YBR095C / RXT2

Subunit of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR095C / RXT2

Click on Significant Values for Screen Details ID:SGTC_79|Compound:0052-0007|FD-Score:4.31|P-value:7.80E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:5.21|P-value:2.35E-6 ID:SGTC_90|Compound:0870-0863|FD-Score:6.16|P-value:3.02E-8 ID:SGTC_142|Compound:0335-0849|FD-Score:4.23|P-value:1.03E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:6.23|P-value:2.16E-8 ID:SGTC_158|Compound:k038-0087|FD-Score:3.86|P-value:3.53E-4 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:4.18|P-value:1.23E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.64|P-value:7.00E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:-3.94|P-value:2.29E-4 ID:SGTC_398|Compound:bronopol|FD-Score:-3.62|P-value:6.35E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:6.24|P-value:2.04E-8 ID:SGTC_663|Compound:1486-0733|FD-Score:3.65|P-value:6.80E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:4.42|P-value:5.13E-5 ID:SGTC_863|Compound:0466-0191|FD-Score:3.66|P-value:6.58E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:4.52|P-value:3.55E-5 ID:SGTC_907|Compound:3448-6986|FD-Score:4.12|P-value:1.48E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:-3.92|P-value:2.51E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:-7.68|P-value:5.03E-12 ID:SGTC_1091|Compound:telmisartan|FD-Score:4.71|P-value:1.74E-5 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:5.60|P-value:4.25E-7 ID:SGTC_1103|Compound:duloxetine|FD-Score:3.76|P-value:4.87E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:7.50|P-value:2.03E-11 ID:SGTC_1164|Compound:k060-0068|FD-Score:5.35|P-value:1.29E-6 ID:SGTC_1406|Compound:3909-7906|FD-Score:-3.99|P-value:1.99E-4 ID:SGTC_1419|Compound:3993-2473|FD-Score:3.68|P-value:6.27E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:4.14|P-value:1.38E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:4.11|P-value:1.53E-4 ID:SGTC_1489|Compound:4065-0444|FD-Score:8.11|P-value:4.73E-13 ID:SGTC_1556|Compound:plumbagin|FD-Score:3.96|P-value:2.57E-4 ID:SGTC_1558|Compound:st069300|FD-Score:3.55|P-value:9.24E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:4.95|P-value:6.90E-6 ID:SGTC_1707|Compound:st032323|FD-Score:5.35|P-value:1.31E-6 ID:SGTC_1717|Compound:st033143|FD-Score:3.86|P-value:3.55E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-5.60|P-value:3.34E-7 ID:SGTC_1719|Compound:st032227|FD-Score:-4.07|P-value:1.52E-4 ID:SGTC_1800|Compound:st050079|FD-Score:-3.56|P-value:7.83E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-4.51|P-value:3.14E-5 ID:SGTC_1959|Compound:st077091|FD-Score:4.05|P-value:1.88E-4 ID:SGTC_1984|Compound:st072354|FD-Score:5.25|P-value:1.95E-6 ID:SGTC_1997|Compound:st073024|FD-Score:3.91|P-value:3.03E-4 ID:SGTC_2009|Compound:4012297|FD-Score:4.64|P-value:2.27E-5 ID:SGTC_2066|Compound:5222451|FD-Score:5.98|P-value:7.44E-8 ID:SGTC_2174|Compound:5790901|FD-Score:3.82|P-value:4.00E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-4.70|P-value:1.52E-5 ID:SGTC_2320|Compound:7373003|FD-Score:3.75|P-value:5.08E-4 ID:SGTC_2322|Compound:7413319|FD-Score:-4.77|P-value:1.15E-5 ID:SGTC_2324|Compound:6149169|FD-Score:5.01|P-value:5.31E-6 ID:SGTC_2346|Compound:9031566|FD-Score:6.06|P-value:4.89E-8 ID:SGTC_2399|Compound:5884133|FD-Score:5.01|P-value:5.40E-6 ID:SGTC_2448|Compound:5185112|FD-Score:4.94|P-value:7.10E-6 ID:SGTC_2517|Compound:totarol|FD-Score:5.15|P-value:3.08E-6 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:4.42|P-value:5.14E-5 ID:SGTC_2544|Compound:sphondin|FD-Score:4.48|P-value:4.19E-5 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:3.74|P-value:5.23E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:3.71|P-value:5.75E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-5.27|P-value:1.46E-6 ID:SGTC_2741|Compound:miltefosine|FD-Score:4.54|P-value:3.39E-5 ID:SGTC_2786|Compound:7743617|FD-Score:3.54|P-value:9.70E-4 ID:SGTC_2814|Compound:7977482|FD-Score:4.03|P-value:2.01E-4 ID:SGTC_2823|Compound:7987624|FD-Score:-4.32|P-value:6.36E-5 ID:SGTC_2988|Compound:9073640|FD-Score:-3.64|P-value:6.13E-4 ID:SGTC_2989|Compound:9073649|FD-Score:-3.57|P-value:7.48E-4 ID:SGTC_3037|Compound:9091026|FD-Score:-3.76|P-value:4.17E-4 ID:SGTC_3044|Compound:9093193|FD-Score:-4.07|P-value:1.48E-4 ID:SGTC_3122|Compound:9126309|FD-Score:4.02|P-value:2.13E-4 ID:SGTC_3210|Compound:9128157|FD-Score:-3.77|P-value:4.08E-4 ID:SGTC_3316|Compound:9136639|FD-Score:-3.94|P-value:2.32E-4 ID:SGTC_3339|Compound:9145883|FD-Score:-3.54|P-value:8.33E-4 ID:SGTC_79|Compound:0052-0007|FD-Score:4.31|P-value:7.80E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:5.21|P-value:2.35E-6 ID:SGTC_90|Compound:0870-0863|FD-Score:6.16|P-value:3.02E-8 ID:SGTC_142|Compound:0335-0849|FD-Score:4.23|P-value:1.03E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:6.23|P-value:2.16E-8 ID:SGTC_158|Compound:k038-0087|FD-Score:3.86|P-value:3.53E-4 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:4.18|P-value:1.23E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.64|P-value:7.00E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:-3.94|P-value:2.29E-4 ID:SGTC_398|Compound:bronopol|FD-Score:-3.62|P-value:6.35E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:6.24|P-value:2.04E-8 ID:SGTC_663|Compound:1486-0733|FD-Score:3.65|P-value:6.80E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:4.42|P-value:5.13E-5 ID:SGTC_863|Compound:0466-0191|FD-Score:3.66|P-value:6.58E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:4.52|P-value:3.55E-5 ID:SGTC_907|Compound:3448-6986|FD-Score:4.12|P-value:1.48E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:-3.92|P-value:2.51E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:-7.68|P-value:5.03E-12 ID:SGTC_1091|Compound:telmisartan|FD-Score:4.71|P-value:1.74E-5 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:5.60|P-value:4.25E-7 ID:SGTC_1103|Compound:duloxetine|FD-Score:3.76|P-value:4.87E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:7.50|P-value:2.03E-11 ID:SGTC_1164|Compound:k060-0068|FD-Score:5.35|P-value:1.29E-6 ID:SGTC_1406|Compound:3909-7906|FD-Score:-3.99|P-value:1.99E-4 ID:SGTC_1419|Compound:3993-2473|FD-Score:3.68|P-value:6.27E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:4.14|P-value:1.38E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:4.11|P-value:1.53E-4 ID:SGTC_1489|Compound:4065-0444|FD-Score:8.11|P-value:4.73E-13 ID:SGTC_1556|Compound:plumbagin|FD-Score:3.96|P-value:2.57E-4 ID:SGTC_1558|Compound:st069300|FD-Score:3.55|P-value:9.24E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:4.95|P-value:6.90E-6 ID:SGTC_1707|Compound:st032323|FD-Score:5.35|P-value:1.31E-6 ID:SGTC_1717|Compound:st033143|FD-Score:3.86|P-value:3.55E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-5.60|P-value:3.34E-7 ID:SGTC_1719|Compound:st032227|FD-Score:-4.07|P-value:1.52E-4 ID:SGTC_1800|Compound:st050079|FD-Score:-3.56|P-value:7.83E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-4.51|P-value:3.14E-5 ID:SGTC_1959|Compound:st077091|FD-Score:4.05|P-value:1.88E-4 ID:SGTC_1984|Compound:st072354|FD-Score:5.25|P-value:1.95E-6 ID:SGTC_1997|Compound:st073024|FD-Score:3.91|P-value:3.03E-4 ID:SGTC_2009|Compound:4012297|FD-Score:4.64|P-value:2.27E-5 ID:SGTC_2066|Compound:5222451|FD-Score:5.98|P-value:7.44E-8 ID:SGTC_2174|Compound:5790901|FD-Score:3.82|P-value:4.00E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-4.70|P-value:1.52E-5 ID:SGTC_2320|Compound:7373003|FD-Score:3.75|P-value:5.08E-4 ID:SGTC_2322|Compound:7413319|FD-Score:-4.77|P-value:1.15E-5 ID:SGTC_2324|Compound:6149169|FD-Score:5.01|P-value:5.31E-6 ID:SGTC_2346|Compound:9031566|FD-Score:6.06|P-value:4.89E-8 ID:SGTC_2399|Compound:5884133|FD-Score:5.01|P-value:5.40E-6 ID:SGTC_2448|Compound:5185112|FD-Score:4.94|P-value:7.10E-6 ID:SGTC_2517|Compound:totarol|FD-Score:5.15|P-value:3.08E-6 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:4.42|P-value:5.14E-5 ID:SGTC_2544|Compound:sphondin|FD-Score:4.48|P-value:4.19E-5 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:3.74|P-value:5.23E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:3.71|P-value:5.75E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-5.27|P-value:1.46E-6 ID:SGTC_2741|Compound:miltefosine|FD-Score:4.54|P-value:3.39E-5 ID:SGTC_2786|Compound:7743617|FD-Score:3.54|P-value:9.70E-4 ID:SGTC_2814|Compound:7977482|FD-Score:4.03|P-value:2.01E-4 ID:SGTC_2823|Compound:7987624|FD-Score:-4.32|P-value:6.36E-5 ID:SGTC_2988|Compound:9073640|FD-Score:-3.64|P-value:6.13E-4 ID:SGTC_2989|Compound:9073649|FD-Score:-3.57|P-value:7.48E-4 ID:SGTC_3037|Compound:9091026|FD-Score:-3.76|P-value:4.17E-4 ID:SGTC_3044|Compound:9093193|FD-Score:-4.07|P-value:1.48E-4 ID:SGTC_3122|Compound:9126309|FD-Score:4.02|P-value:2.13E-4 ID:SGTC_3210|Compound:9128157|FD-Score:-3.77|P-value:4.08E-4 ID:SGTC_3316|Compound:9136639|FD-Score:-3.94|P-value:2.32E-4 ID:SGTC_3339|Compound:9145883|FD-Score:-3.54|P-value:8.33E-4

Top fitness defect scores for YBR095C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1489 4065-0444 8.11 182.0 µM 4.73E-13 1 2.55E-16
2 SGTC_1133 3473-0247 7.50 50.0 µM 2.03E-11 RSC complex & mRNA processing 4 3.14E-14
3 SGTC_513 4245-1575 6.24 41.7 µM 2.04E-8 unfolded protein response 43 2.19E-10
4 SGTC_157 1348-1695 6.23 65.8 µM 2.16E-8 iron homeostasis 21 2.35E-10
5 SGTC_90 0870-0863 6.16 4.6 µM 3.02E-8 14 3.62E-10
6 SGTC_2346 9031566 6.06 143.8 µM 4.89E-8 Golgi 5 6.71E-10
7 SGTC_2066 5222451 5.98 176.0 µM 7.44E-8 heme biosynthesis & mitochondrial translocase 8 1.15E-9
8 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 5.60 15.5 µM 4.25E-7 8 1.06E-8
9 SGTC_1164 k060-0068 5.35 93.7 µM 1.29E-6 8 4.38E-8
10 SGTC_1707 st032323 5.35 6.3 µM 1.31E-6 DNA damage response 30 4.49E-8
11 SGTC_1984 st072354 5.25 53.1 µM 1.95E-6 3 7.45E-8
12 SGTC_86 0417-1630 5.21 471.9 µM 2.35E-6 ubiquinone biosynthesis & proteasome 109 9.44E-8
13 SGTC_2517 totarol 5.15 10.0 µM 3.08E-6 6 1.34E-7
14 SGTC_2324 6149169 5.01 200.0 µM 5.31E-6 7 2.68E-7
15 SGTC_2399 5884133 5.01 200.0 µM 5.40E-6 cell wall signaling 41 2.74E-7
16 SGTC_1631 benzylvanillin 4.95 81.9 µM 6.90E-6 Golgi 11 3.74E-7
17 SGTC_2448 5185112 4.94 27.2 µM 7.10E-6 7 3.88E-7
18 SGTC_1091 telmisartan 4.71 47.6 µM 1.74E-5 4 1.21E-6
19 SGTC_2009 4012297 4.64 12.1 µM 2.27E-5 cell wall signaling 48 1.71E-6
20 SGTC_2741 miltefosine 4.54 3.0 µM 3.39E-5 31 2.85E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.170 4.48E-23 YMR263W SAP30 hom Subunit of a histone deacetylase complex, along with Rpd3p and Sin3p, that is involved in silencing at telomeres, rDNA, and silent mating-type loci; involved in telomere maintenance
0.166 5.31E-22 YAL013W DEP1 hom Transcriptional modulator involved in regulation of structural phospholipid biosynthesis genes and metabolically unrelated genes, as well as maintenance of telomeres, mating efficiency, and sporulation
0.129 6.46E-14 YDR207C UME6 hom Key transcriptional regulator of early meiotic genes, binds URS1 upstream regulatory sequence, couples metabolic responses to nutritional cues with initiation and progression of meiosis, forms complex with Ime1p, and also with Sin3p-Rpd3p
0.129 6.93E-14 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.127 2.02E-13 YHR058C MED6 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; protein abundance increases in response to DNA replication stress
0.123 7.23E-13 YGR196C FYV8 hom Protein of unknown function, required for survival upon exposure to K1 killer toxin
0.123 7.41E-13 YOL004W SIN3 hom Component of the Sin3p-Rpd3p histone deacetylase complex, involved in transcriptional repression and activation of diverse processes, including mating-type switching and meiosis; involved in the maintenance of chromosomal integrity
0.115 2.06E-11 YPL242C IQG1 het Essential protein required for determination of budding pattern; promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.115 2.56E-11 YPL139C UME1 hom Negative regulator of meiosis, required for repression of a subset of meiotic genes during vegetative growth, binding of histone deacetylase Rpd3p required for activity, contains a NEE box and a WD repeat motif; homologous with Wtm1p, Wtm2p
0.111 1.02E-10 YBR260C RGD1 hom GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization
0.110 1.91E-10 YAL053W FLC2 hom Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC2 has a paralog, YOR365C, that arose from the whole genome duplication
0.110 2.10E-10 YLR332W MID2 hom O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p
0.109 2.43E-10 YDR172W SUP35 het Translation termination factor eRF3, has a role in mRNA deadenylation and decay; altered protein conformation creates the [PSI(+)] prion that alters translational fidelity and results in a nonsense suppressor phenotype
0.107 5.71E-10 YNL135C FPR1 hom Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function
0.105 1.02E-9 YPL182C_d YPL182C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CTI6/YPL181W