YBR106W / PHO88

Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR106W / PHO88

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:6.16|P-value:2.76E-6 ID:SGTC_55|Compound:0767-0285|FD-Score:7.59|P-value:1.09E-8 ID:SGTC_58|Compound:0957-0393|FD-Score:6.23|P-value:2.22E-6 ID:SGTC_64|Compound:000l-0018|FD-Score:13.30|P-value:4.48E-23 ID:SGTC_67|Compound:0335-0847|FD-Score:10.80|P-value:6.90E-16 ID:SGTC_71|Compound:0417-1750|FD-Score:-4.19|P-value:9.08E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:5.28|P-value:4.97E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:5.58|P-value:2.00E-5 ID:SGTC_152|Compound:4469-0003|FD-Score:5.35|P-value:4.01E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:7.87|P-value:3.25E-9 ID:SGTC_163|Compound:1327-0036|FD-Score:5.23|P-value:5.89E-5 ID:SGTC_188|Compound:3229-0966|FD-Score:5.39|P-value:3.60E-5 ID:SGTC_192|Compound:3455-0609|FD-Score:10.20|P-value:2.18E-14 ID:SGTC_200|Compound:k038-0079|FD-Score:4.82|P-value:1.94E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:4.58|P-value:3.73E-4 ID:SGTC_249|Compound:wiskostatin|FD-Score:4.31|P-value:7.64E-4 ID:SGTC_252|Compound:miconazole|FD-Score:4.38|P-value:6.35E-4 ID:SGTC_285|Compound:1486-1325|FD-Score:6.52|P-value:7.70E-7 ID:SGTC_286|Compound:k060-0067|FD-Score:6.54|P-value:7.22E-7 ID:SGTC_294|Compound:k038-0071|FD-Score:6.31|P-value:1.64E-6 ID:SGTC_315|Compound:k915-0449|FD-Score:10.70|P-value:1.15E-15 ID:SGTC_332|Compound:4112-0506|FD-Score:7.29|P-value:3.79E-8 ID:SGTC_352|Compound:k048-0007|FD-Score:8.01|P-value:1.75E-9 ID:SGTC_366|Compound:0181-0206|FD-Score:7.81|P-value:4.16E-9 ID:SGTC_367|Compound:0335-0881|FD-Score:6.07|P-value:3.82E-6 ID:SGTC_384|Compound:k007-0144|FD-Score:5.71|P-value:1.30E-5 ID:SGTC_401|Compound:neomycin|FD-Score:4.99|P-value:1.19E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:15.10|P-value:3.20E-29 ID:SGTC_452|Compound:diindolylmethane|FD-Score:5.30|P-value:4.68E-5 ID:SGTC_455|Compound:paf C-16|FD-Score:-4.24|P-value:7.96E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:-4.39|P-value:5.44E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:6.37|P-value:1.35E-6 ID:SGTC_562|Compound:3772-2733|FD-Score:7.64|P-value:8.60E-9 ID:SGTC_568|Compound:1193-0097|FD-Score:6.89|P-value:1.88E-7 ID:SGTC_575|Compound:k072-0246|FD-Score:5.52|P-value:2.37E-5 ID:SGTC_637|Compound:1181-0519|FD-Score:8.83|P-value:3.56E-11 ID:SGTC_642|Compound:0335-0876|FD-Score:4.31|P-value:7.64E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:4.71|P-value:2.60E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:4.53|P-value:4.33E-4 ID:SGTC_661|Compound:1304-0007|FD-Score:7.81|P-value:4.12E-9 ID:SGTC_697|Compound:0508-1955|FD-Score:4.79|P-value:2.10E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:10.10|P-value:3.43E-14 ID:SGTC_738|Compound:1315-0003|FD-Score:-6.29|P-value:1.48E-6 ID:SGTC_768|Compound:0384-0033|FD-Score:5.17|P-value:6.94E-5 ID:SGTC_787|Compound:4152-0075|FD-Score:4.63|P-value:3.26E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:7.74|P-value:5.69E-9 ID:SGTC_805|Compound:3852-0218|FD-Score:4.34|P-value:7.07E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:7.43|P-value:2.10E-8 ID:SGTC_837|Compound:0091-0265|FD-Score:7.45|P-value:1.96E-8 ID:SGTC_846|Compound:0335-0850|FD-Score:8.04|P-value:1.49E-9 ID:SGTC_852|Compound:0418-0143|FD-Score:4.94|P-value:1.37E-4 ID:SGTC_858|Compound:0438-0351|FD-Score:4.27|P-value:8.35E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:-4.49|P-value:4.22E-4 ID:SGTC_862|Compound:0452-0056|FD-Score:-4.48|P-value:4.36E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:7.33|P-value:3.24E-8 ID:SGTC_869|Compound:0564-0080|FD-Score:7.00|P-value:1.21E-7 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:4.97|P-value:1.25E-4 ID:SGTC_929|Compound:2805-0021|FD-Score:4.91|P-value:1.52E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:6.51|P-value:7.86E-7 ID:SGTC_1022|Compound:4477-0945|FD-Score:6.81|P-value:2.53E-7 ID:SGTC_1064|Compound:honokiol|FD-Score:6.20|P-value:2.48E-6 ID:SGTC_1067|Compound:clotrimazole|FD-Score:4.39|P-value:6.11E-4 ID:SGTC_1076|Compound:itraconazole|FD-Score:5.34|P-value:4.21E-5 ID:SGTC_1088|Compound:bifonazole|FD-Score:4.88|P-value:1.61E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:6.07|P-value:3.80E-6 ID:SGTC_1191|Compound:1487-1166|FD-Score:4.86|P-value:1.73E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:6.79|P-value:2.78E-7 ID:SGTC_1475|Compound:4092-1048|FD-Score:4.55|P-value:4.04E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:4.67|P-value:2.95E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:10.40|P-value:7.05E-15 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:4.48|P-value:4.82E-4 ID:SGTC_1617|Compound:st002906|FD-Score:-4.19|P-value:9.14E-4 ID:SGTC_1619|Compound:st003326|FD-Score:-4.17|P-value:9.57E-4 ID:SGTC_1629|Compound:st005085|FD-Score:6.52|P-value:7.60E-7 ID:SGTC_1648|Compound:st011736|FD-Score:4.40|P-value:5.96E-4 ID:SGTC_1651|Compound:st011928|FD-Score:4.38|P-value:6.35E-4 ID:SGTC_1672|Compound:st016598|FD-Score:6.60|P-value:5.79E-7 ID:SGTC_1715|Compound:st032160|FD-Score:5.25|P-value:5.43E-5 ID:SGTC_1720|Compound:st037298|FD-Score:5.06|P-value:9.80E-5 ID:SGTC_1732|Compound:st034308|FD-Score:5.01|P-value:1.11E-4 ID:SGTC_1734|Compound:st037168|FD-Score:-4.19|P-value:9.21E-4 ID:SGTC_1750|Compound:st081859|FD-Score:9.37|P-value:2.33E-12 ID:SGTC_1872|Compound:amphotericin b|FD-Score:5.01|P-value:1.14E-4 ID:SGTC_1895|Compound:st058434|FD-Score:6.23|P-value:2.21E-6 ID:SGTC_1925|Compound:st057770|FD-Score:4.91|P-value:1.51E-4 ID:SGTC_1937|Compound:st074714|FD-Score:4.74|P-value:2.41E-4 ID:SGTC_1953|Compound:st076800|FD-Score:5.23|P-value:5.84E-5 ID:SGTC_2025|Compound:5147754|FD-Score:4.36|P-value:6.69E-4 ID:SGTC_2036|Compound:5160441|FD-Score:11.60|P-value:4.17E-18 ID:SGTC_2038|Compound:4100038|FD-Score:7.63|P-value:9.04E-9 ID:SGTC_2111|Compound:5486399|FD-Score:4.45|P-value:5.34E-4 ID:SGTC_2157|Compound:5649910|FD-Score:5.05|P-value:9.91E-5 ID:SGTC_2181|Compound:6316240|FD-Score:8.24|P-value:5.92E-10 ID:SGTC_2183|Compound:6420625|FD-Score:7.95|P-value:2.29E-9 ID:SGTC_2197|Compound:6588183|FD-Score:7.31|P-value:3.54E-8 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:6.19|P-value:2.54E-6 ID:SGTC_2302|Compound:7771753|FD-Score:6.17|P-value:2.67E-6 ID:SGTC_2322|Compound:7413319|FD-Score:5.00|P-value:1.16E-4 ID:SGTC_2372|Compound:9071633|FD-Score:4.34|P-value:7.07E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:4.58|P-value:3.72E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:7.37|P-value:2.73E-8 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:4.83|P-value:1.86E-4 ID:SGTC_2526|Compound:patulin|FD-Score:-4.68|P-value:2.52E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:5.02|P-value:1.10E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:5.86|P-value:7.73E-6 ID:SGTC_2645|Compound:abamectin|FD-Score:6.45|P-value:1.01E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:13.60|P-value:6.48E-24 ID:SGTC_2659|Compound:sanguinarine|FD-Score:4.67|P-value:2.95E-4 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:6.45|P-value:9.82E-7 ID:SGTC_2757|Compound:clomiphene|FD-Score:4.98|P-value:1.21E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:4.48|P-value:4.92E-4 ID:SGTC_2918|Compound:7977171|FD-Score:7.82|P-value:3.93E-9 ID:SGTC_3059|Compound:1327-0034|FD-Score:5.18|P-value:6.75E-5 ID:SGTC_3081|Compound:9117243|FD-Score:4.83|P-value:1.90E-4 ID:SGTC_3103|Compound:9120822|FD-Score:6.09|P-value:3.64E-6 ID:SGTC_3188|Compound:9110789|FD-Score:4.35|P-value:6.90E-4 ID:SGTC_3214|Compound:9129694|FD-Score:4.45|P-value:5.26E-4 ID:SGTC_3272|Compound:9137413|FD-Score:4.91|P-value:1.49E-4 ID:SGTC_3279|Compound:9140807|FD-Score:8.66|P-value:8.33E-11 ID:SGTC_3303|Compound:9125618|FD-Score:5.18|P-value:6.72E-5 ID:SGTC_3324|Compound:9138759|FD-Score:4.94|P-value:1.37E-4 ID:SGTC_16|Compound:erodoxin|FD-Score:6.16|P-value:2.76E-6 ID:SGTC_55|Compound:0767-0285|FD-Score:7.59|P-value:1.09E-8 ID:SGTC_58|Compound:0957-0393|FD-Score:6.23|P-value:2.22E-6 ID:SGTC_64|Compound:000l-0018|FD-Score:13.30|P-value:4.48E-23 ID:SGTC_67|Compound:0335-0847|FD-Score:10.80|P-value:6.90E-16 ID:SGTC_71|Compound:0417-1750|FD-Score:-4.19|P-value:9.08E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:5.28|P-value:4.97E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:5.58|P-value:2.00E-5 ID:SGTC_152|Compound:4469-0003|FD-Score:5.35|P-value:4.01E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:7.87|P-value:3.25E-9 ID:SGTC_163|Compound:1327-0036|FD-Score:5.23|P-value:5.89E-5 ID:SGTC_188|Compound:3229-0966|FD-Score:5.39|P-value:3.60E-5 ID:SGTC_192|Compound:3455-0609|FD-Score:10.20|P-value:2.18E-14 ID:SGTC_200|Compound:k038-0079|FD-Score:4.82|P-value:1.94E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:4.58|P-value:3.73E-4 ID:SGTC_249|Compound:wiskostatin|FD-Score:4.31|P-value:7.64E-4 ID:SGTC_252|Compound:miconazole|FD-Score:4.38|P-value:6.35E-4 ID:SGTC_285|Compound:1486-1325|FD-Score:6.52|P-value:7.70E-7 ID:SGTC_286|Compound:k060-0067|FD-Score:6.54|P-value:7.22E-7 ID:SGTC_294|Compound:k038-0071|FD-Score:6.31|P-value:1.64E-6 ID:SGTC_315|Compound:k915-0449|FD-Score:10.70|P-value:1.15E-15 ID:SGTC_332|Compound:4112-0506|FD-Score:7.29|P-value:3.79E-8 ID:SGTC_352|Compound:k048-0007|FD-Score:8.01|P-value:1.75E-9 ID:SGTC_366|Compound:0181-0206|FD-Score:7.81|P-value:4.16E-9 ID:SGTC_367|Compound:0335-0881|FD-Score:6.07|P-value:3.82E-6 ID:SGTC_384|Compound:k007-0144|FD-Score:5.71|P-value:1.30E-5 ID:SGTC_401|Compound:neomycin|FD-Score:4.99|P-value:1.19E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:15.10|P-value:3.20E-29 ID:SGTC_452|Compound:diindolylmethane|FD-Score:5.30|P-value:4.68E-5 ID:SGTC_455|Compound:paf C-16|FD-Score:-4.24|P-value:7.96E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:-4.39|P-value:5.44E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:6.37|P-value:1.35E-6 ID:SGTC_562|Compound:3772-2733|FD-Score:7.64|P-value:8.60E-9 ID:SGTC_568|Compound:1193-0097|FD-Score:6.89|P-value:1.88E-7 ID:SGTC_575|Compound:k072-0246|FD-Score:5.52|P-value:2.37E-5 ID:SGTC_637|Compound:1181-0519|FD-Score:8.83|P-value:3.56E-11 ID:SGTC_642|Compound:0335-0876|FD-Score:4.31|P-value:7.64E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:4.71|P-value:2.60E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:4.53|P-value:4.33E-4 ID:SGTC_661|Compound:1304-0007|FD-Score:7.81|P-value:4.12E-9 ID:SGTC_697|Compound:0508-1955|FD-Score:4.79|P-value:2.10E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:10.10|P-value:3.43E-14 ID:SGTC_738|Compound:1315-0003|FD-Score:-6.29|P-value:1.48E-6 ID:SGTC_768|Compound:0384-0033|FD-Score:5.17|P-value:6.94E-5 ID:SGTC_787|Compound:4152-0075|FD-Score:4.63|P-value:3.26E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:7.74|P-value:5.69E-9 ID:SGTC_805|Compound:3852-0218|FD-Score:4.34|P-value:7.07E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:7.43|P-value:2.10E-8 ID:SGTC_837|Compound:0091-0265|FD-Score:7.45|P-value:1.96E-8 ID:SGTC_846|Compound:0335-0850|FD-Score:8.04|P-value:1.49E-9 ID:SGTC_852|Compound:0418-0143|FD-Score:4.94|P-value:1.37E-4 ID:SGTC_858|Compound:0438-0351|FD-Score:4.27|P-value:8.35E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:-4.49|P-value:4.22E-4 ID:SGTC_862|Compound:0452-0056|FD-Score:-4.48|P-value:4.36E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:7.33|P-value:3.24E-8 ID:SGTC_869|Compound:0564-0080|FD-Score:7.00|P-value:1.21E-7 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:4.97|P-value:1.25E-4 ID:SGTC_929|Compound:2805-0021|FD-Score:4.91|P-value:1.52E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:6.51|P-value:7.86E-7 ID:SGTC_1022|Compound:4477-0945|FD-Score:6.81|P-value:2.53E-7 ID:SGTC_1064|Compound:honokiol|FD-Score:6.20|P-value:2.48E-6 ID:SGTC_1067|Compound:clotrimazole|FD-Score:4.39|P-value:6.11E-4 ID:SGTC_1076|Compound:itraconazole|FD-Score:5.34|P-value:4.21E-5 ID:SGTC_1088|Compound:bifonazole|FD-Score:4.88|P-value:1.61E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:6.07|P-value:3.80E-6 ID:SGTC_1191|Compound:1487-1166|FD-Score:4.86|P-value:1.73E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:6.79|P-value:2.78E-7 ID:SGTC_1475|Compound:4092-1048|FD-Score:4.55|P-value:4.04E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:4.67|P-value:2.95E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:10.40|P-value:7.05E-15 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:4.48|P-value:4.82E-4 ID:SGTC_1617|Compound:st002906|FD-Score:-4.19|P-value:9.14E-4 ID:SGTC_1619|Compound:st003326|FD-Score:-4.17|P-value:9.57E-4 ID:SGTC_1629|Compound:st005085|FD-Score:6.52|P-value:7.60E-7 ID:SGTC_1648|Compound:st011736|FD-Score:4.40|P-value:5.96E-4 ID:SGTC_1651|Compound:st011928|FD-Score:4.38|P-value:6.35E-4 ID:SGTC_1672|Compound:st016598|FD-Score:6.60|P-value:5.79E-7 ID:SGTC_1715|Compound:st032160|FD-Score:5.25|P-value:5.43E-5 ID:SGTC_1720|Compound:st037298|FD-Score:5.06|P-value:9.80E-5 ID:SGTC_1732|Compound:st034308|FD-Score:5.01|P-value:1.11E-4 ID:SGTC_1734|Compound:st037168|FD-Score:-4.19|P-value:9.21E-4 ID:SGTC_1750|Compound:st081859|FD-Score:9.37|P-value:2.33E-12 ID:SGTC_1872|Compound:amphotericin b|FD-Score:5.01|P-value:1.14E-4 ID:SGTC_1895|Compound:st058434|FD-Score:6.23|P-value:2.21E-6 ID:SGTC_1925|Compound:st057770|FD-Score:4.91|P-value:1.51E-4 ID:SGTC_1937|Compound:st074714|FD-Score:4.74|P-value:2.41E-4 ID:SGTC_1953|Compound:st076800|FD-Score:5.23|P-value:5.84E-5 ID:SGTC_2025|Compound:5147754|FD-Score:4.36|P-value:6.69E-4 ID:SGTC_2036|Compound:5160441|FD-Score:11.60|P-value:4.17E-18 ID:SGTC_2038|Compound:4100038|FD-Score:7.63|P-value:9.04E-9 ID:SGTC_2111|Compound:5486399|FD-Score:4.45|P-value:5.34E-4 ID:SGTC_2157|Compound:5649910|FD-Score:5.05|P-value:9.91E-5 ID:SGTC_2181|Compound:6316240|FD-Score:8.24|P-value:5.92E-10 ID:SGTC_2183|Compound:6420625|FD-Score:7.95|P-value:2.29E-9 ID:SGTC_2197|Compound:6588183|FD-Score:7.31|P-value:3.54E-8 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:6.19|P-value:2.54E-6 ID:SGTC_2302|Compound:7771753|FD-Score:6.17|P-value:2.67E-6 ID:SGTC_2322|Compound:7413319|FD-Score:5.00|P-value:1.16E-4 ID:SGTC_2372|Compound:9071633|FD-Score:4.34|P-value:7.07E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:4.58|P-value:3.72E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:7.37|P-value:2.73E-8 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:4.83|P-value:1.86E-4 ID:SGTC_2526|Compound:patulin|FD-Score:-4.68|P-value:2.52E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:5.02|P-value:1.10E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:5.86|P-value:7.73E-6 ID:SGTC_2645|Compound:abamectin|FD-Score:6.45|P-value:1.01E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:13.60|P-value:6.48E-24 ID:SGTC_2659|Compound:sanguinarine|FD-Score:4.67|P-value:2.95E-4 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:6.45|P-value:9.82E-7 ID:SGTC_2757|Compound:clomiphene|FD-Score:4.98|P-value:1.21E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:4.48|P-value:4.92E-4 ID:SGTC_2918|Compound:7977171|FD-Score:7.82|P-value:3.93E-9 ID:SGTC_3059|Compound:1327-0034|FD-Score:5.18|P-value:6.75E-5 ID:SGTC_3081|Compound:9117243|FD-Score:4.83|P-value:1.90E-4 ID:SGTC_3103|Compound:9120822|FD-Score:6.09|P-value:3.64E-6 ID:SGTC_3188|Compound:9110789|FD-Score:4.35|P-value:6.90E-4 ID:SGTC_3214|Compound:9129694|FD-Score:4.45|P-value:5.26E-4 ID:SGTC_3272|Compound:9137413|FD-Score:4.91|P-value:1.49E-4 ID:SGTC_3279|Compound:9140807|FD-Score:8.66|P-value:8.33E-11 ID:SGTC_3303|Compound:9125618|FD-Score:5.18|P-value:6.72E-5 ID:SGTC_3324|Compound:9138759|FD-Score:4.94|P-value:1.37E-4

Top fitness defect scores for YBR106W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_450 aminopyrene 15.10 156.0 nM 3.20E-29 1 7.24E-52
2 SGTC_2651 1327-0036 13.60 5.0 µM 6.48E-24 11 3.41E-42
3 SGTC_64 000l-0018 13.30 272.1 µM 4.48E-23 ubiquinone biosynthesis & proteasome 25 1.16E-40
4 SGTC_2036 5160441 11.60 105.0 µM 4.17E-18 NEO1 14 1.29E-31
5 SGTC_67 0335-0847 10.80 266.0 µM 6.90E-16 ubiquinone biosynthesis & proteasome 16 1.40E-27
6 SGTC_315 k915-0449 10.70 187.0 µM 1.15E-15 7 3.56E-27
7 SGTC_1585 2',4'-dihydroxychalcone 10.40 10.4 µM 7.05E-15 2 9.58E-26
8 SGTC_192 3455-0609 10.20 60.9 µM 2.18E-14 1 7.48E-25
9 SGTC_733 4069-0007 10.10 56.1 µM 3.43E-14 ERAD & cell cycle 14 1.70E-24
10 SGTC_1750 st081859 9.37 2.4 µM 2.33E-12 endomembrane recycling 48 3.61E-21
11 SGTC_637 1181-0519 8.83 7.3 µM 3.56E-11 fatty acid desaturase (OLE1) 27 5.09E-19
12 SGTC_3279 9140807 8.66 49.5 µM 8.33E-11 2 2.38E-18
13 SGTC_2181 6316240 8.24 54.3 µM 5.92E-10 1 8.30E-17
14 SGTC_846 0335-0850 8.04 148.0 µM 1.49E-9 ubiquinone biosynthesis & proteasome 8 4.44E-16
15 SGTC_352 k048-0007 8.01 5.1 µM 1.75E-9 ERAD & cell cycle 17 5.95E-16
16 SGTC_2183 6420625 7.95 130.5 µM 2.29E-9 mitochondrial processes 7 9.65E-16
17 SGTC_158 k038-0087 7.87 26.4 µM 3.25E-9 ubiquinone biosynthesis & proteasome 51 1.82E-15
18 SGTC_2918 7977171 7.82 22.1 µM 3.93E-9 4 2.56E-15
19 SGTC_661 1304-0007 7.81 33.6 µM 4.12E-9 1 2.78E-15
20 SGTC_366 0181-0206 7.81 4.3 µM 4.16E-9 Golgi 3 2.84E-15

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.378 7.07E-114 YDL020C RPN4 hom Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress
0.345 3.05E-94 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.291 2.27E-66 YMR067C UBX4 hom UBX domain-containing protein that interacts with Cdc48p; involved in degradation of polyubiquitinated proteins via the ERAD (ER-associated degradation) pathway; modulates the Cdc48p-Nplp-Ufd1p AAA ATPase complex during its role in delivery of misfolded proteins to the proteasome; protein abundance increases in response to DNA replication stress
0.253 3.29E-50 YMR264W CUE1 hom Ubiquitin-binding protein; endoplasmic reticulum membrane protein that recruits the ubiquitin-conjugating enzyme Ubc7p to the ER where it functions in protein degradation; contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination; CUE1 has a paralog, CUE4, that arose from the whole genome duplication
0.242 5.74E-46 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.241 1.85E-45 YER019C-A SBH2 hom Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
0.236 1.18E-43 YML014W TRM9 hom tRNA methyltransferase; catalyzes modification of wobble bases in tRNA anticodons to 2, 5-methoxycarbonylmethyluridine and 5-methoxycarbonylmethyl-2-thiouridine; may act as part of a complex with Trm112p; deletion mutation increases translational infidelity, including amino acid misincorporation and -1 frameshifting, and also confers resistance to zymocin; null mutant displays activation of stress responses
0.230 1.79E-41 YIL030C SSM4 hom Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.229 4.02E-41 YJL168C SET2 hom Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
0.227 1.58E-40 YLR378C SEC61 het Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER
0.227 2.24E-40 YFR007W YFH7 hom Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases
0.227 2.16E-40 YDR537C_d YDR537C_d hom Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W
0.224 1.58E-39 YER041W YEN1 hom Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.222 1.32E-38 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.221 2.04E-38 YML034W SRC1 hom Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance