YBR093C / PHO5

Repressible acid phosphatase (1 of 3) that also mediates extracellular nucleotide-derived phosphate hydrolysis; secretory pathway derived cell surface glycoprotein; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR093C / PHO5

Click on Significant Values for Screen Details ID:SGTC_42|Compound:0133-0086|FD-Score:4.16|P-value:5.52E-6 ID:SGTC_127|Compound:0180-0333|FD-Score:3.25|P-value:3.06E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:3.03|P-value:6.80E-4 ID:SGTC_174|Compound:3553-0389|FD-Score:3.44|P-value:1.43E-4 ID:SGTC_213|Compound:1246-0773|FD-Score:3.18|P-value:4.02E-4 ID:SGTC_269|Compound:exalamide|FD-Score:3.60|P-value:7.26E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:3.28|P-value:2.71E-4 ID:SGTC_493|Compound:zm226600|FD-Score:4.38|P-value:1.85E-6 ID:SGTC_496|Compound:calpeptin|FD-Score:7.64|P-value:3.50E-16 ID:SGTC_504|Compound:lovastatin|FD-Score:3.43|P-value:1.46E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:-5.11|P-value:3.13E-8 ID:SGTC_518|Compound:1021-0119|FD-Score:-3.03|P-value:6.70E-4 ID:SGTC_642|Compound:0335-0876|FD-Score:-3.15|P-value:4.15E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:2.96|P-value:8.96E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:5.06|P-value:4.41E-8 ID:SGTC_661|Compound:1304-0007|FD-Score:5.53|P-value:2.66E-9 ID:SGTC_756|Compound:0508-1999|FD-Score:5.28|P-value:1.20E-8 ID:SGTC_758|Compound:0868-0029|FD-Score:3.13|P-value:4.71E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:3.31|P-value:2.39E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:4.45|P-value:1.33E-6 ID:SGTC_795|Compound:0685-0265|FD-Score:4.11|P-value:7.22E-6 ID:SGTC_932|Compound:2857-0803|FD-Score:3.34|P-value:2.07E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.76|P-value:3.59E-5 ID:SGTC_1154|Compound:4088-0362|FD-Score:2.95|P-value:9.11E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:-4.03|P-value:9.85E-6 ID:SGTC_1260|Compound:0700-1617|FD-Score:-3.90|P-value:1.84E-5 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.39|P-value:1.76E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:3.87|P-value:2.20E-5 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.14|P-value:4.58E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:2.97|P-value:8.63E-4 ID:SGTC_1540|Compound:guanosine|FD-Score:3.51|P-value:1.04E-4 ID:SGTC_1591|Compound:genipin|FD-Score:-3.76|P-value:3.35E-5 ID:SGTC_1746|Compound:st038117|FD-Score:5.36|P-value:7.55E-9 ID:SGTC_1798|Compound:st045719|FD-Score:4.43|P-value:1.48E-6 ID:SGTC_1836|Compound:st055642|FD-Score:-3.75|P-value:3.58E-5 ID:SGTC_1872|Compound:amphotericin b|FD-Score:3.10|P-value:5.26E-4 ID:SGTC_1909|Compound:st060837|FD-Score:3.17|P-value:4.13E-4 ID:SGTC_1942|Compound:st076330|FD-Score:-4.03|P-value:9.80E-6 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.68|P-value:5.06E-5 ID:SGTC_2251|Compound:lansoprazole|FD-Score:-4.79|P-value:1.93E-7 ID:SGTC_2253|Compound:7938677|FD-Score:-2.96|P-value:8.42E-4 ID:SGTC_2452|Compound:5863136|FD-Score:3.12|P-value:4.97E-4 ID:SGTC_2493|Compound:resveratrol|FD-Score:3.30|P-value:2.50E-4 ID:SGTC_2642|Compound:cholecalciferol|FD-Score:2.98|P-value:8.39E-4 ID:SGTC_2998|Compound:9066762|FD-Score:5.08|P-value:3.93E-8 ID:SGTC_3028|Compound:9087778|FD-Score:-3.15|P-value:4.21E-4 ID:SGTC_3071|Compound:9117417|FD-Score:2.97|P-value:8.69E-4 ID:SGTC_3087|Compound:9117406|FD-Score:-2.94|P-value:9.28E-4 ID:SGTC_3091|Compound:9116372|FD-Score:3.17|P-value:4.02E-4 ID:SGTC_3125|Compound:9127534|FD-Score:4.28|P-value:3.02E-6 ID:SGTC_3352|Compound:9151559|FD-Score:3.73|P-value:4.12E-5 ID:SGTC_3353|Compound:9151644|FD-Score:-2.93|P-value:9.40E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:4.16|P-value:5.52E-6 ID:SGTC_127|Compound:0180-0333|FD-Score:3.25|P-value:3.06E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:3.03|P-value:6.80E-4 ID:SGTC_174|Compound:3553-0389|FD-Score:3.44|P-value:1.43E-4 ID:SGTC_213|Compound:1246-0773|FD-Score:3.18|P-value:4.02E-4 ID:SGTC_269|Compound:exalamide|FD-Score:3.60|P-value:7.26E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:3.28|P-value:2.71E-4 ID:SGTC_493|Compound:zm226600|FD-Score:4.38|P-value:1.85E-6 ID:SGTC_496|Compound:calpeptin|FD-Score:7.64|P-value:3.50E-16 ID:SGTC_504|Compound:lovastatin|FD-Score:3.43|P-value:1.46E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:-5.11|P-value:3.13E-8 ID:SGTC_518|Compound:1021-0119|FD-Score:-3.03|P-value:6.70E-4 ID:SGTC_642|Compound:0335-0876|FD-Score:-3.15|P-value:4.15E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:2.96|P-value:8.96E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:5.06|P-value:4.41E-8 ID:SGTC_661|Compound:1304-0007|FD-Score:5.53|P-value:2.66E-9 ID:SGTC_756|Compound:0508-1999|FD-Score:5.28|P-value:1.20E-8 ID:SGTC_758|Compound:0868-0029|FD-Score:3.13|P-value:4.71E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:3.31|P-value:2.39E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:4.45|P-value:1.33E-6 ID:SGTC_795|Compound:0685-0265|FD-Score:4.11|P-value:7.22E-6 ID:SGTC_932|Compound:2857-0803|FD-Score:3.34|P-value:2.07E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.76|P-value:3.59E-5 ID:SGTC_1154|Compound:4088-0362|FD-Score:2.95|P-value:9.11E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:-4.03|P-value:9.85E-6 ID:SGTC_1260|Compound:0700-1617|FD-Score:-3.90|P-value:1.84E-5 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.39|P-value:1.76E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:3.87|P-value:2.20E-5 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.14|P-value:4.58E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:2.97|P-value:8.63E-4 ID:SGTC_1540|Compound:guanosine|FD-Score:3.51|P-value:1.04E-4 ID:SGTC_1591|Compound:genipin|FD-Score:-3.76|P-value:3.35E-5 ID:SGTC_1746|Compound:st038117|FD-Score:5.36|P-value:7.55E-9 ID:SGTC_1798|Compound:st045719|FD-Score:4.43|P-value:1.48E-6 ID:SGTC_1836|Compound:st055642|FD-Score:-3.75|P-value:3.58E-5 ID:SGTC_1872|Compound:amphotericin b|FD-Score:3.10|P-value:5.26E-4 ID:SGTC_1909|Compound:st060837|FD-Score:3.17|P-value:4.13E-4 ID:SGTC_1942|Compound:st076330|FD-Score:-4.03|P-value:9.80E-6 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.68|P-value:5.06E-5 ID:SGTC_2251|Compound:lansoprazole|FD-Score:-4.79|P-value:1.93E-7 ID:SGTC_2253|Compound:7938677|FD-Score:-2.96|P-value:8.42E-4 ID:SGTC_2452|Compound:5863136|FD-Score:3.12|P-value:4.97E-4 ID:SGTC_2493|Compound:resveratrol|FD-Score:3.30|P-value:2.50E-4 ID:SGTC_2642|Compound:cholecalciferol|FD-Score:2.98|P-value:8.39E-4 ID:SGTC_2998|Compound:9066762|FD-Score:5.08|P-value:3.93E-8 ID:SGTC_3028|Compound:9087778|FD-Score:-3.15|P-value:4.21E-4 ID:SGTC_3071|Compound:9117417|FD-Score:2.97|P-value:8.69E-4 ID:SGTC_3087|Compound:9117406|FD-Score:-2.94|P-value:9.28E-4 ID:SGTC_3091|Compound:9116372|FD-Score:3.17|P-value:4.02E-4 ID:SGTC_3125|Compound:9127534|FD-Score:4.28|P-value:3.02E-6 ID:SGTC_3352|Compound:9151559|FD-Score:3.73|P-value:4.12E-5 ID:SGTC_3353|Compound:9151644|FD-Score:-2.93|P-value:9.40E-4

Top fitness defect scores for YBR093C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_496 calpeptin 7.64 138.0 µM 3.50E-16 1 1.11E-14
2 SGTC_661 1304-0007 5.53 33.6 µM 2.66E-9 4 1.65E-8
3 SGTC_1746 st038117 5.36 42.0 µM 7.55E-9 10 4.20E-8
4 SGTC_756 0508-1999 5.28 28.3 µM 1.20E-8 RPP1 & pyrimidine depletion 6 6.38E-8
5 SGTC_2998 9066762 5.08 71.4 µM 3.93E-8 RPP1 & pyrimidine depletion 7 1.85E-7
6 SGTC_659 k018-0002 5.06 107.0 µM 4.41E-8 7 2.05E-7
7 SGTC_769 0302-0231 4.45 76.0 µM 1.33E-6 26 4.39E-6
8 SGTC_1798 st045719 4.43 61.0 µM 1.48E-6 7 4.81E-6
9 SGTC_493 zm226600 4.38 134.0 µM 1.85E-6 mitochondrial processes 10 5.90E-6
10 SGTC_3125 9127534 4.28 49.5 µM 3.02E-6 9 9.17E-6
11 SGTC_42 0133-0086 4.16 60.6 µM 5.52E-6 24 1.57E-5
12 SGTC_795 0685-0265 4.11 78.0 µM 7.22E-6 excess fatty acid 18 2.00E-5
13 SGTC_1264 0783-0040 3.87 158.0 µM 2.20E-5 31 5.47E-5
14 SGTC_1083 didemethylchlorpromazine sulfoxide 3.76 707.4 nM 3.59E-5 redox potentiating 94 8.49E-5
15 SGTC_3352 9151559 3.73 45.6 µM 4.12E-5 16 9.61E-5
16 SGTC_2249 haloperidol 3.68 116.4 µM 5.06E-5 ergosterol depletion effects on membrane 131 1.16E-4
17 SGTC_269 exalamide 3.60 29.0 µM 7.26E-5 ergosterol biosynthesis 28 1.60E-4
18 SGTC_1540 guanosine 3.51 70.6 µM 1.04E-4 14 2.22E-4
19 SGTC_174 3553-0389 3.44 74.3 µM 1.43E-4 35 2.95E-4
20 SGTC_504 lovastatin 3.43 124.0 µM 1.46E-4 23 3.01E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.133 8.78E-15 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.106 7.42E-10 YDR431W_d YDR431W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.102 3.41E-9 YMR115W MGR3 hom Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA
0.101 5.42E-9 YPL252C YAH1 het Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
0.100 6.31E-9 YER048W-A ISD11 het Cysteine desulfurase (Nfs1p) activator; essential for the formation of the persulfide intermediate at the desulfurase active site during pyridoxal phosphate-dependent desulfuration of cysteine; required for mitochondrial iron-sulfur cluster biosynthesis
0.098 1.18E-8 YBR103W SIF2 hom WD40 repeat-containing subunit of the Set3C histone deacetylase complex, which represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus
0.095 3.83E-8 YOR062C_p YOR062C_p hom Protein of unknown function; similar to YKR075Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
0.091 1.38E-7 YFR011C AIM13 hom Mitochondrial protein peripheral to the inner membrane; component of the mitochondrial inner membrane organizing system (MINOS, MitOS, or MICOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture
0.089 2.75E-7 YER009W NTF2 het Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport
0.088 3.22E-7 YNL207W RIO2 het Essential serine kinase involved in the processing of the 20S pre-rRNA into mature 18S rRNA; has similarity to Rio1p
0.086 6.42E-7 YAL018C_p YAL018C_p hom Putative protein of unknown function
0.083 1.62E-6 YDR026C NSI1 hom RNA polymerase I termination factor; binds to rDNA terminator element, required for efficient Pol I termination; required for rDNA silencing at NTS1; facilities association of Sir2p with NTS1, contributes to rDNA stability and cell longevity; interacts physically with Fob1p and RENT subunits, Sir2p and Net1p; may interact with ribosomes, based on co-purification experiments; Myb-like DNA-binding protein; NSI1 has a paralog, REB1, that arose from the whole genome duplication
0.082 2.27E-6 YBR064W_d YBR064W_d hom Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YBR063C
0.081 2.69E-6 YER076C_p YER076C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; analysis of HA-tagged protein suggests a membrane localization
0.077 7.01E-6 YDR376W ARH1 het Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability