Protein interacting with Rvs167p; null mutant is viable and displays elevated frequency of mitochondrial genome loss
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YBR108W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.208 | 3.70E-34 | YGR217W | CCH1 | hom | Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together |
0.178 | 3.20E-25 | YNL106C | INP52 | hom | Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain |
0.172 | 1.09E-23 | YNL105W_d | RRT16_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription |
0.160 | 9.11E-21 | YJR099W | YUH1 | hom | Ubiquitin C-terminal hydrolase that cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1p |
0.155 | 1.85E-19 | YBR156C | SLI15 | hom | Subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly |
0.153 | 4.46E-19 | YDR117C | TMA64 | hom | Protein of unknown function that associates with ribosomes; has a putative RNA binding domain; in mammals the corresponding protein, eIF2D, has been shown to possess translation initiation factor activity |
0.152 | 6.46E-19 | YCR088W | ABP1 | hom | Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization; phosphorylation within its PRR (Proline-Rich Region), mediated by Cdc28p and Pho85p, protects Abp1p from proteolysis mediated by its own PEST sequences |
0.145 | 3.54E-17 | YNL027W | CRZ1 | hom | Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress |
0.140 | 3.39E-16 | YBR169C | SSE2 | hom | Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication |
0.139 | 6.58E-16 | YHL006C | SHU1 | hom | Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function |
0.139 | 6.62E-16 | YOR049C | RSB1 | hom | Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane |
0.139 | 7.25E-16 | YJL187C | SWE1 | hom | Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate |
0.138 | 1.07E-15 | YLL046C | RNP1 | hom | Ribonucleoprotein that contains two RNA recognition motifs (RRM) |
0.136 | 2.79E-15 | YOR320C | GNT1 | hom | N-acetylglucosaminyltransferase capable of modification of N-linked glycans in the Golgi apparatus |
0.134 | 7.48E-15 | YML052W | SUR7 | hom | Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants |