YBR105C / VID24

GID Complex regulatory subunit; binds GID Complex in response to glucose through interactions with complex member Vid28p; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; promotes proteasome-dependent catabolite degradation of FBPase; peripheral membrane protein located at Vid (vacuole import and degradation) vesicles

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR105C / VID24

Click on Significant Values for Screen Details ID:SGTC_34|Compound:0469-0683|FD-Score:3.89|P-value:1.03E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:-3.28|P-value:8.58E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:3.74|P-value:1.77E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:3.36|P-value:6.67E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:3.61|P-value:2.91E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:3.36|P-value:6.86E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:-3.66|P-value:2.30E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.59|P-value:3.06E-4 ID:SGTC_489|Compound:paxilline|FD-Score:3.96|P-value:7.93E-5 ID:SGTC_818|Compound:4072-2707|FD-Score:4.71|P-value:3.47E-6 ID:SGTC_1046|Compound:2001-0062|FD-Score:3.93|P-value:8.77E-5 ID:SGTC_1256|Compound:0570-0116|FD-Score:-3.69|P-value:2.05E-4 ID:SGTC_1688|Compound:st021091|FD-Score:3.37|P-value:6.53E-4 ID:SGTC_2020|Compound:4017018|FD-Score:-3.69|P-value:2.04E-4 ID:SGTC_2052|Compound:5265182|FD-Score:-5.49|P-value:7.41E-8 ID:SGTC_2054|Compound:5233173|FD-Score:10.00|P-value:6.37E-22 ID:SGTC_2059|Compound:5238311|FD-Score:3.55|P-value:3.54E-4 ID:SGTC_2079|Compound:5212404|FD-Score:4.68|P-value:4.06E-6 ID:SGTC_2296|Compound:7971656|FD-Score:-5.15|P-value:4.17E-7 ID:SGTC_2298|Compound:7976326|FD-Score:-4.80|P-value:2.23E-6 ID:SGTC_2311|Compound:7694451|FD-Score:-4.39|P-value:1.32E-5 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:4.22|P-value:2.81E-5 ID:SGTC_2549|Compound:cedrol|FD-Score:4.24|P-value:2.65E-5 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-3.29|P-value:8.25E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:3.69|P-value:2.14E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:5.33|P-value:1.80E-7 ID:SGTC_2781|Compound:5567276|FD-Score:6.19|P-value:1.69E-9 ID:SGTC_2789|Compound:5281112|FD-Score:4.19|P-value:3.16E-5 ID:SGTC_2796|Compound:7949634|FD-Score:-5.09|P-value:5.53E-7 ID:SGTC_2800|Compound:7887935|FD-Score:5.12|P-value:5.04E-7 ID:SGTC_2907|Compound:7721985|FD-Score:3.46|P-value:4.77E-4 ID:SGTC_2942|Compound:9052777|FD-Score:5.24|P-value:2.89E-7 ID:SGTC_2947|Compound:9072639|FD-Score:-5.88|P-value:9.22E-9 ID:SGTC_2950|Compound:9072895|FD-Score:5.83|P-value:1.32E-8 ID:SGTC_2955|Compound:9076254|FD-Score:-3.60|P-value:2.83E-4 ID:SGTC_2957|Compound:9076800|FD-Score:4.59|P-value:6.04E-6 ID:SGTC_2963|Compound:9082507|FD-Score:5.04|P-value:7.57E-7 ID:SGTC_3101|Compound:9120531|FD-Score:4.44|P-value:1.15E-5 ID:SGTC_3236|Compound:9132701|FD-Score:-4.02|P-value:5.92E-5 ID:SGTC_3244|Compound:9134489|FD-Score:-4.35|P-value:1.58E-5 ID:SGTC_3248|Compound:9135562|FD-Score:-4.25|P-value:2.35E-5 ID:SGTC_3250|Compound:9135583|FD-Score:4.24|P-value:2.59E-5 ID:SGTC_3290|Compound:9121031|FD-Score:3.73|P-value:1.86E-4 ID:SGTC_3345|Compound:9148410|FD-Score:4.68|P-value:4.04E-6 ID:SGTC_34|Compound:0469-0683|FD-Score:3.89|P-value:1.03E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:-3.28|P-value:8.58E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:3.74|P-value:1.77E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:3.36|P-value:6.67E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:3.61|P-value:2.91E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:3.36|P-value:6.86E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:-3.66|P-value:2.30E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.59|P-value:3.06E-4 ID:SGTC_489|Compound:paxilline|FD-Score:3.96|P-value:7.93E-5 ID:SGTC_818|Compound:4072-2707|FD-Score:4.71|P-value:3.47E-6 ID:SGTC_1046|Compound:2001-0062|FD-Score:3.93|P-value:8.77E-5 ID:SGTC_1256|Compound:0570-0116|FD-Score:-3.69|P-value:2.05E-4 ID:SGTC_1688|Compound:st021091|FD-Score:3.37|P-value:6.53E-4 ID:SGTC_2020|Compound:4017018|FD-Score:-3.69|P-value:2.04E-4 ID:SGTC_2052|Compound:5265182|FD-Score:-5.49|P-value:7.41E-8 ID:SGTC_2054|Compound:5233173|FD-Score:10.00|P-value:6.37E-22 ID:SGTC_2059|Compound:5238311|FD-Score:3.55|P-value:3.54E-4 ID:SGTC_2079|Compound:5212404|FD-Score:4.68|P-value:4.06E-6 ID:SGTC_2296|Compound:7971656|FD-Score:-5.15|P-value:4.17E-7 ID:SGTC_2298|Compound:7976326|FD-Score:-4.80|P-value:2.23E-6 ID:SGTC_2311|Compound:7694451|FD-Score:-4.39|P-value:1.32E-5 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:4.22|P-value:2.81E-5 ID:SGTC_2549|Compound:cedrol|FD-Score:4.24|P-value:2.65E-5 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-3.29|P-value:8.25E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:3.69|P-value:2.14E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:5.33|P-value:1.80E-7 ID:SGTC_2781|Compound:5567276|FD-Score:6.19|P-value:1.69E-9 ID:SGTC_2789|Compound:5281112|FD-Score:4.19|P-value:3.16E-5 ID:SGTC_2796|Compound:7949634|FD-Score:-5.09|P-value:5.53E-7 ID:SGTC_2800|Compound:7887935|FD-Score:5.12|P-value:5.04E-7 ID:SGTC_2907|Compound:7721985|FD-Score:3.46|P-value:4.77E-4 ID:SGTC_2942|Compound:9052777|FD-Score:5.24|P-value:2.89E-7 ID:SGTC_2947|Compound:9072639|FD-Score:-5.88|P-value:9.22E-9 ID:SGTC_2950|Compound:9072895|FD-Score:5.83|P-value:1.32E-8 ID:SGTC_2955|Compound:9076254|FD-Score:-3.60|P-value:2.83E-4 ID:SGTC_2957|Compound:9076800|FD-Score:4.59|P-value:6.04E-6 ID:SGTC_2963|Compound:9082507|FD-Score:5.04|P-value:7.57E-7 ID:SGTC_3101|Compound:9120531|FD-Score:4.44|P-value:1.15E-5 ID:SGTC_3236|Compound:9132701|FD-Score:-4.02|P-value:5.92E-5 ID:SGTC_3244|Compound:9134489|FD-Score:-4.35|P-value:1.58E-5 ID:SGTC_3248|Compound:9135562|FD-Score:-4.25|P-value:2.35E-5 ID:SGTC_3250|Compound:9135583|FD-Score:4.24|P-value:2.59E-5 ID:SGTC_3290|Compound:9121031|FD-Score:3.73|P-value:1.86E-4 ID:SGTC_3345|Compound:9148410|FD-Score:4.68|P-value:4.04E-6

Top fitness defect scores for YBR105C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2054 5233173 10.00 129.0 µM 6.37E-22 mitochondrial response to ROS 3 7.37E-24
2 SGTC_2781 5567276 6.19 71.4 µM 1.69E-9 12 2.95E-10
3 SGTC_2950 9072895 5.83 21.5 µM 1.32E-8 8 2.78E-9
4 SGTC_2756 carbadox 5.33 75.1 µM 1.80E-7 27 4.85E-8
5 SGTC_2942 9052777 5.24 62.2 µM 2.89E-7 7 8.16E-8
6 SGTC_2800 7887935 5.12 81.8 µM 5.04E-7 RPP1 & pyrimidine depletion 6 1.50E-7
7 SGTC_2963 9082507 5.04 9.0 µM 7.57E-7 10 2.33E-7
8 SGTC_818 4072-2707 4.71 53.5 µM 3.47E-6 5 1.23E-6
9 SGTC_3345 9148410 4.68 3.6 µM 4.04E-6 4 1.46E-6
10 SGTC_2079 5212404 4.68 121.0 µM 4.06E-6 6 1.46E-6
11 SGTC_2957 9076800 4.59 11.5 µM 6.04E-6 14 2.26E-6
12 SGTC_3101 9120531 4.44 49.5 µM 1.15E-5 21 4.56E-6
13 SGTC_3250 9135583 4.24 49.5 µM 2.59E-5 9 1.11E-5
14 SGTC_2549 cedrol 4.24 20.9 µM 2.65E-5 13 1.13E-5
15 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 4.22 100.0 µM 2.81E-5 14 1.21E-5
16 SGTC_2789 5281112 4.19 71.4 µM 3.16E-5 29 1.38E-5
17 SGTC_489 paxilline 3.96 115.0 µM 7.93E-5 PDR1 14 3.76E-5
18 SGTC_1046 2001-0062 3.93 216.0 µM 8.77E-5 20 4.20E-5
19 SGTC_34 0469-0683 3.89 81.8 µM 1.03E-4 SWF1 & branched chain AA biosynthesis 32 5.01E-5
20 SGTC_149 3970-0822 3.74 46.1 µM 1.77E-4 tubulin folding & SWR complex 107 9.03E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.137 1.43E-15 YIL099W SGA1 hom Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation
0.109 2.15E-10 YKL206C ADD66 hom Protein involved in 20S proteasome assembly; forms a heterodimer with Pba1p that binds to proteasome precursors; similar to human PAC2 constituent of the PAC1-PAC2 complex involved in proteasome assembly
0.098 1.16E-8 YML007W YAP1 hom Basic leucine zipper (bZIP) transcription factor; required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; Yap1p is degraded in the nucleus after the oxidative stress has passed; mediates resistance to cadmium; YAP1 has a paralog, CAD1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.092 1.03E-7 YOR101W RAS1 hom GTPase involved in G-protein signaling in adenylate cyclase activation; plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes; relative distribution to the nucleus increases upon DNA replication stress
0.091 1.39E-7 YML087C AIM33 hom Putative protein of unknown function, highly conserved across species; homolog of human CYB5R4; null mutant displays reduced frequency of mitochondrial genome loss; AIM33 has a paralog, PGA3, that arose from the whole genome duplication
0.087 4.94E-7 YKR034W DAL80 hom Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Gzf3p; DAL80 has a paralog, GZF3, that arose from the whole genome duplication
0.084 1.14E-6 YLR093C NYV1 hom v-SNARE component of the vacuolar SNARE complex involved in vesicle fusion; inhibits ATP-dependent Ca(2+) transport activity of Pmc1p in the vacuolar membrane
0.083 1.52E-6 YGL167C PMR1 hom High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease
0.082 1.76E-6 YGL041C-B_p YGL041C-B_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.082 1.94E-6 YPL047W SGF11 hom Integral subunit of SAGA histone acetyltransferase complex, regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA and for H2B deubiquitylation
0.082 2.24E-6 YGL051W MST27 hom Putative integral membrane protein, involved in vesicle formation; forms complex with Mst28p; member of DUP240 gene family; binds COPI and COPII vesicles
0.081 2.50E-6 YPR157W_p TDA6_p hom Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; null mutant is sensitive to expression of the top1-T722A allele
0.074 1.87E-5 YGR199W PMT6 hom Protein O-mannosyltransferase, transfers mannose from dolichyl phosphate-D-mannose to protein serine/threonine residues of secretory proteins; reaction is essential for cell wall rigidity; member of a family of mannosyltransferases
0.073 2.31E-5 YPR020W ATP20 hom Subunit g of the mitochondrial F1F0 ATP synthase; reversibly phosphorylated on two residues; unphosphorylated form is required for dimerization of the ATP synthase complex
0.073 2.41E-5 YGR027C RPS25A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S25, no bacterial homolog; RPS25A has a paralog, RPS25B, that arose from the whole genome duplication