YBR108W / AIM3

Protein interacting with Rvs167p; null mutant is viable and displays elevated frequency of mitochondrial genome loss

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR108W / AIM3

Click on Significant Values for Screen Details ID:SGTC_43|Compound:0570-0105|FD-Score:3.68|P-value:5.15E-5 ID:SGTC_65|Compound:0798-0905|FD-Score:6.04|P-value:8.52E-11 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.00|P-value:6.61E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:-3.09|P-value:4.74E-4 ID:SGTC_295|Compound:k015-0027|FD-Score:-3.03|P-value:6.03E-4 ID:SGTC_477|Compound:mead ethanolamide|FD-Score:3.03|P-value:7.12E-4 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:3.23|P-value:3.34E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:3.46|P-value:1.34E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:3.26|P-value:2.97E-4 ID:SGTC_735|Compound:3076-0345|FD-Score:3.56|P-value:8.88E-5 ID:SGTC_746|Compound:1095-0025|FD-Score:3.25|P-value:3.13E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:4.27|P-value:3.29E-6 ID:SGTC_805|Compound:3852-0218|FD-Score:3.40|P-value:1.72E-4 ID:SGTC_819|Compound:1013-0258|FD-Score:2.97|P-value:8.71E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:3.52|P-value:1.05E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:-3.31|P-value:2.02E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:3.70|P-value:4.76E-5 ID:SGTC_973|Compound:1325-0077|FD-Score:4.22|P-value:4.25E-6 ID:SGTC_1062|Compound:mesoridazine|FD-Score:3.08|P-value:5.95E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:3.08|P-value:5.91E-4 ID:SGTC_1730|Compound:st033808|FD-Score:3.26|P-value:2.97E-4 ID:SGTC_1733|Compound:st037357|FD-Score:-3.78|P-value:2.75E-5 ID:SGTC_1737|Compound:st035557|FD-Score:-4.09|P-value:6.43E-6 ID:SGTC_1778|Compound:st046819|FD-Score:-2.93|P-value:8.60E-4 ID:SGTC_1804|Compound:st050076|FD-Score:-2.90|P-value:9.49E-4 ID:SGTC_1855|Compound:st056195|FD-Score:3.79|P-value:3.18E-5 ID:SGTC_2104|Compound:5389443|FD-Score:3.84|P-value:2.52E-5 ID:SGTC_2158|Compound:5657123|FD-Score:3.06|P-value:6.45E-4 ID:SGTC_2260|Compound:7964312|FD-Score:3.36|P-value:2.03E-4 ID:SGTC_2318|Compound:6029776|FD-Score:-3.03|P-value:6.05E-4 ID:SGTC_2371|Compound:9071574|FD-Score:3.54|P-value:9.66E-5 ID:SGTC_2374|Compound:9071832|FD-Score:3.47|P-value:1.29E-4 ID:SGTC_2485|Compound:5633444|FD-Score:3.54|P-value:9.45E-5 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:3.01|P-value:7.72E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.22|P-value:3.55E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.98|P-value:7.33E-8 ID:SGTC_2834|Compound:9001755|FD-Score:3.24|P-value:3.23E-4 ID:SGTC_2994|Compound:9053520|FD-Score:-3.51|P-value:8.81E-5 ID:SGTC_2998|Compound:9066762|FD-Score:-3.03|P-value:5.90E-4 ID:SGTC_3084|Compound:9116877|FD-Score:-2.92|P-value:8.82E-4 ID:SGTC_3108|Compound:9121785|FD-Score:2.98|P-value:8.65E-4 ID:SGTC_3133|Compound:9127736|FD-Score:-3.14|P-value:3.92E-4 ID:SGTC_3140|Compound:9094243|FD-Score:-3.79|P-value:2.64E-5 ID:SGTC_3165|Compound:9101544|FD-Score:3.09|P-value:5.76E-4 ID:SGTC_3217|Compound:9129673|FD-Score:3.70|P-value:4.89E-5 ID:SGTC_3268|Compound:9137683|FD-Score:3.30|P-value:2.55E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:3.68|P-value:5.15E-5 ID:SGTC_65|Compound:0798-0905|FD-Score:6.04|P-value:8.52E-11 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.00|P-value:6.61E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:-3.09|P-value:4.74E-4 ID:SGTC_295|Compound:k015-0027|FD-Score:-3.03|P-value:6.03E-4 ID:SGTC_477|Compound:mead ethanolamide|FD-Score:3.03|P-value:7.12E-4 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:3.23|P-value:3.34E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:3.46|P-value:1.34E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:3.26|P-value:2.97E-4 ID:SGTC_735|Compound:3076-0345|FD-Score:3.56|P-value:8.88E-5 ID:SGTC_746|Compound:1095-0025|FD-Score:3.25|P-value:3.13E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:4.27|P-value:3.29E-6 ID:SGTC_805|Compound:3852-0218|FD-Score:3.40|P-value:1.72E-4 ID:SGTC_819|Compound:1013-0258|FD-Score:2.97|P-value:8.71E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:3.52|P-value:1.05E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:-3.31|P-value:2.02E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:3.70|P-value:4.76E-5 ID:SGTC_973|Compound:1325-0077|FD-Score:4.22|P-value:4.25E-6 ID:SGTC_1062|Compound:mesoridazine|FD-Score:3.08|P-value:5.95E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:3.08|P-value:5.91E-4 ID:SGTC_1730|Compound:st033808|FD-Score:3.26|P-value:2.97E-4 ID:SGTC_1733|Compound:st037357|FD-Score:-3.78|P-value:2.75E-5 ID:SGTC_1737|Compound:st035557|FD-Score:-4.09|P-value:6.43E-6 ID:SGTC_1778|Compound:st046819|FD-Score:-2.93|P-value:8.60E-4 ID:SGTC_1804|Compound:st050076|FD-Score:-2.90|P-value:9.49E-4 ID:SGTC_1855|Compound:st056195|FD-Score:3.79|P-value:3.18E-5 ID:SGTC_2104|Compound:5389443|FD-Score:3.84|P-value:2.52E-5 ID:SGTC_2158|Compound:5657123|FD-Score:3.06|P-value:6.45E-4 ID:SGTC_2260|Compound:7964312|FD-Score:3.36|P-value:2.03E-4 ID:SGTC_2318|Compound:6029776|FD-Score:-3.03|P-value:6.05E-4 ID:SGTC_2371|Compound:9071574|FD-Score:3.54|P-value:9.66E-5 ID:SGTC_2374|Compound:9071832|FD-Score:3.47|P-value:1.29E-4 ID:SGTC_2485|Compound:5633444|FD-Score:3.54|P-value:9.45E-5 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:3.01|P-value:7.72E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.22|P-value:3.55E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.98|P-value:7.33E-8 ID:SGTC_2834|Compound:9001755|FD-Score:3.24|P-value:3.23E-4 ID:SGTC_2994|Compound:9053520|FD-Score:-3.51|P-value:8.81E-5 ID:SGTC_2998|Compound:9066762|FD-Score:-3.03|P-value:5.90E-4 ID:SGTC_3084|Compound:9116877|FD-Score:-2.92|P-value:8.82E-4 ID:SGTC_3108|Compound:9121785|FD-Score:2.98|P-value:8.65E-4 ID:SGTC_3133|Compound:9127736|FD-Score:-3.14|P-value:3.92E-4 ID:SGTC_3140|Compound:9094243|FD-Score:-3.79|P-value:2.64E-5 ID:SGTC_3165|Compound:9101544|FD-Score:3.09|P-value:5.76E-4 ID:SGTC_3217|Compound:9129673|FD-Score:3.70|P-value:4.89E-5 ID:SGTC_3268|Compound:9137683|FD-Score:3.30|P-value:2.55E-4

Top fitness defect scores for YBR108W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_65 0798-0905 6.04 35.0 µM 8.52E-11 calcium & mitochondrial duress 31 7.58E-10
2 SGTC_2582 agaric acid 4.98 100.0 µM 7.33E-8 redox potentiating 222 3.20E-7
3 SGTC_749 1000-0129 4.27 128.0 µM 3.29E-6 amide catabolism 13 9.70E-6
4 SGTC_973 1325-0077 4.22 65.9 µM 4.25E-6 5 1.22E-5
5 SGTC_2104 5389443 3.84 200.0 µM 2.52E-5 18 6.03E-5
6 SGTC_1855 st056195 3.79 39.6 µM 3.18E-5 60S ribosome export 22 7.44E-5
7 SGTC_970 1315-0089 3.70 19.5 µM 4.76E-5 RSC & ERG11 30 1.07E-4
8 SGTC_3217 9129673 3.70 49.5 µM 4.89E-5 49 1.10E-4
9 SGTC_43 0570-0105 3.68 72.5 µM 5.15E-5 ERG2 113 1.15E-4
10 SGTC_735 3076-0345 3.56 636.0 µM 8.88E-5 39 1.87E-4
11 SGTC_2485 5633444 3.54 17.8 µM 9.45E-5 redox potentiating 63 1.98E-4
12 SGTC_2371 9071574 3.54 200.0 µM 9.66E-5 19 2.02E-4
13 SGTC_911 3456-4043 3.52 236.0 µM 1.05E-4 mitochondrial processes 40 2.18E-4
14 SGTC_2374 9071832 3.47 200.0 µM 1.29E-4 endomembrane recycling 16 2.61E-4
15 SGTC_602 3130-1533 3.46 38.1 µM 1.34E-4 32 2.71E-4
16 SGTC_805 3852-0218 3.40 479.0 µM 1.72E-4 ERAD & cell cycle 93 3.40E-4
17 SGTC_2260 7964312 3.36 200.0 µM 2.03E-4 27 3.95E-4
18 SGTC_3268 9137683 3.30 49.5 µM 2.55E-4 21 4.84E-4
19 SGTC_1730 st033808 3.26 45.1 µM 2.97E-4 73 5.55E-4
20 SGTC_676 falcarinol 3.26 140.0 µM 2.97E-4 85 5.56E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.208 3.70E-34 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.178 3.20E-25 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.172 1.09E-23 YNL105W_d RRT16_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription
0.160 9.11E-21 YJR099W YUH1 hom Ubiquitin C-terminal hydrolase that cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1p
0.155 1.85E-19 YBR156C SLI15 hom Subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly
0.153 4.46E-19 YDR117C TMA64 hom Protein of unknown function that associates with ribosomes; has a putative RNA binding domain; in mammals the corresponding protein, eIF2D, has been shown to possess translation initiation factor activity
0.152 6.46E-19 YCR088W ABP1 hom Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization; phosphorylation within its PRR (Proline-Rich Region), mediated by Cdc28p and Pho85p, protects Abp1p from proteolysis mediated by its own PEST sequences
0.145 3.54E-17 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.140 3.39E-16 YBR169C SSE2 hom Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication
0.139 6.58E-16 YHL006C SHU1 hom Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function
0.139 6.62E-16 YOR049C RSB1 hom Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.139 7.25E-16 YJL187C SWE1 hom Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate
0.138 1.07E-15 YLL046C RNP1 hom Ribonucleoprotein that contains two RNA recognition motifs (RRM)
0.136 2.79E-15 YOR320C GNT1 hom N-acetylglucosaminyltransferase capable of modification of N-linked glycans in the Golgi apparatus
0.134 7.48E-15 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants