YBR107C / IML3

Outer kinetochore protein and component of the Ctf19 complex; involved in the establishment of pericentromeric cohesion during mitosis; prevents non-disjunction of sister chromatids during meiosis II; required for localization of Sgo1p to pericentric sites during meiosis I; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-L and fission yeast fta1

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR107C / IML3

Click on Significant Values for Screen Details ID:SGTC_206|Compound:4546-0025|FD-Score:3.74|P-value:2.71E-5 ID:SGTC_285|Compound:1486-1325|FD-Score:3.56|P-value:6.04E-5 ID:SGTC_287|Compound:k060-0039|FD-Score:-3.36|P-value:1.38E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:4.14|P-value:3.87E-6 ID:SGTC_304|Compound:1310-0298|FD-Score:3.20|P-value:2.77E-4 ID:SGTC_305|Compound:1682-2595|FD-Score:3.68|P-value:3.59E-5 ID:SGTC_379|Compound:3970-0972|FD-Score:3.29|P-value:1.89E-4 ID:SGTC_643|Compound:k048-0106|FD-Score:3.39|P-value:1.25E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:3.68|P-value:3.45E-5 ID:SGTC_873|Compound:0591-4978|FD-Score:3.17|P-value:3.04E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:5.84|P-value:1.40E-10 ID:SGTC_931|Compound:2812-0076|FD-Score:-4.17|P-value:3.13E-6 ID:SGTC_932|Compound:2857-0803|FD-Score:3.88|P-value:1.37E-5 ID:SGTC_972|Compound:1319-0219|FD-Score:3.23|P-value:2.43E-4 ID:SGTC_982|Compound:1491-0518|FD-Score:-3.22|P-value:2.46E-4 ID:SGTC_987|Compound:1497-1013|FD-Score:3.43|P-value:1.06E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.10|P-value:4.06E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:3.49|P-value:8.12E-5 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.81|P-value:1.91E-5 ID:SGTC_1382|Compound:3002-2117|FD-Score:5.12|P-value:1.60E-8 ID:SGTC_1391|Compound:3442-0225|FD-Score:-3.11|P-value:3.80E-4 ID:SGTC_1397|Compound:3532-0190|FD-Score:3.41|P-value:1.14E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:5.33|P-value:4.24E-9 ID:SGTC_1484|Compound:3473-2379|FD-Score:-3.15|P-value:3.16E-4 ID:SGTC_1501|Compound:4491-0275|FD-Score:3.49|P-value:8.02E-5 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:2.97|P-value:6.79E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:-2.90|P-value:8.22E-4 ID:SGTC_1626|Compound:st003712|FD-Score:3.13|P-value:3.59E-4 ID:SGTC_1865|Compound:st057639|FD-Score:-2.96|P-value:6.57E-4 ID:SGTC_1944|Compound:st076371|FD-Score:2.87|P-value:9.61E-4 ID:SGTC_2289|Compound:7946404|FD-Score:3.01|P-value:5.86E-4 ID:SGTC_2290|Compound:7904846|FD-Score:2.94|P-value:7.58E-4 ID:SGTC_2337|Compound:9009472|FD-Score:4.41|P-value:9.29E-7 ID:SGTC_2435|Compound:5706476|FD-Score:3.13|P-value:3.69E-4 ID:SGTC_2446|Compound:5162541|FD-Score:-3.15|P-value:3.25E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:3.42|P-value:1.11E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:3.28|P-value:2.00E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.28|P-value:2.01E-4 ID:SGTC_2694|Compound:st077685|FD-Score:-3.61|P-value:4.63E-5 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.32|P-value:1.69E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.74|P-value:2.67E-5 ID:SGTC_2820|Compound:7989630|FD-Score:2.97|P-value:6.76E-4 ID:SGTC_2829|Compound:7992743|FD-Score:3.03|P-value:5.31E-4 ID:SGTC_2933|Compound:9026794|FD-Score:3.78|P-value:2.24E-5 ID:SGTC_3069|Compound:9117009|FD-Score:2.92|P-value:8.00E-4 ID:SGTC_3155|Compound:9099265|FD-Score:3.21|P-value:2.65E-4 ID:SGTC_3162|Compound:9099653|FD-Score:2.94|P-value:7.40E-4 ID:SGTC_3274|Compound:9138298|FD-Score:2.99|P-value:6.29E-4 ID:SGTC_3327|Compound:9140648|FD-Score:6.15|P-value:1.54E-11 ID:SGTC_3336|Compound:9143619|FD-Score:2.93|P-value:7.84E-4 ID:SGTC_3347|Compound:9188721|FD-Score:3.86|P-value:1.54E-5 ID:SGTC_206|Compound:4546-0025|FD-Score:3.74|P-value:2.71E-5 ID:SGTC_285|Compound:1486-1325|FD-Score:3.56|P-value:6.04E-5 ID:SGTC_287|Compound:k060-0039|FD-Score:-3.36|P-value:1.38E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:4.14|P-value:3.87E-6 ID:SGTC_304|Compound:1310-0298|FD-Score:3.20|P-value:2.77E-4 ID:SGTC_305|Compound:1682-2595|FD-Score:3.68|P-value:3.59E-5 ID:SGTC_379|Compound:3970-0972|FD-Score:3.29|P-value:1.89E-4 ID:SGTC_643|Compound:k048-0106|FD-Score:3.39|P-value:1.25E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:3.68|P-value:3.45E-5 ID:SGTC_873|Compound:0591-4978|FD-Score:3.17|P-value:3.04E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:5.84|P-value:1.40E-10 ID:SGTC_931|Compound:2812-0076|FD-Score:-4.17|P-value:3.13E-6 ID:SGTC_932|Compound:2857-0803|FD-Score:3.88|P-value:1.37E-5 ID:SGTC_972|Compound:1319-0219|FD-Score:3.23|P-value:2.43E-4 ID:SGTC_982|Compound:1491-0518|FD-Score:-3.22|P-value:2.46E-4 ID:SGTC_987|Compound:1497-1013|FD-Score:3.43|P-value:1.06E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.10|P-value:4.06E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:3.49|P-value:8.12E-5 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.81|P-value:1.91E-5 ID:SGTC_1382|Compound:3002-2117|FD-Score:5.12|P-value:1.60E-8 ID:SGTC_1391|Compound:3442-0225|FD-Score:-3.11|P-value:3.80E-4 ID:SGTC_1397|Compound:3532-0190|FD-Score:3.41|P-value:1.14E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:5.33|P-value:4.24E-9 ID:SGTC_1484|Compound:3473-2379|FD-Score:-3.15|P-value:3.16E-4 ID:SGTC_1501|Compound:4491-0275|FD-Score:3.49|P-value:8.02E-5 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:2.97|P-value:6.79E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:-2.90|P-value:8.22E-4 ID:SGTC_1626|Compound:st003712|FD-Score:3.13|P-value:3.59E-4 ID:SGTC_1865|Compound:st057639|FD-Score:-2.96|P-value:6.57E-4 ID:SGTC_1944|Compound:st076371|FD-Score:2.87|P-value:9.61E-4 ID:SGTC_2289|Compound:7946404|FD-Score:3.01|P-value:5.86E-4 ID:SGTC_2290|Compound:7904846|FD-Score:2.94|P-value:7.58E-4 ID:SGTC_2337|Compound:9009472|FD-Score:4.41|P-value:9.29E-7 ID:SGTC_2435|Compound:5706476|FD-Score:3.13|P-value:3.69E-4 ID:SGTC_2446|Compound:5162541|FD-Score:-3.15|P-value:3.25E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:3.42|P-value:1.11E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:3.28|P-value:2.00E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.28|P-value:2.01E-4 ID:SGTC_2694|Compound:st077685|FD-Score:-3.61|P-value:4.63E-5 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.32|P-value:1.69E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.74|P-value:2.67E-5 ID:SGTC_2820|Compound:7989630|FD-Score:2.97|P-value:6.76E-4 ID:SGTC_2829|Compound:7992743|FD-Score:3.03|P-value:5.31E-4 ID:SGTC_2933|Compound:9026794|FD-Score:3.78|P-value:2.24E-5 ID:SGTC_3069|Compound:9117009|FD-Score:2.92|P-value:8.00E-4 ID:SGTC_3155|Compound:9099265|FD-Score:3.21|P-value:2.65E-4 ID:SGTC_3162|Compound:9099653|FD-Score:2.94|P-value:7.40E-4 ID:SGTC_3274|Compound:9138298|FD-Score:2.99|P-value:6.29E-4 ID:SGTC_3327|Compound:9140648|FD-Score:6.15|P-value:1.54E-11 ID:SGTC_3336|Compound:9143619|FD-Score:2.93|P-value:7.84E-4 ID:SGTC_3347|Compound:9188721|FD-Score:3.86|P-value:1.54E-5

Top fitness defect scores for YBR107C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3327 9140648 6.15 26.9 µM 1.54E-11 2 3.96E-10
2 SGTC_911 3456-4043 5.84 236.0 µM 1.40E-10 mitochondrial processes 3 2.64E-9
3 SGTC_1454 4239-0054 5.33 42.6 µM 4.24E-9 6 4.93E-8
4 SGTC_1382 3002-2117 5.12 298.0 µM 1.60E-8 3 1.54E-7
5 SGTC_2337 9009472 4.41 200.0 µM 9.29E-7 20 5.08E-6
6 SGTC_302 1094-0063 4.14 18.9 µM 3.87E-6 8 1.74E-5
7 SGTC_932 2857-0803 3.88 154.0 µM 1.37E-5 27 5.15E-5
8 SGTC_3347 9188721 3.86 44.7 µM 1.54E-5 26 5.71E-5
9 SGTC_1367 1812-0510 3.81 76.9 µM 1.91E-5 24 6.89E-5
10 SGTC_2933 9026794 3.78 32.5 µM 2.24E-5 24 7.87E-5
11 SGTC_2794 7785382 3.74 27.3 µM 2.67E-5 44 9.17E-5
12 SGTC_206 4546-0025 3.74 72.0 µM 2.71E-5 NEO1 83 9.29E-5
13 SGTC_673 1082-0474 3.68 110.0 µM 3.45E-5 RSC complex & mRNA processing 73 1.15E-4
14 SGTC_305 1682-2595 3.68 20.8 µM 3.59E-5 RNA processing & uracil transport 31 1.19E-4
15 SGTC_285 1486-1325 3.56 46.0 µM 6.04E-5 26 1.86E-4
16 SGTC_1501 4491-0275 3.49 38.4 µM 8.02E-5 20 2.37E-4
17 SGTC_1277 0873-0036 3.49 22.0 µM 8.12E-5 PDR1 40 2.40E-4
18 SGTC_987 1497-1013 3.43 404.0 µM 1.06E-4 20 3.01E-4
19 SGTC_2619 obliquin 3.42 87.9 µM 1.11E-4 cell wall 181 3.13E-4
20 SGTC_1397 3532-0190 3.41 20.1 µM 1.14E-4 13 3.22E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.139 7.20E-16 YJL159W HSP150 hom O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication
0.101 4.19E-9 YDR210W_p YDR210W_p hom Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.099 8.85E-9 YKL220C FRE2 hom Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels
0.097 1.68E-8 YFL037W TUB2 het Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
0.097 2.04E-8 YJL019W MPS3 het Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p
0.093 6.86E-8 YOR374W ALD4 hom Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed
0.091 1.46E-7 YHR013C ARD1 hom Subunit of protein N-terminal acetyltransferase NatA; NatA is comprised of Nat1p, Ard1p, and Nat5p; acetylates many proteins and thus affects telomeric silencing, cell cycle, heat-shock resistance, mating, and sporulation; human Ard1p levels are elevated in cancer cells; protein abundance increases in response to DNA replication stress
0.087 4.01E-7 YNR039C ZRG17 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Msc2p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; zinc-regulated directly through Zap1p; transcription induced under conditions of zinc deficiency
0.085 8.71E-7 YJL013C MAD3 hom Subunit of the spindle-assembly checkpoint complex, which delays anaphase onset in cells with defects in mitotic spindle assembly; pseudosubstrate inhibitor of APC(Cdc20), the anaphase promoting complex involved in securin (Pds1p) turnover
0.083 1.64E-6 YER022W SRB4 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; homozygosity of the human MED17 L371P mutation is associated with infantile cerebral and cerebellar atrophy with poor myelination
0.082 2.09E-6 YHR047C AAP1 hom Arginine/alanine amino peptidase; overproduction stimulates glycogen accumulation; AAP1 has a paralog, APE2, that arose from the whole genome duplication
0.082 2.23E-6 YEL066W HPA3 hom D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitro
0.080 3.20E-6 YDR088C SLU7 het RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain
0.080 3.26E-6 YMR132C_p JLP2_p hom Protein of unknown function, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein)
0.079 4.86E-6 YGR232W NAS6 hom Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); ortholog of human oncoprotein gankyrin, which interacts with the Rb tumor suppressor and CDK4/6