E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:3.18|P-value:2.66E-4 ID:SGTC_906|Compound:1165-0455|FD-Score:-2.93|P-value:6.61E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:3.63|P-value:3.94E-5 ID:SGTC_1098|Compound:clofazimine|FD-Score:4.67|P-value:1.75E-7 ID:SGTC_1138|Compound:3761-0006|FD-Score:3.41|P-value:1.01E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:-2.86|P-value:8.67E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:7.51|P-value:1.22E-16 ID:SGTC_1265|Compound:0819-1001|FD-Score:-4.02|P-value:5.26E-6 ID:SGTC_1279|Compound:0874-0590|FD-Score:2.94|P-value:6.86E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:3.01|P-value:5.33E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.15|P-value:3.08E-4 ID:SGTC_1385|Compound:3091-4834|FD-Score:-3.04|P-value:4.27E-4 ID:SGTC_1436|Compound:4092-1007|FD-Score:-3.31|P-value:1.41E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:2.97|P-value:6.22E-4 ID:SGTC_1531|Compound:st059297|FD-Score:3.08|P-value:4.07E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:2.85|P-value:9.71E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:3.15|P-value:3.09E-4 ID:SGTC_1709|Compound:st033179|FD-Score:-2.96|P-value:5.91E-4 ID:SGTC_1719|Compound:st032227|FD-Score:3.49|P-value:7.22E-5 ID:SGTC_1792|Compound:st045773|FD-Score:2.92|P-value:7.46E-4 ID:SGTC_1855|Compound:st056195|FD-Score:3.08|P-value:3.97E-4 ID:SGTC_1882|Compound:5615643|FD-Score:3.17|P-value:2.81E-4 ID:SGTC_1919|Compound:st067113|FD-Score:-3.14|P-value:2.90E-4 ID:SGTC_2178|Compound:5812956|FD-Score:-4.60|P-value:2.30E-7 ID:SGTC_2280|Compound:7785178|FD-Score:-2.94|P-value:6.33E-4 ID:SGTC_2285|Compound:7945142|FD-Score:-3.76|P-value:1.88E-5 ID:SGTC_2341|Compound:7987486|FD-Score:2.85|P-value:9.78E-4 ID:SGTC_2345|Compound:9052315|FD-Score:3.33|P-value:1.43E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:2.88|P-value:8.65E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:2.99|P-value:5.65E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.88|P-value:1.20E-5 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:3.17|P-value:2.82E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:-2.88|P-value:7.77E-4 ID:SGTC_2927|Compound:9011802|FD-Score:-2.96|P-value:5.86E-4 ID:SGTC_2987|Compound:9018338|FD-Score:-2.84|P-value:9.11E-4 ID:SGTC_3015|Compound:9080845|FD-Score:3.44|P-value:8.97E-5 ID:SGTC_3178|Compound:9107506|FD-Score:2.87|P-value:8.80E-4 ID:SGTC_3218|Compound:9131285|FD-Score:-4.26|P-value:1.49E-6 ID:SGTC_3221|Compound:9128209|FD-Score:-4.50|P-value:4.08E-7 ID:SGTC_3302|Compound:9125395|FD-Score:2.84|P-value:9.93E-4 ID:SGTC_3314|Compound:9135860|FD-Score:2.89|P-value:8.42E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:3.50|P-value:6.88E-5 ID:SGTC_183|Compound:3914-0051|FD-Score:4.56|P-value:3.34E-7 ID:SGTC_220|Compound:paclitaxel|FD-Score:-3.22|P-value:2.09E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:3.04|P-value:4.68E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:3.18|P-value:2.66E-4 ID:SGTC_906|Compound:1165-0455|FD-Score:-2.93|P-value:6.61E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:3.63|P-value:3.94E-5 ID:SGTC_1098|Compound:clofazimine|FD-Score:4.67|P-value:1.75E-7 ID:SGTC_1138|Compound:3761-0006|FD-Score:3.41|P-value:1.01E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:-2.86|P-value:8.67E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:7.51|P-value:1.22E-16 ID:SGTC_1265|Compound:0819-1001|FD-Score:-4.02|P-value:5.26E-6 ID:SGTC_1279|Compound:0874-0590|FD-Score:2.94|P-value:6.86E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:3.01|P-value:5.33E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.15|P-value:3.08E-4 ID:SGTC_1385|Compound:3091-4834|FD-Score:-3.04|P-value:4.27E-4 ID:SGTC_1436|Compound:4092-1007|FD-Score:-3.31|P-value:1.41E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:2.97|P-value:6.22E-4 ID:SGTC_1531|Compound:st059297|FD-Score:3.08|P-value:4.07E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:2.85|P-value:9.71E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:3.15|P-value:3.09E-4 ID:SGTC_1709|Compound:st033179|FD-Score:-2.96|P-value:5.91E-4 ID:SGTC_1719|Compound:st032227|FD-Score:3.49|P-value:7.22E-5 ID:SGTC_1792|Compound:st045773|FD-Score:2.92|P-value:7.46E-4 ID:SGTC_1855|Compound:st056195|FD-Score:3.08|P-value:3.97E-4 ID:SGTC_1882|Compound:5615643|FD-Score:3.17|P-value:2.81E-4 ID:SGTC_1919|Compound:st067113|FD-Score:-3.14|P-value:2.90E-4 ID:SGTC_2178|Compound:5812956|FD-Score:-4.60|P-value:2.30E-7 ID:SGTC_2280|Compound:7785178|FD-Score:-2.94|P-value:6.33E-4 ID:SGTC_2285|Compound:7945142|FD-Score:-3.76|P-value:1.88E-5 ID:SGTC_2341|Compound:7987486|FD-Score:2.85|P-value:9.78E-4 ID:SGTC_2345|Compound:9052315|FD-Score:3.33|P-value:1.43E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:2.88|P-value:8.65E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:2.99|P-value:5.65E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.88|P-value:1.20E-5 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:3.17|P-value:2.82E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:-2.88|P-value:7.77E-4 ID:SGTC_2927|Compound:9011802|FD-Score:-2.96|P-value:5.86E-4 ID:SGTC_2987|Compound:9018338|FD-Score:-2.84|P-value:9.11E-4 ID:SGTC_3015|Compound:9080845|FD-Score:3.44|P-value:8.97E-5 ID:SGTC_3178|Compound:9107506|FD-Score:2.87|P-value:8.80E-4 ID:SGTC_3218|Compound:9131285|FD-Score:-4.26|P-value:1.49E-6 ID:SGTC_3221|Compound:9128209|FD-Score:-4.50|P-value:4.08E-7 ID:SGTC_3302|Compound:9125395|FD-Score:2.84|P-value:9.93E-4 ID:SGTC_3314|Compound:9135860|FD-Score:2.89|P-value:8.42E-4

Top fitness defect scores for YBR092C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1260 0700-1617 7.51 7.8 µM 1.22E-16 calcium & mitochondrial duress 4 2.85E-14
2 SGTC_1098 clofazimine 4.67 15.1 µM 1.75E-7 heme biosynthesis & mitochondrial translocase 12 1.47E-6
3 SGTC_183 3914-0051 4.56 30.6 µM 3.34E-7 60S ribosome export 10 2.55E-6
4 SGTC_2627 acetyl isogambogic acid 3.88 100.0 µM 1.20E-5 TSC3-RPN4 48 5.28E-5
5 SGTC_967 1306-0166 3.63 352.0 µM 3.94E-5 48 1.44E-4
6 SGTC_180 1486-1293 3.50 102.8 µM 6.88E-5 51 2.32E-4
7 SGTC_1719 st032227 3.49 49.2 µM 7.22E-5 38 2.42E-4
8 SGTC_3015 9080845 3.44 49.5 µM 8.97E-5 16 2.90E-4
9 SGTC_1138 3761-0006 3.41 1.0 µM 1.01E-4 14 3.21E-4
10 SGTC_2345 9052315 3.33 157.4 µM 1.43E-4 42 4.31E-4
11 SGTC_518 1021-0119 3.18 62.6 µM 2.66E-4 ERG2 79 7.30E-4
12 SGTC_1882 5615643 3.17 20.0 µM 2.81E-4 TRP & mitochondrial translation 47 7.67E-4
13 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 3.17 100.0 µM 2.82E-4 44 7.68E-4
14 SGTC_1371 2421-0008 3.15 32.7 µM 3.08E-4 mitochondrial processes 82 8.29E-4
15 SGTC_1631 benzylvanillin 3.15 81.9 µM 3.09E-4 Golgi 63 8.30E-4
16 SGTC_1855 st056195 3.08 39.6 µM 3.97E-4 60S ribosome export 58 0.00103
17 SGTC_1531 st059297 3.08 52.4 µM 4.07E-4 55 0.00105
18 SGTC_427 1354-0053 3.04 47.3 µM 4.68E-4 60 0.00118
19 SGTC_1345 1488-0192 3.01 31.4 µM 5.33E-4 50 0.00132
20 SGTC_2621 lithochol-11-enic acid 2.99 100.0 µM 5.65E-4 80 0.00139

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.149 5.09E-18 YML060W OGG1 hom Mitochondrial glycosylase/lyase that specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA, contributes to UVA resistance
0.141 2.79E-16 YPR067W ISA2 hom Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa1p and possibly Iba57p; localizes to the mitochondrial intermembrane space, overexpression of ISA2 suppresses grx5 mutations
0.114 3.08E-11 YLR071C RGR1 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for glucose repression, HO repression, RME1 repression and sporulation
0.113 5.16E-11 YEL034W HYP2 het Translation elongation factor eIF-5A; may function in translation initiation; structural homolog of bacterial EF-P; undergoes an essential hypusination modification; HYP2 has a paralog, ANB1, that arose from the whole genome duplication
0.112 8.21E-11 YMR167W MLH1 hom Protein required for mismatch repair in mitosis and meiosis as well as crossing over during meiosis; forms a complex with Pms1p and Msh2p-Msh3p during mismatch repair; human homolog is associated with hereditary non-polyposis colon cancer
0.108 3.70E-10 YAR030C_d YAR030C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YAR029W and the verified gene PRM9
0.102 2.88E-9 YDR382W RPP2B hom Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
0.099 1.06E-8 YHR175W-A_p YHR175W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.097 1.54E-8 YNL146C-A_p YNL146C-A_p hom Putative protein of unknown function
0.097 2.08E-8 YBR067C TIP1 hom Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
0.094 5.24E-8 YKL015W PUT3 hom Transcriptional activator of proline utilization genes, constitutively binds PUT1 and PUT2 promoter sequences as a dimer and undergoes a conformational change to form the active state; differentially phosphorylated in the presence of different nitrogen sources; has a Zn(2)-Cys(6) binuclear cluster domain
0.085 7.89E-7 YHL047C ARN2 hom Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C
0.083 1.41E-6 YIL158W AIM20 hom Putative protein of unknown function; overexpression causes a cell cycle delay or arrest; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; null mutant displays elevated frequency of mitochondrial genome loss; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.082 2.29E-6 YPR009W SUT2 hom Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; highly similar to Sut1p
0.081 2.31E-6 YIR014W_p YIR014W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; YIR014W is a non-essential gene