YBR099C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR099C / YBR099C

Click on Significant Values for Screen Details ID:SGTC_68|Compound:0986-0284|FD-Score:-4.21|P-value:2.40E-6 ID:SGTC_73|Compound:0327-0325|FD-Score:6.30|P-value:5.14E-12 ID:SGTC_75|Compound:0159-0059|FD-Score:-3.05|P-value:4.61E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:3.19|P-value:3.00E-4 ID:SGTC_244|Compound:nsc-207895|FD-Score:10.90|P-value:1.40E-32 ID:SGTC_248|Compound:streptozotocin|FD-Score:8.77|P-value:1.35E-21 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:3.63|P-value:4.60E-5 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:9.79|P-value:1.86E-26 ID:SGTC_268|Compound:camptothecin|FD-Score:14.70|P-value:1.79E-57 ID:SGTC_322|Compound:k048-0136|FD-Score:3.09|P-value:4.37E-4 ID:SGTC_334|Compound:1502-1024|FD-Score:-3.04|P-value:4.83E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:5.00|P-value:3.39E-8 ID:SGTC_558|Compound:k064-0027|FD-Score:3.30|P-value:1.92E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:3.29|P-value:2.01E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:-5.85|P-value:1.16E-10 ID:SGTC_720|Compound:r052-1644|FD-Score:3.02|P-value:5.78E-4 ID:SGTC_775|Compound:4577-0580|FD-Score:3.78|P-value:2.30E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:3.91|P-value:1.25E-5 ID:SGTC_782|Compound:0083-0095|FD-Score:4.66|P-value:2.52E-7 ID:SGTC_784|Compound:4579-0127|FD-Score:3.32|P-value:1.78E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:3.00|P-value:6.25E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:3.57|P-value:5.87E-5 ID:SGTC_858|Compound:0438-0351|FD-Score:3.35|P-value:1.52E-4 ID:SGTC_917|Compound:harmaline|FD-Score:2.92|P-value:8.24E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:5.57|P-value:9.09E-10 ID:SGTC_1015|Compound:4130-4525|FD-Score:4.17|P-value:3.46E-6 ID:SGTC_1027|Compound:k015-0025|FD-Score:2.95|P-value:7.59E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:-2.90|P-value:8.03E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.03|P-value:5.49E-4 ID:SGTC_1079|Compound:idarubicin|FD-Score:4.42|P-value:9.65E-7 ID:SGTC_1082|Compound:camptothecin|FD-Score:20.70|P-value:7.37E-111 ID:SGTC_1272|Compound:0839-0021|FD-Score:3.73|P-value:2.94E-5 ID:SGTC_1290|Compound:0986-0249|FD-Score:4.17|P-value:3.45E-6 ID:SGTC_1298|Compound:1079-1278|FD-Score:3.10|P-value:4.27E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.78|P-value:2.29E-5 ID:SGTC_1410|Compound:3909-8106|FD-Score:3.50|P-value:8.23E-5 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.74|P-value:2.84E-5 ID:SGTC_1460|Compound:k062-0059|FD-Score:4.47|P-value:7.36E-7 ID:SGTC_1530|Compound:rhein|FD-Score:-3.07|P-value:4.32E-4 ID:SGTC_1686|Compound:st019653|FD-Score:3.00|P-value:6.11E-4 ID:SGTC_1707|Compound:st032323|FD-Score:9.07|P-value:5.68E-23 ID:SGTC_1731|Compound:st035964|FD-Score:3.63|P-value:4.61E-5 ID:SGTC_1746|Compound:st038117|FD-Score:5.72|P-value:3.29E-10 ID:SGTC_1770|Compound:st043884|FD-Score:4.67|P-value:2.34E-7 ID:SGTC_1784|Compound:st039334|FD-Score:3.02|P-value:5.72E-4 ID:SGTC_1837|Compound:st055472|FD-Score:-3.15|P-value:3.10E-4 ID:SGTC_1845|Compound:st056753|FD-Score:7.14|P-value:6.15E-15 ID:SGTC_1915|Compound:st067105|FD-Score:3.35|P-value:1.53E-4 ID:SGTC_1971|Compound:st069429|FD-Score:2.96|P-value:7.08E-4 ID:SGTC_1974|Compound:st069448|FD-Score:3.11|P-value:4.08E-4 ID:SGTC_2017|Compound:5132927|FD-Score:-3.29|P-value:1.78E-4 ID:SGTC_2023|Compound:5144124|FD-Score:3.29|P-value:1.96E-4 ID:SGTC_2068|Compound:5226020|FD-Score:-3.62|P-value:4.18E-5 ID:SGTC_2116|Compound:5511452|FD-Score:3.43|P-value:1.09E-4 ID:SGTC_2121|Compound:5257820|FD-Score:3.17|P-value:3.18E-4 ID:SGTC_2126|Compound:5251174|FD-Score:4.38|P-value:1.15E-6 ID:SGTC_2211|Compound:7117706|FD-Score:2.87|P-value:9.89E-4 ID:SGTC_2259|Compound:7964009|FD-Score:3.80|P-value:2.14E-5 ID:SGTC_2283|Compound:7944793|FD-Score:2.93|P-value:8.05E-4 ID:SGTC_2360|Compound:9040895|FD-Score:4.06|P-value:6.00E-6 ID:SGTC_2455|Compound:5377712|FD-Score:3.36|P-value:1.47E-4 ID:SGTC_2467|Compound:5474540|FD-Score:-3.59|P-value:4.88E-5 ID:SGTC_2472|Compound:5377652|FD-Score:2.87|P-value:9.89E-4 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:-2.85|P-value:9.65E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.04|P-value:5.38E-4 ID:SGTC_2671|Compound:danthron|FD-Score:3.84|P-value:1.76E-5 ID:SGTC_2807|Compound:7945238|FD-Score:-4.08|P-value:4.76E-6 ID:SGTC_2813|Compound:7971799|FD-Score:-3.30|P-value:1.69E-4 ID:SGTC_2856|Compound:9022925|FD-Score:6.56|P-value:7.33E-13 ID:SGTC_2859|Compound:9028643|FD-Score:4.82|P-value:1.03E-7 ID:SGTC_2910|Compound:7948405|FD-Score:3.02|P-value:5.73E-4 ID:SGTC_3024|Compound:9090631|FD-Score:3.07|P-value:4.83E-4 ID:SGTC_3029|Compound:9088683|FD-Score:-2.87|P-value:9.06E-4 ID:SGTC_3134|Compound:9127454|FD-Score:-3.11|P-value:3.65E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:-4.21|P-value:2.40E-6 ID:SGTC_73|Compound:0327-0325|FD-Score:6.30|P-value:5.14E-12 ID:SGTC_75|Compound:0159-0059|FD-Score:-3.05|P-value:4.61E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:3.19|P-value:3.00E-4 ID:SGTC_244|Compound:nsc-207895|FD-Score:10.90|P-value:1.40E-32 ID:SGTC_248|Compound:streptozotocin|FD-Score:8.77|P-value:1.35E-21 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:3.63|P-value:4.60E-5 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:9.79|P-value:1.86E-26 ID:SGTC_268|Compound:camptothecin|FD-Score:14.70|P-value:1.79E-57 ID:SGTC_322|Compound:k048-0136|FD-Score:3.09|P-value:4.37E-4 ID:SGTC_334|Compound:1502-1024|FD-Score:-3.04|P-value:4.83E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:5.00|P-value:3.39E-8 ID:SGTC_558|Compound:k064-0027|FD-Score:3.30|P-value:1.92E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:3.29|P-value:2.01E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:-5.85|P-value:1.16E-10 ID:SGTC_720|Compound:r052-1644|FD-Score:3.02|P-value:5.78E-4 ID:SGTC_775|Compound:4577-0580|FD-Score:3.78|P-value:2.30E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:3.91|P-value:1.25E-5 ID:SGTC_782|Compound:0083-0095|FD-Score:4.66|P-value:2.52E-7 ID:SGTC_784|Compound:4579-0127|FD-Score:3.32|P-value:1.78E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:3.00|P-value:6.25E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:3.57|P-value:5.87E-5 ID:SGTC_858|Compound:0438-0351|FD-Score:3.35|P-value:1.52E-4 ID:SGTC_917|Compound:harmaline|FD-Score:2.92|P-value:8.24E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:5.57|P-value:9.09E-10 ID:SGTC_1015|Compound:4130-4525|FD-Score:4.17|P-value:3.46E-6 ID:SGTC_1027|Compound:k015-0025|FD-Score:2.95|P-value:7.59E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:-2.90|P-value:8.03E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.03|P-value:5.49E-4 ID:SGTC_1079|Compound:idarubicin|FD-Score:4.42|P-value:9.65E-7 ID:SGTC_1082|Compound:camptothecin|FD-Score:20.70|P-value:7.37E-111 ID:SGTC_1272|Compound:0839-0021|FD-Score:3.73|P-value:2.94E-5 ID:SGTC_1290|Compound:0986-0249|FD-Score:4.17|P-value:3.45E-6 ID:SGTC_1298|Compound:1079-1278|FD-Score:3.10|P-value:4.27E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.78|P-value:2.29E-5 ID:SGTC_1410|Compound:3909-8106|FD-Score:3.50|P-value:8.23E-5 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.74|P-value:2.84E-5 ID:SGTC_1460|Compound:k062-0059|FD-Score:4.47|P-value:7.36E-7 ID:SGTC_1530|Compound:rhein|FD-Score:-3.07|P-value:4.32E-4 ID:SGTC_1686|Compound:st019653|FD-Score:3.00|P-value:6.11E-4 ID:SGTC_1707|Compound:st032323|FD-Score:9.07|P-value:5.68E-23 ID:SGTC_1731|Compound:st035964|FD-Score:3.63|P-value:4.61E-5 ID:SGTC_1746|Compound:st038117|FD-Score:5.72|P-value:3.29E-10 ID:SGTC_1770|Compound:st043884|FD-Score:4.67|P-value:2.34E-7 ID:SGTC_1784|Compound:st039334|FD-Score:3.02|P-value:5.72E-4 ID:SGTC_1837|Compound:st055472|FD-Score:-3.15|P-value:3.10E-4 ID:SGTC_1845|Compound:st056753|FD-Score:7.14|P-value:6.15E-15 ID:SGTC_1915|Compound:st067105|FD-Score:3.35|P-value:1.53E-4 ID:SGTC_1971|Compound:st069429|FD-Score:2.96|P-value:7.08E-4 ID:SGTC_1974|Compound:st069448|FD-Score:3.11|P-value:4.08E-4 ID:SGTC_2017|Compound:5132927|FD-Score:-3.29|P-value:1.78E-4 ID:SGTC_2023|Compound:5144124|FD-Score:3.29|P-value:1.96E-4 ID:SGTC_2068|Compound:5226020|FD-Score:-3.62|P-value:4.18E-5 ID:SGTC_2116|Compound:5511452|FD-Score:3.43|P-value:1.09E-4 ID:SGTC_2121|Compound:5257820|FD-Score:3.17|P-value:3.18E-4 ID:SGTC_2126|Compound:5251174|FD-Score:4.38|P-value:1.15E-6 ID:SGTC_2211|Compound:7117706|FD-Score:2.87|P-value:9.89E-4 ID:SGTC_2259|Compound:7964009|FD-Score:3.80|P-value:2.14E-5 ID:SGTC_2283|Compound:7944793|FD-Score:2.93|P-value:8.05E-4 ID:SGTC_2360|Compound:9040895|FD-Score:4.06|P-value:6.00E-6 ID:SGTC_2455|Compound:5377712|FD-Score:3.36|P-value:1.47E-4 ID:SGTC_2467|Compound:5474540|FD-Score:-3.59|P-value:4.88E-5 ID:SGTC_2472|Compound:5377652|FD-Score:2.87|P-value:9.89E-4 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:-2.85|P-value:9.65E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.04|P-value:5.38E-4 ID:SGTC_2671|Compound:danthron|FD-Score:3.84|P-value:1.76E-5 ID:SGTC_2807|Compound:7945238|FD-Score:-4.08|P-value:4.76E-6 ID:SGTC_2813|Compound:7971799|FD-Score:-3.30|P-value:1.69E-4 ID:SGTC_2856|Compound:9022925|FD-Score:6.56|P-value:7.33E-13 ID:SGTC_2859|Compound:9028643|FD-Score:4.82|P-value:1.03E-7 ID:SGTC_2910|Compound:7948405|FD-Score:3.02|P-value:5.73E-4 ID:SGTC_3024|Compound:9090631|FD-Score:3.07|P-value:4.83E-4 ID:SGTC_3029|Compound:9088683|FD-Score:-2.87|P-value:9.06E-4 ID:SGTC_3134|Compound:9127454|FD-Score:-3.11|P-value:3.65E-4

Top fitness defect scores for YBR099C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1082 camptothecin 20.70 424.9 nM 7.37E-111 DNA damage response 3 3.33E-95
2 SGTC_268 camptothecin 14.70 39.6 µM 1.79E-57 DNA damage response 2 1.62E-49
3 SGTC_244 nsc-207895 10.90 1.3 µM 1.40E-32 DNA damage response 3 3.35E-28
4 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 9.79 44.4 nM 1.86E-26 DNA damage response 14 5.94E-23
5 SGTC_1707 st032323 9.07 6.3 µM 5.68E-23 DNA damage response 11 5.76E-20
6 SGTC_248 streptozotocin 8.77 5.2 mM 1.35E-21 DNA damage response 3 8.74E-19
7 SGTC_1845 st056753 7.14 3.0 µM 6.15E-15 TSC3-RPN4 6 4.51E-13
8 SGTC_2856 9022925 6.56 19.5 µM 7.33E-13 3 2.74E-11
9 SGTC_73 0327-0325 6.30 16.2 µM 5.14E-12 DNA damage response 13 1.46E-10
10 SGTC_1746 st038117 5.72 42.0 µM 3.29E-10 8 5.21E-9
11 SGTC_974 1326-0144 5.57 138.0 µM 9.09E-10 ERG2 13 1.25E-8
12 SGTC_362 0310-0100 5.00 9.0 µM 3.39E-8 RPP1 & pyrimidine depletion 11 2.81E-7
13 SGTC_2859 9028643 4.82 45.5 µM 1.03E-7 6 7.33E-7
14 SGTC_1770 st043884 4.67 66.3 µM 2.34E-7 7 1.48E-6
15 SGTC_782 0083-0095 4.66 30.5 µM 2.52E-7 14 1.59E-6
16 SGTC_1460 k062-0059 4.47 9.2 µM 7.36E-7 Golgi 5 3.99E-6
17 SGTC_1079 idarubicin 4.42 2.4 µM 9.65E-7 DNA damage response 15 5.04E-6
18 SGTC_2126 5251174 4.38 33.9 µM 1.15E-6 19 5.86E-6
19 SGTC_1290 0986-0249 4.17 10.2 µM 3.45E-6 DNA intercalators 20 1.51E-5
20 SGTC_1015 4130-4525 4.17 82.0 µM 3.46E-6 60S ribosome export 17 1.52E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.619 0 YDR386W MUS81 hom Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p
0.597 1.38E-322 YBR098W MMS4 hom Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p
0.549 2.21E-263 YDL059C RAD59 hom Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p
0.432 1.02E-152 YDR076W RAD55 hom Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p
0.400 6.90E-129 YGL175C SAE2 hom Endonuclease that processes hairpin DNA structures with the MRX complex; involved in meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents
0.375 1.67E-112 YJL092W SRS2 hom DNA helicase and DNA-dependent ATPase involved in DNA repair and checkpoint recovery, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat expansion; affects genome stability
0.366 8.53E-107 YDR004W RAD57 hom Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p
0.363 3.83E-105 YGL163C RAD54 hom DNA-dependent ATPase that stimulates strand exchange; modifies the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family; forms nuclear foci upon DNA replication stress
0.325 3.44E-83 YBL088C TEL1 hom Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; regulates P-body formation induced by replication stress; homolog of human ataxia-telangiectasia mutated (ATM) gene, the gene responsible for ataxia telangiectasia (AT) (OMIM 607585)
0.285 1.12E-63 YJL047C RTT101 hom Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex with a role in anaphase progression; implicated in Mms22-dependent DNA repair; involved with Mms1p in nonfunctional rRNA decay; modified by the ubiquitin-like protein, Rub1p
0.244 1.43E-46 YER095W RAD51 hom Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein
0.217 5.18E-37 YPR066W UBA3 hom Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern
0.199 2.07E-31 YML095C RAD10 hom Single-stranded DNA endonuclease (with Rad1p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human ERCC1 protein
0.194 7.84E-30 YMR048W CSM3 hom Replication fork associated factor; required for stable replication fork pausing; component of the DNA replication checkpoint pathway; required for accurate chromosome segregation during meiosis; forms nuclear foci upon DNA replication stress
0.185 3.82E-27 YMR201C RAD14 hom Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein