YBR103W / SIF2

WD40 repeat-containing subunit of the Set3C histone deacetylase complex, which represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR103W / SIF2

Click on Significant Values for Screen Details ID:SGTC_137|Compound:0438-0332|FD-Score:3.37|P-value:5.75E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:3.63|P-value:2.32E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:8.40|P-value:2.74E-16 ID:SGTC_193|Compound:1273-0060|FD-Score:4.06|P-value:4.52E-5 ID:SGTC_201|Compound:4262-0159|FD-Score:3.73|P-value:1.61E-4 ID:SGTC_218|Compound:alverine citrate|FD-Score:3.27|P-value:8.12E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:3.43|P-value:4.69E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:5.32|P-value:1.48E-7 ID:SGTC_320|Compound:4092-0846|FD-Score:5.51|P-value:5.50E-8 ID:SGTC_327|Compound:1273-0057|FD-Score:3.86|P-value:1.01E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.66|P-value:1.98E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:3.76|P-value:1.43E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.47|P-value:3.89E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:4.41|P-value:1.08E-5 ID:SGTC_604|Compound:1000-0114|FD-Score:3.21|P-value:9.95E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:4.42|P-value:1.02E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:6.26|P-value:7.85E-10 ID:SGTC_795|Compound:0685-0265|FD-Score:3.41|P-value:5.18E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:3.52|P-value:3.47E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:3.80|P-value:1.23E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:4.44|P-value:9.54E-6 ID:SGTC_1072|Compound:oxiconazole|FD-Score:3.96|P-value:6.81E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:6.17|P-value:1.34E-9 ID:SGTC_1085|Compound:doxorubicin|FD-Score:-3.38|P-value:5.48E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:-3.38|P-value:5.38E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:4.72|P-value:2.62E-6 ID:SGTC_1277|Compound:0873-0036|FD-Score:4.41|P-value:1.07E-5 ID:SGTC_1315|Compound:1237-0019|FD-Score:4.45|P-value:9.11E-6 ID:SGTC_1317|Compound:1273-0028|FD-Score:7.18|P-value:2.23E-12 ID:SGTC_1471|Compound:k673-0312|FD-Score:3.24|P-value:8.87E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.75|P-value:1.53E-4 ID:SGTC_1640|Compound:st009078|FD-Score:5.29|P-value:1.66E-7 ID:SGTC_1658|Compound:st012944|FD-Score:-3.36|P-value:5.71E-4 ID:SGTC_1659|Compound:st012954|FD-Score:4.12|P-value:3.63E-5 ID:SGTC_1675|Compound:st018485|FD-Score:4.47|P-value:8.28E-6 ID:SGTC_1679|Compound:4130-1276|FD-Score:4.13|P-value:3.45E-5 ID:SGTC_1687|Compound:st020778|FD-Score:3.48|P-value:4.04E-4 ID:SGTC_1694|Compound:st024011|FD-Score:3.35|P-value:6.23E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:3.89|P-value:8.80E-5 ID:SGTC_1728|Compound:st035614|FD-Score:6.40|P-value:3.46E-10 ID:SGTC_1817|Compound:st052116|FD-Score:3.83|P-value:1.12E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:3.56|P-value:3.00E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:3.28|P-value:7.89E-4 ID:SGTC_1916|Compound:st067606|FD-Score:3.32|P-value:7.00E-4 ID:SGTC_1941|Compound:st076221|FD-Score:4.03|P-value:5.16E-5 ID:SGTC_1962|Compound:st076595|FD-Score:-3.44|P-value:4.36E-4 ID:SGTC_1972|Compound:st070201|FD-Score:3.63|P-value:2.36E-4 ID:SGTC_2034|Compound:5197015|FD-Score:4.13|P-value:3.37E-5 ID:SGTC_2185|Compound:6113692|FD-Score:3.43|P-value:4.79E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.15|P-value:3.21E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:6.60|P-value:9.55E-11 ID:SGTC_2292|Compound:7671323|FD-Score:3.32|P-value:6.87E-4 ID:SGTC_2332|Compound:7982454|FD-Score:6.49|P-value:1.95E-10 ID:SGTC_2363|Compound:9053361|FD-Score:3.93|P-value:7.56E-5 ID:SGTC_2456|Compound:5770359|FD-Score:3.37|P-value:5.81E-4 ID:SGTC_2460|Compound:5552655|FD-Score:-4.92|P-value:9.95E-7 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.08|P-value:4.19E-5 ID:SGTC_2638|Compound:epoxomicin|FD-Score:3.21|P-value:9.96E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:7.58|P-value:1.37E-13 ID:SGTC_2776|Compound:terbinafine|FD-Score:4.14|P-value:3.35E-5 ID:SGTC_2778|Compound:tioconazole|FD-Score:4.64|P-value:3.83E-6 ID:SGTC_2939|Compound:9044578|FD-Score:-4.71|P-value:2.65E-6 ID:SGTC_2995|Compound:9067767|FD-Score:4.64|P-value:3.88E-6 ID:SGTC_3152|Compound:9099253|FD-Score:4.21|P-value:2.48E-5 ID:SGTC_3311|Compound:9131146|FD-Score:3.68|P-value:1.94E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:3.37|P-value:5.75E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:3.63|P-value:2.32E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:8.40|P-value:2.74E-16 ID:SGTC_193|Compound:1273-0060|FD-Score:4.06|P-value:4.52E-5 ID:SGTC_201|Compound:4262-0159|FD-Score:3.73|P-value:1.61E-4 ID:SGTC_218|Compound:alverine citrate|FD-Score:3.27|P-value:8.12E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:3.43|P-value:4.69E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:5.32|P-value:1.48E-7 ID:SGTC_320|Compound:4092-0846|FD-Score:5.51|P-value:5.50E-8 ID:SGTC_327|Compound:1273-0057|FD-Score:3.86|P-value:1.01E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.66|P-value:1.98E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:3.76|P-value:1.43E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.47|P-value:3.89E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:4.41|P-value:1.08E-5 ID:SGTC_604|Compound:1000-0114|FD-Score:3.21|P-value:9.95E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:4.42|P-value:1.02E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:6.26|P-value:7.85E-10 ID:SGTC_795|Compound:0685-0265|FD-Score:3.41|P-value:5.18E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:3.52|P-value:3.47E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:3.80|P-value:1.23E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:4.44|P-value:9.54E-6 ID:SGTC_1072|Compound:oxiconazole|FD-Score:3.96|P-value:6.81E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:6.17|P-value:1.34E-9 ID:SGTC_1085|Compound:doxorubicin|FD-Score:-3.38|P-value:5.48E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:-3.38|P-value:5.38E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:4.72|P-value:2.62E-6 ID:SGTC_1277|Compound:0873-0036|FD-Score:4.41|P-value:1.07E-5 ID:SGTC_1315|Compound:1237-0019|FD-Score:4.45|P-value:9.11E-6 ID:SGTC_1317|Compound:1273-0028|FD-Score:7.18|P-value:2.23E-12 ID:SGTC_1471|Compound:k673-0312|FD-Score:3.24|P-value:8.87E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.75|P-value:1.53E-4 ID:SGTC_1640|Compound:st009078|FD-Score:5.29|P-value:1.66E-7 ID:SGTC_1658|Compound:st012944|FD-Score:-3.36|P-value:5.71E-4 ID:SGTC_1659|Compound:st012954|FD-Score:4.12|P-value:3.63E-5 ID:SGTC_1675|Compound:st018485|FD-Score:4.47|P-value:8.28E-6 ID:SGTC_1679|Compound:4130-1276|FD-Score:4.13|P-value:3.45E-5 ID:SGTC_1687|Compound:st020778|FD-Score:3.48|P-value:4.04E-4 ID:SGTC_1694|Compound:st024011|FD-Score:3.35|P-value:6.23E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:3.89|P-value:8.80E-5 ID:SGTC_1728|Compound:st035614|FD-Score:6.40|P-value:3.46E-10 ID:SGTC_1817|Compound:st052116|FD-Score:3.83|P-value:1.12E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:3.56|P-value:3.00E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:3.28|P-value:7.89E-4 ID:SGTC_1916|Compound:st067606|FD-Score:3.32|P-value:7.00E-4 ID:SGTC_1941|Compound:st076221|FD-Score:4.03|P-value:5.16E-5 ID:SGTC_1962|Compound:st076595|FD-Score:-3.44|P-value:4.36E-4 ID:SGTC_1972|Compound:st070201|FD-Score:3.63|P-value:2.36E-4 ID:SGTC_2034|Compound:5197015|FD-Score:4.13|P-value:3.37E-5 ID:SGTC_2185|Compound:6113692|FD-Score:3.43|P-value:4.79E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.15|P-value:3.21E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:6.60|P-value:9.55E-11 ID:SGTC_2292|Compound:7671323|FD-Score:3.32|P-value:6.87E-4 ID:SGTC_2332|Compound:7982454|FD-Score:6.49|P-value:1.95E-10 ID:SGTC_2363|Compound:9053361|FD-Score:3.93|P-value:7.56E-5 ID:SGTC_2456|Compound:5770359|FD-Score:3.37|P-value:5.81E-4 ID:SGTC_2460|Compound:5552655|FD-Score:-4.92|P-value:9.95E-7 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.08|P-value:4.19E-5 ID:SGTC_2638|Compound:epoxomicin|FD-Score:3.21|P-value:9.96E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:7.58|P-value:1.37E-13 ID:SGTC_2776|Compound:terbinafine|FD-Score:4.14|P-value:3.35E-5 ID:SGTC_2778|Compound:tioconazole|FD-Score:4.64|P-value:3.83E-6 ID:SGTC_2939|Compound:9044578|FD-Score:-4.71|P-value:2.65E-6 ID:SGTC_2995|Compound:9067767|FD-Score:4.64|P-value:3.88E-6 ID:SGTC_3152|Compound:9099253|FD-Score:4.21|P-value:2.48E-5 ID:SGTC_3311|Compound:9131146|FD-Score:3.68|P-value:1.94E-4

Top fitness defect scores for YBR103W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_178 4092-0806 8.40 87.5 µM 2.74E-16 ergosterol depletion effects on membrane 18 2.28E-17
2 SGTC_2752 diclazuril 7.58 33.1 µM 1.37E-13 40 1.79E-14
3 SGTC_1317 1273-0028 7.18 910.0 nM 2.23E-12 azole & statin 23 3.57E-13
4 SGTC_2250 alverine citrate 6.60 130.0 µM 9.55E-11 40 2.01E-11
5 SGTC_2332 7982454 6.49 138.9 µM 1.95E-10 13 4.31E-11
6 SGTC_1728 st035614 6.40 33.8 µM 3.46E-10 7 7.97E-11
7 SGTC_769 0302-0231 6.26 76.0 µM 7.85E-10 6 1.92E-10
8 SGTC_1083 didemethylchlorpromazine sulfoxide 6.17 707.4 nM 1.34E-9 redox potentiating 25 3.40E-10
9 SGTC_320 4092-0846 5.51 5.3 µM 5.50E-8 ergosterol depletion effects on membrane 21 1.83E-8
10 SGTC_312 4092-0653 5.32 6.8 µM 1.48E-7 ergosterol depletion effects on membrane 47 5.27E-8
11 SGTC_1640 st009078 5.29 66.4 µM 1.66E-7 2 5.96E-8
12 SGTC_1168 k815-0004 4.72 80.5 µM 2.62E-6 DNA damage response 7 1.15E-6
13 SGTC_2778 tioconazole 4.64 65.1 nM 3.83E-6 ergosterol depletion effects on membrane 43 1.73E-6
14 SGTC_2995 9067767 4.64 71.4 µM 3.88E-6 15 1.75E-6
15 SGTC_1675 st018485 4.47 24.5 µM 8.28E-6 60S ribosome export 15 3.95E-6
16 SGTC_1315 1237-0019 4.45 3.7 µM 9.11E-6 7 4.37E-6
17 SGTC_1019 4262-0212 4.44 3.4 µM 9.54E-6 ergosterol depletion effects on membrane 46 4.59E-6
18 SGTC_700 3453-2283 4.42 142.0 µM 1.02E-5 amide catabolism 15 4.94E-6
19 SGTC_1277 0873-0036 4.41 22.0 µM 1.07E-5 PDR1 17 5.17E-6
20 SGTC_594 1487-1584 4.41 10.8 µM 1.08E-5 19 5.25E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.264 1.59E-54 YCR033W SNT1 hom Subunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein; mutant has increased aneuploidy tolerance
0.230 2.27E-41 YGL194C HOS2 hom Histone deacetylase and subunit of Set3 and Rpd3L complexes; required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; co-localizes with Cmr1p in nuclear foci in response to DNA damage by MMS
0.222 1.29E-38 YOR030W DFG16 hom Probable multiple transmembrane protein; involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; is glycosylated and phosphorylated; interacts with Rim21p and Rim9p in the plasma membrane to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; required for accumulation of processed Rim101p
0.216 1.39E-36 YIL112W HOS4 hom Subunit of the Set3 complex, which is a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; potential Cdc28p substrate
0.209 2.46E-34 YDR213W UPC2 hom Sterol regulatory element binding protein; induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; relocates from intracellular membranes to perinuclear foci on sterol depletion; UPC2 has a paralog, ECM22, that arose from the whole genome duplication
0.202 3.60E-32 YLR350W ORM2 hom Evolutionarily conserved protein, similar to Orm1p; required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control; protein abundance increases in response to DNA replication stress
0.193 1.38E-29 YGL233W SEC15 het Essential 113 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; interacts with and functions as a downstream effector of active, GTP-bound Sec4p, a Rab family GTPase
0.192 3.50E-29 YBR102C EXO84 het Exocyst subunit with dual roles in exocytosis and spliceosome assembly; subunit of the the exocyst complex which mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane (PM) prior to SNARE-mediated fusion; required for exocyst assembly and targeting the complex to specific sites on the bud tip PM; associates the U1 snRNP; role in pre-mRNA splicing and prespliceosome formation; possible Cdc28 substrate
0.189 3.28E-28 YHL027W RIM101 hom Cys2His2 zinc-finger transcriptional repressor; involved in alkaline responsive gene repression as part of adaptation to a alkaline conditions; involved in cell wall assembly; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by alkaline-dependent proteolytic processing which results in removal of the C-terminal tail; similar to A. nidulans PacC
0.185 3.16E-27 YNL294C RIM21 hom pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH
0.184 8.59E-27 YGL045W RIM8 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family
0.180 8.65E-26 YIL170W HXT12 hom Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family
0.180 1.03E-25 YLR170C APS1 hom Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex
0.175 1.51E-24 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.174 3.75E-24 YIL068C SEC6 het Essential 88kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; anchors the assembled complex to sites of secretion; interacts with SM-like protein and SNARE regulator Sec1p and may recruit it to sites of secretion; interacts with Sec9p and inhibits formation of the t-SNARE complex between Sec9p and Sso1p